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André Nascimento Defends PhD Thesis in Biotechnology and Biosciences

André Nascimento Defends PhD Thesis in Biotechnology and Biosciences | iBB | Scoop.it

André Nascimento defended his PhD thesis in Biotechnology and Biosciences on Monday the 6th april 2020 (14:00 H). During the last years, and under the supervision of Ana Azevedo from BERG-iBB and Steven Cramer and Pankaj Karande from the Rensselaer Polytechnic Institute (US), André developed and explored affinity peptides and multimodal ligands for the purification of Fab antibody fragments. The title of the thesis is “Development of a novel purification platform for Fab antibody fragments based on affinity peptides and multimodal ligands”.

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André Nascimento Delivers Oral Presentation at Affinity 2019

André Nascimento Delivers Oral Presentation at Affinity 2019 | iBB | Scoop.it

André Nascimento from BERG-IBB delivered an oral presentation at the Affinity 2019 Conference titled “Debottlenecking process development using a microfluidic high-throughput platfrom”. The work involves a collaboration between researchers from BERG-iBB and the Rensselaer Polytechnic Institute. The meeting brought together scientists and engineers from academia and industry to exchange knowledge in the field of affinity technology, molecular recognition and its application in industry for health and disease, bioprocessing and biosensing. The conference took place in Stockholm on the 26-18 th June.

Aptech Visa's comment, July 9, 2019 8:36 AM
Saskatchewan Express Entry
https://www.aptechvisa.com/sinp-saskatchewan-express-entry
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BIOTecnico Student André Nascimento Shares Results on Microfluidic Purification of Antibody Fragments 

BIOTecnico Student André Nascimento Shares Results on Microfluidic Purification of Antibody Fragments  | iBB | Scoop.it
André Nascimento, a 2nd year student of the BIOTECnico PhD Program presents highlights of his project on the use of microfluidics for the optimization of antibody fragment purification during the 2nd joint BIOTECnico and AEM PhD Programs workshop that took place at Instituto Superior Técnico on the 15th and 16th February.
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Screening Peptide Affinity Ligands for Fab Fragment Purification by Phage Display

Screening Peptide Affinity Ligands for Fab Fragment Purification by Phage Display | iBB | Scoop.it

Antibody fragments (Fabs) are one of the most applied alternatives to monoclonal antibodies (mAbs), with already four Fab-based therapeutics in the market. Despite their similarity with mAbs, there is no scalable, robust and cost-efficient purification platform yet available. In this work, phage display was applied to find affinity peptides ligands as an effective purification strategy for Fabs. Two different phage biopanning schemes were designed and three peptide affinity ligands with the ability of binding Fab fragments were developed. With the methodology herein described, it is possible to find ligands within short periods of time, being the efficacy of this peptide affinity solution demonstrated in a real column purification scenario. The work  was published in Biotechnology Progress is part of the PhD thesis of André Nascimento and stems from a collaboration between BERG-IBB and Professors Steve Cramer and Pankaj Karande from RPI.

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Studies on the Purification of Antibody Fragments

Studies on the Purification of Antibody Fragments | iBB | Scoop.it
Antigen-binding fragments (Fabs) are becoming increasingly prevalent as an alternative to full-length monoclonal antibodies. In this work, researchers from BERG-iBB (Ana Azevedo and Raquel Aires-Barros) in collaboration INESC-MN (João Pedro conde and Virginia Chu), studied the recovery of the Fab fragments through different downstream purification schemes using a miniaturized platform anchored on a microfluidic chromatography lab-on-a-chip. This work is part of André Nascimento´s PhD thesis in Biotechnology and Biosciences. Click on title to learn more in the journal Separation and Purification Technology.
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