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Recent Developments in Enzyme Immobilization for Food Production

Recent Developments in Enzyme Immobilization for Food Production | iBB | Scoop.it

Greener, cost-effective methodologies for food processing and production have been actively looked after because of increased demand due to growing population. Enzymes, as green and highly efficient catalysts, have been a mainstay of food technology. However, the advantageous features of enzymes are negatively impacted by their long-term instability, harsh industrial operational conditions and challenges for enzyme recovery and reuse. Immobilized enzyme formulations have been developed to address these limitations. In a recently published book chapter, Filipe Carvalho and Pedro Fernandes (iBB-BERG) present the latest finding and trends on the design and application of immobilized enzyme for food production and processing. The chapter was published in the book Value Addition in Food Products and Processing using Enzyme Technology, published by Academic Press.

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Twin Seminars on Biocatalytic Process Development and Biosurfactant Production

Twin Seminars on Biocatalytic Process Development and Biosurfactant Production | iBB | Scoop.it

The 3rd Edition of iBB seminars will continue on the 27th May with short talks from Filipe Carvalho - "Biocatalytic Process Development: Bioprocess engineering tools and industrial application of marine biocatalysts" and Nuno Faria - "Towards biosurfactant sustainable production: novel perspectives on mannosylerythritol lipids biotechnological production and applications". Join us next monday (13h00 h, room VA.1, IST-Alameda) to learn more about Filipe's and Nuno's research at BERG.

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Enzymatic Synthesis of Chiral Amino-Alcohols in a Continuous-Flow Microreactor System

Enzymatic Synthesis of Chiral Amino-Alcohols in a Continuous-Flow Microreactor System | iBB | Scoop.it

Chiral amino-alcohols are key building blocks in the production of optically pure pharmaceuticals. While many of these compounds can be synthesized enzymatically, the rapid process development and intensification continues to be challenging. A recent contribution co-authored by BERG-iBB researchers Pedro Fernandes and Filipe Carvalho with UCL colleagues led by Nicolas Szita presents a novel microreactor-based approach based on free enzymes for the synthesis of the chiral building block ABT. The system couples a transketolase- and a transaminase-catalyzed reaction and is operated continuously. The presented approach illustrates how continuous-flow microreactors can be applied for the design and optimization of biocatalytic processes. Click on title to learn more about the work on Biotechnology and Bioengineering. Photo: 3D model of transketolase from Escherichia coli (pdb 1QGD).

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Filipe Carvalho to Defend PhD Thesis in Biotechnology and Biosciences

Filipe Carvalho to Defend PhD Thesis in Biotechnology and Biosciences | iBB | Scoop.it

Filipe Daniel Ramos de Carvalho will be defending his Ph D thesis in Biotechnology and Biosciences at Instituto Superior Técnico, monday the 7th December 2015 (10:00 H, room PA3). During the last years, and under the supervision of Pedro Fernandes from BERG-IBB, Filipe developed microreactors to study and carry out enzyme-catalysed biotransformations. The title of Filipe's  thesis is “Development of enzyme microreactors and application in biocatalysis”. 

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The INMARE Legacy

The INMARE Legacy | iBB | Scoop.it

A video overview of the output of INMARE (‘Industrial Applications of Marine Enzymes’), a four-year European research project that set out to transform the enzyme biodiscovery process and to isolate new enzymes from the ocean, has been made available by the consortium. The goal of INMARE was to shorten & streamline the industrial enzyme pipeline by increasing the value of enzyme collections and to identify new lead products and prototypes during the projects lifetime. INMARE brought together several industrial and academic partners, including iBB-IST. The project received funding from the EU’s Horizon 2020 research and innovation programme under grant agreement No. 634486.

 

Photo details; sea shore by Cascais, Copyright Carla de Carvalho, 2017. 

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Featured Photo: Cover of Biotechnol. Bioeng. Credits BERG-iBB Contribution

Featured Photo: Cover of Biotechnol. Bioeng. Credits BERG-iBB Contribution | iBB | Scoop.it

Description: Cover image of Biotechnology and Bioengineering, based on the article "Enzymatic synthesis of chiral amino-alcohols by coupling transketolase and transaminase-catalyzed reactions in a cascading continuous-flow microreactor system". Design Credit: Winter Mraz, Frozen Ink Designs., Copyright Wiley 2017.


Context: BERG-iBB researchers Pedro Fernandes and Filipe Carvalho, working in collaboration with UCL colleagues led by Nicolas Szita, have published a novel microreactor-based approach based on free enzymes for the synthesis of the chiral building block ABT. The work was performed in the context of iBB's Strategic Area 2: Advanced Bioprocess Engineering. (Click on title to learn more).

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A Bespoke Capillary Wall-Coated Microreactor

A Bespoke Capillary Wall-Coated Microreactor | iBB | Scoop.it

The use of microscale set-ups for the fast development of bioprocesses has been gaining momentum. Within this, continuous flow operation for enzymatic reaction is particularly appealing, as it allows for steady state and ease of automation. In a paper recently published in the journal Catalysts, Pedro Fernandes and Filipe Carvalho from BERG-iBB, together with Marco Marques from UCL, presented a prototype of a home-made, easy to assemble capillary enzymatic microreactor. The assembly of the device only required materials commonly found in research labs, proved to be reproducible and reliable, and allowed for the detailed characterization of the model reaction system chosen, the production of invert syrup from sucrose. It is foreseen that the device can be easily adapted to other reaction systems and thus further disseminate the use of miniaturized set-ups for bioprocess development. Click on title to learn more.

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Bioprocess Intensification Through Enzymatic Microreactors

Bioprocess Intensification Through Enzymatic Microreactors | iBB | Scoop.it

Microreactors have been gaining increased relevance as preferred process intensification tools. Microreactors present several advantages over conventional batch reactors, namely mass and heat transfer, high surface to volume ratios, minute consumption of chemicals, ease of automation and better process control. Within the scope of this exciting area of research, Pedro Fernandes and Filipe Carvalho from BERG-iBB recently designed, assembled and run a low-cost continuous flow enzyme microreactor, allowing for detailed characterization of biocatalytic systems with immobilized enzymes in particulate form. Moreover, the microreactor enabled continuous enzymatic sucrose hydrolysis for 1 month, with sustained substrate conversion of roughly 100%.

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