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Institute for Bioengineering and Biosciences
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Osteogenic Differentiation of Human Mesenchymal Stem Cells by the Single Action of Luminescent Polyurea Oxide Biodendrimers

Osteogenic Differentiation of Human Mesenchymal Stem Cells by the Single Action of Luminescent Polyurea Oxide Biodendrimers | iBB | Scoop.it

Polyurea oxide (PURO) biodendrimers are a class of dendrimers that can trigger osteogenic differentiation of human mesenchymal stem cells (hMSCs). The effect of PURO biodendrimers in the differentiation of hMSCs was found by the single addition to a standard growth medium for MSCs differentiation (without differentiation inducers, e.g. dexamethasone, ascorbic acid, and β-glycerophosphate). These results, published in ACS Applied Bio Materials by Rita Pires and Vasco Bonifácio from BSIRG-iBB and with colleague João Conde from NOVA Medical School, constitute the first report of in vitro osteodifferentiation fully regulated by synthetic soft polymers. The outstanding role of dendrimers in nanomedicine, under clinic translation, combined with this feature is envisaged to foster PURO dendrimers as an important strategy in cell therapy and regenerative medicine.

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Rita Pires Wins "A flash on chemistry" Photography Award

Rita Pires Wins "A flash on chemistry" Photography Award | iBB | Scoop.it

Rita Pires won the Photography Award "A flash on chemistry", promoted by the Group of Young Chemists of the Portuguese Society of Chemistry. This Award was aimed at praising the importance of the Periodic Table and of the Chemical Elements through original photographs.


"It's not a vision of Space or any distant planet, what we see is a round-bottom flask. Pure chemistry. Inside, hydrogen builds bridges between the tentacular arms of a polyurea dendrimer. The result is fascinating, a blue, intense and intrinsic fluorescence. The rare phenomenon, also observed in nature during the aggregation of beta sheets of amyloid fibers, is explained by the delocalization of electrons through the hydrogen bonds. It is not a planet, but we travel with our gaze. Chemical elements highlighted: Hydrogen, Nitrogen, Oxygen and Carbon."

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Photodiodes: Principles and Recent Advances

Photodiodes: Principles and Recent Advances | iBB | Scoop.it

Photodiodes are on the rise. In the past decade many efforts have been made to deliver cheaper, more flexible, and increasingly better performing photodiode devices. The demand for enhanced optoelectronics led to the development of new inorganic, organic, and hybrid materials. A tutorial review published in Journal of Materials NanoScience by Rita Pires and Vasco Bonifácio from BSIRG-iBB describes in detail the working principles, the characterization, fabrication (types and architectures) and major applications of photodiodes. Recent applications, mainly in imaging, sensing and healthcare are also presented.

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