iBB

Virus-like particles (VLPs) are promising candidates for a new generation of biopharmaceuticals. In a recent publication in the Journal Separation and Purification Technology, BERG researchers led by Raquel Aires-Barros and working in collaboration with INESC-MN and the company Icosagen (Estonia) describe a microfluidic system for the recovery of  HIV-like particles from cell supernatants by aqueous two phase extraction. The system features 100 width × 20 μm wide microchannels and continuous pumping of the two immiscible phases. The results obtained show that it is possible to carry out extraction under miniaturized conditions. This opens up the possibility for the set up of a highthroughput microfluidic platform for the screening of optimal extraction conditions for the recovery of biologicals. 

 

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Photo details: SEM micrograph of HIV particles infecting a human H9 T cell. NIAID 2009, PD, Wikimedia commons.