In a study recently published in Allergy, a MedUni Vienna research team shows that COVID-19 leads to considerable long-term changes in the immune system, even in mild cases. The findings could help to better understand the long-term consequences of an infection with SARS-CoV-2.

Soybean, as a globally critical leguminous crop, faces continuous threats from different pathogens, which profoundly affect global production. Although the genetic interactions between soybean and pathogens have attracted extensive attention and research, the complex biochemical responses remain...

In this review, we summarize the design, development, and current place in multiple sclerosis therapy for ublituximab.

Researchers at the vast facility describe the ‘pre-pandemic’ jabs being made there as a ‘first line of defence’...

Budding new plant biology research is paving the potential to produce food crops that not only survive but thrive in salty conditions. With salt estimated to affect up to 30% of arable land worldwide—jeopardizing the survival of crops—the salinity crisis is a costly burden on agricultural...

A new study of radar experiment data from the Cassini-Huygens mission to Saturn has yielded fresh insights related to the makeup and activity of the liquid hydrocarbon seas near the north pole of Titan, the largest of Saturn's 146 known moons.

The grapes that give us wine likely originated in the New World 60 million years ago, according to new research.

Plant pathogens often infect specific tissues, causing significant agricultural losses. Recent studies highlight the crucial role of small RNAs (sRNAs), including miRNAs, in regulating these interactions.

A research team developed hybrid bio-nanostructures then used them to fabricate fibrous solar cells (FSCs) and fibrous organic light-emitting diodes (FOLEDs) that demonstrated high performance and stability across a wide temperature range, from minus 80 degrees Celsius to 150 degrees Celsius.

Antibiotics are widely used in clinical treatment and animal production as an effective means to combat microbial infections. Antimicrobial peptides, as potential alternatives to antibiotics, have shown promising applications.

Despite assurances from the federal government that bird flu will be eradicated from the nation's dairy cows, some experts worry the disease is here to stay.

Angiogenin, an enzyme that plays a critical role in cellular stress responses and aids vascular formation, has previously been implicated in the formation of solid cancer tumors, neurodegenerative disorders and epigenetic inheritance, and has been the focus of intense study by scientists for four...

One hundred years ago, the discovery of a skull in South Africa's North West province altered our understanding of human evolution. The juvenile skull was dubbed the Taung Child by Raymond Dart, an anatomist at the University of the Witwatersrand, who first described it.

Building upon groundbreaking research demonstrating how the SARS-CoV-2 virus disrupts mitochondrial function in multiple organs, researchers from Children's Hospital of Philadelphia (CHOP) demonstrated that mitochondrially-targeted antioxidants could reduce the effects of the virus while avoiding...

While half the global population relies on rice as a staple, about 15% of rice produced each year is contaminated by potentially fatal aflatoxins. Seeing this threaten lives in her home country of Kenya prompted a graduate research assistant to focus on eradicating the risk through safer storage...

An international research collaboration has uncovered a new mechanism of the crosstalk between microtubules and actin cytoskeleton during cell division and revealed unique characteristics of the previously unexplored protein FAM110A.

CRISPR-Cas systems, defense systems in bacteria, have become a plentiful source of technologies for molecular diagnostics. Researchers at the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg have expanded this extensive toolbox.

A series of experiments with highly pathogenic H5N1 avian influenza (HPAI H5N1) viruses circulating in infected U.S. dairy cattle found that viruses derived from lactating dairy cattle induced severe disease in mice and ferrets when administered via intranasal inoculation.

A team of astronomers has identified a temperate exoplanet as a promising super-Earth ice or water world.

In a study published in the journal National Science Review, researchers developed an amplifiable protein identification method called "AmproCode."...

Researchers reveal both direct and indirect mechanisms of SARS-CoV-2-induced lymphopenia, highlighting the role of CD147 and alternative viral entry routes into T cells.

Researchers investigated whether COVID-19-related sensory deficiencies are associated with transcriptome changes in the foliate papillae area of the tongue.

Background More than a year after recovering from COVID-19, a large proportion of individuals, many of whom work in the healthcare sector, still report olfactory dysfunctions. However, olfactory dysfunction was common already before the COVID-19 pandemic, making it necessary to also consider the...

During the COVID-19 pandemic, the EMA Emergency Task Force (ETF) issued two guidance documents on regulatory requirements for COVID-19 vaccines. The first, issued in November 2020, covered clinical requirements for COVID-19 vaccine approval, and the second, issued in February 2021, addressed quality, non-clinical, clinical and clinical requirements for SARS-CoV-2 variant vaccines. Since these documents were published there have been several developments in the field of COVID-19 vaccines. In parallel, the predominant circulating variants of SARS-CoV-2 continue to evolve over time and the immunity of the European Union (EU) population to prior and current variants has increased due to natural exposures and vaccination campaigns. Experience with applications for scientific advice and for marketing authorisation since 2021 have pointed to the need for revision of the guidance documents. It is proposed to consolidate the two guidance documents into a single guideline that covers the non-clinical and clinical aspects of the development of vaccines against COVID-19.Keywords: Vaccine platforms, mRNA, immunobridging, effectiveness, SARS-COV-2, regulatory requirements, sarbecovirus, broad coverage Current version Concept paper on the revision of the COVID-19 vaccines guidance documentsConsultation dates: 01/07/2024 to 30/09/2024Reference Number: EMA/CHMP/276798/2024 English (EN) (187.42 KB - PDF)First published: 01/07/2024View Related content Multidisciplinary: vaccinesCOVID-19 guidance: assessment and marketing authorisationCOVID-19 vaccines: key factsClinical evaluation of new vaccinesShare this page