iBB
46.4K views | +5 today
Follow
iBB
Institute for Bioengineering and Biosciences
Curated by iBB
Your new post is loading...
Your new post is loading...
Scoop.it!

Why do Fireflies Shine?

Why do Fireflies Shine? | iBB | Scoop.it

Vasco Bonifácio was invited to participate in the program “Explain me as if were 5 years old”, an IST initiative that consists of informal conversations about science for curious children and adults. In this program, which was broadcast live on Facebook on the afternoon of November 28, 2020, Vasco presented the session “Why do fireflies shine?”. In this session, chaired by Joana Lobo Antunes (Communication and Public Relations Office of IST), Vasco Bonifácio explained the phenomena of bioluminescence, chemiluminescence and phosphorescence and how these physical-chemical processes are related to research in the area of cancer treatment that he has been developing in recent years. There was also time to carry out live experiments, which delighted the young audience and to answer many questions! The program was recorded and is available on the program's website (Episode 12).

iBB's insight:

https://explicame.tecnico.ulisboa.pt/episodio-12.html

No comment yet.
Scoop.it!

Cysteine Metabolic Circuitries: Druggable Targets in Cancer

Cysteine Metabolic Circuitries: Druggable Targets in Cancer | iBB | Scoop.it

To enable survival in adverse conditions, cancer cells undergo global metabolic adaptations. The amino acid cysteine actively contributes to cancer metabolic remodelling on three different levels: in its free form (redox control), as a substrate to produce hydrogen sulphide (H2S) (stimulation of cellular bioenergetics), and as a carbon source (epigenetic regulation, biomass and energy production). In review published in the British Journal of Cancer, Vasco Bonifácio from BSIRG-iBB and colleagues from CEDOC and ITQB provide a systematic portrayal of the role of cysteine in cancer biology as a source of carbon and sulphur atoms, the pivotal role of cysteine in different metabolic pathways and the importance of H2S as an energetic substrate and signalling molecule.

No comment yet.
Scoop.it!

Photodiodes: Principles and Recent Advances

Photodiodes: Principles and Recent Advances | iBB | Scoop.it

Photodiodes are on the rise. In the past decade many efforts have been made to deliver cheaper, more flexible, and increasingly better performing photodiode devices. The demand for enhanced optoelectronics led to the development of new inorganic, organic, and hybrid materials. A tutorial review published in Journal of Materials NanoScience by Rita Pires and Vasco Bonifácio from BSIRG-iBB describes in detail the working principles, the characterization, fabrication (types and architectures) and major applications of photodiodes. Recent applications, mainly in imaging, sensing and healthcare are also presented.

No comment yet.
Scoop.it!

Osteogenic Differentiation of Human Mesenchymal Stem Cells by the Single Action of Luminescent Polyurea Oxide Biodendrimers

Osteogenic Differentiation of Human Mesenchymal Stem Cells by the Single Action of Luminescent Polyurea Oxide Biodendrimers | iBB | Scoop.it

Polyurea oxide (PURO) biodendrimers are a class of dendrimers that can trigger osteogenic differentiation of human mesenchymal stem cells (hMSCs). The effect of PURO biodendrimers in the differentiation of hMSCs was found by the single addition to a standard growth medium for MSCs differentiation (without differentiation inducers, e.g. dexamethasone, ascorbic acid, and β-glycerophosphate). These results, published in ACS Applied Bio Materials by Rita Pires and Vasco Bonifácio from BSIRG-iBB and with colleague João Conde from NOVA Medical School, constitute the first report of in vitro osteodifferentiation fully regulated by synthetic soft polymers. The outstanding role of dendrimers in nanomedicine, under clinic translation, combined with this feature is envisaged to foster PURO dendrimers as an important strategy in cell therapy and regenerative medicine.

No comment yet.
Scoop.it!

Urease Next-generation Inhibition Therapy

Urease Next-generation Inhibition Therapy | iBB | Scoop.it

The project URE-LOCKERS - Urease next-generation inhibition therapy, was recently awarded to Nuno Martinho (PI, BSIRG) and Vasco Bonifácio (Co-PI, BSIRG). This project, with a total funding of 243 k€, was funded by FC&T Portugal (Ref. PTDC/MED-QUI/3542/2020). The current excessive use of broad-spectrum antibiotics is leading to a rising health concern of bacterial resistance. Finding novel approaches that target specific microbial pathways is therefore highly desirable, particularly for non-immediate life-threatening infections. URE-LOCKERS proposes a novel nanotherapeutic approach against Helicobacter pylori infections, alternative to conventional antibiotics, based on especially designed polyurea dendrimers.

No comment yet.
Scoop.it!

Synthesis of Fluorescent Water-Soluble Block Co-polymers

Synthesis of Fluorescent Water-Soluble Block Co-polymers | iBB | Scoop.it

The ability of block co-polymers to self-assemble and form micelles in solution can potentially be explored to deliver poorly soluble chemotherapeutic agents. Researchers from BSIRG-iBB led by Vasco Bonifácio, working in collaboration with colleagues from Universidade Nova, have synthesized new block copolymers of oligo-2-oxazoline and linear oligo(ethylenimine) that are water-soluble and show an intrinsic blue fluorescence. The synthesis uses a green protocol and allows a precise control of the oligo(ethylenimine) backbone. The work was published in Advanced Materials Letters.

No comment yet.