A pair of new enantiomeric stilbene dimers, (+)- and (−)-cajanusine [(+)-1 and (−)-1], with a unique coupling pattern were isolated from the leaves of Cajanus cajan. Their structures including absolute configurations were elucidated on the basis of comprehensive spectroscopic and single-crystal X-ray diffraction analyses, as well as CD calculations. The plausible biogenetic pathway of 1 was also proposed. Additionally, (±)-1, (+)-1, and (−)-1 exhibited inhibitory activities on the growth of human hepatocellular carcinoma cells.
Xiao-Long Li†‡, Bing-Xin Zhao†‡, Xiao-Jun Huang†‡, Dong-Mei Zhang†, Ren-Wang Jiang†, Ying-Jie Li†, Yu-Qing Jian†‡, Ying Wang*†‡, Yao-Lan Li*†, and Wen-Cai Ye
Org. Lett., Article ASAP
Publication Date (Web): December 2, 2013