Isolation, Structure Elucidation, and Biological Activity of Maltepolides: Remarkable Macrolides from Myxobacteria | Natural Products Chemistry |

Epoxide “swing”: A family of polyketide macrolactones originating from maltepolide E was discovered in Sorangium cellulosum So ce1485. Their structure was established by NMR experiments, molecular modeling, and X-ray crystallography. Maltepolides induce rather rare morphological changes in the dividing transformed cell lines (see picture in the background).


Dr. Herbert Irschik1,Dr. Peter Washausen1,Dr. Florenz Sasse1,Dr. Jörg Fohrer2,Dr. Volker Huch3,Prof. Dr. Rolf Müller1,4,Dr. Evgeny V. Prusov

Angewandte Chemie International Edition

Article first published online: 16 APR 2013

DOI: 10.1002/anie.201210113


Via NatProdChem