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Institute for Bioengineering and Biosciences
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The Azurin-Derived Peptide CT-p19LC Exhibits Membrane-Active Properties and Induces Cancer Cell Death

The Azurin-Derived Peptide CT-p19LC Exhibits Membrane-Active Properties and Induces Cancer Cell Death | iBB | Scoop.it

The bacterial protein azurin shows an unexpected therapeutic effect against various types of cancer. This property seems to result from its unique structural and surface features. A 28-residue peptide (named p28) derived from the middle part of azurin has been subjected to various studies and reached two clinical trials phase I in US. In a recent paper published in Biomedicines, a iBB team (Ana Rita Garizo, Lígia Coelho, Sandra Pinto, Tiago Dias, Fábio Fernandes, Nuno Bernardes and Arsénio M Fialho) were able to identified another anticancer bioactive peptide (CT-p19LC) derived from the C-terminal of azurin. CT-p19LC proved to interact preferentially with cancer cells, causing a significative inhibition of cell proliferation in a dose dependent manner. Moreover, it is proposed that the mode of action of CT-p19LC involves perturbation or disruption of cancer cell membranes. Overall this study highlights the relevance of azurin as a source of bioactive peptides with potential application in cancer therapies.

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Tiago Dias to Defend PhD Thesis in Bioengineering and Biosciences

Tiago Dias to Defend PhD Thesis in Bioengineering and Biosciences | iBB | Scoop.it
Tiago Dias will be defending his Ph D thesis in Biotechnology and Biosciences at Instituto Superior Técnico, tuesday the 10th may 2016 (15:00 H, room PA3). During the last years, and under the supervision of Joaquim Cabral and Margarida Diogo from BERG-IBB, Tiago focused his efforts on the study of the signaling behind the differentiation of stem cells into neuroectoderm, mesoderm (cardiomyocytes) and endoderm. The title of Tiago's thesis is “Human Pluripotent Stem Cell Signaling and Cardiac Lineage Commitment”.
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