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Institute for Bioengineering and Biosciences
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Twin Seminars on Immunoreactive Virulence Factors and Multi-organoid Systems

Twin Seminars on Immunoreactive Virulence Factors and Multi-organoid Systems | iBB | Scoop.it

The 3rd Edition of iBB seminars will continue on the 8th July with short talks from Sílvia Sousa - "Exploitation of immunoreactive virulence factors to fight Burkholderia cepacia complex infections" and Cláudia Miranda - "Towards multi-organoid systems for drug screening applications". Join us next monday (13h00 h, room VA.1, IST-Alameda) to learn more about Sívias's and Cláudia's research.

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Featured Photo: hiPSC-Derived Astrocytes and Neurons

Featured Photo: hiPSC-Derived Astrocytes and Neurons | iBB | Scoop.it
Description: Culture of hiPSC-derived astrocytes (green) and neurons (red), featured photo by Cláudia Miranda, Copyright BERG-iBB 2016.

Context: BERG researchers led by Joaquim Cabral, Margarida Diogo and Tiago Fernandes are developing new methodologies for neural differentiation of human induced pluripotent stem cells (hiPSC). The work is being performed in the context of iBB’s Strategic Area 1: Stem Cell Engineering.
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Neural Induction of Human Induced Pluripotent Stem Cells for Neurodevelopmental Toxicity Studies

Neural Induction of Human Induced Pluripotent Stem Cells for Neurodevelopmental Toxicity Studies | iBB | Scoop.it

The ability to differentiate neural progenitors (NP) from human induced pluripotent stem cells (hiPSCs) provides an opportunity to develop new applications for cellular therapy, disease modelling and drug screening. SCERG-iBB researchers developed a platform that can be applied towards the study of the effect of neurotoxic molecules that impair normal embryonic development, such as the antiepileptic drug valproic acid (VPA). It was verified that exposure to VPA led to a prevalence of NP structures over neuronal differentiation, confirmed by analysis of the expression of neural cell adhesion molecule, and neural rosette number and morphology. This methodology can potentially complement current toxicity tests for the detection of teratogenic compounds that can interfere with normal embryonic development. The work was published in Toxicology Letters.

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