In this study, the scientists find that the grafts of hPSC-derived maturing GABAergic interneurons generate inhibitory postsynaptic responses in host hippocampal neurons. They showed that this type of neuron graft is capable of suppressing seizures and ameliorating behavioral abnormalities such as cognitive deficits, aggressiveness, and hyperactivity.
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In this study, the scientists find that the grafts of hPSC-derived maturing GABAergic interneurons generate inhibitory postsynaptic responses in host hippocampal neurons. They showed that this type of neuron graft is capable of suppressing seizures and ameliorating behavioral abnormalities such as cognitive deficits, aggressiveness, and hyperactivity.
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