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Project ranks billions of drug interactions

Project ranks billions of drug interactions | healthcare technology | Scoop.it

For decades, drug development was mostly a game of trial and error, with brute-force candidate screens throwing up millions more duds than winners. Researchers are now using computers to get a head start. By analysing the chemical structure of a drug, they can see if it is likely to bind to, or ‘dock’ with, a biological target such as a protein. Such algorithms are particularly useful for finding potentially toxic side effects that may come from unintended dockings to structurally similar, but untargeted, proteins.


Last week, researchers presented a computational effort that assesses billions of potential dockings on the basis of drug and protein information held in public databases. The result, a website called Drugable (drugable.com) that is backed by the US National Library of Medicine (NLM), is still in testing, but it will eventually be available for free, allowing researchers to predict how and where a compound might work in the body, purely on the basis of chemical structure


more at original : http://www.nature.com/news/project-ranks-billions-of-drug-interactions-1.14245

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Vaccination Passports - What are they?

Vaccination Passports - What are they? | healthcare technology | Scoop.it

As mass vaccination programs are being rolled out globally, vaccine passports have become a major topic of discussion.

 

COVID test results and proof of vaccine will be required in many countries for quarantine-free travel, just as it has been for polio and yellow fever vaccinations in the past.

 

Countries will need to look at convenient and secure ways for verifying COVID-19 test results and vaccination information at airports and borders.

 

The International Air Transport Association (IATA) has also called for a “global standard to securely record digital proof of vaccination”.  They have been promoting the IATA Travel Pass Initiative (https://www.iata.org/en/programs/passenger/travel-pass/)

 

 

In February, Qantas completed a trial run of an app for this purpose on an international repatriation flight from Frankfurt to Darwin.

 

The idea behind the app is that health or border officials and airline staff may be able to easily verify COVID-19 test results and vaccination history of an individual.

 

The app links customers with certified testing labs to allow their results to be automatically uploaded onto it.

 

Similar digital solutions are being developed in several other countries around the world to enable travel again. For instance, travellers from Singapore will receive a notarized certificate following a negative COVID-19 test that they can present at airports around the world.

 

Another example is France taking part in a month-long trial of a vaccine passport that leverages a smart phone app. 

 

Its important that such digital health technologies, whether apps or chip cards, or health tracker add ons, be easy to use. It important that the process  be as seamless as possible for flyers share the relevant information as well as get the information validated by the ground and air staff so they people can  travel internationally, again, safely!

 

 

image source: https://foto.wuestenigel.com/person-hands-holding-a-covid-19-passport/

 

image license:

https://creativecommons.org/licenses/by/2.0/

 

 

harold john's curator insight, August 22, 2021 8:50 PM

  

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The Intersection of ChatGPT, Clinical Medicine, and Medical Education | healthcare technology | Scoop.it

As we progress deeper into the digital age, the robust development and application of advanced artificial intelligence (AI) technology, specifically generative language models like ChatGPT (OpenAI), have potential implications in all sectors including medicine.

 

ChatGPT, a generative language model launched by OpenAI in November 2022 has essentially has essentially revolutionized the IT world.. What makes ChatGPT a promising tool is the vast amounts of data used in its training and its ability to generate human-like conversations covering diverse topics.

 

The unprecedented capacity of ChatGPT to generate human-like responses, refined through Reinforcement Learning with Human Feedback, could significantly reshape the pedagogical methodologies within medical education.

 

The use of AI in medicine, including the use of generative language models, is often accompanied by challenges and contentions. Some common challenges include privacy, data security, algorithmic transparency and explainability, errors and liability, as well as regulatory issues associated with AI medicine.

 

Lately, the use of generative language models in scientific writing has also stirred up controversies in the academic and publishing communities. Some journals have declined ChatGPT as a coauthor, whereas others have happily accepted manuscripts authored by ChatGPT

 

Through a comprehensive review and the authors’ personal experiences, this viewpoint article elucidates the pros, cons, and ethical considerations of using ChatGPT within clinical medicine and notably, its implications for medical education.

 

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Holistic Human-Serving Digitization of Health Care Needs Integrated Automated System-Level Assessment Tools

Holistic Human-Serving Digitization of Health Care Needs Integrated Automated System-Level Assessment Tools | healthcare technology | Scoop.it

Digital health tools, platforms, and artificial intelligence– or machine learning–based clinical decision support systems are increasingly part of health delivery approaches, with an ever-greater degree of system interaction.

 

Critical to the successful deployment of these tools is their functional integration into existing clinical routines and workflows. This depends on system interoperability and on intuitive and safe user interface design.

 

Its extremely important that research and efforts are directed towards minimizing emergent workflow stress and ensuring purposeful design for integration.

 

Usability of tools in practice is as important as algorithm quality.

 

Regulatory and health technology assessment frameworks recognize the importance of these factors to a certain extent, but their focus remains mainly on the individual product rather than on emergent system and workflow effects.

 

The measurement of performance and user experience has so far been performed in ad hoc, nonstandardized ways by individual actors using their own evaluation approaches.

 

This paper proposes that a standard framework for system-level and holistic evaluation which be built into interacting digital systems to enable systematic and standardized system-wide, multiproduct, postmarket surveillance and technology assessment.

 

Such a system could be made available to developers through regulatory or assessment bodies as an application programming interface and could be a requirement for digital tool certification, just as interoperability is. This would enable health systems and tool developers to collect system-level data directly from real device use cases, enabling the controlled and safe delivery of systematic quality assessment or improvement studies suitable for the complexity and interconnectedness of clinical workflows using developing digital health technologies.

 

read the entire paper at https://www.jmir.org/2023/1/e50158

 

 

nrip's insight:

In recent conversations with FIND and WHO we have mutually discussed the framework which needs to be defined and put in place for identifying effectiveness in AI tools for use in medicine at the provider level. The basic reasoning behind our conversations has been to ensure that the trust factor behind a particular AI technology being used in healthcare is created and then via regular monitoring maintained rather than simply buying into far fetched stories. This paper and several others on this topic will be highlighted here , and further on Plus91's medium blog we will put several frameworks together

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Transforming Chronic Care Management: A Comprehensive, Technology-Driven Approach

Transforming Chronic Care Management: A Comprehensive, Technology-Driven Approach | healthcare technology | Scoop.it
A strategic approach to chronic care management (CCM) is essential.
 
This approach should integrate advanced technology with a deep comprehension of healthcare’s fundamental principles, effectively tackling the current challenges and proactively shaping the future of healthcare.
 
Emphasizing patient-centered solutions, this methodology is set to revolutionize the management of chronic diseases, thereby impacting patient care and healthcare economics significantly.
 

This strategy’s critical element is distinguishing between care management (CM) and case management. Care management represents a holistic approach to reducing health risks and costs across populations. It involves identifying at-risk populations, tailoring services to their needs, and deploying appropriate personnel for service delivery.

 

Conversely, case management focuses more on individual patients, offering various services to aid in navigating the healthcare system, ensuring efficient care transitions, and addressing specific patient needs.

 

Integrating Population Health Management (PHM) and CCM systems offers a solution to managing chronic diseases. PHM systems, which adopt a community-centered approach, work in tandem with CCM systems that concentrate on individual patient care. This synergy allows for effective management of both community health and individual patient needs

 

read the rest of this piece at https://www.healthcareittoday.com/2024/02/22/transforming-chronic-care-management-a-comprehensive-technology-driven-approach/

 

 

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Emerging Technologies Shaping the Health IT Landscape and How They Contribute to Improving Patient Outcomes and Healthcare Delivery

Emerging Technologies Shaping the Health IT Landscape and How They Contribute to Improving Patient Outcomes and Healthcare Delivery | healthcare technology | Scoop.it

The world of healthcare is ever-evolving. We are learning and growing every day, which means we are also coming up with new ideas, technologies, and practices every day.

 

 

what emerging technologies in Health IT are currently shaping the landscape,

and how do they contribute to improved patient outcomes and healthcare delivery?

 

This Healthcare IT today's article has a collection of opinions from people from the ever growing digital health community.

 

includes thoughts like

- proactive patient communication and automated text updates for patient approved people

 

- using adaptive AI for patient communication

 

- using AI in billing to bring about a fairness to costs

 

- using ambient documentation to improve patient provider connections in the presence of an EHR

 

- use of digital therapeutics

 

amongst others

 

read the article at

 

https://www.healthcareittoday.com/2024/02/12/emerging-technologies-shaping-the-health-it-landscape-and-how-they-contribute-to-improving-patient-outcomes-and-healthcare-delivery/

 

 

 

Daniel Fonkeng's curator insight, March 30, 4:32 AM
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Tool could predict drug combos that spark antibiotic resistance

Tool could predict drug combos that spark antibiotic resistance | healthcare technology | Scoop.it

Scientists propose a modeling framework that could predict how antibiotic resistance will evolve in response to different drug combinations.

 

A new framework may suggest which drug combinations would speed up, slow down, or even reverse antibiotic resistance.

 

The research could help doctors optimize the choice, timing, dose, and sequence of antibiotics used to treat common infections in order to help halt the growing threat of antibiotic resistance to modern medicine.

 

“Drug combinations are a particularly promising approach for slowing resistance, but the evolutionary impacts of combination therapy remain difficult to predict, especially in a clinical setting,” says Erida Gjini, a researcher at the University of Lisbon, Portugal, and first author of the paper in eLife.

 

read more at https://www.futurity.org/antibiotic-resistance-drug-combinations-2605182-2/

 

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Silicone wristbands detect chemicals harmful to pregnancy

Silicone wristbands detect chemicals harmful to pregnancy | healthcare technology | Scoop.it
Silicone wristbands are just as good as traditional testing methods at detecting chemicals in the air that can be harmful during pregnancy.

 

Inexpensive, convenient silicone wristbands can measure exposure to a class of chemicals that can be harmful during pregnancy, researchers report.

 

The researchers found that the wristbands, when used as passive samplers, have the ability to bind smaller molecular weight semi-volatile polycyclic aromatic hydrocarbons (PAHs) in a similar pattern as active sampling. PAHs are a class of chemicals that occur naturally in coal, crude oil, and gasoline and are produced when coal, oil, gas, wood, garbage, and tobacco are burned.

 

The use of wristbands is appealing because it is inexpensive and easy to wear,”

 

access the study at https://doi.org/10.1038/s41370-021-00348-y

 

read the original unedited article at https://www.futurity.org/silicone-wristbands-polycyclic-aromatic-hydrocarbons-chemicals-pregnancy-2602202/

 

 

MinnesotaHypnosis's comment, August 6, 2021 12:35 PM
nice
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Audio-Only Telehealth Has its Fans (Patients) and its Critics (Providers)

Audio-Only Telehealth Has its Fans (Patients) and its Critics (Providers) | healthcare technology | Scoop.it

While the US debates the value of the modality, a South Korean survey finds that patients like to use audio-only telehealth platforms to connect with their care provider - but their providers aren’t so sure.

 

While telehealth is not legally allowed in South Korea, the Ministry of Health and Welfare temporarily permitted its use due to hospital closures at the start of the pandemic.

 

Between February 24 and March 7, 2020, 6,840 patients used audio-based telehealth.

 

Researchers sent surveys to patients and providers alike to gauge their satisfaction with the telehealth platform, which includes landline telephones and online services without video. They asked questions about ease-of-use, interaction quality, reliability, satisfaction, and future use.

 

Around 87 % of patients reported that they were satisfied with their provider interaction and felt they could effectively express their feelings during an audio-only telehealth visit.

 

Most patients (87.1 %) also responded that their telehealth visit was just as reliable as an in-person visit would have been.

 

Meanwhile, the providers’ opinions differed drastically.

 

Less than 10 % of doctors and nurses were satisfied with their ability to interact with patients through an audio-only telehealth visit compared to in-person visits (7.3 % and 9 %, respectively).

 

Only 14 % of providers felt that the visits were as reliable as an in-person visit.

 

Patients and providers also had differing opinions on the convenience of telehealth.

 

Nearly 80 % of patients were satisfied with the convenience of telehealth and found it easy to use.

 

Providers were not as satisfied, with only 38.2 % of doctors and 30 percent of nurses reporting that they found telehealth convenient.

 

Overall, providers felt the negatives outweighed the positives for audio-only telehealth. While 85.8 % of the doctors and nurses agreed that telehealth is appropriate for emergency situations such as a pandemic, only 27.7 said it would be appropriate at all times.

 

In contrast, 40 % of the doctors and nurses surveyed said telehealth would be appropriate if it involved an audio-visual platform, saying it would be easier to fully examine and diagnose a patient’s condition.

 

read more at https://mhealthintelligence.com/news/audio-only-telehealth-has-its-fans-patients-and-its-critics-providers

 

 

nrip's insight:

Its the age old conundrum plaguing digital health. Who is the benefactor of the solutions, the tools, the technologies? The doctor or the patient ?

 

The significant gap in the perceived value of tools and technologies has always existed within healthcare, which is why it has become critical for digital health firms to realize how to look at value provision to all those involved/actors/stakeholders/users/users or users

 

that will also determine how big a role telehealth plays post the pandemic.

 

Blue's curator insight, July 24, 2021 7:44 PM

The idea of being able to literally have a check-up has jumped to the forefront in terms of convenience. While some believe Audio-only is a level of impersonal (providers), most whom needed to use the service (patients) believed it was very effect in terms of being diagnosed. Practitioners of the medical arts feel that this innovative idea can be expanded for a more accurate interaction with patients by also integrating visual/video with this program. With the rapid expansion of tech, it may not be long before you only need to actually go to the hospital when in need of critical care. This would lead to hospitals being able to take in more patients that actually need to be there vs ones taking up space because of the "convenience" of being closer physically. The one drawback I foresee may be the fact of availability of your actual doctor, though it could be be supplemented by other professionals in the field.

MinnesotaHypnosis's comment, August 6, 2021 12:35 PM
good
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Examining the cybersecurity of our medical health devices

Examining the cybersecurity of our medical health devices | healthcare technology | Scoop.it

Healthcare data is the number one target for cybercriminals and is 10 times more valuable than credit card data alone.

 

During the "Are your Medical Devices Cybersecure?" webinar on 14 July, moderator Andrew Pearce, Senior Digital Health Strategist of Analytics at HIMSS spoke with two subject matter experts on cybersecurity trends in healthcare, as they shared their recommendations on identifying and addressing gaps.

 

Contextualising the imminent threat of cybersecurity in healthcare, Richard Staynings, Chief Security Strategist of Cylera said, "These changes (in healthcare) have led to the emergence of a gap between advances in digital maturity and advances in security maturity, as digital transformation outpaces the industry’s ability to secure new technology."

 

Staynings pointed out that most healthcare providers might have "at best a poor inventory of IoT assets'', with few understanding the associated risks. He said that this creates “massive gaps in security risk management just waiting to be exploited".

 

Adding that providers cannot risk-assess what they do not know about, he shared that the industry needs better tools and processes to identify and assess growing IoT "connected" assets.

 

read more at https://www.healthcareitnews.com/news/apac/examining-cybersecurity-our-medical-health-devices

 

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AI predicts diabetes risk by measuring fat around the heart

AI predicts diabetes risk by measuring fat around the heart | healthcare technology | Scoop.it

The distribution of fat in the body can influence a person's risk of developing various diseases. The commonly used measure of body mass index (BMI) mostly reflects fat accumulation under the skin, rather than around the internal organs. In particular, there are suggestions that fat accumulation around the heart may be a predictor of heart disease, and has been linked to a range of conditions, including atrial fibrillation, diabetes, and coronary artery disease.

 

A team led by researchers from Queen Mary University of London has developed a new artificial intelligence (AI) tool that is able to automatically measure the amount of fat around the heart from MRI scan images.

 

Using the new tool, the team was able to show that a larger amount of fat around the heart is associated with significantly greater odds of diabetes, independent of a person's age, sex, and body mass index.

 

The research team invented an AI tool that can be applied to standard heart MRI scans to obtain a measure of the fat around the heart automatically and quickly, in under three seconds. This tool can be used by future researchers to discover more about the links between the fat around the heart and disease risk, but also potentially in the future, as part of a patient's standard care in hospital.

 

The research team tested the AI algorithm's ability to interpret images from heart MRI scans of more than 45,000 people, including participants in the UK Biobank, a database of health information from over half a million participants from across the UK.

 

The team found that the AI tool was accurately able to determine the amount of fat around the heart in those images, and it was also able to calculate a patient's risk of diabetes

 

read the research published at https://www.frontiersin.org/articles/10.3389/fcvm.2021.677574/full

 

read more at https://www.sciencedaily.com/releases/2021/07/210707112427.htm

 

also at the QMUL website https://www.qmul.ac.uk/media/news/2021/smd/ai-predicts-diabetes-risk-by-measuring-fat-around-the-heart-.html

 

Mougenot Léa's curator insight, January 9, 2023 9:37 AM
A team has developed a new artificial intelligence tool that is very interesting because it can measure the amount of fat around the heart from MRI images. This tool may revolutionise medicine because it is currently impossible to measure the amount of fat around the heart manually without this new tool. In addition, the team was able to show that more fat around the heart is associated with a significantly higher likelihood of diabetes, regardless of a person's age, gender and body mass index.
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Data Crunchers to the Rescue

Data Crunchers to the Rescue | healthcare technology | Scoop.it

Until recently, clinicians didn’t have good tools for personalized genetic analysis.

 

But that’s changing, thanks to quantitative biology. The discipline merges mathematical, statistical, and computational methods to study living organisms.

 

Quantitative biologists develop algorithms that chew through big datasets and try to make sense of them. In case of rare genetic disorders, that means analyzing loads of data from multiple patients to understand how their genes work in tandem with each other.

 

Researchers hope to give clinicians a peek at what their patients’ genes are doing, helping devise personalized therapies.

 

In recent years, DNA-sequencing technologies have matured to the point where a smart algorithm can parse genetic data from multiple patients and their families—and find tale-telling trends much faster than experiments on rodents can

 

read the entire post at https://nautil.us/issue/102/hidden-truths/data-crunchers-to-the-rescue

 

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Regenstrief study shows EHRs underperforming for primary care

Regenstrief study shows EHRs underperforming for primary care | healthcare technology | Scoop.it

Electronic health records are overloading outpatient docs with info in "disparate files and folders rather than presenting comprehensive, actionable data in a context that gives meaning," say researchers in a VA-funded study

 

A primary care physician may care for 2,500 or more patients in a given year, and many of their patient encounters may last only 20 minutes – much of which is often spent at a computer with a back turned to the patient.

 

It's become a truism by now that electronic health records are often viewed askance by primary care docs, many of whom see them as detrimental to the patient encounter.

 

A new report from U.S. Department of Veterans Affairs, Regenstrief Institute and Indiana University details just how outpatient EHRs are often failing the physicians who use them.

 

Why it matters

EHRs "are not rising to the challenges faced by primary care physicians because EHRs have not been designed or tailored to their specific needs,"

 

The report draws on eight years of close study of EHR use patterns to argue for wider acceptance of "human factor approach for the design or redesign of EHR user interfaces."

 

many EHRs as currently configured make it too difficult for primary care docs to do their job in a streamlined and efficacious manner

 

– requiring navigation through multiple screens and tabs to find basic information, increasing redundancy and decreasing efficiency.

 

Something as simple as auto-save – a default capability for most online shopping, for instance – is missing from many EHR systems.

 

Roots of the problem

The study traces the roots of the challenge to the fact that many EHRs were initially designed for specialists and hospitals – without much attention to the specific needs of primary care physicians.

For Primary care physicians, effective decision-making is grounded in perception and comprehension of a patient's dynamic situation."

 

For example, they note, an outpatient doc's choice to stop a patient's use of a particular medication will usually be informed by trends in that patient's blood pressure or cholesterol numbers, or other medications taken over the course of a month – all holistic information with implications for the patient's future health trajectory, but data that isn't always readily seen on a single EHR screen.

 

Technology needs to adapt to humans' needs, abilities, and limitations in healthcare delivery as it has in other domains.

 

EHRs should be redesigned to improve situational awareness for busy primary care physicians and support their tasks including reviewing patient information, care coordination, and shared decision-making."

 

read more at https://www.healthcareitnews.com/news/regenstrief-study-shows-ehrs-underperforming-primary-care

 

 

nrip's insight:

An 8 year old study in a space where there is change every few months does make me wonder. I know clients make EMR vendors update a features every other quarter. So how did the study track that? Did it instead use the data from older period of time

 

That said, the crux of the study results -- EHRs "are not rising to the challenges faced by primary care physicians because EHRs have not been designed or tailored to their specific needs,"

 

Everyone agrees with this, and yet most vendors do little to change it. Most of the EMR's in the name of an upgrade get a makeover and look like the next generation of web solutions, with the same functionalities, same workflows, same mannerism in how they work. No good ...

 

For good software systems, the workflow must adapt and then enhance and move the users ahead.

Instead, in the last 16 years most EHRs are still happy figuring out how to adapt to workflows, and the newbies on the dock look like dashboard template from the coolest web design agency from Bucharest or Bangalore

 

 

george sperco's curator insight, August 13, 2022 10:40 AM


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Can Machines Control Our Brains?

Can Machines Control Our Brains? | healthcare technology | Scoop.it

Once, the prospect of manipulating the human mind with brain implants and radio beams ignited public fears that curtailed this line of research for decades. But now there is a resurgence using even more advanced technology. Laser beams, ultrasound, electromagnetic pulses, mild alternating and direct current stimulation and other methods now allow access to, and manipulation of, electrical activity in the brain with far more sophistication than the needlelike electrodes Manuel Rodriguez Delgado stabbed into brains.

 

Billionaires Elon Musk of Tesla and Mark Zuckerberg of Facebook are leading the charge, pouring millions of dollars into developing brain-computer interface (BCI) technology. Musk says he wants to provide a “superintelligence layer” in the human brain to help protect us from artificial intelligence, and Zuckerberg reportedly wants users to upload their thoughts and emotions over the internet without the bother of typing.

 

But fact and fiction are easily blurred in these deliberations.

 

How does this technology actually work, and what is it capable of?

 

Today’s BCI devices work by analyzing data, in much the same way that Amazon tries to predict what book you might want next. Computers monitoring streams of electrical activity, picked up by a brain implant or a removable electrode cap, learn to recognize how the traffic pattern changes when a person makes an intended limb movement.

 

Advances in brain-computer interface technology are impressive, but we’re not close to anything resembling mind control.

 

read this excellent essay at https://www.quantamagazine.org/how-brain-computer-interface-technology-is-different-from-mind-control-20210517/

 

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Ranking the Next Pandemic - Eyes on Disease X

Ranking the Next Pandemic - Eyes on Disease X | healthcare technology | Scoop.it

The past several decades have seen an alarming spike in communicable disease outbreaks worldwide. Given a confluence of host, virologic, environmental, and human factors, experts agree that the next pandemic could already be on the horizon.

 

 

In a globalized world, changes in how people use land and interact with their ecosystems—such as rapid deforestation and agricultural expansion—have resulted in humans and animals coming into more frequent and intense contact with one another, increasing opportunities for what is known as "zoonotic disease spillover."

 

 

In the past few years alone, numerous disease outbreaks have had suspected or confirmed zoonotic origin, including mpox (formerly known as monkeypox), Ebola virus disease, dengue fever, and COVID-19.

 

Experts also recognize the need to prepare for another possible Disease X, a term used to describe a currently unknown pathogen with pandemic potential.

 

To direct resources toward the most high-consequence pathogens, it is paramount that leaders have an accurate concept of pandemic risk—for individual viruses as well as viral families. Several institutions are developing disease rankings at national and global levels, including the Priority Zoonotic Diseases Lists facilitated by the U.S. Centers for Disease Control and Prevention and the Research and Development (R&D) Blueprint created by the World Health Organization. 

 

The original SpillOver risk ranking framework (SpillOver 1.0), an open-source webtool launched by researchers at the University of California, Davis One Health Institute, estimated the relative spillover potential of wildlife-origin viruses to humans based on a series of host, viral, and environmental risk factors determined via expert opinion and scientific evidence. 

 

Its next iteration, SpillOvers 2.0, has rebranded to better describe the diversity and frequency of virus spillovers to people. The new platform uses a One Health approach, which recognizes the interdependence of human, animal, and environmental health. It will expand to include domestic animal and vector-borne viruses and assess pandemic risk rather than just spillover risk for wildlife viruses.

 

 

 

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Applications of large language models in cancer care: current evidence and future perspectives

Applications of large language models in cancer care: current evidence and future perspectives | healthcare technology | Scoop.it

Large language models (LLM's) are computer models able to perform a wide range of natural language processing tasks, including content generation, question answering, or language translation.

 

The development of LLMs is a recent success in the field of generative artificial intelligence (AI).

 

In recent months, a growing number of studies aimed to assess their potential applications in the field of medicine, including cancer care. In this review, the authors described the present published evidence for using LLMs in oncology. All the available studies assessed ChatGPT, an advanced language model developed by OpenAI, alone or compared to other LLMs, such as Google Bard, Chatsonic, and Perplexity.

 

Although ChatGPT could provide adequate information on the screening or the management of specific solid tumors, it also demonstrated a significant error rate and a tendency toward providing obsolete data.

 

Therefore, an accurate, expert-driven verification process remains mandatory to avoid the potential for misinformation and incorrect evidence. Overall, although this new generative AI-based technology has the potential to revolutionize the field of medicine, including that of cancer care, it will be necessary to develop rules to guide the application of these tools to maximize benefits and minimize risks.

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Impact of the Narcotics Information Management System on Opioid Use Among Outpatients With Musculoskeletal and Connective Tissue Disorders

Impact of the Narcotics Information Management System on Opioid Use Among Outpatients With Musculoskeletal and Connective Tissue Disorders | healthcare technology | Scoop.it

South Korea introduced a new health care IT system named the Narcotics Information Management System (NIMS) with the objective of managing all aspects of opioid use, including manufacturing, distribution, sales, disposal, etc.

 

The authors conducted an analysis using national claims data from 45,582 patients diagnosed with musculoskeletal and connective tissue disorders between 2016 and 2020.  The approach included using an interrupted time-series analysis and constructing segmented regression models. Within these models, the authors considered the primary intervention to be the implementation of NIMS, while we treated the COVID-19 outbreak as the secondary event.

 

To comprehensively assess inappropriate opioid use, we examined 4 key indicators, as established in previous studies:

(1) the proportion of patients on high-dose opioid treatment,

(2) the proportion of patients receiving opioid prescriptions from multiple providers,

(3) the overlap rate of opioid prescriptions per patient, and

(4) the naloxone use rate among opioid users.

 

 

This study suggests that, in its current form, the NIMS may not have brought significant improvements to the identified indicators of opioid overuse and misuse. Additionally, the COVID-19 outbreak exhibited no significant influence on opioid use patterns.

 

 

The absence of real-time monitoring feature within the NIMS could be a key contributing factor. Further exploration and enhancements are needed to maximize the NIMS’ impact on curbing inappropriate opioid use.

 

 

read the original at https://publichealth.jmir.org/2024/1/e47130/

 

 

 

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Digital Transformation of Public Health for Noncommunicable Diseases (NCDs)

Digital Transformation of Public Health for Noncommunicable Diseases (NCDs) | healthcare technology | Scoop.it

The recent SARS-CoV-2 pandemic underscored the effectiveness and rapid deployment of digital public health interventions, notably the digital proximity tracing apps, leveraging Bluetooth capabilities to trace and notify users about potential infection exposures.

 

Digital proximity tracings showcased the promise of digital public health.

 

As the world pivots from pandemic responses, it becomes imperative to address noncommunicable diseases (NCDs) that account for a vast majority of health care expenses and premature disability-adjusted life years lost.

 

The narrative of digital transformation in the realm of NCD public health is distinct from infectious diseases.

 

The power of artificial intelligence (AI) in this digital transformation is noteworthy.

 

  • AI can automate repetitive tasks, facilitating health care providers to prioritize personal interactions, especially those that cannot be digitalized like emotional support.
  • Moreover, AI presents tools for individuals to be proactive in their health management. However, the human touch remains irreplaceable;
  • AI serves as a companion guiding through the health care landscape.

 

Digital evolution, while revolutionary, poses its own set of challenges.

 

Issues of equity and access are at the forefront. Vulnerable populations, whether due to economic constraints, geographical barriers, or digital illiteracy, face the threat of being marginalized further.

 

This transformation mandates an inclusive strategy, focusing on not amplifying existing health disparities but eliminating them.

 

Population-level digital interventions in NCD prevention demand societal agreement.

 

Policies, like smoking bans or sugar taxes, though effective, might affect those not directly benefiting. Hence, all involved parties, from policy makers to the public, should have a balanced perspective on the advantages, risks, and expenses of these digital shifts.

 

For a successful digital shift in public health, especially concerning NCDs, AI’s potential to enhance efficiency, effectiveness, user experience, and equity—the “quadruple aim”—is undeniable.

 

However, it is vital that AI-driven initiatives in public health domains remain purposeful, offering improvements without compromising other objectives.

 

The broader success of digital public health hinges on transparent benchmarks and criteria, ensuring maximum benefits without sidelining minorities or vulnerable groups.

 

Especially in population-centric decisions, like resource allocation, AI’s ability to avoid bias is paramount.

 

Therefore, the continuous involvement of stakeholders, including patients and minority groups, remains pivotal in the progression of AI-integrated digital public health.

 

read the original paper at https://publichealth.jmir.org/2024/1/e49575/

 

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Evolution is not as random as previously thought, finds new study

Evolution is not as random as previously thought, finds new study | healthcare technology | Scoop.it

A new study has found that the evolutionary trajectory of a genome may be influenced by its evolutionary history, rather than determined by numerous factors and historical accidents

 

This could allow scientists to explore which genes could be useful to tackle real-world issues such as antibiotic resistance, disease, and climate change.

 

We can use this approach to synthesize new kinds of genetic constructs that could be used to develop new drugs or vaccines.

 

The implications of the research are far-reaching and could lead to:

  • Novel Genome Design—allowing scientists to design synthetic genomes and providing a roadmap for the predictable manipulation of genetic material.
  • Combating Antibiotic Resistance—Understanding the dependencies between genes can help identify the 'supporting cast' of genes that make antibiotic resistance possible, paving the way for targeted treatments.
  • Climate Change Mitigation—Insights from the study could inform the design of microorganisms engineered to capture carbon or degrade pollutants, thereby contributing to efforts to combat climate change.
  • Medical Applications—The predictability of gene interactions could revolutionize personalized medicine by providing new metrics for disease risk and treatment efficacy

 

more at the original source  https://phys.org/news/2024-01-evolution-random-previously-thought.html

 

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Using participatory action research principles to guide a mHealth app-based intervention to improve oncology care

Using participatory action research principles to guide a mHealth app-based intervention to improve oncology care | healthcare technology | Scoop.it

Women with hormone receptor-positive, early-stage breast cancer who adhere to adjuvant endocrine therapy (AET) reduce the risk of cancer recurrence and mortality.

 

AET, however, is associated with adverse symptoms that often result in poor adherence. We applied participatory action research (PAR) principles to conduct focus groups and interviews to refine and enhance a web-enabled app intervention that facilitates patient-provider communication about AET-related symptoms and other barriers to adherence.

 

 

THRIVE app content reflects researchers’ partnership with a racially diverse sample of breast cancer survivors and healthcare providers and adherence to participatory design by incorporating patient-requested app features, app aesthetics, and message content.

 

The app has the potential to improve AET adherence and quality of life among breast cancer survivors and reduce disparities in mortality rates for Black women by facilitating communication with healthcare providers.

 

read more at https://www.docwirenews.com/abstracts/journal-abstracts/thrive-intervention-development-using-participatory-action-research-principles-to-guide-a-mhealth-app-based-intervention-to-improve-oncology-care-2/

 

Candra Satriya's curator insight, October 7, 2021 9:30 PM
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Applications of virtual and augmented reality in infectious disease epidemics with a focus on the COVID-19 outbreak

Applications of virtual and augmented reality in infectious disease epidemics with a focus on the COVID-19 outbreak | healthcare technology | Scoop.it

The pandemics of major infectious diseases often cause public health, economic, and social problems. Virtual reality (VR) and augmented reality (AR), as two novel technologies, have been used in many fields for emergency management of disasters. The objective of this paper was to review VR and AR applications in the emergency management of infectious outbreaks with an emphasis on the COVID-19 outbreak.

 

It appears that VR and AR technologies can play a positive role during infectious disease outbreaks.

 

VR and AR have been widely used in the prevention and response phases of emergency management during infectious disease pandemics, such as SARS and Ebola pandemics, especially for educating and training purposes for the public.

 

During the COVID-19 outbreak, these technologies have the potential to be used in various fields, including

 

1) clinical context (e.g., telehealth, drug discovery, patient assessment, mental health management),

2) entertainment (e.g., video call, meditation, gaming),

3) business and industry (e.g., holding meetings and conferences, marketing), and

4) education (e.g., in schools and universities, for healthcare providers, and VR-based content for improving public health).

 

These technologies can be used in the above-mentioned fields by providing their different features for facilitating the challenges of COVID-19.

 

However, to respond to COVID-19, all applications of VR and AR should be considered as a supportive approach alongside other information technologies.

 

We believe that VR and AR have a substantial potential to impact the emergency management of COVID-19 or any infectious disease pandemics; however, these potentials need to be studied in a more robust manner.

 

read the paper ta https://www.sciencedirect.com/science/article/pii/S2352914821000691

 

 

 

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Healthcare APIs: A Two-Way Street | Healthcare IT Today

Healthcare APIs: A Two-Way Street | Healthcare IT Today | healthcare technology | Scoop.it

Enabling bi-directional APIs is one way to offer speed, efficiency and security while preserving the most necessary components of human intervention. These closed-loop data retrieval processes will shape the future of ROI in healthcare for higher quality and faster intake and fulfillment.

 

Bi-directional APIs give healthcare providers maximum data visibility and control. Here’s how they’re shaping the future of release of information.

 

In recent years, a fire has been lit under healthcare’s use of application programming interfaces (APIs). Actually, it has been a FHIR [Fast Healthcare Interoperability Resources] as regulations encourage electronic medical record (EMR) vendors to continue to build its standards into their systems, expanding functionality and improving usability. But that does not mean the road to digitization and interoperability has been seamless, particularly as it relates to release of information (ROI).

 

more at https://www.healthcareittoday.com/2021/07/22/healthcare-apis-a-two-way-street/

 

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Team finds 'footprint' of coronavirus outbreak from 20K years ago

Team finds 'footprint' of coronavirus outbreak from 20K years ago | healthcare technology | Scoop.it

A team of researchers analyzed the genomes of more than 2,500 modern humans from 26 worldwide populations, to better understand how humans have adapted to historical coronavirus outbreaks.

 

The team used computational methods to uncover genetic traces of adaptation to coronaviruses, the family of viruses responsible for three major outbreaks in the last 20 years, including the ongoing COVID-19 pandemic.

 

Traces of the outbreak are evident in the genetic makeup of people from that area, they’ve found.

 

A coronavirus epidemic broke out in the East Asia region more than 20,000 years ago, as per their findings.

 

The discovery of a coronavirus outbreak from 20,000 years ago is "like finding fossilized dinosaur footprints instead of finding fossilized bones directly.

 

The work shows that over the course of the epidemic, selection favored certain variants of human genes involved in the virus-cell interactions that could have led to a less severe disease. Studying the “tracks” left by ancient viruses can help researchers better understand how the genomes of different human populations adapted to viruses that have emerged as important drivers of human evolution.

 

The study’s authors say their research could help identify viruses that have caused epidemics in the distant past and may do so in the future. Studies like theirs help researchers compile a list of potentially dangerous viruses and then develop diagnostics, vaccines, and drugs for the event of their return.

 

read the paper at https://www.cell.com/current-biology/fulltext/S0960-9822(21)00794-6

 

 

more at https://www.futurity.org/coronavirus-epidemic-viruses-2597742/

 

nrip's insight:

The promise of evolutionary genetic analyses as a new tool in fighting the outbreaks of the future

nrip's curator insight, July 19, 2021 10:52 PM

The promise of evolutionary genetic analyses as a new tool in fighting the outbreaks of the future

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Making the COVID-19 Pandemic a Driver for Digital Health in Brazil

Making the COVID-19 Pandemic a Driver for Digital Health in Brazil | healthcare technology | Scoop.it

The COVID-19 outbreak exposed several problems faced by health systems worldwide, especially concerning the safe and rapid generation and sharing of health data. However, this pandemic scenario has also facilitated the rapid implementation and monitoring of technologies in the health field.

 

In view of the occurrence of the public emergency caused by SARS-CoV-2 in Brazil, the Department of Informatics of the Brazilian Unified Health System created a contingency plan. In this paper, we aim to report the digital health strategies applied in Brazil and the first results obtained during the fight against COVID-19. Conecte SUS, a platform created to store all the health data of an individual throughout their life, is the center point of the Brazilian digital strategy.

 

Access to the platform can be obtained through an app by the patient and the health professionals involved in the case. Health data sharing became possible due to the creation of the National Health Data Network (Rede Nacional de Dados em Saúde, RNDS).

 

A mobile app was developed to guide citizens regarding the need to go to a health facility and to assist in disseminating official news about the virus. The mobile app can also alert the user if they have had contact with an infected person. The official numbers of cases and available hospital beds are updated and published daily on a website containing interactive graphs.

 

These data are obtained due to creating a web-based notification system that uses the RNDS to share information about the cases.

 

Preclinical care through telemedicine has become essential to prevent overload in health facilities. The exchange of experiences between medical teams from large centers and small hospitals was made possible using telehealth.

 

Brazil took a giant step toward digital health adoption, creating and implementing important initiatives; however, these initiatives do not yet cover the entire health system. It is expected that the sharing of health data that are maintained and authorized by the patient will become a reality in the near future.

 

The intention is to obtain better clinical outcomes, cost reduction, and faster and better services in the public health network.

 

read more at https://publichealth.jmir.org/2021/6/e28643/

 

 

nrip's insight:

The whole context of health data sharing became evident and the need stronger than ever before amid the covid19 pandemic. Here daily updates of epidemiological data for control and decision-making by governments and health system were required.

 

The use of apps within healthcare  (mHealth) is now a reality, and the number of mobile apps created has been increasing.

 

MHealth apps have been implemented for training, information sharing, risk assessment, self-management of symptoms, contact tracing, home monitoring, and decision making. They are considered valuable tools for citizens, health professionals, and decision-makers in facing critical challenges imposed by the pandemic.

 

The COVID-19 pandemic has demonstrated the importance and usefulness of digital health strategies and has allowed the insertion of these solutions into health care systems in the long term

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