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"Set your phages to stun"

"Set your phages to stun" | Virology News | Scoop.it
Engineered phage viruses show promise as targeted assassins - genetic manipulation might make it easier for them to gain regulatory approval

Many phage infect and replicate inside bacteria, killing them. This makes phages a possible alternative to antibiotics as resistance to these drugs grows. What’s more, most phages infect only one species or even a few strains within a species; antibiotics aren’t so selective.

But that specificity is a problem: it might not be clear which pathogenic bacterial strain is present in an infection, so a cocktail of several phages might be needed to guarantee effective treatment. Each may have to pass regulatory approval separately.

Timothy Lu and his colleagues at the Massachusetts Institute of Technology aim to get round this by making a single phage modifiable with bacteria-attacking machinery from other phages. In theory, that could reduce regulatory hold-ups.

 

E coli and lambda phage graphic by Russell Kightley Media

Ed Rybicki's insight:

Couldn't resist that byline - it's part of the article - so that I could get some mileage out of something mildly upsetting.

It's just that someone else has yet AGAIN had my good idea before I did.

There I was, reading about and blogging on bacteria co-opting phage tail assemblies as weapons against other phages, and dreaming up ways of using them creatively - and someone else had gone and done it.

That is, used an engineered phage genome and presumably head structure with a variety of tail assemblies (which determine the binding specificity) in order to target as many bacterial types as possible.

Very clever!  It's what may make phage therapy into a science instead of an art.

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Virology News
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PDB-101: Goodsell Gallery: Coronavirus Life Cycle

PDB-101: Goodsell Gallery: Coronavirus Life Cycle | Virology News | Scoop.it

This illustration shows a cross section through a cell infected with a coronavirus such as SARS-CoV-2. It shows a time point when the virus is actively replicating, and new viruses are being created. The cell’s molecules are shown in blues and greens, and the viral molecules are shown in pinks and purples. The illustration integrates the current state of knowledge, but many aspects of the virus and its life cycle are still actively being studied, so portions of the painting are speculative. Additional resources for exploring coronavirus are available at PDB-101 and the main RCSB PDB site.


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Quasar upends ideas about black hole formation

Quasar upends ideas about black hole formation | Virology News | Scoop.it
A new discovery "presents the biggest challenge yet for the theory of black hole formation and growth in the early universe."...
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A brave new way to bring the coronavirus vaccine to the masses

A brave new way to bring the coronavirus vaccine to the masses | Virology News | Scoop.it
SINGAPORE - The world has faced no other crisis in recent times that has so highlighted our need for global cooperation.. Read more at straitstimes.com.
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COVID-19 affects human neurons, mini-brains show

COVID-19 affects human neurons, mini-brains show | Virology News | Scoop.it
Does COVID-19 affect the brain? A new study shows that the coronavirus can infect the human brain cells and multiply.
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Once there's a COVID-19 vaccine, who'll get access?

Once there's a COVID-19 vaccine, who'll get access? | Virology News | Scoop.it
"...it's wrong to think that a [COVID-19 vaccine] will be a flick-of-a-switch solution that saves the entire world at once."...
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Within-Host Viral Diversity: A Window into Viral Evolution | Annual Review of Virology

Within-Host Viral Diversity: A Window into Viral Evolution | Annual Review of Virology | Virology News | Scoop.it
The evolutionary dynamics of a virus can differ within hosts and across populations. Studies of within-host evolution provide an important link between experimental studies of virus evolution and l...
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Regeneron starts trial of Covid-19 antibody cocktail

Regeneron starts trial of Covid-19 antibody cocktail | Virology News | Scoop.it
Regeneron Pharmaceuticals has commenced the first clinical trial of its dual antibody cocktail, REGN-COV2, which is meant to prevent and treat Covid-19.
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Sinovac says its Covid-19 vaccine generated immune responses

Sinovac says its Covid-19 vaccine generated immune responses | Virology News | Scoop.it
Sinovac Biotech announced preliminary study results showing its experimental Covid-19 vaccine generated immune responses in patients and was safe.
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Asymptomatic transmission of coronavirus appears to be worse than SARS or influenza — 5 reasons you should care

Asymptomatic transmission of coronavirus appears to be worse than SARS or influenza — 5 reasons you should care | Virology News | Scoop.it
Asymptomatic transmission ‘is the Achilles’ heel of COVID-19 pandemic control,’ one study says.
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CDC director urges Americans to get flu vaccine during coronavirus pandemic

CDC director urges Americans to get flu vaccine during coronavirus pandemic | Virology News | Scoop.it
Experts continue warning about the devastating effects of a second wave of coronavirus cases, but a top U.S. health official says it will be even worse if Americans don’t get a flu shot.
tarek11223344's curator insight, June 24, 4:14 AM

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Reopening schools requires major caution

Reopening schools requires major caution | Virology News | Scoop.it
Experts call for large-scale viral testing in children, contract tracing, and other actions to avoid compounding the COVID-19 crisis as schools reopen.
Alicyn Benton's curator insight, June 25, 12:21 AM
This topic definitely needs to be checked into with additional precautions! I say that due to schools not being able to dictate parents sending their children to school. We can always say please don’t send your children if they are sick and they still do. This will then put not only other students but faculty members at risk.
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Spectrum of neurological manifestations associated with SARS-CoV-2 infection

Spectrum of neurological manifestations associated with SARS-CoV-2 infection | Virology News | Scoop.it
All neurological manifestations UK-wide surveillance of neurological and neuropsychiatric complications of COVID19 the first 153 patients. Preprint Neurologic manifestations in hospitalized patients with COVID-19: The ALBACOVID registry.
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Measles-mumps-rubella-varicella Combination Vaccine and the Risk of Febrile Seizures

Among 12- to 23-month-olds who received their first dose of measles-containing vaccine, fever and seizure were elevated 7 to 10 days after vaccination. Vaccination with MMRV results in 1 additional febrile seizure for every 2300 doses given instead of separate MMR + varicella vaccines.
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Deep phenotyping of 34,128 patients hospitalised with COVID-19 and a comparison with 81,596 influenza patients in America, Europe and Asia: an international network study

medRxiv - The Preprint Server for Health Sciences...
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The line is forming for a COVID-19 vaccine. Who should be at the front?

The line is forming for a COVID-19 vaccine. Who should be at the front? | Virology News | Scoop.it
U.S.and World Health Organization are already debating how to prioritize the initial distribution of a coveted vaccine...
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Inovio’s coronavirus vaccine candidate delivers promising results in Phase 1 trial 

Inovio’s coronavirus vaccine candidate delivers promising results in Phase 1 trial  | Virology News | Scoop.it
Inovio released a coronavirus vaccine update to announce that its experimental DNA drug generated immune responses in 94% of volunteers enrolled in Phase 1 trials. The company is part of the US government’s Operation Warp Speed initiative to fast-track the development of COVID-19 vaccines.
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Aussie human trials for local vaccine start

Aussie human trials for local vaccine start | Virology News | Scoop.it
One of Australia's COVID-19 vaccine candidates made by South Australian company Vaxine is kicking off its human trials in Adelaide on Thursday.
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Covid-19 vaccine by Ahmedabad-based Zydus Cadila gets DCGI nod for human clinical trials 

Covid-19 vaccine by Ahmedabad-based Zydus Cadila gets DCGI nod for human clinical trials  | Virology News | Scoop.it
India News: After Bharat Biotech's Covaxin, another potential Covid-19 vaccine indigenously developed by Ahmedabad-based Zydus Cadila Healthcare Ltd got the nod f...
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Industrial Meat 101: Could Large Livestock Operations Cause the Next Pandemic?

Industrial Meat 101: Could Large Livestock Operations Cause the Next Pandemic? | Virology News | Scoop.it
Novel viruses have been emerging in CAFOs for years. Advocates say coronavirus should act as a wake-up call.
linda tonui's curator insight, June 28, 5:42 AM
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Black Iberian Pig For Sale

The Iberian pig is an animal of the porcine breed, the name also applies to varieties belonging to what is known as the “Iberian trunk”, which includes black and red, furry or hairless breeds. The Iberian pigs, predominant in the Iberian Peninsula shared between Spain and Portugal, are highly appreciated animals in the gastronomic sector as they produce the famous Iberian ham and different types of sausages. Black Iberian Pig For sale in USA at Kentucky Cattle Range.

The Iberian pig 

The Iberian pig is a unique species with characteristics that differentiate it from other animals of the same species, such as the ability to infiltrate fat in the muscle. Physically speaking, these animals have a well-proportioned head and a pointed muzzle. Unlike other types of pigs, the Iberian has a powerful neck, a drooping dewlap, medium-sized ears in the form of a visor and a large belly. Its extremities, the ones we are most interested in when talking about ham, are thin.

The Iberian pigs, as their name suggests, belong to a breed native to the Iberian Peninsula, located between Spain and Portugal, where there are two groups of breeds listed below:

  • Celtic pig (practically extinct)
  • Iberian Pig
  • Size:

    Medium to large animals, around 600 – 900 pounds at maturity.

    Temperament:

    Excellent disposition. Friendly and curious.

    • Iberian black layer, which includes the varieties Lampiño and Entrepelado.
    • Iberian red layer, which includes the varieties Retinta or Colorada, Rubia de Cádiz, Manchanda de Jabugo and Torbiscal.

The most widely used variety in the world of ham is Retinta or Colorada which, in addition to being very prolific, allows for greater use after slaughtering the animal. So, the most important thing to know is that the Iberian pig is a native breed of animal. Its physiological capacity to store fat between muscles makes it have a high gastronomic value. The Iberian pigs are the only pigs in the world from which it is possible to obtain Iberian ham, a product with a very particular aroma, flavor and texture, also healthy and nutritious.

Iberian Ham and products

In the production of Iberian ham, not only the breed (which is fundamental) is important, but also the process of breeding the animal. Although in theory all pigs are used to make ham, only the so-called white pig and the Iberian pig are used to make a ham. The latter is the key piece in the production of Iberian ham. The different types of ham and Iberian products are given by the percentage of purity of the animal’s breed and the food it has fed on.

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Canadian expert says he is confident COVID-19 vaccine is months, not years away

Canadian expert says he is confident COVID-19 vaccine is months, not years away | Virology News | Scoop.it
Dr.Gary Kobinger says there are more than 100 possible vaccines in development for COVID-19 around the world...
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In Second Blow To Hydroxychloroquine, FDA Warns Against Combining With Remdesivir

In Second Blow To Hydroxychloroquine, FDA Warns Against Combining With Remdesivir | Virology News | Scoop.it
We're sure Dr. Fauci approves...
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CureVac gets German backing for coronavirus vaccine, but says it's independent

CureVac gets German backing for coronavirus vaccine, but says it's independent | Virology News | Scoop.it
BioPharma...
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Way before stars form, space clouds hold building blocks of life

Way before stars form, space clouds hold building blocks of life | Virology News | Scoop.it
"This tells us that the basic organic chemistry needed for life is present in the raw gas prior to the formation of stars and planets."...
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Self-swab COVID tests may be just as accurate

Self-swab COVID tests may be just as accurate | Virology News | Scoop.it
COVID-19 tests that have patients swab their own noses are as accurate as the more invasive tests that health care workers administer, a small study finds.
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Modeling the Effectiveness of Respiratory Protective Devices in Reducing Influenza Outbreak

Outbreaks of influenza represent an important health concern worldwide. In many cases, vaccines are only partially successful in reducing the infection rate, and respiratory protective devices (RPDs) are used as a complementary countermeasure.
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AstraZeneca takes next steps towards broad and equitable access to Oxford University’s COVID-19 vaccine

AstraZeneca has taken the next steps in its commitment to broad and equitable global access to the University of Oxford’s COVID-19 vaccine, following landmark agreements with the Coalition for Epidemic Preparedness Innovations (CEPI), Gavi the Vaccine Alliance, and the Serum Institute of India (SII). The Company today reached a $750m agreement with CEPI and Gavi to support the manufacturing, procurement and distribution of 300 million doses of the vaccine, with delivery starting by the end of the year. In addition, AstraZeneca reached a licensing agreement with SII to supply one billion doses for low and middle-income countries, with a commitment to provide 400 million before the end of 2020. Together, the agreements mark the latest commitments to enable global access to the vaccine, including to low and middle-income countries, beyond AstraZeneca’s recent partnerships with the UK and US. 

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