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Institute for Bioengineering and Biosciences
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TORC2-Ypk1 Activity is Involved in Acetic Acid Adaptation

TORC2-Ypk1 Activity is Involved in Acetic Acid Adaptation | iBB | Scoop.it

Acetic acid accumulation inhibits yeast growth and fermentation, impairing many yeast-based biotechnological processes, in particular lignocellulosic biorefineries. A recent study published in Biochemical Journal, performed by BSRG-iBB researchers led by Prof. Isabel Sá-Correia and started in the framework of the PhD in Biotechnology and Bioscience of Joana Guerreiro, in collaboration with researchers from Jeremy Thorner´s Lab at University of California, Berkeley, demonstrated that acetic acid tolerance requires sphingolipid biosynthesis. This process is mediated by the TORC2-dependent Ypk1 kinase, a key regulator of the sphingolipid biosynthetic pathway. It was thus proposed the manipulation of the flux into the sphingolipid biosynthetic pathway as a novel rational way to increase acetic acid tolerance of industrial yeast strains.

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Insights Into Acetic Acid–Induced Programmed Cell Death Response in the Food Spoilage Yeast Zygosaccharomyces bailii

Insights Into Acetic Acid–Induced Programmed Cell Death Response in the Food Spoilage Yeast Zygosaccharomyces bailii | iBB | Scoop.it

The control of spoilage yeasts in acidic food and beverages preserved by acetic acid addition, for which Zygosaccharomyces bailii is considered the most problematic species, is essential to the Food Industry. In a study recently published in Microbial Cell, BSRG-iBB researchers led by Prof. Isabel Sá-Correia and having the PhD student Joana Guerreiro as 1st author, in collaboration with researchers from Universidade do Minho, provided a genome-wide integrative view of the global response to acetic acid-induced programmed cell death (PCD) in a Z. bailii-derived hybrid strain. Based on a quantitative proteomic analysis, results suggest the existence of several processes involved in PCD, some of which similar to known biochemical hallmarks of mammalian apoptosis, possibly determining cell fate towards pro-death or pro-survival pathways. Click on title to learn more.

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