INTELIGENCIA GLOBAL
23.7K views | +0 today
Follow
INTELIGENCIA GLOBAL
Sabiduría para la vida es la meta. Su busca es philo-sophia, trabajar juntos buscando la Sophia-Sapientia-Mahat que nos permita vivir más humanamente. Pero para lograr esta meta hay que saber aprender, es decir incorporar a la vida todo tipo de conocimientos a traves de la formación.
Your new post is loading...
Your new post is loading...
Rescooped by Saberes Sin Fronteras OVS from Neuroscience_topics
Scoop.it!

Structural mechanism of glutamate receptor activation and desensitization

Structural mechanism of glutamate receptor activation and desensitization | INTELIGENCIA GLOBAL | Scoop.it

Ionotropic glutamate receptors are ligand-gated ion channels that mediate excitatory synaptic transmission in the vertebrate brain. To gain a better understanding of how structural changes gate ion flux across the membrane, we trapped rat AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) and kainate receptor subtypes in their major functional states and analysed the resulting structures using cryo-electron microscopy. We show that transition to the active state involves a ‘corkscrew’ motion of the receptor assembly, driven by closure of the ligand-binding domain. Desensitization is accompanied by disruption of the amino-terminal domain tetramer in AMPA, but not kainate, receptors with a two-fold to four-fold symmetry transition in the ligand-binding domains in both subtypes. The 7.6 Å structure of a desensitized kainate receptor shows how these changes accommodate channel closing. These findings integrate previous physiological, biochemical and structural analyses of glutamate receptors and provide a molecular explanation for key steps in receptor gating. (...) - by Meyerson JR et al., Nature, published online 03 August 2014


Via Julien Hering, PhD
more...
No comment yet.
Rescooped by Saberes Sin Fronteras OVS from Neuroscience_topics
Scoop.it!

Structural mechanism of glutamate receptor activation and desensitization

Structural mechanism of glutamate receptor activation and desensitization | INTELIGENCIA GLOBAL | Scoop.it

Ionotropic glutamate receptors are ligand-gated ion channels that mediate excitatory synaptic transmission in the vertebrate brain. To gain a better understanding of how structural changes gate ion flux across the membrane, we trapped rat AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) and kainate receptor subtypes in their major functional states and analysed the resulting structures using cryo-electron microscopy. We show that transition to the active state involves a ‘corkscrew’ motion of the receptor assembly, driven by closure of the ligand-binding domain. Desensitization is accompanied by disruption of the amino-terminal domain tetramer in AMPA, but not kainate, receptors with a two-fold to four-fold symmetry transition in the ligand-binding domains in both subtypes. The 7.6 Å structure of a desensitized kainate receptor shows how these changes accommodate channel closing. These findings integrate previous physiological, biochemical and structural analyses of glutamate receptors and provide a molecular explanation for key steps in receptor gating. (...) - by Meyerson JR et al., Nature, published online 03 August 2014


Via Julien Hering, PhD
more...
No comment yet.