New Insight Into the Transposition of IS2-type Mobile Genetic Elements | iBB |

In a recent paper published in Applied Microbiology and Biotechnology, researchers from BERG-iBB, MIT, Institut Pasteur, Instituto Politécnico de Setúbal and University of New York unravel new genetic and environmental determinants that shape the transposition rate of type 2 insertion sequences (IS2). These were found to encompass asymmetries in target DNA composition, medium composition, growth-phase, and production scale. The importance of these findings is manifold, going from the design of safer DNA-based therapeutics to the ON/OFF regulation of synthetic genetic circuits. Click on title to learn more.


Photo: South Tower at IST, home of iBB labs.