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Acetic acid accumulation inhibits yeast growth and fermentation, impairing many yeast-based biotechnological processes, in particular lignocellulosic biorefineries. A recent study published in Biochemical Journal, performed by BSRG-iBB researchers led by Prof. Isabel Sá-Correia and started in the framework of the PhD in Biotechnology and Bioscience of Joana Guerreiro, in collaboration with researchers from Jeremy Thorner´s Lab at University of California, Berkeley, demonstrated that acetic acid tolerance requires sphingolipid biosynthesis. This process is mediated by the TORC2-dependent Ypk1 kinase, a key regulator of the sphingolipid biosynthetic pathway. It was thus proposed the manipulation of the flux into the sphingolipid biosynthetic pathway as a novel rational way to increase acetic acid tolerance of industrial yeast strains.
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