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Institute for Bioengineering and Biosciences
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Development of Cell-derived Extracellular Matrices to Enhance Bone Regeneration

Development of Cell-derived Extracellular Matrices to Enhance Bone Regeneration | iBB | Scoop.it

Cultured cell-derived extracellular matrix (ECM) has been used as a scaffold for tissue engineering settings to create a biomimetic microenvironment, providing physical, chemical and mechanical cues to cells and support cellular activities, mimicking the composition and organization of native ECM microenvironment. In a recent study published in Journal of Tissue Engineering and Regenerative Medicine, researchers from SCERG-iBB working with colleagues from the Rensselaer Polytechnic Institute developed a new strategy to produce different combinations of decellularized cultured cell-derived ECM obtained from different cultured cell types, namely mesenchymal stem/stromal cells (MSC) and human umbilical vein endothelial cells (HUVEC), as well as the co-culture of MSC:HUVEC and investigate the effects of its various compositions on osteogenic differentiation and angiogenic properties of human bone marrow (BM)-derived MSC, vital features for adult bone tissue regeneration and repair. These results suggest that decellularized ECM derived from a co-culture of MSC:HUVEC impacts the osteogenic and angiogenic capabilities of BM MSC, suggesting the potential use of MSC:HUVEC ECM as a therapeutic product to improve clinical outcomes in bone regeneration. 

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Marta Costa Defends PhD Thesis in Bioengineering

Marta Costa Defends PhD Thesis in Bioengineering | iBB | Scoop.it
Marta Costa will be defending her Ph D thesis in Bioengineering (MIT Portugal program) at Instituto Superior Técnico, friday the 24th may 2017 (11:00 H, room PA3). During the last years, and under the supervision of Frederico Ferreira and Cláudia Lobato Silva from SCERG-IBB, and from Todd McDevitt from the USA, Cláudia focused her efforts on the manipulation of the microenvironment of MSCs. The title of Marta's thesis is “Engineering the microenvironment of Mesenchymal Stem/Stromal Cells (MSC) to tune their trophic activity”.
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