21st Century Innovative Technologies and Developments as also discoveries, curiosity ( insolite)...

Digestion problems such as constipation or difficulty swallowing can double the chance of Parkinson’s disease, according to research.

The origins of Alzheimer’s disease, strokes and brain aneurysms have been linked to the gastrointestinal tract. While there is evidence that Parkinson’s could also begin in the gut, there have been few studies of its relationship to particular digestive disorders.

Now a study has established that four gut conditions could be an early warning sign of Parkinson’s disease. It “is the first to establish substantial observational evidence” that a clinical diagnosis of gut issues “might specifically predict the development of Parkinson’s disease”, the authors conclude.

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Parkinson’s disease is an insidious disease: by the time it manifests as the typical motor dysfunctions such as tremors or muscle rigidity, portions of the brain have already been irreversibly destroyed. By this stage, the disease will have often begun already decades earlier.

In search of an early portent of the disease, researchers led by Prof. Paul Wilmes, head of the Eco-Systems Biology Group at the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg, may now have found one in the gut: they have shown that the bacterial community in the gut of Parkinson’s patients differs from that of healthy people even at a very early stage of the disease. The researchers present their results in the scientific journal “Movement Disorders”.

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http://www.scoop.it/t/luxembourg-europe/?&tag=University+Luxembourg

Et ginn nei Erkenntnisser, wat d'Parkinson-Krankheet ubelaangt. En Duerchbroch fir d'Fuerscher vum "Luxembourg Center for Systems Biomedicine".

Um Ursprong steet en eenzegaartege Prozess: D'Fuersche mat gespenten Hautzelle vu Lëtzebuerger Patienten. De Schlëssel zum Erfolleg läit an der Zesummenaarbecht vum "Luxembourg Center for Systems Biomedicine" mat der Parkinson Research Clinic, der Biobank an dem Fond National de la Recherche. Wärend 7 Joer huet d'Team vum LCSB zesumme mat internationale Kolleege geschafft.  "Eng ganz seele Mutatioun, déi um Ursprong vu Parkinson ass, konnt net just identifizéiert ginn. Ma och d'Manéier, wéi déi Mutatioun derzou bäidréit, dat de Patient krank gëtt, konnt entschlësselt ginn", sou den Dokter Ibrahim Boussaad vum Luxembourg Centre for Systems Biomedicine.

D'Fuerscher ronderëm de Prof. Dr. Rejko Krüger hunn deemno an den Zelle vun engem Patient Substanzen entdeckt, mat deenen et méiglech gëtt, op d'mannst zum Deel, d'Parkinson-Krankheet ze heelen. Klinesch Tester um Mënsch, wat e Medikament ubelaangt, gouf et bis elo nach keng. Just a Kulturen am Labo.

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La maladie de Parkinson est associée à des défauts des mitochondries. Or, une réponse immunitaire trouvant son origine dans l’intestin pourrait empêcher le développement de la maladie...

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