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All debates on Nanobioethics and Nanoethics must have the level of excellence (and not just part of them). 
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CRLX101 is a dynamically tumor-targeted nanopharmaceutical designed to concentrate in tumors and release its payload, camptothecin, over an extended period of time, prolonging drug exposure at the site of action.
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Author, Editor: Tilda Barliya PhD We previously started a discussion on Transdermal Drug Delivery system (TDDS), see: http://pharmaceuticalintelligence.com/2013/01/28/introduction-to-transdermal-de...
Luís Bastos's insight:
Effective peptide and protein delivery to the skin has received much attention in the pharmaceutical industry, with many companies developing a variety of delivery devices to force peptides and proteins into and across the epithelium of the skin. Despite these many attempts, effective delivery of high-molecular-mass compounds has at best been poor. The water-in-oil microemulsion system may overcome the water-impermeable barrier of the epidermis and allows for effective delivery of highly water-soluble molecules such as peptides and proteins following topical application.
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Using Laser Technology, Aleksandr Ovsianikov from the Vienna University of Technology wants to create microstructures with embedded living cells. This project will be funded by an ERC Starting Grant.
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The behavior of cells strongly depends on their environment. If they are to be researched and manipulated, it is crucial to embed them in suitable surroundings. Aleksandr Ovsianikov is developing a laser system, which allows living cells to be incorporated into intricate taylor-made structures, similar to biological tissue, in which cells are surrounded by the extracellular matrix. This technology is particularly important for artificially growing biotissue, for finding new drugs or for stem cell research.
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Certain drugs are toxic by nature.For example, anti-cancer drugs developed to kill diseased cells also harm healthy ones.Read more about Magnetic nanovehicles control, target drug release in the bodyComments... Via Razvan Liviu
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A Free To Access Nanotechnology Information Site, Sections Include A Nanotechnology Journal, Nanotechnology News, New Nanotechnology Products, Nanotechnology Suppliers/Companies, Nanotechnology Experts, Nanotechnology Courses, Nanotechnology...
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NanoSmart Pharmaceuticals, a private biotechnology company, has entered into a research collaboration agreement with University of California Los Angeles (UCLA) to continue the development of NanoSmart's novel drug delivery platform for the treatment of cancer and other life-threatening diseases.
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Drug Delivery: Peptides modified with a lipid group form tightly wrapped nanofibers that can slip into the brains of mice
Luís Bastos's curator insight,
16 January 2013, 10:48
Drug Delivery: Peptides modified with a lipid group form tightly wrapped nanofibers that can slip into the brains of mice
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LONDON (Reuters) - When it comes to protecting millions of people from deadly infectious diseases, Mark Kendall thinks a fingertip-sized patch covered in thousands of vaccine-coated microscopic spikes is the future.
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When it comes to protecting millions of people from deadly infectious diseases, Mark Kendall thinks a fingertip-sized patch covered in thousands of vaccine-coated microscopic spikes is the future.
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Luís Bastos's insight:
Marinus Pharmaceuticals, Inc. is pleased to announce $21 million in new Series C financing from U.S. venture capital firm Domain Associates, LLC, Rusnano subsidiary RusnanoMedInvest (RMI), and co-investors Canaan Partners, Sofinnova Ventures and Foundation Medical Partners. Based in Branford, Connecticut, Marinus is the developer of the first-in-class, neuroactive steroid Ganaxolone.
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Recent advances in nanomedicine have generated platforms that contain imaging and therapeutic agents allowing for a seamless integration of disease detection, therapy, and monitoring. These functional nanoparticles may serve as contrast ...
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UNeMed is seeking parties interested in collaborative research to co-develop and commercialize tunable multimodal ultrasmall superparamagnetic iron oxide (M-USPIO) particles as a research tool for in vivo image-guided drug delivery.
Luís Bastos's curator insight,
6 January 2013, 20:25
UNeMed is seeking parties interested in collaborative research to co-develop and commercialize tunable multimodal ultrasmall superparamagnetic iron oxide (M-USPIO) particles as a research tool for in vivo image-guided drug delivery.
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... technology of this century because of its wide-ranging potential applications in many fields such as: healthcare, electronics, photonics, biotechnology, engineering products, pharmaceuticals, drug delivery, catalysis, electronic devices,...
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The field of Dendrimers has recently emerged as the most commercially viable technology of this century because of its wide-ranging potential applications in many fields such as: healthcare, electronics, photonics, biotechnology, engineering products, pharmaceuticals, drug delivery, catalysis, electronic devices, environmental issues and nanotechnologies. Dendrimer as a drug deliveryagent is a promising, safe and selective drug delivery option.
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Three pharmaceutical firms are trying to restore a mechanism that normally tells cells to die if their DNA is badly damaged, an approach that might work against half of all cancers.
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Y. He: Silicon-Nanowire-Based Nanocarriers with Ultrahigh Drug-Loading Capacity for In V... http://t.co/kG6XwA1r http://t.co/HO984kCn
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Author: Tilda Barliya PhD Ocular drug delivery is a very challenging field for pharmaceutical scientists. The unique structure of the eye restricts the entry of drug molecules at the required site...
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Ophthalmic drug delivery, more than any other route of administration, may benefit to a full extent from the characteristics of nano-sized drug particles.
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Specific molecules on white blood cells' membranes signal to other cells that they belong in the body. By coating nanoparticle drug vehicles with these same lipids and proteins, scientists at the Methodist Hospital Research Institute in Houston have created "LeukoLike Vectors," or LLVs, that are similarly welcomed by the immune system.
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Author, Editor: Tilda Barliya PhD Transdermal drug delivery is a very exciting and challenging research area. It is defined as the administration of therapeutic drugs through the skin. The human ...
Luís Bastos's insight:
The potential of using the intact skin as the port of drug administration to the human body has been recognized for several decades, however the skin is a very difficult barrier to the ingress of materials allowing only small quantities of a drug to penetrate over a period of time.
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Layer-by-Layer Micro and Nano Drug Encapsulation with Eolyelectrolytes – Research & Development – Issue 15, 2011 – Pharma Focus Asia via Layer-by-Layer Micro and Nano Drug Encapsulation with Eolyelectrolytes ...
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Layer-by-layer encapsulation gives a very stable fine dispersion, so fine that a dollar coin is visible when looked at through the clear dispersion.
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/PRNewswire/ -- NanoSmart Pharmaceuticals, a private biotechnology company, has entered into a research collaboration agreement with University of California Los Angeles (UCLA) to continue the development of NanoSmart's novel drug delivery platform...
Luís Bastos's insight:
NanoSmart Pharmaceuticals, a private biotechnology company, has entered into a research collaboration agreement with University of California Los Angeles (UCLA) to continue the development of NanoSmart's novel drug delivery platform for the treatment of cancer and other life-threatening diseases.
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Implementing Nanotechnology and Novel Drug Delivery Systems to Improve Dissolution and Solubilization (New article!
Luís Bastos's insight:
Conventional excipients such as surfactants, cosolvents are often added to improve drug solubility for both oral and parenteral routes. Complexation with cyclodextrins or formulating oil in water emulsions are also employed to improve poorly soluble drugs. Today the growing demand to fabricate drug delivery systems capable of encapsulating high levels of active ingredients with additional benefits such as drug targeting capability has resulted in a plethora of technologies exploiting the unique physical properties of nano-sized structures. Nanotechnologies such as nano-crystals, solid lipid nanoparticles (SLN), nano-emulsion, polymeric nanoparticles, liposomes and polymeric self-assemblies have been employed to enhance drug solubilization. In this review, we will focus on four types; namely nano-crystals, SLN, liposomes and polymeric self-assemblies.
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CytImmune and AstraZeneca have entered into an agreement to study the feasibility of a new cancer nanomedicine that will bind an oncology compound from AstraZeneca to CytImmune’s CYT-6091 nanomedicine platform.
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Luís Bastos's insight:
Marinus Pharmaceuticals, Inc. is pleased to announce $21 million in new Series C financing from U.S. venture capital firm Domain Associates, LLC, Rusnano subsidiary RusnanoMedInvest (RMI), and co-investors Canaan Partners, Sofinnova Ventures and Foundation Medical Partners.
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Fars News Agency Iran's Health Ministry Qualifies 2nd Nano Drug for Marketing Fars News Agency After passing the preliminary production stages and acquiring basic approvals from Food and Medicine Organization of the Health Ministry, the medicine...
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Iran is due to present a second nano drug to domestic markets after the product received the approval of the Iranian Health Ministry's Nanotechnology Committee.
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Nanotechnology and HIV/AIDS treatment. December 25, 2012 by tildabarliya. Author: Tilda Barliya, PhD. AIDS was first reported in 1981 followed by the identification of HIV as the cause of the disease in 1983 and is now a global pandemic ...
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While there is exciting potential for nanomedicine in the treatment of HIV/AIDS, challenges remain to be overcome before the potential is realized.
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allAfrica: African news and information for a global audience
Luís Bastos's insight:
After years of political instability and international isolation, Zimbabwe now aims to revive science and use nanotechnology to research and produce drugs, particularly treatments for tuberculosis (TB) and HIV/AIDS.
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