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BioNTech hat einige Krebs-Impfstoffe in der Pipeline | #Research #Cancer

BioNTech hat einige Krebs-Impfstoffe in der Pipeline | #Research #Cancer | 21st Century Innovative Technologies and Developments as also discoveries, curiosity ( insolite)... | Scoop.it

Nach den Covid-19-Impfstoffen steht bei BioNTech jetzt vor allem die Entwicklung neuer Therapien gegen Krebs im Fokus."Diese Programme sind strategisch auf unsere Vision ausgerichtet, Patientinnen und Patienten mit soliden Tumoren einen bedeutenden therapeutischen Nutzen bieten zu können - unabhängig davon, ob sie sich im frühen Stadium einer Erkrankung befinden oder diese bereits vorangeschritten ist", sagte Ugur Sahin, CEO und Mitgründer von BioNTech. Man habe wesentliche Fortschritte gemacht und bereite nun den Beginn der ersten klinischen Phase-3-Studie im Bereich Onkologie vor.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Cancer

 

https://www.scoop.it/topic/21st-century-innovative-technologies-and-developments/?&tag=Research

 

Gust MEES's insight:

Nach den Covid-19-Impfstoffen steht bei BioNTech jetzt vor allem die Entwicklung neuer Therapien gegen Krebs im Fokus."Diese Programme sind strategisch auf unsere Vision ausgerichtet, Patientinnen und Patienten mit soliden Tumoren einen bedeutenden therapeutischen Nutzen bieten zu können - unabhängig davon, ob sie sich im frühen Stadium einer Erkrankung befinden oder diese bereits vorangeschritten ist", sagte Ugur Sahin, CEO und Mitgründer von BioNTech. Man habe wesentliche Fortschritte gemacht und bereite nun den Beginn der ersten klinischen Phase-3-Studie im Bereich Onkologie vor.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Cancer

 

https://www.scoop.it/topic/21st-century-innovative-technologies-and-developments/?&tag=Research

 

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Cancer-killing virus shows promise in patients | #Research #Health 

Cancer-killing virus shows promise in patients | #Research #Health  | 21st Century Innovative Technologies and Developments as also discoveries, curiosity ( insolite)... | Scoop.it

A new type of cancer therapy that uses a common virus to infect and destroy harmful cells is showing big promise in early human trials, say UK scientists.

One patient's cancer vanished, while others saw their tumours shrink.

The drug is a weakened form of the cold sore virus - herpes simplex - that has been modified to kill tumours.

Larger and longer studies will be needed, but experts say the injection might ultimately offer a lifeline to more people with advanced cancers.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Cancer

 

https://www.scoop.it/topic/21st-century-innovative-technologies-and-developments/?&tag=Research

 

Gust MEES's insight:

A new type of cancer therapy that uses a common virus to infect and destroy harmful cells is showing big promise in early human trials, say UK scientists.

One patient's cancer vanished, while others saw their tumours shrink.

The drug is a weakened form of the cold sore virus - herpes simplex - that has been modified to kill tumours.

Larger and longer studies will be needed, but experts say the injection might ultimately offer a lifeline to more people with advanced cancers.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Cancer

 

https://www.scoop.it/topic/21st-century-innovative-technologies-and-developments/?&tag=Research

 

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Wirkstoff lässt Darmkrebs komplett verschwinden - Sogar Ärzte sind überrascht - Gesundheit | #Research #Cancer #Health #Santé 

Wirkstoff lässt Darmkrebs komplett verschwinden - Sogar Ärzte sind überrascht - Gesundheit | #Research #Cancer #Health #Santé  | 21st Century Innovative Technologies and Developments as also discoveries, curiosity ( insolite)... | Scoop.it

Hoffnung für Darmkrebspatienten: Bei der Teststudie für ein Medikament gegen Darmkrebs soll die Krankheit bei allen teilnehmenden Menschen verschwunden sein. Dies habe selbst die behandelnden Ärzte überrascht, berichtet die „Daily Mail“.

Demnach wurden 18 Erkrankte mit dem Wirkstoff Dostarlimab behandelt. Ein Jahr nach der Behandlung sei der Darmkrebs aus den Körpern der Probanden verschwunden. Seine Studienergebnisse veröffentlichte das Forscherteam des New Yorker Memorial Sloan Kettering Cancer Center im „New England Journal of Medicine“.

 

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https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Cancer

 

Gust MEES's insight:

Hoffnung für Darmkrebspatienten: Bei der Teststudie für ein Medikament gegen Darmkrebs soll die Krankheit bei allen teilnehmenden Menschen verschwunden sein. Dies habe selbst die behandelnden Ärzte überrascht, berichtet die „Daily Mail“.

Demnach wurden 18 Erkrankte mit dem Wirkstoff Dostarlimab behandelt. Ein Jahr nach der Behandlung sei der Darmkrebs aus den Körpern der Probanden verschwunden. Seine Studienergebnisse veröffentlichte das Forscherteam des New Yorker Memorial Sloan Kettering Cancer Center im „New England Journal of Medicine“.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Cancer

 

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Luftqualität in Wohngebieten | Feinstaubbelastung durch Holzöfen | #Cancer 

Luftqualität in Wohngebieten | Feinstaubbelastung durch Holzöfen | #Cancer  | 21st Century Innovative Technologies and Developments as also discoveries, curiosity ( insolite)... | Scoop.it

Feinstaubbelastung durch Holzöfen: Während es sich drinnen Menschen am Kamin gemütlich machen, schädigt der Holzrauch draußen die Gesundheit.

 

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https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Cancer

 

 

Gust MEES's insight:

Feinstaubbelastung durch Holzöfen: Während es sich drinnen Menschen am Kamin gemütlich machen, schädigt der Holzrauch draußen die Gesundheit.

 

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https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Cancer

 

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Les cigarettes électroniques parfumées pourraient être mauvaises pour le coeur, surtout celles au menthol | #Research #eCigarettes #Vaping #Health #Santé #Gesundheit

Les cigarettes électroniques parfumées pourraient être mauvaises pour le coeur, surtout celles au menthol | #Research #eCigarettes #Vaping #Health #Santé #Gesundheit | 21st Century Innovative Technologies and Developments as also discoveries, curiosity ( insolite)... | Scoop.it

La cigarette électronique est devenue la principale alternative au tabac pour des millions de fumeurs dans le monde. Pourtant, elle n'en serait pas moins nocive. Selon une étude menée par des chercheurs de l'école de médecine de Stanford, le liquide qui permet d'aromatiser la vapeur des cigarettes électroniques pourrait augmenter le risque de maladies cardiovasculaires, la première cause de mortalité dans le monde, deuxième en France.

 

Les scientifiques ont étudié l'effet de ces e-liquides sur les cellules endothéliales. Ces cellules tapissent l'intérieur des vaisseaux sanguins et jouent un rôle essentiel dans la santé cardiaque et cardiovasculaire.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=eCigarettes

 

Gust MEES's insight:

La cigarette électronique est devenue la principale alternative au tabac pour des millions de fumeurs dans le monde. Pourtant, elle n'en serait pas moins nocive. Selon une étude menée par des chercheurs de l'école de médecine de Stanford, le liquide qui permet d'aromatiser la vapeur des cigarettes électroniques pourrait augmenter le risque de maladies cardiovasculaires, la première cause de mortalité dans le monde, deuxième en France.

 

Les scientifiques ont étudié l'effet de ces e-liquides sur les cellules endothéliales. Ces cellules tapissent l'intérieur des vaisseaux sanguins et jouent un rôle essentiel dans la santé cardiaque et cardiovasculaire.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=eCigarettes

 

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Israeli scientists discover how to trigger pancreatic cancer cells to self-destruct | #Research #Health

Israeli scientists discover how to trigger pancreatic cancer cells to self-destruct | #Research #Health | 21st Century Innovative Technologies and Developments as also discoveries, curiosity ( insolite)... | Scoop.it

Israeli scientists say a new study has shown that a small molecule called PJ34 has triggered the self-destruction of human pancreatic cancer cells in mice. According to the research, published in the peer-reviewed open-access biomedical journal Oncotarget, the administration of the molecule reduced the number of cancer cells in developed tumors by up to 90 percent in 30 days.

The study was led by Professor Malka Cohen-Armon and her team at Tel Aviv University’s Sackler Faculty of Medicine, in collaboration with Dr. Talia Golan and her team at the Cancer Research Center at Sheba Medical Center, and conducted with transplantations of human pancreatic cancer cells into immunocompromised mice, or xenografts.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Cancer

 

 

Gust MEES's insight:

Israeli scientists say a new study has shown that a small molecule called PJ34 has triggered the self-destruction of human pancreatic cancer cells in mice. According to the research, published in the peer-reviewed open-access biomedical journal Oncotarget, the administration of the molecule reduced the number of cancer cells in developed tumors by up to 90 percent in 30 days.

The study was led by Professor Malka Cohen-Armon and her team at Tel Aviv University’s Sackler Faculty of Medicine, in collaboration with Dr. Talia Golan and her team at the Cancer Research Center at Sheba Medical Center, and conducted with transplantations of human pancreatic cancer cells into immunocompromised mice, or xenografts.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Cancer

 

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Bursitis – Wikipedia | Studentenellenbogen („student’s elbow“) | Schleimbeutel Entzündung | #BerufsKrankheiten #ICT 

Bursitis

Klassifikation nach ICD-10 M70 Krankheiten des Weichteilgewebes im Zusammenhang mit Beanspruchung, Überbeanspruchung und Druck M70.1 Bursitis im Bereich der Hand M70.2 Bursitis olecrani M70.3 Sonstige Bursitis im Bereich des Ellenbogens M70.4 Bursitis praepatellaris M70.5 Sonstige Bursitis im Bereich des Knies M70.6 Bursitis trochanterica M70.7 Sonstige Bursitis im Bereich der Hüfte M71.1 Sonstige infektiöse Bursitis M71.4 Bursitis calcarea M71.5 Sonstige Bursitis, anderenorts nicht klassifiziert M71.9 Bursopathie, nicht näher bezeichnet- Bursitis o.n.A.

Studentenellenbogen („student’s elbow“)

 

 
Gust MEES's insight:
Studentenellenbogen („student’s elbow“)

 

 
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Zerstört multiresistente Keime: Neues Antibiotikum entdeckt

Zerstört multiresistente Keime: Neues Antibiotikum entdeckt | 21st Century Innovative Technologies and Developments as also discoveries, curiosity ( insolite)... | Scoop.it

Wie die Universität Zürich auf ihrer Homepage bekannt gibt, haben Forscher der Hochschule und der Polyphor AG ein neues Antibiotikum entdeckt, das gegen mehrere Bakterien wirksam ist und multiresistente Keime zerstören kann.

 

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https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Antibiotics

 

Gust MEES's insight:

Wie die Universität Zürich auf ihrer Homepage bekannt gibt, haben Forscher der Hochschule und der Polyphor AG ein neues Antibiotikum entdeckt, das gegen mehrere Bakterien wirksam ist und multiresistente Keime zerstören kann.

 

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https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Antibiotics

 

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More deaths reported among rising cases of lung disease cases that could be due to vaping | #Health #eCigarettes

More deaths reported among rising cases of lung disease cases that could be due to vaping | #Health #eCigarettes | 21st Century Innovative Technologies and Developments as also discoveries, curiosity ( insolite)... | Scoop.it

(CNN) US health officials announced Friday that they are now aware of at least 450 possible cases of severe lung disease that could be caused by vaping.

These cases, which have occurred in 33 states and one jurisdiction, include some cases that are still under investigation by state health officials.
A third confirmed death was also revealed in Indiana, and a fourth remains under investigation as a possible case. Two other deaths -- one in Illinois and one in Oregon -- had been previously reported.
One week ago, the US Centers for Disease Control and Prevention announced it was aware of at least 215 cases in 25 states, although that number did not include additional cases still under investigation.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=eCigarettes

 

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(CNN) US health officials announced Friday that they are now aware of at least 450 possible cases of severe lung disease that could be caused by vaping.

These cases, which have occurred in 33 states and one jurisdiction, include some cases that are still under investigation by state health officials.
A third confirmed death was also revealed in Indiana, and a fourth remains under investigation as a possible case. Two other deaths -- one in Illinois and one in Oregon -- had been previously reported.
One week ago, the US Centers for Disease Control and Prevention announced it was aware of at least 215 cases in 25 states, although that number did not include additional cases still under investigation.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=eCigarettes

 

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Darmkrebs: Immer mehr junge Menschen erkranken, dabei wäre der Schutz simpel | #Research #Cancer #Health 

Darmkrebs: Immer mehr junge Menschen erkranken, dabei wäre der Schutz simpel | #Research #Cancer #Health  | 21st Century Innovative Technologies and Developments as also discoveries, curiosity ( insolite)... | Scoop.it

Onkologen sind besorgt, weil bei den Unter-30-Jährigen die Darmkrebsfälle deutlich zunehmen. Gesündere Ernährung und mehr Bewegung von Kindheit an könnte das Risiko senken. Aber auch das familiäre Risiko müsste mehr beachtet werden – es führt häufig zu Darmkrebs in jungen Jahren.

Die meisten Krebspatienten sind bei der Diagnose jenseits der 60. Das gilt auch für Darmkrebs, die zweithäufigste Krebserkrankung in Deutschland. Die Hälfte der Patienten ist über 70, wenn sie von ihrer Erkrankung erfährt. Allerdings registrieren Onkologen in den letzten Jahren eine Zunahme von Darmkrebsfällen bei Menschen unter 50. Besonders groß ist der Zuwachs bei den ganz jungen Erwachsenen von 20 bis 29 Jahren.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Cancer

 

Gust MEES's insight:

Onkologen sind besorgt, weil bei den Unter-30-Jährigen die Darmkrebsfälle deutlich zunehmen. Gesündere Ernährung und mehr Bewegung von Kindheit an könnte das Risiko senken. Aber auch das familiäre Risiko müsste mehr beachtet werden – es führt häufig zu Darmkrebs in jungen Jahren.

Die meisten Krebspatienten sind bei der Diagnose jenseits der 60. Das gilt auch für Darmkrebs, die zweithäufigste Krebserkrankung in Deutschland. Die Hälfte der Patienten ist über 70, wenn sie von ihrer Erkrankung erfährt. Allerdings registrieren Onkologen in den letzten Jahren eine Zunahme von Darmkrebsfällen bei Menschen unter 50. Besonders groß ist der Zuwachs bei den ganz jungen Erwachsenen von 20 bis 29 Jahren.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Cancer

 

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Was ist ein Prädiabetes? | #Health #Santé #Gesundheit 

Was ist ein Prädiabetes? | #Health #Santé #Gesundheit  | 21st Century Innovative Technologies and Developments as also discoveries, curiosity ( insolite)... | Scoop.it

Wann ein Typ-2-Diabetes vorliegt, dafür gibt es klare Definitionen: Überschreitet die Menge an Traubenzucker (Glukose) im Blut eine bestimmte Schwelle, sprechen Ärzte von der Zuckerkrankheit. Sie ist zum Beispiel erreicht, wenn der Blutzucker auf über 126 Milligramm pro Deziliter (mg/dl) beziehungsweise 7,0 Millimol pro Liter (mmol/l) geklettert ist. Bei Gesunden liegen die Zuckerwerte unter 100 mg/dl beziehungsweise unter 5,6 mmol/l.

Grauzone Prädiabetes
Doch was ist mit den Menschen, bei denen der Zuckerspiegel bereits über der Norm liegt, die Definition für einen Diabetes aber noch nicht erfüllt ist? Sie befinden sich in einer Art Grauzone. "Die amerikanische Diabetes-Gesellschaft bezeichnet diese Grauzone auch als ‚Prädiabetes‘, also als ein Vorstadium zum Diabetes", sagt Professor Dirk Müller-Wieland, Pressesprecher der Deutschen Diabetes Gesellschaft.

Betroffene besitzen ein erhöhtes Risiko, in den kommenden Jahren einen Diabetes zu entwickeln. Je früher Menschen mit dieser Risikokonstellation erkannt werden, desto besser. Denn in diesem Fall besteht eine gute Chance, die Zuckerkrankheit mit vergleichsweise einfachen Lebensstiländerungen noch abzuwenden.

Wann liegt ein Prädiabetes vor?
Nach derzeitiger Definition sprechen Ärzte von einem Prädiabetes, wenn eines der folgenden Kriterien erfüllt ist:

Blutzuckerkonzentration nüchtern: zwischen 100 und 125 mg/dl (5,6-6,9 mmol/l)
Blutzuckerkonzentration zwei Stunden nach Gabe von Glukose (Glukosetoleranz): zwischen 140 und 199 mg/dl bzw. 7,8-11,0 mmol/l
Langzeitzuckerwert HbA1c: zwischen 5,7 und 6,4 Prozent
"Derartige Werte deuten darauf hin, dass das Insulin nicht mehr richtig wirkt und der Blutzucker nur noch eingeschränkt in die Zellen aufgenommen wird", sagt Müller-Wieland. Das Hormon Insulin hat die Aufgabe, den Zucker aus den Blutbahnen in die Zellen zu schleusen. Sprechen diese nicht mehr richtig auf Insulin an, bezeichnen Ärzte das als Insulinresistenz. Die Folge: Die Glukose verbleibt im Blut und der Blutzuckerspiegel ist dauerhaft erhöht. Vor allem Übergewicht, Bewegungsmangel und eine genetische Veranlagung tragen zu dieser Entwicklung bei.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Medicine

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Diabetes

 

Gust MEES's insight:

Wann ein Typ-2-Diabetes vorliegt, dafür gibt es klare Definitionen: Überschreitet die Menge an Traubenzucker (Glukose) im Blut eine bestimmte Schwelle, sprechen Ärzte von der Zuckerkrankheit. Sie ist zum Beispiel erreicht, wenn der Blutzucker auf über 126 Milligramm pro Deziliter (mg/dl) beziehungsweise 7,0 Millimol pro Liter (mmol/l) geklettert ist. Bei Gesunden liegen die Zuckerwerte unter 100 mg/dl beziehungsweise unter 5,6 mmol/l.

Grauzone Prädiabetes
Doch was ist mit den Menschen, bei denen der Zuckerspiegel bereits über der Norm liegt, die Definition für einen Diabetes aber noch nicht erfüllt ist? Sie befinden sich in einer Art Grauzone. "Die amerikanische Diabetes-Gesellschaft bezeichnet diese Grauzone auch als ‚Prädiabetes‘, also als ein Vorstadium zum Diabetes", sagt Professor Dirk Müller-Wieland, Pressesprecher der Deutschen Diabetes Gesellschaft.

Betroffene besitzen ein erhöhtes Risiko, in den kommenden Jahren einen Diabetes zu entwickeln. Je früher Menschen mit dieser Risikokonstellation erkannt werden, desto besser. Denn in diesem Fall besteht eine gute Chance, die Zuckerkrankheit mit vergleichsweise einfachen Lebensstiländerungen noch abzuwenden.

Wann liegt ein Prädiabetes vor?
Nach derzeitiger Definition sprechen Ärzte von einem Prädiabetes, wenn eines der folgenden Kriterien erfüllt ist:

Blutzuckerkonzentration nüchtern: zwischen 100 und 125 mg/dl (5,6-6,9 mmol/l)
Blutzuckerkonzentration zwei Stunden nach Gabe von Glukose (Glukosetoleranz): zwischen 140 und 199 mg/dl bzw. 7,8-11,0 mmol/l
Langzeitzuckerwert HbA1c: zwischen 5,7 und 6,4 Prozent
"Derartige Werte deuten darauf hin, dass das Insulin nicht mehr richtig wirkt und der Blutzucker nur noch eingeschränkt in die Zellen aufgenommen wird", sagt Müller-Wieland. Das Hormon Insulin hat die Aufgabe, den Zucker aus den Blutbahnen in die Zellen zu schleusen. Sprechen diese nicht mehr richtig auf Insulin an, bezeichnen Ärzte das als Insulinresistenz. Die Folge: Die Glukose verbleibt im Blut und der Blutzuckerspiegel ist dauerhaft erhöht. Vor allem Übergewicht, Bewegungsmangel und eine genetische Veranlagung tragen zu dieser Entwicklung bei.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Medicine

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Diabetes

 

 

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A High-Tech Pill to End Drug Injections | #Health #Robotics #Insulin #Diabetes

A High-Tech Pill to End Drug Injections | #Health #Robotics #Insulin #Diabetes | 21st Century Innovative Technologies and Developments as also discoveries, curiosity ( insolite)... | Scoop.it

Here was the challenge for bioengineers: Find a way to for patients to take drugs — like insulin or monoclonal antibodies used to treat cancers and other diseases — without injections.

The medicines are made of molecules too big to be absorbed through the stomach or intestines; in any event, the drugs would be quickly degraded by the body’s harsh digestive system.

Now, a team of scientists may have found a solution that delivers these drugs in a capsule a person can swallow. Their inspiration? A tortoise that always rights itself after rolling over.

The test device, called Soma, is shaped like the tortoise’s shell. Inside is a miniature post made of insulin. After the tiny device positions itself against the stomach wall, the post pops out and injects insulin. The device then travels through the colon and eventually is eliminated by the patient.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Diabetes

 

Gust MEES's insight:

Here was the challenge for bioengineers: Find a way to for patients to take drugs — like insulin or monoclonal antibodies used to treat cancers and other diseases — without injections.

The medicines are made of molecules too big to be absorbed through the stomach or intestines; in any event, the drugs would be quickly degraded by the body’s harsh digestive system.

Now, a team of scientists may have found a solution that delivers these drugs in a capsule a person can swallow. Their inspiration? A tortoise that always rights itself after rolling over.

The test device, called Soma, is shaped like the tortoise’s shell. Inside is a miniature post made of insulin. After the tiny device positions itself against the stomach wall, the post pops out and injects insulin. The device then travels through the colon and eventually is eliminated by the patient.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Diabetes

 

John Randle's curator insight, June 23, 2020 6:40 AM

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Colonoscopy - Wikipedia | #ProactiveTHINKing #Cancer #Health #Santé #Gesundheit 

Colonoscopy - Wikipedia

Colonoscopy () or coloscopy () is the endoscopic examination of the large bowel and the distal part of the small bowel with a CCD camera or a fiber optic camera on a flexible tube passed through the anus. It can provide a visual diagnosis (e.g., ulceration, polyps) and grants the opportunity for biopsy or removal of suspected colorectal cancer lesions.

Colonoscopy (/ˌkɒləˈnɒskəpi/) or coloscopy (/kəˈlɒskəpi/)[1] is the endoscopic examination of the large bowel and the distal part of the small bowel with a CCD camera or a fiber optic camera on a flexible tube passed through the anus. It can provide a visual diagnosis (e.g., ulceration, polyps) and grants the opportunity for biopsy or removal of suspected colorectal cancer lesions. Colonoscopy can remove polyps as small as one millimetre or less. Once polyps are removed, they can be studied with the aid of a microscope to determine if they are precancerous or not. It can take up to 15 years for a polyp to turn cancerous.

Colonoscopy is similar to sigmoidoscopy—the difference being related to which parts of the colon each can examine. A colonoscopy allows an examination of the entire colon (1200–1500 mm in length). A sigmoidoscopy allows an examination of the distal portion (about 600 mm) of the colon, which may be sufficient because benefits to cancer survival of colonoscopy have been limited to the detection of lesions in the distal portion of the colon.[2][3][4]

A sigmoidoscopy is often used as a screening procedure for a full colonoscopy, often done in conjunction with a fecal occult blood test (FOBT). About 5% of these screened patients are referred to colonoscopy.[5]

Virtual colonoscopy, which uses 2D and 3D imagery reconstructed from computed tomography (CT) scans or from nuclear magnetic resonance (MR) scans, is also possible, as a totally non-invasive medical test, although it is not standard and still under investigation regarding its diagnostic abilities. Furthermore, virtual colonoscopy does not allow for therapeutic maneuvers such as polyp/tumour removal or biopsy nor visualization of lesions smaller than 5 millimeters. If a growth or polyp is detected using CT colonography, a standard colonoscopy would still need to be performed. Additionally, surgeons have lately been using the term pouchoscopy to refer to a colonoscopy of the ileo-anal pouch.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Cancer

 

Gust MEES's insight:

Colonoscopy (/ˌkɒləˈnɒskəpi/) or coloscopy (/kəˈlɒskəpi/)[1] is the endoscopic examination of the large bowel and the distal part of the small bowel with a CCD camera or a fiber optic camera on a flexible tube passed through the anus. It can provide a visual diagnosis (e.g., ulceration, polyps) and grants the opportunity for biopsy or removal of suspected colorectal cancer lesions. Colonoscopy can remove polyps as small as one millimetre or less. Once polyps are removed, they can be studied with the aid of a microscope to determine if they are precancerous or not. It can take up to 15 years for a polyp to turn cancerous.

Colonoscopy is similar to sigmoidoscopy—the difference being related to which parts of the colon each can examine. A colonoscopy allows an examination of the entire colon (1200–1500 mm in length). A sigmoidoscopy allows an examination of the distal portion (about 600 mm) of the colon, which may be sufficient because benefits to cancer survival of colonoscopy have been limited to the detection of lesions in the distal portion of the colon.[2][3][4]

A sigmoidoscopy is often used as a screening procedure for a full colonoscopy, often done in conjunction with a fecal occult blood test (FOBT). About 5% of these screened patients are referred to colonoscopy.[5]

Virtual colonoscopy, which uses 2D and 3D imagery reconstructed from computed tomography (CT) scans or from nuclear magnetic resonance (MR) scans, is also possible, as a totally non-invasive medical test, although it is not standard and still under investigation regarding its diagnostic abilities. Furthermore, virtual colonoscopy does not allow for therapeutic maneuvers such as polyp/tumour removal or biopsy nor visualization of lesions smaller than 5 millimeters. If a growth or polyp is detected using CT colonography, a standard colonoscopy would still need to be performed. Additionally, surgeons have lately been using the term pouchoscopy to refer to a colonoscopy of the ileo-anal pouch.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Cancer

 

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Forschern gelingt medizinischer Durchbruch - Nanospritze gegen Krebszellen | #Research #Cancer

Forschern gelingt medizinischer Durchbruch - Nanospritze gegen Krebszellen | #Research #Cancer | 21st Century Innovative Technologies and Developments as also discoveries, curiosity ( insolite)... | Scoop.it

Was nützen die besten Wirkstoffe, wenn sie nicht dort landen, wo sie hin sollen? Forschern scheint jetzt der Durchbruch gelungen zu sein. Molekulare Spritzen tragen punktgenau den Wirkstoff in die gewünschte Zelle. Der von Bakterien abgekupferte Trick könnte die Krebstherapie revolutionieren.

 

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https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Cancer

 

https://www.scoop.it/topic/21st-century-innovative-technologies-and-developments/?&tag=Research

 

Gust MEES's insight:

Was nützen die besten Wirkstoffe, wenn sie nicht dort landen, wo sie hin sollen? Forschern scheint jetzt der Durchbruch gelungen zu sein. Molekulare Spritzen tragen punktgenau den Wirkstoff in die gewünschte Zelle. Der von Bakterien abgekupferte Trick könnte die Krebstherapie revolutionieren.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Cancer

 

https://www.scoop.it/topic/21st-century-innovative-technologies-and-developments/?&tag=Research

 

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Krebs: Ursachen, Behandlung, Häufigkeit und Vorbeugung | Neuer Bluttest erkennt 50 Krebsarten | #Cancer #Health 

Krebs: Ursachen, Behandlung, Häufigkeit und Vorbeugung | Neuer Bluttest erkennt 50 Krebsarten | #Cancer #Health  | 21st Century Innovative Technologies and Developments as also discoveries, curiosity ( insolite)... | Scoop.it

Neuer Bluttest erkennt 50 Krebsarten
Fakt ist: Je früher Krebs entdeckt wird, desto besser kann er behandelt werden. Dann ist der Tumor kleiner und leichter zu entfernen. Zugleich ist die Wahrscheinlichkeit, dass Krebszellen bereits gestreut haben und es Metastasen gibt, geringer.

Zu den gängigsten Diagnose-Methoden gehören Röntgen- und Ultraschalluntersuchungen. Direkt im Blut der Patient:innen Tumor-Zellen zu erkennen, ist seit langem Ziel der Forschung. Bisher war die Diagnostik in diesem Bereich nicht sehr ausgereift und Krebs-Erkrankungen häufig schon fortgeschritten.

Ein neuer Bluttest will das ändern: Über 50 unterschiedliche Krebsarten soll der Test mit einer einzigen Blutprobe erkennen - und gleichzeitig den Ursprung im Körper auffinden.

Das Wissenschaftler:innen erhofft sich dadurch, Tumore auszuspüren, die sonst nur schwer zu entdecken sind - beispielsweise bei Bauchspeicheldrüsen-Krebs.  "Diese Studie deutet darauf hin, dass es Hoffnung gibt, Krebsarten zu erkennen, die derzeit nicht erkannt werden können", erklärte Professor Deborah Schrag aus dem Forschungsteam.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Cancer

 

https://www.scoop.it/topic/21st-century-innovative-technologies-and-developments/?&tag=Research

 

Gust MEES's insight:

Neuer Bluttest erkennt 50 Krebsarten
Fakt ist: Je früher Krebs entdeckt wird, desto besser kann er behandelt werden. Dann ist der Tumor kleiner und leichter zu entfernen. Zugleich ist die Wahrscheinlichkeit, dass Krebszellen bereits gestreut haben und es Metastasen gibt, geringer.

Zu den gängigsten Diagnose-Methoden gehören Röntgen- und Ultraschalluntersuchungen. Direkt im Blut der Patient:innen Tumor-Zellen zu erkennen, ist seit langem Ziel der Forschung. Bisher war die Diagnostik in diesem Bereich nicht sehr ausgereift und Krebs-Erkrankungen häufig schon fortgeschritten.

Ein neuer Bluttest will das ändern: Über 50 unterschiedliche Krebsarten soll der Test mit einer einzigen Blutprobe erkennen - und gleichzeitig den Ursprung im Körper auffinden.

Das Wissenschaftler:innen erhofft sich dadurch, Tumore auszuspüren, die sonst nur schwer zu entdecken sind - beispielsweise bei Bauchspeicheldrüsen-Krebs.  "Diese Studie deutet darauf hin, dass es Hoffnung gibt, Krebsarten zu erkennen, die derzeit nicht erkannt werden können", erklärte Professor Deborah Schrag aus dem Forschungsteam.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Cancer

 

https://www.scoop.it/topic/21st-century-innovative-technologies-and-developments/?&tag=Research

 

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Welche gesundheitlichen und sozialen Folgen hat der Freizeitkonsum von Cannabis? | #Research #Drugs #Health #Santé #Gesundheit 

Welche gesundheitlichen und sozialen Folgen hat der Freizeitkonsum von Cannabis? | #Research #Drugs #Health #Santé #Gesundheit  | 21st Century Innovative Technologies and Developments as also discoveries, curiosity ( insolite)... | Scoop.it

Zusammenfassung der wissenschaftlichen Erkenntnisse über die Folgen von psychoaktivem Cannabis auf das körperliche, psychische und soziale Wohlbefinden von Freizeitnutzern.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/topic/21st-century-innovative-technologies-and-developments/?&tag=Cannabis

 

Gust MEES's insight:

Zusammenfassung der wissenschaftlichen Erkenntnisse über die Folgen von psychoaktivem Cannabis auf das körperliche, psychische und soziale Wohlbefinden von Freizeitnutzern.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/topic/21st-century-innovative-technologies-and-developments/?&tag=Cannabis

 

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Kartilaginäre Exostose (Osteochondrom) am Talus (Sprunggelenk) | www.gelenk-doktor.de | #Health #Santé #Gesundheit

Kartilaginäre Exostose (Osteochondrom) am Talus (Sprunggelenk) | www.gelenk-doktor.de | #Health #Santé #Gesundheit | 21st Century Innovative Technologies and Developments as also discoveries, curiosity ( insolite)... | Scoop.it

Die kartilaginäre Exostose am Fuß und Sprunggelenk ist ein gutartiger Knochentumor. Die kartilaginäre Exostose wird auch als Osteochondrom bezeichnet. Die Exostose besteht aus langsam verknöcherndem Knorpel und Knochengewebe. Dieses Osteochondrom kann praktisch an allen Knochen als gutartige Wucherung der Epiphysenfuge (Wachstumszone) des Körpers vorkommen. 

 

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https://www.scoop.it/topic/21st-century-innovative-technologies-and-developments/?&tag=Health

 

Gust MEES's insight:

Die kartilaginäre Exostose am Fuß und Sprunggelenk ist ein gutartiger Knochentumor. Die kartilaginäre Exostose wird auch als Osteochondrom bezeichnet. Die Exostose besteht aus langsam verknöcherndem Knorpel und Knochengewebe. Dieses Osteochondrom kann praktisch an allen Knochen als gutartige Wucherung der Epiphysenfuge (Wachstumszone) des Körpers vorkommen. 

 

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https://www.scoop.it/topic/21st-century-innovative-technologies-and-developments/?&tag=Health

 

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Vaping linked to bad breath, tooth decay, oral cancer, study finds | #eCigarettes #Health

Vaping linked to bad breath, tooth decay, oral cancer, study finds | #eCigarettes #Health | 21st Century Innovative Technologies and Developments as also discoveries, curiosity ( insolite)... | Scoop.it

A new study suggests that the aerosol vape users inhale deposits bad bacteria into the mouth. The bad bacteria increase a person's risk of cavities, infection, bad breath, and oral cancer.
If left untreated, poor oral health conditions can affect the rest of a person's body. Chronic oral health problems have been linked to diabetes, Alzheimer's, and heart disease.
The study author suggested e-cigarette users work towards cessation to prevent oral health problems.

 

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https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=eCigarettes

 

Gust MEES's insight:

A new study suggests that the aerosol vape users inhale deposits bad bacteria into the mouth. The bad bacteria increase a person's risk of cavities, infection, bad breath, and oral cancer.
If left untreated, poor oral health conditions can affect the rest of a person's body. Chronic oral health problems have been linked to diabetes, Alzheimer's, and heart disease.
The study author suggested e-cigarette users work towards cessation to prevent oral health problems.

 

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https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=eCigarettes

 

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E-Zigaretten: Erhöhtes Risiko für Lungenkrankheiten wie Asthma und COPD | #eCigarettes #Vaping #Health #Santé #Gesundheit

E-Zigaretten: Erhöhtes Risiko für Lungenkrankheiten wie Asthma und COPD | #eCigarettes #Vaping #Health #Santé #Gesundheit | 21st Century Innovative Technologies and Developments as also discoveries, curiosity ( insolite)... | Scoop.it

Dampfer von E-Zigaretten haben ein erhöhtes Risiko für chronische Lungenkrankheiten wie COPD, Asthma und Bronchitis. Das schreiben US-Forscher, nachdem sie Tausende Menschen - darunter Dampfer, Tabakraucher, Ex-Raucher und Nichtraucher - über einen Zeitraum von zwei Jahren befragt hatten. Die Wahrscheinlichkeit, innerhalb dieser Zeit zu erkranken, war für Dampfer um 30 Prozent höher als für abstinente Menschen, wie die Wissenschaftler im Fachmagazin "American Journal of Preventive Medicine" berichten. Bei Tabakrauchern war die Wahrscheinlichkeit um etwa 150 Prozent höher.

 

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https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=eCigarettes

 

Gust MEES's insight:

Dampfer von E-Zigaretten haben ein erhöhtes Risiko für chronische Lungenkrankheiten wie COPD, Asthma und Bronchitis. Das schreiben US-Forscher, nachdem sie Tausende Menschen - darunter Dampfer, Tabakraucher, Ex-Raucher und Nichtraucher - über einen Zeitraum von zwei Jahren befragt hatten. Die Wahrscheinlichkeit, innerhalb dieser Zeit zu erkranken, war für Dampfer um 30 Prozent höher als für abstinente Menschen, wie die Wissenschaftler im Fachmagazin "American Journal of Preventive Medicine" berichten. Bei Tabakrauchern war die Wahrscheinlichkeit um etwa 150 Prozent höher.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=eCigarettes

 

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Vaping May Be Worse for Heart Than Tobacco, New Study Finds | #eCigarettes #Smoking #Health

Vaping May Be Worse for Heart Than Tobacco, New Study Finds | #eCigarettes #Smoking #Health | 21st Century Innovative Technologies and Developments as also discoveries, curiosity ( insolite)... | Scoop.it

E-cigarettes may be more harmful to a smoker’s heart than traditional tobacco cigarettes. That’s the finding of new research from Cedars-Sinai Medical Center in Los Angeles, presented today (Nov. 11) at an American Heart Association scientific conference.

The Cedars-Sinai team compared the hearts of 10 non-smokers to the hearts of 10 tobacco smokers and 10 e-cigarette smokers. All the people in the study were younger than 40, and all were otherwise healthy. In response to a mild bout of exercise, measures of blood flow increased in the hearts of the non-smokers. Among the tobacco smokers, this increase was blunted. But among the e-cigarette smokers, there was no increase at all. “This suggests e-cigarettes cause an abnormality that impedes blood flow regulation in the heart,” says Dr. Florian Rader, coauthor of the study and a heart specialist at Cedars-Sinai’s Smidt Heart Institute.

 

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https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=eCigarettes

 

Gust MEES's insight:

E-cigarettes may be more harmful to a smoker’s heart than traditional tobacco cigarettes. That’s the finding of new research from Cedars-Sinai Medical Center in Los Angeles, presented today (Nov. 11) at an American Heart Association scientific conference.

The Cedars-Sinai team compared the hearts of 10 non-smokers to the hearts of 10 tobacco smokers and 10 e-cigarette smokers. All the people in the study were younger than 40, and all were otherwise healthy. In response to a mild bout of exercise, measures of blood flow increased in the hearts of the non-smokers. Among the tobacco smokers, this increase was blunted. But among the e-cigarette smokers, there was no increase at all. “This suggests e-cigarettes cause an abnormality that impedes blood flow regulation in the heart,” says Dr. Florian Rader, coauthor of the study and a heart specialist at Cedars-Sinai’s Smidt Heart Institute.

 

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https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=eCigarettes

 

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Der Tag: Zahl der Toten nach E-Zigaretten-Konsum steigt weiter | #Health #Santé #Gesundheit #eCigarettes 

Der Tag: Zahl der Toten nach E-Zigaretten-Konsum steigt weiter | #Health #Santé #Gesundheit #eCigarettes  | 21st Century Innovative Technologies and Developments as also discoveries, curiosity ( insolite)... | Scoop.it

Die Zahl der Todesfälle in den USA nach Benutzung von E-Zigaretten ist auf mindestens drei gestiegen. Ein vierter Tod werde in diesem Zusammenhang untersucht, sagte Dana Meaney-Delman von der US-Gesundheitsbehörde CDC. "Wir wissen von drei Toten und einem Fall, der untersucht wird." Insgesamt seien den Behörden mittlerweile 450 mögliche Erkrankungen in mehr als 30 Bundesstaaten gemeldet worden.

In den USA hatten sich die Meldungen ungeklärter Lungenerkrankungen, die nach dem Konsum von E-Zigaretten auftreten, in den vergangenen Wochen gehäuft. Die Symptome reichten von Atembeschwerden, Atemnot und Brustschmerzen bis hin zu Fällen von Magen-Darm-Erkrankungen mit Erbrechen und Durchfall.

 

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https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=eCigarettes

 

Gust MEES's insight:

Die Zahl der Todesfälle in den USA nach Benutzung von E-Zigaretten ist auf mindestens drei gestiegen. Ein vierter Tod werde in diesem Zusammenhang untersucht, sagte Dana Meaney-Delman von der US-Gesundheitsbehörde CDC. "Wir wissen von drei Toten und einem Fall, der untersucht wird." Insgesamt seien den Behörden mittlerweile 450 mögliche Erkrankungen in mehr als 30 Bundesstaaten gemeldet worden.

In den USA hatten sich die Meldungen ungeklärter Lungenerkrankungen, die nach dem Konsum von E-Zigaretten auftreten, in den vergangenen Wochen gehäuft. Die Symptome reichten von Atembeschwerden, Atemnot und Brustschmerzen bis hin zu Fällen von Magen-Darm-Erkrankungen mit Erbrechen und Durchfall.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=eCigarettes

 

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Gen-Therapie gegen Krebs an Leipziger Uni-Klinik getestet - mit Erfolgsaussicht | #Research #Cancer #Health #Santé #Gesundheit #Kymriah

Gen-Therapie gegen Krebs an Leipziger Uni-Klinik getestet - mit Erfolgsaussicht | #Research #Cancer #Health #Santé #Gesundheit #Kymriah | 21st Century Innovative Technologies and Developments as also discoveries, curiosity ( insolite)... | Scoop.it

Sie soll die Lebenserwartung deutlich verlängern oder gar zur Heilung führen: eine neue Gen-Therapie gegen Krebs. Jetzt kam sie zum ersten Mal an der Uniklinik Leipzig zum Einsatz - an einem Patienten mit Lymphdrüsenkrebs. Die Therapie habe bei ihm angeschlagen, berichten die Ärzte.

Am Leipziger Universitätsklinikum (UKL) wurde ein Patient mit Lymphdrüsenkrebs zum ersten Mal mit einer Gen-Therapie behandelt – mit Aussicht auf Erfolg. Nachdem sie alle anderen Therapiemöglichkeiten ausgeschöpft hatten, entschieden sich die Ärzte für eine Kombination aus Zell- und Gen-Therapie, die erst im August vergangenen Jahres in Europa zugelassen wurde. Ihr Name: Kymriah.

 

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https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Cancer

 

Gust MEES's insight:

Sie soll die Lebenserwartung deutlich verlängern oder gar zur Heilung führen: eine neue Gen-Therapie gegen Krebs. Jetzt kam sie zum ersten Mal an der Uniklinik Leipzig zum Einsatz - an einem Patienten mit Lymphdrüsenkrebs. Die Therapie habe bei ihm angeschlagen, berichten die Ärzte.

Am Leipziger Universitätsklinikum (UKL) wurde ein Patient mit Lymphdrüsenkrebs zum ersten Mal mit einer Gen-Therapie behandelt – mit Aussicht auf Erfolg. Nachdem sie alle anderen Therapiemöglichkeiten ausgeschöpft hatten, entschieden sich die Ärzte für eine Kombination aus Zell- und Gen-Therapie, die erst im August vergangenen Jahres in Europa zugelassen wurde. Ihr Name: Kymriah.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Cancer

 

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COPD: Warnzeichen beachten! Lungenkrankheit kündigt sich Jahre vorher an | #Health #Santé #Gesundheit

COPD: Warnzeichen beachten! Lungenkrankheit kündigt sich Jahre vorher an | #Health #Santé #Gesundheit | 21st Century Innovative Technologies and Developments as also discoveries, curiosity ( insolite)... | Scoop.it

Bald wird die Lungenerkrankung COPD die dritthäufigste Todesursache sein. COPD zerstört nicht nur die Lunge, sondern auch das Herz. Mit der richtigen Behandlung ließe sich das abbremsen. Voraussetzung: bei den ersten Anzeichen zum Arzt gehen. Auf was Sie achten sollten und welche Therapien helfen.

 

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https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Health

 

Gust MEES's insight:

Bald wird die Lungenerkrankung COPD die dritthäufigste Todesursache sein. COPD zerstört nicht nur die Lunge, sondern auch das Herz. Mit der richtigen Behandlung ließe sich das abbremsen. Voraussetzung: bei den ersten Anzeichen zum Arzt gehen. Auf was Sie achten sollten und welche Therapien helfen.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Health

 

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How the Microbiome Could Be the Key to New Cancer Treatments | Science

How the Microbiome Could Be the Key to New Cancer Treatments | Science | 21st Century Innovative Technologies and Developments as also discoveries, curiosity ( insolite)... | Scoop.it

When we looked at stool from breast and lung cancer patients, we discovered that important bacteria were missing from the microbiome,” Culler says. The absence of certain gut microbes, mostly Firmicutes bacteria, could explain why immune checkpoint inhibitors—drugs that block cancer-friendly proteins and help facilitate the immune system’s response to cancer cells—don’t work on some patients. “We believe that those bacteria are important for the immune system to be able to respond to those drugs,” Culler says.

Along with fellow chemical engineer Steve Van Dien, Culler cofounded Persephone Biome in the summer of 2017 to study the relationship between gut bacteria and cancer. Named for Persephone, the Greek goddess of vegetation who appears in the spring and descends back into the underworld after harvesttime, Culler’s company is gearing up for clinical trials that will test specific gut microbes to see if they improve the function of checkpoint inhibitors in breast and non-small cell lung cancer patients. (A second product will focus on CAR-T cell therapy, which uses patients’ own immune cells that have been genetically engineered to treat their cancer.)

“Our goal is to create therapeutics to convert non-responders into responders,” Culler says, referring to patients who do or do not respond to checkpoint inhibitors. Her company hopes to engineer a mix of selected gut bacteria that can be taken in pill form to heal patients’ microbiomes, which can be damaged by antibiotics and poor diet, as she discussed recently in a talk at TEDx San Diego.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Cancer

 

Gust MEES's insight:

When we looked at stool from breast and lung cancer patients, we discovered that important bacteria were missing from the microbiome,” Culler says. The absence of certain gut microbes, mostly Firmicutes bacteria, could explain why immune checkpoint inhibitors—drugs that block cancer-friendly proteins and help facilitate the immune system’s response to cancer cells—don’t work on some patients. “We believe that those bacteria are important for the immune system to be able to respond to those drugs,” Culler says.

Along with fellow chemical engineer Steve Van Dien, Culler cofounded Persephone Biome in the summer of 2017 to study the relationship between gut bacteria and cancer. Named for Persephone, the Greek goddess of vegetation who appears in the spring and descends back into the underworld after harvesttime, Culler’s company is gearing up for clinical trials that will test specific gut microbes to see if they improve the function of checkpoint inhibitors in breast and non-small cell lung cancer patients. (A second product will focus on CAR-T cell therapy, which uses patients’ own immune cells that have been genetically engineered to treat their cancer.)

“Our goal is to create therapeutics to convert non-responders into responders,” Culler says, referring to patients who do or do not respond to checkpoint inhibitors. Her company hopes to engineer a mix of selected gut bacteria that can be taken in pill form to heal patients’ microbiomes, which can be damaged by antibiotics and poor diet, as she discussed recently in a talk at TEDx San Diego.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Cancer

 

good health's curator insight, January 15, 11:56 AM

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Mit Baumwanzen gegen resistente Bakterien | #Research #Antibiotikum #Thanatin #Health

Mit Baumwanzen gegen resistente Bakterien | #Research #Antibiotikum #Thanatin #Health | 21st Century Innovative Technologies and Developments as also discoveries, curiosity ( insolite)... | Scoop.it

Immer mehr Bakterien werden immun gegen die bekannten Antibiotika. Neue Mittel müssen her, die anders wirken als die bisherigen. Forschende der Universität und der ETH Zürich berichten nun von der bisher unbekannten Wirkweise eines Antibiotikums aus einer Baumwanze.

Das natürliche Antibiotikum Thanatin aus einer nordamerikanischen Baumwanze wirkt gegen sogenannte gramnegative Bakterien. Dazu gehören zum Beispiel krankmachende Stämme des Darmbakteriums Escherichia coli. Ein Forschungsteam der Universität und der ETH Zürich hat entschlüsselt, wie genau dieses Antibiotikum die Bakterien eliminiert. Und sind auf einen neuen Wirkmechanismus gestoßen, wie die Universität am Donnerstag mitteilte.


Thanatin blockiert Baustein-Transport

Wie die Forschenden um John A. Robinson von der Uni Zürich im Fachblatt «Science Advances» berichten, verhindert Thanatin den Aufbau der Schutzhülle der Bakterien. Genauer gesagt: der äußeren von zwei übereinanderliegenden Zellmembranen, die die Erreger umgeben. Die äußere Membran hat eine wichtige Abwehrfunktion und verhindert, dass für das Bakterium toxische Substanzen ins Zellinnere gelangen.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Antibiotics

 

Gust MEES's insight:

Immer mehr Bakterien werden immun gegen die bekannten Antibiotika. Neue Mittel müssen her, die anders wirken als die bisherigen. Forschende der Universität und der ETH Zürich berichten nun von der bisher unbekannten Wirkweise eines Antibiotikums aus einer Baumwanze.

Das natürliche Antibiotikum Thanatin aus einer nordamerikanischen Baumwanze wirkt gegen sogenannte gramnegative Bakterien. Dazu gehören zum Beispiel krankmachende Stämme des Darmbakteriums Escherichia coli. Ein Forschungsteam der Universität und der ETH Zürich hat entschlüsselt, wie genau dieses Antibiotikum die Bakterien eliminiert. Und sind auf einen neuen Wirkmechanismus gestoßen, wie die Universität am Donnerstag mitteilte.


Thanatin blockiert Baustein-Transport

Wie die Forschenden um John A. Robinson von der Uni Zürich im Fachblatt «Science Advances» berichten, verhindert Thanatin den Aufbau der Schutzhülle der Bakterien. Genauer gesagt: der äußeren von zwei übereinanderliegenden Zellmembranen, die die Erreger umgeben. Die äußere Membran hat eine wichtige Abwehrfunktion und verhindert, dass für das Bakterium toxische Substanzen ins Zellinnere gelangen.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://www.scoop.it/t/21st-century-innovative-technologies-and-developments/?&tag=Antibiotics

 

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