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Medicago Announces 2012 Second Quarter Financial Results [H1N1 vaccine]

Medicago Announces 2012 Second Quarter Financial Results [H1N1 vaccine] | Virology News | Scoop.it
Medicago Announces 2012 Second Quarter Financial Results PR Newswire QUEBEC CITY, Aug. 14, 2012 QUEBEC CITY , Aug. 14, 2012 /PRNewswire/ - Medicago Inc.

"Subsequent to the second quarter:

Announced the successful completion of a key milestone under an agreement with the Defense Advanced Research Projects Agency (DARPA). The milestone was the production of at least 10 million doses of H1N1 VLP influenza vaccine candidate in one month (the "rapid fire test"). The rapid fire test was conducted at Medicago's facility in Durham, North Carolina. As part of the rapid fire test, production of the H1N1 VLP influenza vaccine candidate began on March 25th, 2012, and was completed in 30 days on April 24th, 2012. The production lots were then tested by a third party laboratory to confirm both the immunogenicity of the vaccine candidate and the number of doses produced. Testing confirmed that a single dose of the H1N1 VLP influenza vaccine candidate induced protective levels of neutralizing antibodies in an animal model. The production of significantly more than 10 million doses, as defined by the testing conditions, were confirmed."

 

This is a big, big deal - because they did this via transient expression in plants, thus proving pretty much beyond doubt that this is now a serious vaccine manufacturing technology.  Going green: the sensible thing to do...B-)

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Virology News
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Efficacy, safety, and immunogenicity of an inactivated, adjuvanted enterovirus 71 vaccine in infants and children: a multiregion, double-blind, randomised, placebo-controlled, phase 3 trial

Efficacy, safety, and immunogenicity of an inactivated, adjuvanted enterovirus 71 vaccine in infants and children: a multiregion, double-blind, randomised, placebo-controlled, phase 3 trial | Virology News | Scoop.it
EV71vac is safe, well-tolerated, and highly effective in preventing EV71 associated
diseases in children aged 2–71 months.
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Nasal symbiont Staphylococcus epidermidis restricts the cellular entry of influenza virus into the nasal epithelium 

Nasal symbiont Staphylococcus epidermidis restricts the cellular entry of influenza virus into the nasal epithelium  | Virology News | Scoop.it
Our recent study presented that human nasal commensal Staphylococcus epidermidis could potentiate antiviral immunity in the nasal mucosa through interferon-related innate responses. Here, we found that human nasal commensal S.
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Can this soil microbe boost artificial photosynthesis?

Can this soil microbe boost artificial photosynthesis? | Virology News | Scoop.it
"This bacterial enzyme is the most efficient carbon fixer that we know of, and we came up with a neat explanation of what it can do."...
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Official numbers may miss 20% of COVID deaths

Official numbers may miss 20% of COVID deaths | Virology News | Scoop.it
The United States has just marked one million deaths from COVID-19. But a new study suggests that the true count is closer to 1.2 million deaths.
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World's First Malaria Vaccine Expands Rollout

World's First Malaria Vaccine Expands Rollout | Virology News | Scoop.it
The results from a WHO pilot points to more countries in sub-Saharan Africa receiving the world's first malaria vaccine.
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Emerging Novel Reassortant Influenza A(H5N6) Viruses in Poultry and Humans, China, 2021

Emerging Novel Reassortant Influenza A(H5N6) Viruses in Poultry and Humans, China, 2021 | Virology News | Scoop.it
Emerging Novel Reassortant Influenza A(H5N6) Viruses in Poultry and Humans, China, 2021...
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Bird flu H5N1 spreads to foxes in US, 4 die –

Bird flu H5N1 spreads to foxes in US, 4 die – | Virology News | Scoop.it
New York:   Four red baby foxes in the US reportedly died in what is known as the first case of...
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Structure-based design of 5'-substituted 1,2,3-triazolylated oseltamivir derivatives as potent influenza neuraminidase inhibitors

Resistant viruses containing mutant neuraminidases (NAs) with diminished drug affinity continue to emerge, and new anti-influenza agents are urgently required.Several potent inhibitors targeting the hydrophobic 150-cavity of viral NAs have been developed by modifying the antiviral drugs, oseltamivi...
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From Outbreak to Near Disappearance: How Did Non-pharmaceutical Interventions Against COVID-19 Affect the Transmission of Influenza Virus?

Influenza shares the same putative transmission pathway with coronavirus disease 2019 (COVID-19), and causes tremendous morbidity and mortality annually globally.Since the transmission of COVID-19 in China, a series of non-pharmaceutical interventions (NPIs) against to the disease have been impleme...
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Estimating the life course of influenza A(H3N2) antibody responses from cross-sectional data

The immunity of a host population against specific influenza A strains can influence a number of important biological processes, from the emergence of new virus strains to the effectiveness of vaccination programmes.
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Africa’s first Covid-19 vaccine factory has not received a single order 

Africa’s first Covid-19 vaccine factory has not received a single order  | Virology News | Scoop.it
Throughout the coronavirus pandemic, many African countries have lagged far behind much of the world in getting their people vaccinated — and some countries have had difficulty distributing what doses they did get.
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Left-Handed Nanoparticle Adjuvant Boosts Flu Vaccine Efficacy in Mice by 25%

Left-Handed Nanoparticle Adjuvant Boosts Flu Vaccine Efficacy in Mice by 25% | Virology News | Scoop.it
Tests on human immune cells showed that chiral nanoparticles induced an immune response even in the absence of antigen.
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Aspen In Talks With African Leaders on Low Covid Vaccine Orders - BNN Bloomberg

Aspen In Talks With African Leaders on Low Covid Vaccine Orders - BNN Bloomberg | Virology News | Scoop.it
Aspen Pharmacare Holdings Ltd. is in talks with African leaders about how to raise demand for Covid-19 vaccines after the continent’s biggest drugmaker warned a lack of orders may force it to stop making the shots.
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Mutations in DNA polymerase δ subunit 1 mediate CMD2-type resistance to Cassava Mosaic Geminiviruses

Mutations in DNA polymerase δ subunit 1 mediate CMD2-type resistance to Cassava Mosaic Geminiviruses | Virology News | Scoop.it
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution...
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Flu vaccine cuts risk of heart attack in following year by 34 per cent

Flu vaccine cuts risk of heart attack in following year by 34 per cent | Virology News | Scoop.it
A meta-analysis of studies involving 9000 people suggests those who receive a flu vaccine also gain some protection against heart attacks...
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Bacteria that 'record' data can check gut health

Bacteria that 'record' data can check gut health | Virology News | Scoop.it
Modified bacteria that can log data about their surroundings may be a good way to non-invasively get information about gut health, research in mice shows.
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Britain gives first European approval to Valneva COVID shot

Britain gives first European approval to Valneva COVID shot | Virology News | Scoop.it
Britain approved Valneva's COVID-19 vaccine on Thursday, becoming the first European country to clear the use of the French firm's shot in a move that boosted its shares by more than 20%.
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North Korea and Eritrea are the only two countries without vaccines

North Korea and Eritrea are the only two countries without vaccines | Virology News | Scoop.it
North Korea, like Eritrea, has refused to join vaccine-sharing initiatives....
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South Africa in new surge of COVID from versions of omicron 

South Africa in new surge of COVID from versions of omicron  | Virology News | Scoop.it
JOHANNESBURG (AP) — South Africa is experiencing a surge of new COVID-19 cases driven by two omicron sub-variants, according to health experts. For about three weeks the country has seen increasing numbers of new cases and somewhat higher hospitalizations, but not increases in severe cases and...
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Safety and Immunogenicity of BNT162b2 Coadministered With SIIV in Adults 18 Through 64 Years of Age

Safety and Immunogenicity of BNT162b2 Coadministered With SIIV in Adults 18 Through 64 Years of Age - Full Text View.
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A rapid water bath PCR combined with lateral flow assay for the simultaneous detection of SARS-CoV-2 and influenza B virus

The outbreak of the coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in significant global health and economic threats to the human society.
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Covid nasal spray could be next leap in coronavirus vaccine development

Covid nasal spray could be next leap in coronavirus vaccine development | Virology News | Scoop.it
A nasal spray could block the transmission of Covid-19, scientists say...
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A Brutal Wave of Bird Flu Spotlights the Need for a Poultry Vaccine

A Brutal Wave of Bird Flu Spotlights the Need for a Poultry Vaccine | Virology News | Scoop.it
More than 27 million birds have died or been slaughtered, and wild birds are dying too. Without a shot, farmers have to rely on vigilance and culling their flocks.
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Requirements for the Packaging of Geminivirus Circular Single-Stranded DNA: Effect of DNA Length and Coat Protein Sequence

Requirements for the Packaging of Geminivirus Circular Single-Stranded DNA: Effect of DNA Length and Coat Protein Sequence | Virology News | Scoop.it
Geminivirus particles, consisting of a pair of twinned isometric structures, have one of the most distinctive capsids in the virological world. Until recently, there was little information as to how these structures are generated.
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Malaria vaccine reaches more than one million children in Africa

Malaria vaccine reaches more than one million children in Africa | Virology News | Scoop.it
The vaccination programme was launched in Ghana, Kenya and Malawi in 2019...
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