NAFLD NASH cirrhosis from the Fatty Liver Foundation
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Novel microbiome-based diagnostic tool can identify liver fibrosis, cirrhosis

Novel microbiome-based diagnostic tool can identify liver fibrosis, cirrhosis | NAFLD NASH cirrhosis from the Fatty Liver Foundation | Scoop.it
Chronic liver disease represents a major global public health problem affecting an estimated 844 million people, according to the World Health Organization. It is among the top causes of mortality in Australia, the UK and the United States.
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NAFLD NASH cirrhosis from the Fatty Liver Foundation
News and research about fatty liver disease. The Fatty Liver Foundation is the voice of #FattyLiver, #NAFLD & #NASH patients. The only national patient organization aimed at improving screening, education & outreach for victims of fatty liver disease. https://www.fattyliverfoundation.org/
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Novel microbiome-based diagnostic tool can identify liver fibrosis, cirrhosis

Novel microbiome-based diagnostic tool can identify liver fibrosis, cirrhosis | NAFLD NASH cirrhosis from the Fatty Liver Foundation | Scoop.it
Chronic liver disease represents a major global public health problem affecting an estimated 844 million people, according to the World Health Organization. It is among the top causes of mortality in Australia, the UK and the United States.
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JCI - Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis

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The small intestine shields the liver from fructose-induced steatosis

The small intestine shields the liver from fructose-induced steatosis | NAFLD NASH cirrhosis from the Fatty Liver Foundation | Scoop.it
Per capita fructose consumption has increased 100-fold over the last century1. Epidemiological studies suggest that excessive fructose consumption, and especially consumption of sweet drinks, is associated with hyperlipidaemia, non-alcoholic fatty liver disease, obesity and diabetes2–7. Fructose metabolism begins with its phosphorylation by the enzyme ketohexokinase (KHK), which exists in two alternatively spliced forms8. The more active isozyme, KHK-C, is expressed most strongly in the liver, but also substantially in the small intestine9,10 where it drives dietary fructose absorption and conversion into other metabolites before fructose reaches the liver11–13. It is unclear whether intestinal fructose metabolism prevents or contributes to fructose-induced lipogenesis and liver pathology. Here we show that intestinal fructose catabolism mitigates fructose-induced hepatic lipogenesis. In mice, intestine-specific KHK-C deletion increases dietary fructose transit to the liver and gut microbiota and sensitizes mice to fructose’s hyperlipidaemic effects and hepatic steatosis. In contrast, intestine-specific KHK-C overexpression promotes intestinal fructose clearance and decreases fructose-induced lipogenesis. Thus, intestinal fructose clearance capacity controls the rate at which fructose can be safely ingested. Consistent with this, we show that the same amount of fructose is more strongly lipogenic when drunk than eaten, or when administered as a single gavage, as opposed to multiple doses spread over 45 min. Collectively, these data demonstrate that fructose induces lipogenesis when its dietary intake rate exceeds the intestinal clearance capacity. In the modern context of ready food availability, the resulting fructose spillover drives metabolic syndrome. Slower fructose intake, tailored to intestinal capacity, can mitigate these consequences. Modulating the capacity of the intestinal epithelium to catabolize fructose is shown to alter fructose-induced lipogenesis in the mouse liver, suggesting that fructose clearance in the small intestine protects from steatosis.
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Skin temperature variability is an independent predictor of survival in patients with cirrhosis - Bottaro - 2020 - Physiological Reports - Wiley Online Library

Skin temperature variability is an independent predictor of survival in patients with cirrhosis - Bottaro - 2020 - Physiological Reports - Wiley Online Library | NAFLD NASH cirrhosis from the Fatty Liver Foundation | Scoop.it
Abstract Background Cirrhosis is a disease with multisystem involvement. It has been documented that patients with cirrhosis exhibit abnormal patterns of fluctuation in their body temperature. Howe...
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Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts

Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts | NAFLD NASH cirrhosis from the Fatty Liver Foundation | Scoop.it
In a modelling study, Naeimeh Atabaki-Pasdar and colleagues apply machine learning techniques to develop models to predict non-alcoholic fatty liver disease diagnosis using multi-omic and clinical data from individuals with and without type 2 diabetes in the IMI DIRECT cohorts.
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New Blood Test Developed to Improve Liver Cancer Screening

New Blood Test Developed to Improve Liver Cancer Screening | NAFLD NASH cirrhosis from the Fatty Liver Foundation | Scoop.it
Liver Cancer Screening...
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Muscles support a strong immune system

Muscles support a strong immune system | NAFLD NASH cirrhosis from the Fatty Liver Foundation | Scoop.it
In the fight against cancer or chronic infections, the immune system must be active over long periods of time. However, in the long run, the immune defense system often becomes exhausted. Scientists at the German Cancer Research Center (DKFZ) have now found initial evidence in mice that skeletal muscles help to keep the immune system functional in chronic diseases.
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Strength training increases muscle strength and size in patients with cirrhosis

Strength training increases muscle strength and size in patients with cirrhosis | NAFLD NASH cirrhosis from the Fatty Liver Foundation | Scoop.it
Three hours of weekly strength training combined with protein supplements leads to both bigger and stronger muscles in patients with cirrhosis. This is shown by a new study from Aarhus University and Aarhus University Hospital.
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Effects of a carbohydrate‐restricted diet on hepatic lipid content in adolescents with non‐alcoholic fatty liver disease: A pilot, randomized trial - Goss - 2020 - Pediatric Obesity

Effects of a carbohydrate‐restricted diet on hepatic lipid content in adolescents with non‐alcoholic fatty liver disease: A pilot, randomized trial - Goss - 2020 - Pediatric Obesity | NAFLD NASH cirrhosis from the Fatty Liver Foundation | Scoop.it
Summary Background Non‐alcoholic fatty liver disease (NAFLD) has emerged as the most common form of liver disease among adolescents in industrialized countries. While lifestyle intervention remains...
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NAFLD in pregnancy increases risks for mother and baby

NAFLD in pregnancy increases risks for mother and baby | NAFLD NASH cirrhosis from the Fatty Liver Foundation | Scoop.it
Women with non-alcoholic fatty liver disease (NAFLD) should receive preconception counselling on increased maternal and infant risks, while pregnant mothers may benefit from evaluation by a high-risk obstetrics team, recommend scientists in the Journal of Hepatology.
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Ammonia Levels Do Not Guide Clinical Management of Patients With Hepatic Encephalopathy Caused by Cirrhosis

Inpatient management of HE with lactulose was not influenced by either the presence or level of ammonia level, suggesting that ammonia levels do not guide therapy in clinical practice.
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Inflammation and insulin resistance

Inflammation and insulin resistance | NAFLD NASH cirrhosis from the Fatty Liver Foundation | Scoop.it
Over a hundred years ago, high doses of salicylates were shown to lower glucose levels in diabetic patients. This should have been an important clue to link inflammation to the pathogenesis of type 2 diabetes (T2D), but the antihyperglycemic and antiinflammatory ...
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Med Diet Beneficial for Bowel Disease Patients, Study Suggests

Med Diet Beneficial for Bowel Disease Patients, Study Suggests | NAFLD NASH cirrhosis from the Fatty Liver Foundation | Scoop.it
Patients suffering from IBD who adhered to the Mediterranean diet for six months benefited from a decline in their body mass index and experienced lower levels of inflammation as well as less disease activity.
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FDA issues complete response letter for obeticholic acid for fibrosis due to NASH

FDA issues complete response letter for obeticholic acid for fibrosis due to NASH | NAFLD NASH cirrhosis from the Fatty Liver Foundation | Scoop.it
The FDA issued a complete response letter for the new drug application for obeticholic acid for treatment of fibrosis due to nonalcoholic steatohepatitis, according to a press release from Intercept Pharmaceutical Inc. “Today represents a setback first and foremost for NASH patients with advanced fibrosis who have bene waiting far too long for a therapy to treat their disease,” Mark
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When the liver gets stiff, the tough get moving - Nguyen - 2020 - Journal of Gastroenterology and Hepatology

When the liver gets stiff, the tough get moving - Nguyen - 2020 - Journal of Gastroenterology and Hepatology | NAFLD NASH cirrhosis from the Fatty Liver Foundation | Scoop.it
Abstract Liver stiffness measurement (LSM) by FibroScan‐determined transient elastography is a noninvasive approach to estimate liver fibrosis severity. In non‐alcoholic fatty liver disease (NAFLD)...
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Mediterranean diet linked to lower inflammation, healthy aging

Mediterranean diet linked to lower inflammation, healthy aging | NAFLD NASH cirrhosis from the Fatty Liver Foundation | Scoop.it
A study published Feb.17, 2020, in the journal Gut suggests that lower rates of chronic disease among people who eat a Mediterranean diet might be due…...
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Covid-19 breakthrough: Fatty liver sufferers more likely to be hospitalised with Covid-19

Covid-19 breakthrough: Fatty liver sufferers more likely to be hospitalised with Covid-19 | NAFLD NASH cirrhosis from the Fatty Liver Foundation | Scoop.it
In fact those who were fat or obese had no extra risk of covid complications if their liver fat was in a healthy range.However, those who were obese, and had...
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Novel Antisense Drug Shows Promise in Slowing Fatty Liver Disease

Novel Antisense Drug Shows Promise in Slowing Fatty Liver Disease | NAFLD NASH cirrhosis from the Fatty Liver Foundation | Scoop.it
Using a first-of-its-class drug in a clinical trial, an international research effort headed by a scientist at University of California San Diego School...
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Coffee consumption and risk of hepatocellular carcinoma: a meta-analysis of eleven epidemiological studies

Coffee consumption and risk of hepatocellular carcinoma: a meta-analysis of eleven epidemiological studies | NAFLD NASH cirrhosis from the Fatty Liver Foundation | Scoop.it
Growing evidence has shown that coffee consumption is inversely related with the risk of hepatocellular carcinoma. It is suggested that caffeine maintains strong antioxidative activity. With this property, coffee intake may lead to the inhibition of cell ...
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Fast smartphone self-test for COVID-19 developed

Fast smartphone self-test for COVID-19 developed | NAFLD NASH cirrhosis from the Fatty Liver Foundation | Scoop.it
By depositing a saliva sample on a tiny device attached to your smartphone, you could find out in five minutes if you're infected, say pharmacists at Université de Montréal. The researchers are working on a technique to screen for COVID-19 using a smartphone.
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Non-alcoholic fatty liver disease: causes, diagnosis, cardiometabolic consequences, and treatment strategies

Non-alcoholic fatty liver disease: causes, diagnosis, cardiometabolic consequences, and treatment strategies | NAFLD NASH cirrhosis from the Fatty Liver Foundation | Scoop.it
The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide.
In some patients with NAFLD, isolated steatosis can progress to advanced stages with
non-alcoholic steatohepatitis (NASH) and fibrosis, increasing the risk of cirrhosis
and hepatocellular carcinoma.
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Scientists develop blood test to help improve liver cancer screening

Scientists develop blood test to help improve liver cancer screening | NAFLD NASH cirrhosis from the Fatty Liver Foundation | Scoop.it
Scientists have developed a new test that can help identify people who are likely to develop hepatocellular carcinoma (HCC), the most common form of liver cancer. The approach uses a simple blood test to check for the patient's previous exposure to certain viruses.
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Fructose vs. Glucose and Metabolism: Do the Metabolic Differences Matter?

Depending on the cardiometabolic endpoint in question, fructose has variable effects when replacing glucose. In the absence of clear evidence of net harm, there is no justification to replace fructose with glucose in the diet.
LiverSavers insight:

Details matter, this is primarily about heart disease but includes a throwaway comment about not affecting NAFLD. The unregulated dose-dependent challenge to liver health of fructose should be considered in a review like this.

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Going Beyond the Biopsy & Adopting Noninvasive Technologies

Going Beyond the Biopsy & Adopting Noninvasive Technologies | NAFLD NASH cirrhosis from the Fatty Liver Foundation | Scoop.it
Did you know millions of people across the world are affected by a silent disease that is damaging their internal organs and often goes undetected until it is too late?  Nonalcoholic Steatohepatitis (NASH) is a potentially fatal condition affecting up to 12% of adults worldwide, an estimated 115...
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Perinatal Nutritional Reprogramming of the Epigenome Promotes Subsequent Development of Nonalcoholic Steatohepatitis - Gutierrez Sanchez - 2018 - Hepatology Communications - Wiley Online Library

Perinatal Nutritional Reprogramming of the Epigenome Promotes Subsequent Development of Nonalcoholic Steatohepatitis - Gutierrez Sanchez - 2018 - Hepatology Communications - Wiley Online Library | NAFLD NASH cirrhosis from the Fatty Liver Foundation | Scoop.it
With the epidemic of obesity, nonalcoholic fatty liver disease (NAFLD) has become the most common pediatric liver disease. The influence of a perinatal obesity‐inducing diet (OID) on the developmen...
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