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Rabies Vaccine Protects Nonhuman Primates against Deadly Ebola Virus

Rabies Vaccine Protects Nonhuman Primates against Deadly Ebola Virus | Virology News | Scoop.it
The research team is pursuing the inactivated rabies/Ebola vaccine for use in humans. The live vaccine is being developed for use in protecting wildlife at risk of Ebola virus infection in Africa, which could also serve to prevent transmission into the human population. 
Ed Rybicki's insight:

I missed this one at the time - and it is an interesting piece of news.  Basically, the research team cloned the Ebola envelope glycoprotein GP1 into the extant rabies virus vaccine strain genome, and tested a live version, a replication-deficient version, and a killed whole virion version in macaques.

Their results are interesting enough - 100% protection against challenge for live, 50% for the other two - that they plan to follow up to see whether or not additional doses could improve protection in the two non-replicating versions, and to make a "multivalent filovirus vaccine".

This can only be welcome news against the backdrop of the still-ongoing epidemic in West Africa - where two other vaccines (recombinant vesicular stomatitis and chimpanzee adenovirus) are probably going to be trialled next year. The rabies version at least is based on a very well characterised vaccine that already protects against an extremely deadly disease - it remains to be seen how well the other two do.

 

I forgot to mention that I found reference to this article on "The Zombie Research Society"'s blog site: http://zombieresearchsociety.com/archives/25562. A very apt place if one considers the parallels that are already being drawn between Ebola and a "zombie virus".

And because I like zombies B-)

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Topical news snippets about viruses that affect people.  And other things. Like Led Zeppelin. And zombies B-)
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The Vaccine Makers Project

The Vaccine Makers Project | Virology News | Scoop.it
Materials are updated as needed. The Vaccine Education Center staff regularly reviews materials for accuracy. You should not consider the information in this site to be specific, professional medical advice for your personal health or for your family's personal health.
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The unequal impact of the Spanish flu in South Africa

The unequal impact of the Spanish flu in South Africa | Virology News | Scoop.it
The 1918 Influenza epidemic in South Africa exacerbated existing large racial inequalities in access to institutionalized medical treatment...
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No vaccine, no French Open for Djokovic as rules tighten

No vaccine, no French Open for Djokovic as rules tighten | Virology News | Scoop.it
Novak Djokovic risks being frozen out of tennis as he chases a record 21st Grand Slam title, with rules on travellers who are unvaccinated against COVID-19 tightening in the third year of the pandemic and some tournaments reconsidering exemptions.
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France to push EU states to approve avian flu vaccine for poultry

France to push EU states to approve avian flu vaccine for poultry | Virology News | Scoop.it
Two vaccines will soon be tested in France in response to the worst avian influenza outbreak Europe has ever faced, French Agriculture Minister Julien Denormandie has announced. The aim is for them to be approved for all 27 EU member states.
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Israeli trial, world's first, finds 4th dose ‘not good enough’ against Omicron

Expert at Sheba Medical Center says jab raises COVID antibody levels, but there are ‘still a lot of infections’ among those who received it...
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Queen’s swans culled after bird flu outbreak on the Thames

Queen’s swans culled after bird flu outbreak on the Thames | Virology News | Scoop.it
Vets had the unfortunate task of putting down 26 of the swans on the Thames after six were pulled from the river earlier in January...
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ADHD drug may protect against Alzheimer's neurodegeneration

ADHD drug may protect against Alzheimer's neurodegeneration | Virology News | Scoop.it
A repurposed ADHD medication that boosts norepinephrine levels could stall neurodegeneration in people with early signs of Alzheimer’s disease.
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Doomscrolling is a unique behavior, not just a trendy name

Doomscrolling is a unique behavior, not just a trendy name | Virology News | Scoop.it
"Doomscrolling" isn't just a new name for an existing behavior, researchers say. It's a unique behavior all its own, according to a new study.
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Which countries offer the best (and worst) end-of-life care?

Which countries offer the best (and worst) end-of-life care? | Virology News | Scoop.it
"Most people in the world die badly—many through no treatment at all and many through excessive often futile treatment that increases suffering."...
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California kids 12 and up could get COVID vaccine without parent OK

California kids 12 and up could get COVID vaccine without parent OK | Virology News | Scoop.it
The bill is the first to be introduced this year by a group of Democratic lawmakers pledging to strengthen vaccination laws and target misinformation amid the COVID-19 pandemic.
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Moderna data shows mRNA isn’t a quick fix for the flu vaccine

Moderna data shows mRNA isn’t a quick fix for the flu vaccine | Virology News | Scoop.it
Moderna presented early data from clinical trials of its mRNA-based flu vaccine. The shots didn’t generate more antibodies than shots already on the market.
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Roles of two distinct alphasatellites modulating geminivirus pathogenesis

Roles of two distinct alphasatellites modulating geminivirus pathogenesis | Virology News | Scoop.it
Background Alphasatellites are small coding DNA satellites frequently associated with a begomovirus/betasatellite complex, where they are known to modulate virulence and symptom development. Two distinct alphasatellites, namely, Cotton leaf curl Multan alphasatellite (CLCuMuA), and Gossypium...
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The Return of the Flu

The Return of the Flu | Virology News | Scoop.it
The flu has returned to some countries with high rates of natural immunity against SARS-CoV-2. In contrast, countries with high vaccination rates but low natural immunity rates are seeing record new covid waves, although at lower hospitalization and death rates than before.
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Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection

Author summary Interferon responses are part of the primary host defenses against infections. However, excessive inflammation is often a major factor in severe disease or even death in respiratory infections such as influenza, as it can lead to acute respiratory distress syndrome and sepsis-like...
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Return of the flu: EU faces threat of prolonged 'twindemic'

Return of the flu: EU faces threat of prolonged 'twindemic' | Virology News | Scoop.it
Influenza has returned to Europe at a faster-than-expected rate this winter after almost disappearing last year, raising concerns about a prolonged "twindemic" with COVID-19 amid some doubts about the effectiveness of flu vaccines.
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Covid-flu joint booster vaccine possible late 2023: Moderna

Covid-flu joint booster vaccine possible late 2023: Moderna | Virology News | Scoop.it
Moderna aims to roll out a combined Covid-flu-RSV booster vaccine in late 2023, the US pharmaceutical firm said Monday, hoping a joint jab...
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H5N1 Flu Outbreak In Burkina Faso

H5N1 Flu Outbreak In Burkina Faso | Virology News | Scoop.it
Flu outbreaks continue to be a major crisis in the poultry industry.The year didn't start so well for poultry farmers in Burkina Faso, not only did it affect...
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With Covid, we’ll never have a normal flu season again

With Covid, we’ll never have a normal flu season again | Virology News | Scoop.it
This terrible Covid and flu season is a preview of the post-pandemic normal.
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CORBEVAX, a new patent-free COVID-19 vaccine, could be a pandemic game changer globally

CORBEVAX uses recombinant DNA technology that many countries already have the infrastructure to produce. Artis777 via iStock/Getty Images PlusThe world now has a new COVID-19 vaccine in its arsenal, and at a fraction of the cost per dose.
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Development and Clinical Validation of a Potential Penside Colorimetric Loop-Mediated Isothermal Amplification Assay of Porcine Circovirus Type 3 

Development and Clinical Validation of a Potential Penside Colorimetric Loop-Mediated Isothermal Amplification Assay of Porcine Circovirus Type 3  | Virology News | Scoop.it
Porcine circovirus type 3 (PCV3), a novel circovirus, imposes great burdens on the global pig industry. The penside tests for detecting PCV3 are critical for assessing the epidemiological status and working out disease prevention and control programs due to the unavailability of a commercial...
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French Authorities Order Killing of 2.5 Million Poultry Over Bird Flu

French Authorities Order Killing of 2.5 Million Poultry Over Bird Flu | Virology News | Scoop.it
PARIS—The French farming ministry on Thursday said that a total of 2.5 million birds needed to be killed ...
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‘Phenomenal level’ of bird flu in UK, chief vet says after thousands culled

‘Phenomenal level’ of bird flu in UK, chief vet says after thousands culled | Virology News | Scoop.it
The disease is understood to have been spread by migratory birds flying back from the north of Russia and eastern Europe.
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Thailand on Alert After Bird Flu Kills Chinese Woman, Infects 61

Thailand livestock officials have gone on high alert over reports out of China that a woman died of bird flu. Department of Livestock Development Director-General Sorravis Thaneto said Friday the Chinese government announced that a 54-year-old woman from Sichuan Province has died from the H5N6...
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Antidepressant prevents most serious COVID-19 complications

Antidepressant prevents most serious COVID-19 complications | Virology News | Scoop.it
New research confirms an earlier study that the antidepressant fluvoxamine prevents some of the most serious complications of COVID-19.
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Functional implications of residues of the B′ motif of geminivirus replication initiator protein in its helicase activity

Functional implications of residues of the B′ motif of geminivirus replication initiator protein in its helicase activity | Virology News | Scoop.it
Geminivirus replication initiator protein (Rep) is a multifunctional viral protein required for replication. During the process of viral replication, Rep acts as a site- and strand-specific endonuc...
Ed Rybicki's insight:
Hey, I'm still a geminivirologist at heart B-) 
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