Virology News
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Virology News
Topical news snippets about viruses that affect people.  And other things. Like Led Zeppelin. And zombies B-)
Curated by Ed Rybicki
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Study finds HIV-specific CD4 cells that control viral levels

Study finds HIV-specific CD4 cells that control viral levels | Virology News | Scoop.it
A subpopulation of the immune cells targeted by HIV may play an important role in controlling viral loads after initial infection, potentially helping to determine how quickly infection will progress.

Interesting...so it's not just CD8 T cells that directly control HIV-infected cells.
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Antivirals for Treatment of Influenza: A Systematic Review and Meta-analysis of Observational Studies

Antivirals for Treatment of Influenza: A Systematic Review and Meta-analysis of Observational Studies | Virology News | Scoop.it

Meta-analyses of the few studies providing effects with adjustment for confounders suggest that in high-risk populations, oral oseltamivir may reduce mortality (odds ratio, 0.23 [95% CI, 0.13 to 0.43]; low-quality evidence), hospitalization (odds ratio, 0.75 [CI, 0.66 to 0.89]; low-quality evidence), and duration of symptoms (33 hours [CI, 21 to 45 hours]; very low–quality evidence) compared with no treatment. Earlier treatment with oseltamivir was generally associated with better outcomes. Inhaled zanamivir may lead to shorter symptom duration (23 hours [CI, 17 to 28 hours]; moderate-quality evidence) and fewer hospitalizations (odds ratio, 0.66 [CI, 0.37 to 1.18]) but more complications than no treatment. Direct comparison of oral oseltamivir and inhaled zanamivir suggests no important differences in key outcomes. Data from 1 study suggests that oral amantadine may reduce mortality and pneumonia associated with influenza A. No included study evaluated rimantadine.

 

Image courtesy of Russell Kightley Media

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Mmegi Online :: Facebook is the new front in HIV/AIDS war

FRANCISTOWN: Poor knowledge about HIV/Aids and other sexually transmitted diseases among young people has compelled a Gaborone-based youth to create a group on the popular social network, Facebook, to enlighten his peers about the scourge.

 

Ex Africa, semper aliquid novi.  Or a Facebook page, in this case.

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HIV epidemic "driven by colonialism in Africa" a century ago

HIV epidemic "driven by colonialism in Africa" a century ago | Virology News | Scoop.it
Tinderbox: How the West Sparked the AIDS Epidemic and How the World Can Finally Overcome It, attempts to pinpoint the birth and early life of HIV and AIDS.

 

Considering a wealth of evidence, the authors suggest that the European Scramble for Africa during the late 19th and early 20th century helped turn localised outbreaks of the infection into a global epidemic.
Read more: http://www.dailymail.co.uk/health/article-2107605/HIV-epidemic-driven-colonialism-Africa-century-ago.html#ixzz1nhlAqwEM

 

I suppose if you build roads and cities, people will use the roads to get to the cities - and bring whatever they have with them.  Including viruses.

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How Google can predict your flu-related hospital visit

How Google can predict your flu-related hospital visit | Virology News | Scoop.it

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Google Flu Trends has become a public health tool.

Four years ago, Google launched Google Flu Trends, which estimates the prevalence of flu outbreaks based on how many people are searching for things like “fever” or “flu medication.” The search metrics have tracked incredibly closely with Center for Disease Control data....

 

Google: slowly assimilating everything you do.

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Has vaccine reaction made cat lethargic? - STLtoday.com

Has vaccine reaction made cat lethargic?STLtoday.comI took her to the vet, had her checked out, vaccinated, etc. At the time, the vet estimated that she was about 2. The other day, I took her in for her yearly rabies shot.

 

Do some people really have nothing better to worry about?  How about: yes, there may be some reaction to the vaccine - BUT YOUR FRIKKIN' CAT WON'T GET RABIES!!!

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General Assembly, CDC Diverge on HPV Vaccine

General Assembly, CDC Diverge on HPV Vaccine | Virology News | Scoop.it
While Virginia is moving to repeal the requirement that girls get vaccinated against the human papillomavirus, the federal government and a major medical association are urging just the opposite: that boys as well as girls receive the vaccine...

 

There ought to be an IQ test to participate in civil society...

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Virology Journal | Lassa virus-like particles displaying all major immunological determinants as a vaccine candidate for Lassa hemorrhagic fever

Lassa fever is a neglected tropical disease with significant impact on the health care system, society, and economy of Western and Central African nations where it is endemic.

 

An older article, but...

"LASV VLP can be generated displaying high levels of immunogenic viral proteins, and that small laboratory scale mammalian expression systems are capable of producing multi-milligram quantities of pseudoparticles. These VLP are structurally and morphologically similar to native LASV virions, but lack replicative functions, and thus can be safely generated in low biosafety level settings. LASV VLP were immunogenic in mice in the absence of adjuvants, with mature IgG responses developing within a few weeks after the first immunization. These studies highlight the relevance of a VLP platform for designing an optimal vaccine candidate against Lassa hemorrhagic fever, and warrant further investigation in lethal challenge animal models to establish their protective potential.

 

People need to start paying attention to this virus...and another candidate for Green Technology.

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Virology Journal | Genetic relationships and epidemiological links between wild type 1 poliovirus isolates in Pakistan and Afghanistan

Efforts have been made to eliminate wild poliovirus transmission since 1988 when the World Health Organization began its global eradication campaign. Since then, the incidence of polio has decreased significantly. However, serotype 1 and serotype 3 still circulate endemically in Pakistan and Afghanistan. Both countries constitute a single epidemiologic block representing one of the three remaining major global reservoirs of poliovirus transmission. In this study we used genetic sequence data to investigate transmission links among viruses from diverse locations during 2005-2007.

 

The last places on the planet where wild-type polio is circulating: the focus will definitely become more obsessive

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The Malian HIV Warrior Presidents Can't Say No To - AllAfrica.com

The Malian HIV Warrior Presidents Can't Say No To - AllAfrica.com | Virology News | Scoop.it
The Malian HIV Warrior Presidents Can't Say No ToAllAfrica.com

He pressed China to admit that HIV was spreading rapidly among gay men and drug users and that the 500000 Chinese working in Africa and 40 million migrant labourers, many of whom visit...

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Amazon.com: Phage Display In Biotechnology and Drug Discovery eBook: Sachdev S. Sidhu: Kindle Store

Amazon.com: Phage Display In Biotechnology and Drug Discovery eBook: Sachdev S.

"The first and only guide to showcase the impact of phage display technology on drug discovery, this reference details the theories, principles, and methods impacting the field and demonstrates applications for peptide phage display, protein phage display, and the development of novel antibodies. Highlighting the current and future role of phage display in the development of protein therapeutics, this book provides a comprehensive overview that will prove invaluable to anyone researching recombinant antibodies."

 

Phages and biotechnology: what's not to like?  The price, possibly??

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Sexually transmitted diseases caused by viruses - by PRS - Helium

There are four  sexually transmitted diseases (STDs) that are caused by viruses.  They are Human Immunodeficiency Virus (HIV), Human Papillomavirus (HPV), Herpes Simplex Virus (HSV), and Hepatitis C.

 

Useful refresher, in case you thought it was time to get back on the circuit.

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Editor's concern over bird flu

Editor's concern over bird flu | Virology News | Scoop.it
The editor of a leading scientific journal says he will publish full details of controversial research into the bird flu virus, unless the World Health Organization gives scientists crucial information.

 

Go Bruce...!!

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Trade Secrets: We Will Speak for You

Trade Secrets: We Will Speak for You | Virology News | Scoop.it
It will have been very hard to miss, in recent weeks, the worldwide furore that has erupted over the so-called “killer flu” that came out of laboratories in The Netherlands and in Wisconsin.  Essentially, for those living under a rock somewhere, both...

Ed gets annoyed.
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allAfrica.com: South Africa: New Reports Chart Progress - and Costs - in HIV Fight

allAfrica.com: South Africa: New Reports Chart Progress - and Costs - in HIV Fight | Virology News | Scoop.it
Although in its sixth year of publication, this year's barometer is the first to include data on early infant HIV testing for babies born to HIV-positive mothers and shows that about half of all babies born to HIV-positive mothers are now being tested for the virus at six weeks of age, an important step to ensuring they access the early HIV treatment recommended for all children younger than one under national guidelines. In 2009, only about a quarter of such babies were being tested using the sensitive polymerase chain reaction - tests that confirm whether HIV-exposed infants are HIV-positive.

The report also found that almost all pregnant women are now tested for HIV, which has helped lower mother-to-child HIV transmission to below 4 percent in the country.

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Flu Virus Discovered In Bats

Flu Virus Discovered In Bats | Virology News | Scoop.it
Scientists from the US Centers for Disease Control and Prevention (CDC) have discovered evidence of a new influenza type A virus in Guatemalan fruit bats.

 

"...for reassortment to occur, the bat flu virus would have to be capable of infecting a different animal, such as a pig, horse or dog, at the same time as a human flu virus.

So far, the bat flu virus has only been found in little yellow-shouldered bats. These fruit bats are not native to the US, but quite common in Central and South America. The bats don't bite people, but it is feasible they could shed the virus onto foods like fruit and vegetables that are then eaten by humans and other animals."

 

And if you watched "Contagion", you will remember the bulldozer knocking down the tree, which disturbed the bat, which roosted in a pigpen, where pigs ate the faeces, and - recombination occurred!

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Weaponising bird flu? We don't need to weaponise no bird flu....

Weaponising bird flu?  We don't need to weaponise no bird flu.... | Virology News | Scoop.it

My family and I just watched "Contagion" on pay TV - and were most impressed.  Reasonably true to life, all sorts of realistic scenarios, Ian Lipkin appearing as an extra - and one wonderful quote:

 

"Someone doesn't have to weaponise the bird flu. The birds are doing that". Contagion is only a movie - but that's so true.

 

Oh, and an uncredited appearance by Darren Martin's wonderful recombination analysis package, RDP 3.0 - at 1hr 15 min from the end.

 

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Celine Dion cancels several Las Vegas shows due to virus that affects vocal cords - Washington Post

Celine Dion cancels several Las Vegas shows due to virus that affects vocal cords - Washington Post | Virology News | Scoop.it
Celine Dion cancels several Las Vegas shows due to virus that affects vocal cordsWashington PostLAS VEGAS — Singer Celine Dion has canceled several upcoming concerts in Las Vegas because of a virus.

 

One could speculate as to what it is -like respiratory syncytial virus - or simply say "thank you, virus!"

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Amazon.com: The Virus and the Vaccine: The True Story of a Cancer-Causing Monkey Virus, Contaminated Polio Vaccine, and the Millions of Americans Exposed (9780312278724): Debbie Bookchin, Jim Schum...

Amazon.com: The Virus and the Vaccine: The True Story of a Cancer-Causing Monkey Virus, Contaminated Polio Vaccine, and the Millions of Americans Exposed (9780312278724): Debbie Bookchin, Jim Schumacher: Books (The Virus and the Vaccine: The True ...

 

Sad thing is, it really is true - I've used it as a cautionary tale to my students for nigh on 30 years

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Mystery virus kills thousands of lambs - Telegraph

Mystery virus kills thousands of lambs - Telegraph | Virology News | Scoop.it
Thousands of lambs have been killed by a new virus that is threatening the
survival of many British farms.

 

Schmallenberg bites deep.  Be interesting to see where it came from originally!

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Virology Journal | Abstract | Disassembly and reassembly of human papillomavirus virus-like particles produces more virion-like antibody reactivity

Virology Journal | Abstract | Disassembly and reassembly of human papillomavirus virus-like particles produces more virion-like antibody reactivity | Virology News | Scoop.it
VLPs were subjected to post-purification disassembly and reassembly (D/R) treatment during bioprocessing to improve VLP immunoreactivity and stability. The post-D/R HPV16 VLPs and their complex with H16.V5 neutralizing antibody Fab fragments were visualized by cryo electron microscopy, showing VLPs densely decorated with antibody. Along with structural improvements, post-D/R VLPs showed markedly higher antigenicity to conformational and neutralizing monoclonal antibodies (mAbs) H16.V5, H16.E70 and H263.A2, whereas binding to mAbs recognizing linear epitopes (H16.J4, H16.O7, and H16.H5) was greatly reduced. Strikingly, post-D/R VLPs showed no detectable binding to H16.H5, indicating that the H16.H5 epitope is not accessible in fully assembled VLPs. An atomic homology model of the entire HPV16 VLP was generated based on previously determined high-resolution structures of bovine papillomavirus and HPV16 L1 pentameric capsomeres.

 

Image courtesy of Russell Kightley Media

 

 

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Bacteriophage T4 and Its Relatives. A Series of Critical Reviews: Amazon.co.uk: Jim D Karam, Eric S Miller: Books

Bacteriophage T4 and Its Relatives.A Series of Critical Reviews: Amazon.co.uk: Jim D Karam, Eric S Miller: Books...

 

Gotta love T4: it's EVERYWHERE...and the coolest piece of nanotechnology on the planet

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H5N1: Vietnam: Human trials for H5N1 vaccine successful

Via VietNam News: Human trials for birdflu vaccine successful.

Viet Nam has successfully produced experimental version of bird flu vaccine to combat the virus which has killed 62 people in 9 years, researchers at Vaccine and Biological Production Company No.1, said.

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New Vaccination Guidelines: HepB for Diabetics; HPV for Young Men

New Vaccination Guidelines: HepB for Diabetics; HPV for Young Men | Virology News | Scoop.it
There were a number of changes to the 2012 clinical guidelines that doctors follow for adult immunizations, released by a federal panel.

 

Yet another recommendation that young men get HPV vaccinations: time to start listening, boys!

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Enhanced pneumonia and disease in pigs vaccinated wi... [Vaccine. 2011] - PubMed - NCBI

"...these results suggest that inactivated SIV vaccines may potentiate clinical signs, inflammation and pneumonia following challenge with divergent homosubtypic viruses that do not share cross-reacting HI or SN antibodies."

 

Or: getting vaccinated with the wrong strain may hurt you during an epi/pandemic.

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