Virology News
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Virology News
Topical news snippets about viruses that affect people.  And other things. Like Led Zeppelin. And zombies B-)
Curated by Ed Rybicki
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The Malian HIV Warrior Presidents Can't Say No To - AllAfrica.com

The Malian HIV Warrior Presidents Can't Say No To - AllAfrica.com | Virology News | Scoop.it
The Malian HIV Warrior Presidents Can't Say No ToAllAfrica.com

He pressed China to admit that HIV was spreading rapidly among gay men and drug users and that the 500000 Chinese working in Africa and 40 million migrant labourers, many of whom visit...

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Amazon.com: Phage Display In Biotechnology and Drug Discovery eBook: Sachdev S. Sidhu: Kindle Store

Amazon.com: Phage Display In Biotechnology and Drug Discovery eBook: Sachdev S.

"The first and only guide to showcase the impact of phage display technology on drug discovery, this reference details the theories, principles, and methods impacting the field and demonstrates applications for peptide phage display, protein phage display, and the development of novel antibodies. Highlighting the current and future role of phage display in the development of protein therapeutics, this book provides a comprehensive overview that will prove invaluable to anyone researching recombinant antibodies."

 

Phages and biotechnology: what's not to like?  The price, possibly??

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Sexually transmitted diseases caused by viruses - by PRS - Helium

There are four  sexually transmitted diseases (STDs) that are caused by viruses.  They are Human Immunodeficiency Virus (HIV), Human Papillomavirus (HPV), Herpes Simplex Virus (HSV), and Hepatitis C.

 

Useful refresher, in case you thought it was time to get back on the circuit.

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Editor's concern over bird flu

Editor's concern over bird flu | Virology News | Scoop.it
The editor of a leading scientific journal says he will publish full details of controversial research into the bird flu virus, unless the World Health Organization gives scientists crucial information.

 

Go Bruce...!!

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Vaccines for HIV: A new design strategy

Vaccines for HIV: A new design strategy | Virology News | Scoop.it
HIV has eluded vaccine-makers for thirty years, in part due to the virus' extreme ability to mutate.

 

With a mathematical tool called random matrix theory, the team searched for high-order evolutionary constraints in the so-called Gag region of HIV. The researchers were looking for collectively co-evolving groups of amino acids with a high number of negative correlations (meaning multiple mutations would destroy the virus) and a low number of positive correlations (meaning the virus could survive multiple mutations). They found this combination in a region, which they call Gag sector 3, that is involved in stabilizing the protein shell of the virus: too many mutations here, and the virus' structure would collapse.

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Flu vaccine helps prevent too-small babies

Flu vaccine helps prevent too-small babies | Virology News | Scoop.it
Vaccinating pregnant women against the flu protects their babies from being born too small, new research suggests.

 

And, in the case of H1N1(2009) flu, may stop the mothers dying.  Yet more reasons to vaccinate everyone!

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Virology Journal | Abstract | Rabies molecular virology, diagnosis, prevention and treatment

Virology Journal | Abstract | Rabies molecular virology, diagnosis, prevention and treatment | Virology News | Scoop.it
Rabies is an avertable viral disease caused by the rabid animal to the warm blooded animals (zoonotic) especially human. Rabies occurs in more than 150 countries and territories.

 

A very useful review on something that is an underestimated problem in developing countries.

Image courtesy of Russell Kightley Media (http://www.rkm.com.au)

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Virology Journal | Rapid detection of sacbrood virus (SBV) by one-step reverse transcription loop-mediated isothermal amplification assay

Sacbrood virus (SBV) primarily infects honeybee broods, and in order to deal with the problem cost effective detection methods are required.

 

...and LAMP (http://en.wikipedia.org/wiki/Loop-mediated_isothermal_amplification) turns out to be a good way to do it!  Like this...

http://nar.oxfordjournals.org/content/28/12/e63/F1.large.jpg

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Hepatitis C-related deaths outpace HIV deaths, study says | From …

Hepatitis C-related deaths outpace HIV deaths, study says | From … | Virology News | Scoop.it
Hepatitis C-related deaths outpace HIV deaths, study says | From … http://t.co/iP0ktxnz...

 

...but not in Africa or Asia, I'd be willing to bet.

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Complete sequence of a cryptic virus from hemp (Cannabis sativa)

Complete sequence of a cryptic virus from hemp (Cannabis sativa) | Virology News | Scoop.it

ARCHIVES OF VIROLOGY
Volume 157, Number 2, 383-385

 

Hemp (Cannabis sativa) was found to be a useful propagation host for hop latent virus, a carlavirus. However, when virus preparations were analysed by electron microscopy, along with the expected filamentous particles, spherical particles with a diameter of around 34 nm were found. RNA from virus preparations was purified, and cDNA was prepared and cloned. Sequence information was used to search databases, and the greatest similarity was found with Primula malacoides virus 1, a putative new member of the genus Partitivirus. The full sequences of RNA 1 and RNA 2 of this new hemp cryptic virus were obtained.

 

Hey, man...this weed's like, cryptic, man...B-)

Can we now expect Cannabis mosaic, Cannabis leaf curl, Cannabis mild mottle and Cannabis reality distortion viruses?

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With Final Review of Phase IIb Viral Load Data Completed, Researchers Confirm Statistically Significant Reduction of … | StemCell Therapy MD

OSLO, NORWAY--(Marketwire -02/15/12)- Bionor Pharma (Oslo: BIONOR.OL - News) News Summary Final review of phase IIb data confirms statistically significant 64% reduction of viral load set point (average of the last two viral load measurements...

 

And here come more therapeutic vaccine interventions for AIDS patients: the gates are opening....

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Stuxnet Virus Infected 16000 Computers, Iran Says

Stuxnet Virus Infected 16000 Computers, Iran Says | Virology News | Scoop.it
TEHRAN, Iran (AP) — A senior Iranian intelligence official says an estimated 16000 computers were infected by the Stuxnet virus. The powerful virus targeted Iran's nuclear facilities and other industrial sites in 2010, and ...

 

ViroBlogy readers will know I think computer viruses are quite legitimate life forms - and should we be more worried about this, which is a genuinely engineered infectious agent, than H5N1?

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Egypt - Report of H9 influenza in poultry in 9 provinces - more than 50% mortality rate - FluTrackers

Egypt - Report of H9 influenza in poultry in 9 provinces - more than 50% mortality rate Egypt...

 

Interesting - as much for the machine translation as for anything else, which renders the content pretty much inscrutable.  But bottom line: H9N2 in Egypt and causing a problem in poultry.  Like the Twitter revolution, this may spread and spread....

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H5N1: Vietnam: Human trials for H5N1 vaccine successful

Via VietNam News: Human trials for birdflu vaccine successful.

Viet Nam has successfully produced experimental version of bird flu vaccine to combat the virus which has killed 62 people in 9 years, researchers at Vaccine and Biological Production Company No.1, said.

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New Vaccination Guidelines: HepB for Diabetics; HPV for Young Men

New Vaccination Guidelines: HepB for Diabetics; HPV for Young Men | Virology News | Scoop.it
There were a number of changes to the 2012 clinical guidelines that doctors follow for adult immunizations, released by a federal panel.

 

Yet another recommendation that young men get HPV vaccinations: time to start listening, boys!

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Enhanced pneumonia and disease in pigs vaccinated wi... [Vaccine. 2011] - PubMed - NCBI

"...these results suggest that inactivated SIV vaccines may potentiate clinical signs, inflammation and pneumonia following challenge with divergent homosubtypic viruses that do not share cross-reacting HI or SN antibodies."

 

Or: getting vaccinated with the wrong strain may hurt you during an epi/pandemic.

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H5N1 bird flu infection may be more common, less deadly, than thought

H5N1 bird flu infection may be more common, less deadly, than thought | Virology News | Scoop.it
The World Health Organization says the H5N1 bird flu kills nearly 60% of people who become infected, but a study released Thursday suggests the true fatality rate may actually be much lower.

 

...meaning a lot more people have been infected.  Possibly meaning the next pandemic is closer than we thought.

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CDC Warns That New Swine Flu Strain Has 'Pandemic Potential' - US News and World Report

The CDC says the strain has infected at least 18 Americans since 2010.

 

SO while you were all fussing about H5N1....

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GlaxoSmithKline steps in to fund flu vaccine program

GlaxoSmithKline steps in to fund flu vaccine program | Virology News | Scoop.it
A pharmaceutical giant is picking up the federal government's slack in funding a program aimed at curbing flu infections.

 

...and will inevitably own it....

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A Promising Trial HIV vaccine in Canada

A Promising Trial HIV vaccine in Canada | Virology News | Scoop.it
While an estimated 30 HIV vaccines are being tested around the world, one trial in Canada promises to be unique. After decades of research, development, and high hopes, scientists at the University of Western Ontario are ready to test a new type of vaccine known as SAV001 that they hope will prevent HIV infections.

What makes this trial different, said lead researcher Chil-Yong Kang, Ph.D., is that this is the first preventive vaccine to use a “killed whole” HIV-1 virus to activate a person’s immune system. This version of the virus, however, would be genetically altered so it would not be able to cause HIV infection. For insurance, the virus is also inactivated by using chemicals and radiation.

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The Scientist Who Discovered Hepatitis C Says He's Now Discovered the Vaccine

The Scientist Who Discovered Hepatitis C Says He's Now Discovered the Vaccine | Virology News | Scoop.it
In a poetic turn of virology, the scientist who discovered hepatitis C in 1989 has now also discovered a vaccine that will hopefully treat and prevent the disease.

 

Just shows you: stick with a thing for 20+ years....

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JN | Abstract | Sendai Virus-based Liposomes Enable Targeted Cytosolic Delivery of Nanoparticles in Brain Tumor-Derived Cells

These findings are the first to utilize the Sendai virus to achieve cytosolic, targeted intracellular binding of Qdots within Human brain tumor cells. The results are significant to the continued applicability of nanoparticles used for the molecular labeling of cancer cells to determine tumor heterogeneity, grade, and chemotherapeutic resistivity.

 

It is to like: using liposomes fused to inactivated Sendai to deliver Qdots.  Vironanotech rules!

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Monkey vaccine hints at how to stop HIV : Nature News & Comment

Monkey vaccine hints at how to stop HIV : Nature News & Comment | Virology News | Scoop.it

A vaccine made of an adenovirus prime and a modified-pox-virus boost was best at stopping infection. Three-quarters of the monkeys that received no vaccine developed SIV after one exposure, whereas only 12% of the animals that got the best vaccine did so.

 

Prime-boost studies and a good infection model...nice virology and vaccinology.  And a possible route to a human HIV vaccine

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The Tower : Contagious Virus Affects GW Students

"The norovirus has affected about 85 students this week, according to the GW University Student Health Service. Although experts are still unsure of where the virus originated, most of the cases have been found at the Foggy Bottom campus."

 

To be renamed the Soggy Bottom campus??  Sorry, couldn't resist...B-)

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H5N1 Pandemic Information News: A/H5N1 virus mutates against vaccines

I'm assuming this is in Vietnam, seeing as details are a little sketchy, but this could be getting serious.

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