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Institute for Bioengineering and Biosciences
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The Hrk1 kinase is a determinant of acetic acid tolerance in yeast by modulating H+ and K+ homeostasis

The Hrk1 kinase is a determinant of acetic acid tolerance in yeast by modulating H+ and K+ homeostasis | iBB | Scoop.it
A new study from iBB,  Instituto Superior Técnico, has unveiled molecular mechanisms underlying yeast tolerance to acetic acid stress. Understanding these mechanisms is crucial for enhancing yeast performance in industrial applications for a circular bio-based economy.  Notably, the Hrk1 kinase has emerged as a novel key player in acetic acid stress response and tolerance. Hrk1 was shown to play a role in the activation of plasma membrane H+-ATPase, thereby maintaining pH homeostasis, and in the modulation of plasma membrane potential under acetic acid-stressed cultivation. Potassium (K+) supplementation of the growth medium led to a notable improvement in acetic acid stress tolerance of the hrk1∆ strain. Moreover, abrogation of this kinase's expression was shown to confer a physiological advantage to growth under K+ limitation in the absence of acetic acid stress. The work was led by Prof. Isabel Sá-Correia and the first author is the PhD student in Biotechnology and Biosciences, Miguel Antunes. The contribution of Dr Hana Sychrová's laboratory, Institute of Physiology, Czech Academy of Sciences in the context of Yeast4Bio COST Action CA18229 funded by STSM grant, is acknowledged.

 

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The NPR/Hal family of kinases in S. cerevisiae and other yeasts

The NPR/Hal family of kinases in S. cerevisiae and other yeasts | iBB | Scoop.it

Protein kinases are essential as signal transductors for a proper cellular response to extracellular stimuli. A BSRG-iBB review paper, just published in Computational and Structural Biotechnology Journal gathers the available information regarding the NPR/Hal5 family of kinases in Saccharomyces cerevisiae and non-Saccharomyces species of clinical and biotechnological relevance. These kinases - for which information is scarce and scattered across scientific literature - are essential modulators of yeast nutrient availability responses and ion homeostasis. This publication has as first-author the PhD student Miguel Antunes of the IST PhD programme in Biotechnology and Biosciences and the FCT-DP BIOTECnico - and as a corresponding author his thesis supervisor, Professor Isabel Sá-Correia.

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Check full paper at: https://doi.org/10.1016/j.csbj.2022.10.006

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More on the participation of IBB in FEMS2023

More on the participation of IBB in FEMS2023 | iBB | Scoop.it

Massive representation of IBB at FEMS 2023, the largest Microbiology meeting in Europe, that took place in Hamburg, 9-13 July 2023. PhD students Sara Gomes (Poster entitled “Evolution of Burkholderia multivorans traits required for persistent infections of the cystic fibrosis lung”), Mirela Ferreira (Poster entitled “Characterization of multicellular aggregates formed by Burkholderia multivorans”), Marta Mota (Co-chairing the Industrial Microbiology and Bioeconomy Session and Offered Talk entitled “Candida boidinii, an oleaginous methylotrophic yeast species attractive as a platform for methanol-based biomanufacturing”), Miguel Antunes (Offered Talk entitled “The Hrk1 kinase as a modulator of ion homeostasis and acetic acid stress tolerance in yeast”) and Inês Costa (Offered Talk entitled “Candida glabrata’s genomic plasticity shapes the clinical evolution of biofilm formation”) have presented their work. Miguel Cacho Teixeira (Member of the Program Committee, Charing the Genetics and Genomics Session and Invited Talk entitled “Drug transporters in pathogenic yeasts: in the crossroad between drug resistance and pathogenesis”) and Isabel Sá-Correia (Co-chairing the Yeast strategies to resist relevant stresses in bioindustries and fungal biology and chemistry Session and Invited Talk entitled “Mechanisms underlying adaptation and tolerance to short-chain fatty acids in yeasts”) were also invited to participate. Altogether, all have enjoyed the conference and the chance to re/connect with colleagues and friends from the European microbiology community.

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https://www.fems2023.org/

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