Kawasaki disease is an acute paediatric vasculitis of unknown origin. Environmental exposures have been suggested to contribute to disease development, but these remain to be defined.WHAT THIS STUDY ADDSThe findings suggest that infections are closely linked with Kawasaki disease, with a wider temporal association than previously described.Further, the data imply that many different agents may induce Kawasaki disease.
Gene II Protein (Gp2/P2) is a nicking enzyme of the M13 bacteriophage that plays a role in the DNA replication of the viral genome. P2 recognizes a specific sequence at the f1 replication origin and nicks one of the strands and starts replication.
Ed Rybicki's insight:
Turns out that either M13 Rep recognises geminivirus Ori sequences, or the geminivirus Rep recognises M13 - because a geminivirus genomes cloned into M13 can be liberated as a replicon in E coli!
As experts continue monitoring and surveying the environment and the nation's food supply for H5N1 bird flu, a rash of dead cats has many officials on edge.
Over half of our genomes consist of thousands of remnants of ancient viral DNA, known as transposable elements, which are widespread across the tree of life. Once dismissed as the "dark side" of the genome, researchers at Helmholtz Munich and Ludwig-Maximilians-Universität (LMU) have now revealed their crucial role in early embryo development. The study is published in the journal Cell.
Kawasaki disease is an acute paediatric vasculitis of unknown origin. Environmental exposures have been suggested to contribute to disease development, but these remain to be defined.WHAT THIS STUDY ADDSThe findings suggest that infections are closely linked with Kawasaki disease, with a wider temporal association than previously described.Further, the data imply that many different agents may induce Kawasaki disease.
Researchers have identified a novel genetic risk factor for SARS-CoV-2 infection, providing new insights into the virus's ability to invade human cells. SARS-CoV-2 is the virus that spreads COVID-19.
During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, the development of efficient serological tests for monitoring the dynamics of the disease as well as the immune response after illness or vaccination was critical.
Researchers from Tokyo Metropolitan University have created nanostructured alumina surfaces which are strongly antibacterial but can be used to culture cells. They found that anodic porous alumina (APA) surfaces prepared using electrochemistry in concentrated sulfuric acid had unprecedented resistance to bacterial growth, but did not hamper cell cultures.
In a groundbreaking study conducted by researchers at Uppsala University, crucial insights have been gained regarding the mechanisms by which the Semliki Forest virus infiltrates the central nervous system.
Background and Objectives: People living with HIV/AIDS have been impacted notably by the COVID-19 pandemic in diverse dimensions. Although some impacts of COVID-19 on PLHIV have been well documented, there is still insufficient research that captures the overall understanding of the implications...
New findings from the National Institutes of Health's (NIH) Researching COVID to Enhance Recovery (RECOVER) Initiative suggest that infection with SARS-CoV-2, the virus that causes COVID-19, may be associated with an increase in the number of myalgic encephalomyelitis/chronic fatigue syndrome...
Becoming Led Zeppelin explores the origins of this iconic group and their meteoric rise in just one year against all the odds.
Powered by awe-inspiring, psychedelic, never-before-seen footage, performances, and music, Bernard MacMahon’s experiential cinematic odyssey explores Led Zeppelin’s creative, musical, and personal origin story. The film is told in Led Zeppelin’s own words and is the first officially sanctioned film on the group.
Background: The Influenza A virus (IAV), a pathogen affecting the respiratory system, represents a major risk to public health worldwide. Immunization remains the foremost strategy to control the transmission of IAV.
Scientists at Harvard Medical School and Boston University Chobanian & Avedisian School of Medicine have mapped a critical component of the Nipah virus, a highly lethal bat-borne pathogen that has caused outbreaks in humans almost every year since it was identified in 1999.
Science has revealed some of the secrets of the X chromosome, but many remain. In humans, female cells contain two X chromosomes (XX) and male cells contain one (XY). In each female cell, one X chromosome must be inactivated—crumpled up in such a way that the genetic code it contains cannot be read out.
Studies conducted in mice have shown that the COVID-19 vaccine being developed by researchers at the University of São Paulo's Medical School (FM-USP) in Brazil is safe and efficacious.
Genetically speaking, it's a bacterium's worst-case scenario: During transcription, newly minted RNA sticks to its DNA template, forming a 3-stranded structure known as an R-loop. While these structures have some important roles to play in a cell, R-loops in the wrong place at the wrong time can be disastrous, leading to DNA breaks, mutations, and cell death.
A deadly bird flu outbreak has wreaked havoc on U.S. chicken farms, claiming the lives of over 20 million egg-laying chickens last quarter, marking the worst impact on America's egg supply since the outbreak began in 2022.
DNA sequencing was revolutionized after scientists discovered a new bacterium in the hot springs of Yellowstone National Park, and today it's a common research technique.
The mosquito-borne Zika virus is known for causing microcephaly, a birth defect in which abnormal brain development results in a smaller-than-expected head.
Germany took further steps Monday to limit the potential spread of foot-and-mouth disease, as an outbreak of the virus threatened to hit the country's agricultural exports.
An often-overlooked mechanism of gene regulation may be involved in the failure of antifungal drugs in the clinic, claims a German-Austrian research team led by the Leibniz Institute for Natural Product Research and Infection Biology–Hans Knöll Institute (Leibniz-HKI). Their study, published in Nucleic Acids Research, focused on the mold fungus Aspergillus fumigatus, which can cause life-threatening infections, especially in immunocompromised people.
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been associated with various hematological disorders. Understanding the pathology of erythrocytes (red blood cells) in coronavirus infection may provide insights into disease severity and progression.
Germany on Friday registered three cases of foot-and-mouth disease in water buffalo on a farm near Berlin, the country's first reported cases of the livestock disease since 1988.
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