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The Role of Selected Natural Biomolecules in Sperm Production and Functionality

The Role of Selected Natural Biomolecules in Sperm Production and Functionality | Vitae Herbae   - personalized  natural medicine | Scoop.it
Emerging evidence from in vivo as well as in vitro studies indicates that natural biomolecules may play important roles in the prevention or management of a wide array of chronic diseases. Furthermore, the use of natural compounds in the treatment o
Pasquale Valente's insight:
Le prove raccolte da studi clinici, esperimenti in vitro e studi in vivo suggeriscono che i composti naturali selezionati influiscono su obiettivi chiave relativi al metabolismo mitocondriale degli spermatozoi e al comportamento motorio, allo stress ossidativo, all'infiammazione, all'integrità del DNA e alla morte cellulare. La maggior parte dei rapporti sottolinea gli effetti migliorativi, stimolanti e protettivi delle biomolecole naturali sulla funzione degli spermatozoi.
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Berberine suppresses bladder cancer cell proliferation by inhibiting JAK1-STAT3 signaling via upregulation of miR-17-5p - ScienceDirect

Berberine suppresses bladder cancer cell proliferation by inhibiting JAK1-STAT3 signaling via upregulation of miR-17-5p - ScienceDirect | Vitae Herbae   - personalized  natural medicine | Scoop.it
Hyperactivation of signal transducer and activator of transcription 3 (STAT3) is strongly associated with cancer initiation, progression, metastasis, …
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La Berberina ha esercitato effetti antitumorali sulle cellule del carcinoma della vescica  inibendo la via di segnalazione Janus chinasi 1 (JAK1) -STAT3 attraverso la sovraregolazione di miR-17-5p, che si lega direttamente al 3'UTR di JAK1 e STAT3, sottoregolando le loro espressioni.
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The crucial role of multiomic approach in cancer research and clinically relevant outcomes

The crucial role of multiomic approach in cancer research and clinically relevant outcomes | Vitae Herbae   - personalized  natural medicine | Scoop.it
Cancer is a complex, whole-body disease that involves multiple abnormalities in the levels of DNA, RNA, protein, metabolite and medical imaging. Biological omics including genomics, transcriptomics, proteomics, metabolomics and radiomics aims to systematically understand carcinogenesis in different biological levels, which is driving the shift of cancer research paradigm from single parameter model to multi-parameter systematical model. The rapid development of various omics technologies is driving one to conveniently get multi-omics data, which accelerates predictive, preventive and personalized medicine (PPPM) practice allowing prediction of response with substantially increased accuracy, stratification of particular patients and eventual personalization of medicine. This review article describes the methodology, advances, and clinically relevant outcomes of different “omics” technologies in cancer research, and especially emphasizes the importance and scientific merit of integrating multi-omics in cancer research and clinically relevant outcomes.
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" Integration of multiple omics data is essential to cancer research and fits the reality of a cancer, which will provide a holistic view of what really happened during normal cell malignant transformation and tumor progression, and have the potential in improvement of targeted therapy and the effectiveness of traditional therapies, in clarification of molecular mechanisms of cancer therapeutic resistance, and in discovery of novel biomarkers and targeted drugs."
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Sloan Kettering Institute Scientists Solve a 100-Year-Old Mystery about Cancer

Sloan Kettering Institute Scientists Solve a 100-Year-Old Mystery about Cancer | Vitae Herbae   - personalized  natural medicine | Scoop.it
Scientists have long known that cancer cells and immune cells have an uncommon hunger for glucose but haven’t understood why. A new study offers an answer.
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"As with immune cells, cancer cells may employ Warburg metabolism as a way to sustain the activity of this signaling pathway and therefore ensure their continued growth and division. The results raise the intriguing possibility that doctors could curb cancer growth by blocking the activity of LDHA — the Warburg “switch.”
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Natural Products Targeting the Mitochondria in Cancers

Natural Products Targeting the Mitochondria in Cancers | Vitae Herbae   - personalized  natural medicine | Scoop.it
There are abundant sources of anticancer drugs in nature that have a broad prospect in anticancer drug discovery. Natural compounds, with biological activities extracted from plants and marine and microbial metabolites, have significant antitumor effects
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Most of the compounds  with anticancer activity targeting mitochondria are terpenoids, phenols, and flavonoids. Some of these compounds regulate the expression level of Bcl-2 family proteins, some induce ROS production, some alter metabolism, and some target mitochondrial complexes.
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The Power of Phytochemicals Combination in Cancer Chemoprevention

The Power of Phytochemicals Combination in Cancer Chemoprevention | Vitae Herbae   - personalized  natural medicine | Scoop.it
L'articolo affronta il tema dell'efficacia di combinazioni di sostanze fitochimiche nella terapia del cancro, verosimilmente in virtù  della loro capacità di modulare contemporaneamente  diverse vie di segnalazione che promuovono la morte cellulare, inibiscono la proliferazione e l'invasione cellulare, sensibilizzano le cellule cancerose e potenziano il sistema immunitario. 
Combinazioni di agenti antitumorali citotossici e inibitori di sostanze fitochimiche potrebbero agire insieme producendo meccanismi inibitori contro la crescita del tumore
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Chemoprevention of Prostate Cancer by Natural Agents: Evidence from Molecular and Epidemiological Studies

Chemoprevention of Prostate Cancer by Natural Agents: Evidence from Molecular and Epidemiological Studies | Vitae Herbae   - personalized  natural medicine | Scoop.it
Evidence from various recent experimental, clinical and epidemiological studies indicates that select dietary micronutrients (i.e., lycopene, epigallocatechin gallate, sulforaphane, indole-3-carbinol, resveratrol, quercetin, curcumin & piperine) and zinc play a key role in prostate cancer prevention and progression and therefore hold great promise for the future overall management of prostate cancer.
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Medicinal plants and their isolated phytochemicals for the management of chemotherapy-induced neuropathy: therapeutic targets and clinical perspective | DARU Journal of Pharmaceutical Sciences | Fu...

Medicinal plants and their isolated phytochemicals for the management of chemotherapy-induced neuropathy: therapeutic targets and clinical perspective | DARU Journal of Pharmaceutical Sciences | Fu... | Vitae Herbae   - personalized  natural medicine | Scoop.it
Chemotherapy, as one of the main approaches of cancer treatment, is accompanied with several adverse effects, including chemotherapy-induced peripheral neuropathy (CIPN). Since current methods to control the condition are not completely effective, new treatment options should be introduced. Medicinal plants can be suitable candidates to be assessed regarding their effects in CIPN. Current paper reviews the available preclinical and clinical studies on the efficacy of herbal medicines in CIPN. Electronic databases including PubMed, Scopus, and Cochrane library were searched with the keywords “neuropathy” in the title/abstract and “plant”, “extract”, or “herb” in the whole text. Data were collected from inception until April 2018. Plants such as chamomile (Matricaria chamomilla L.), sage (Salvia officinalis L.), cinnamon (Cinnamomum cassia (L.) D. Don), and sweet flag (Acorus calamus L.) as well as phytochemicals like matrine, curcumin, and thioctic acid have demonstrated beneficial effects in animal models of CIPN via prevention of axonal degeneration, decrease in total calcium level, improvement of endogenous antioxidant defense mechanisms such as superoxide dismutase and reduced glutathione, and regulation of neural cell apoptosis, nuclear factor-ĸB, cyclooxygenase-2, and nitric oxide signaling. Also, five clinical trials have evaluated the effect of herbal products in patients with CIPN. There are currently limited clinical evidence on medicinal plants for CIPN which shows the necessity of future mechanistic studies, as well as well-designed clinical trial for further confirmation of the safety and efficacy of herbal medicines in CIPN.


Graphical abstract

Schematic mechanisms of medicinal plants to prevent chemotherapy-induced neuropathy: NO: nitric oxide, TNF: tumor necrosis factor, PG: prostaglandin, NF-ĸB: nuclear factor kappa B, LPO: lipid peroxidation, ROS: reactive oxygen species, COX: cyclooxygenase, IL: interleukin, ERK: extracellular signal-related kinase, X: inhibition, ↓: induction.






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Flavonoids in Cancer and Apoptosis

Flavonoids in Cancer and Apoptosis | Vitae Herbae   - personalized  natural medicine | Scoop.it
Cancer is the second leading cause of death globally. Although, there are many different approaches to cancer treatment, they are often painful due to adverse side effects and are sometimes ineffective due to increasing resistance to classical anti-cance
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Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation | Critical Care | Full Text

Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation | Critical Care | Full Text | Vitae Herbae   - personalized  natural medicine | Scoop.it
The combination of thiamine, ascorbic acid, and hydrocortisone has recently emerged as a potential adjunctive therapy to antibiotics, infectious source control, and supportive care for patients with sepsis and septic shock. In the present manuscript, we provide a comprehensive review of the pathophysiologic basis and supporting research for each element of the thiamine, ascorbic acid, and hydrocortisone drug combination in sepsis. In addition, we describe potential areas of synergy between these therapies and discuss the strengths/weaknesses of the two studies to date which have evaluated the drug combination in patients with severe infection. Finally, we describe the current state of current clinical practice as it relates to the thiamine, ascorbic acid, and hydrocortisone combination and present an overview of the randomized, placebo-controlled, multi-center Ascorbic acid, Corticosteroids, and Thiamine in Sepsis (ACTS) trial and other planned/ongoing randomized clinical trials.
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Fisetin, a dietary flavonoid, induces apoptosis of cancer cells by inhibiting HSF1 activity through blocking its binding to the hsp70 promoter | Carcinogenesis | Oxford Academic

Fisetin, a dietary flavonoid, induces apoptosis of cancer cells by inhibiting HSF1 activity through blocking its binding to the hsp70 promoter | Carcinogenesis | Oxford Academic | Vitae Herbae   - personalized  natural medicine | Scoop.it
Summary. HSF1-dependent HSP70/BAG3 expression protects cancer cells from apoptosis by stabilizing anti-apoptotic Bcl-2 family proteins. We identified fisetin a
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A Review of Herbal Therapy in Multiple Sclerosis

A Review of Herbal Therapy in Multiple Sclerosis | Vitae Herbae   - personalized  natural medicine | Scoop.it
Multiple sclerosis is a complex autoimmune disorder which characterized by demyelination and axonal loss in the central nervous system (CNS). Several evidences indicate that some new drugs and stem cell therapy have opened a new horizon for multiple sclerosi
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The inhibitory effect of melatonin on human prostate cancer | Cell Communication and Signaling | Full Text

The inhibitory effect of melatonin on human prostate cancer | Cell Communication and Signaling | Full Text | Vitae Herbae   - personalized  natural medicine | Scoop.it
Prostate cancer (PCa) is one of the most commonly diagnosed human cancers in males. Nearly 191,930 new cases and 33,330 new deaths of PCa are estimated in 2020. Androgen and androgen receptor pathways played essential roles in the pathogenesis of PCa. Androgen depletion therapy is the most used therapies for primary PCa patients. However, due to the high relapse and mortality of PCa, developing novel noninvasive therapies have become the focus of research. Melatonin is an indole-like neurohormone mainly produced in the human pineal gland with a prominent anti-oxidant property. The anti-tumor ability of melatonin has been substantially confirmed and several related articles have also reported the inhibitory effect of melatonin on PCa, while reviews of this inhibitory effect of melatonin on PCa in recent 10 years are absent. Therefore, we systematically discuss the relationship between melatonin disruption and the risk of PCa, the mechanism of how melatonin inhibited PCa, and the synergistic benefits of melatonin and other drugs to summarize current understandings about the function of melatonin in suppressing human prostate cancer. We also raise several unsolved issues that need to be resolved to translate currently non-clinical trials of melatonin for clinic use. We hope this literature review could provide a solid theoretical basis for the future utilization of melatonin in preventing, diagnosing and treating human prostate cancer.





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Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases

Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases | Vitae Herbae   - personalized  natural medicine | Scoop.it

Aging is a major risk factor for numerous human pathologies, including cardiovascular, metabolic, musculoskeletal, and neurodegenerative conditions and various malignancies. While our understanding of aging is far from complete, recent advances suggest  that targeting fundamental aging processes can delay, prevent, or alleviate age-related disorders. Cellular senescence is physiologically beneficial in several contexts, but it has causal roles in multiple chronic diseases.

Pasquale Valente's insight:
"Regulated by both genes and the environment, aging is highly complex, as partially reflected by the diversity of its hallmarks, including telomere attrition, genomic instability, epigenetic alterations, mitochondrial dysfunction, loss of protein homeostasis (proteostasis), stem cell exhaustion, deregulated nutrient sensing, immune system decline, and cellular senescence".
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Flavonoids against the Warburg phenotype—concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism

Flavonoids against the Warburg phenotype—concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism | Vitae Herbae   - personalized  natural medicine | Scoop.it
The Warburg effect is characterised by increased glucose uptake and lactate secretion in cancer cells resulting from metabolic transformation in tumour tissue. The corresponding molecular pathways switch from oxidative phosphorylation to aerobic glycolysis
Pasquale Valente's insight:
"Therapeutic strategies focused on specific cancer metabolism linked to the Warburg effect are currently under extensive consideration . Naturally occurring bioactive compounds of plants demonstrate clinically relevant beneficial effects against cancer development and progression.Flavonoids may modulate almost all key processes involved in carcinogenesis including apoptosis, proliferation, angiogenesis and metastatic progression. Individualised patient profiling could be a powerful instrument for implementing targeted ‘anti-Warburg’ measures in the context of predictive, preventive and personalised medicine."
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Eat Yourself to Live: Autophagy’s Role in Health and Disease

Eat Yourself to Live: Autophagy’s Role in Health and Disease | Vitae Herbae   - personalized  natural medicine | Scoop.it
New details of the molecular process by which our cells consume themselves point to therapeutic potential.
Pasquale Valente's insight:
"Therapeutically targeting a pathway as critical as autophagy is not straightforward."
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Natural Compounds with Potential to Modulate Cancer Therapies and Self-Reactive Immune Cells

Natural Compounds with Potential to Modulate Cancer Therapies and Self-Reactive Immune Cells | Vitae Herbae   - personalized  natural medicine | Scoop.it
Cancer-related deaths are approaching 10 million each year. Survival statistics for some cancers, such as ovarian cancer, have remained unchanged for decades, with women diagnosed at stage III or IV having over 80% chance of a lethal cancer recurrenc
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366228/

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Effect of Active Ingredients of Chinese Herbal Medicine on the Rejuvenation of Healthy Aging: Focus on Stem Cells
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Dietary Phytochemicals Targeting Cancer Stem Cells

Dietary Phytochemicals Targeting Cancer Stem Cells | Vitae Herbae   - personalized  natural medicine | Scoop.it
There is an increasing awareness of the importance of a diet rich in fruits and vegetables for human health. Cancer stem cells (CSCs) are characterized as a subpopulation of cancer cells with aberrant regulation of self-renewal, proliferation or apoptosi
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Impacts of Gut Bacteria on Human Health and Diseases

Impacts of Gut Bacteria on Human Health and Diseases | Vitae Herbae   - personalized  natural medicine | Scoop.it
Gut bacteria are an important component of the microbiota ecosystem in the human gut, which is colonized by 10[14] microbes, ten times more than the human cells. Gut bacteria play an important role in human health, such as supplying essential nutrients
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Curcumin increases breast cancer cell sensitivity to cisplatin by decreasing FEN1 expression

Curcumin increases breast cancer cell sensitivity to cisplatin by decreasing FEN1 expression | Vitae Herbae   - personalized  natural medicine | Scoop.it
Flap endonuclease 1 (FEN1) overexpression promotes breast cancer. We investigated the role of FEN1 in cisplatin resistance and the chemosensitizing effects of curcumin in breast cancer cells. We demonstrated that FEN1 overexpression promotes cisplati
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Vitamin C may encourage blood cancer stem cells to die

Vitamin C may encourage blood cancer stem cells to die | Vitae Herbae   - personalized  natural medicine | Scoop.it
Vitamin C may "tell" faulty stem cells in the bone marrow to mature and die normally, instead of multiplying to cause blood cancers. This is the finding of a study led by researchers from Perlmutter Cancer Center at NYU Langon
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Emerging Anti-Aging Strategies - Scientific Basis and Efficacy

Emerging Anti-Aging Strategies - Scientific Basis and Efficacy | Vitae Herbae   - personalized  natural medicine | Scoop.it
The prevalence of age-related diseases is in an upward trend due to increased life expectancy in humans. Age-related conditions are among the leading causes of morbidity and death worldwide currently. Therefore, there is an urgent need to find apt intervention
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Medical Plants and Nutraceuticals for Amyloid-β Fibrillation Inhibition

Medical Plants and Nutraceuticals for Amyloid-β Fibrillation Inhibition | Vitae Herbae   - personalized  natural medicine | Scoop.it
Plaque formation due to amyloid-β oligomerization and fibrillation is a key issue for its deposition in the brains of dementia and Alzheimer’s disease patients. Related drugs preventing this peptide fibril accumulation bear the potentia
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