Hashimoto's Encephalopathy
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The Laboratory Diagnosis of Autoimmune Encephalitis

The Laboratory Diagnosis of Autoimmune Encephalitis | Hashimoto's Encephalopathy | Scoop.it
Autoimmune encephalitis is a group of encephalitis syndromes that cause altered mentality, memory decline, or seizures in association with the presence of serum and cerebrospinal fluid (CSF) autoantibodies (auto-Abs). An early diagnosis enables earl
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Clinical course, therapeutic responses and outcomes in relapsing MOG antibody-associated demyelination

Clinical course, therapeutic responses and outcomes in relapsing MOG antibody-associated demyelination | Hashimoto's Encephalopathy | Scoop.it
Objective We characterised the clinical course, treatment and outcomes in 59 patients with relapsing myelin oligodendrocyte glycoprotein (MOG) antibody-associated demyelination.

Methods We evaluated clinical phenotypes, annualised relapse rates (ARR) prior and on immunotherapy and Expanded Disability Status Scale (EDSS), in 218 demyelinating episodes from 33 paediatric and 26 adult patients.

Results The most common initial presentation in the cohort was optic neuritis (ON) in 54% (bilateral (BON) 32%, unilateral (UON) 22%), followed by acute disseminated encephalomyelitis (ADEM) (20%), which occurred exclusively in children. ON was the dominant phenotype (UON 35%, BON 19%) of all clinical episodes. 109/226 (48%) MRIs had no brain lesions. Patients were steroid responsive, but 70% of episodes treated with oral prednisone relapsed, particularly at doses <10 mg daily or within 2 months of cessation. Immunotherapy, including maintenance prednisone (P=0.0004), intravenous immunoglobulin, rituximab and mycophenolate, all reduced median ARRs on-treatment. Treatment failure rates were lower in patients on maintenance steroids (5%) compared with non-steroidal maintenance immunotherapy (38%) (P=0.016). 58% of patients experienced residual disability (average follow-up 61 months, visual loss in 24%). Patients with ON were less likely to have sustained disability defined by a final EDSS of ≥2 (OR 0.15, P=0.032), while those who had any myelitis were more likely to have sustained residual deficits (OR 3.56, P=0.077).

Conclusion Relapsing MOG antibody-associated demyelination is strongly associated with ON across all age groups and ADEM in children. Patients are highly responsive to steroids, but vulnerable to relapse on steroid reduction and cessation.
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John Libbey Eurotext - Epileptic Disorders - Myoclonic status epilepticus as a presentation of caspr2 antibody-associated autoimmune encephalitis

John Libbey Eurotext - Epileptic Disorders - Myoclonic status epilepticus as a presentation of caspr2 antibody-associated autoimmune encephalitis | Hashimoto's Encephalopathy | Scoop.it
Vidéo Illustrations Auteurs Sudarshini Ramanathan 1 2 Chong H Wong 1 Zebunnessa Rahman 1 Russell C Dale 2 David Fulcher 3 Andrew F Bleasel 1 * 1 Department of Neurology, Westmead Hospital, and Sydney Medical School, University of Sydney 2 Neuroimmunology group, Institute for Neuroscience and...
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Hashimoto's encephalopathy and anti-MOG antibody encephalitis: 50 years after Lord Brain's description

To consider the role of anti-MOG Abs associated encephalitis in Hashimoto's Encephalitis
(HE).
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Mechanisms of Caspr2 antibodies in autoimmune encephalitis and neuromyotonia | MyNeuroNews

Abstract Objective: To determine the pathogenic mechanisms of autoantibodies to the cell adhesion molecule Caspr2 in acquired neuromyotonia an
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Make a difference in the lives of children and adults with autoimmune encephalitis today - #GivingTuesday and Amazon Smile

Make a difference in the lives of children and adults with autoimmune encephalitis today - #GivingTuesday and Amazon Smile | Hashimoto's Encephalopathy | Scoop.it
Make a difference in the lives of children and adults who are suffering from this rare form of brain inflammation. #GivingTuesday is today! Black Friday and Cyber Monday have passed so now please take the time to give to others in need. Your gift to the Autoimmune Encephalitis Alliance is used to help patients find …
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Hashimoto's Encephalopathy

Hashimoto's Encephalopathy | Hashimoto's Encephalopathy | Scoop.it
Hashimoto’s Encephalopathy (aka Steroid Responsive Encephalopathy Associated with Thyroiditis) is a type of autoimmune condition which effects the brain either in the form of acute inflammation or a waxing/waning course with diffuse brain dysfunction. | See more ideas about Autoimmune, Adipose tissue and Chronic pain.
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4 Things You Should Know If Your Partner Is Chronically Ill

4 Things You Should Know If Your Partner Is Chronically Ill | Hashimoto's Encephalopathy | Scoop.it
Does your partner have a chronic illness? Here's are four tips to help you navigate your relationship.
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Practice Current: When do you suspect autoimmune encephalitis and what is the role of antibody testing?

Practice Current: When do you suspect autoimmune encephalitis and what is the role of antibody testing?.
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Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis

Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis | Hashimoto's Encephalopathy | Scoop.it
Article
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Long-term neurobehavioral outcomes in Autoimmune Encephalitis

Long-term neurobehavioral outcomes in Autoimmune Encephalitis | Hashimoto's Encephalopathy | Scoop.it
One of the first studies on long-term neurobehavioral outcomes in patients affected by AE will be presented by Anusha Yeshokumar, MD, during the upcoming Encephalitis Society meeting in London. This may be difficult news for some AE patients, however at times it is comforting to know that what one suffers is not unusual. The study found that …
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CUMC Celebrates 2017-2018, Issue 2

CUMC Celebrates 2017-2018, Issue 2 | Hashimoto's Encephalopathy | Scoop.it
CUMC Celebrates acknowledges individuals at Columbia University Medical Center for their grants, honors, and leadership positions.
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Your Support Saved My Life

Your Support Saved My Life | Hashimoto's Encephalopathy | Scoop.it
Autoimmune encephalitis survivor Bob Givens shares his story of thanksgiving for the Florence Forth community and their support of the AE Alliance.
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Myoclonic disorders: a practical approach for diagnosis and treatment

Myoclonic disorders: a practical approach for diagnosis and treatment | Hashimoto's Encephalopathy | Scoop.it
Myoclonus is a sudden, brief, involuntary muscle jerk. It is caused by abrupt muscle contraction, in the case of positive myoclonus, or by sudden cessation of ongoing muscular activity, in the case of negative myoclonus (NM). Myoclonus may be classifie
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Psychosis: an autoimmune disease?

Psychosis: an autoimmune disease? | Hashimoto's Encephalopathy | Scoop.it
Psychotic disorders are common and disabling. Overlaps in clinical course in addition to epidemiological and genetic associations raise the possibility that autoimmune mechanisms may underlie some psychoses, potentially offering novel therapeutic approaches.
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Autoimmune encephalitis: a case series and comprehensive review of the literature | QJM: An International Journal of Medicine | Oxford Academic

Autoimmune encephalitis: a case series and comprehensive review of the literature | QJM: An International Journal of Medicine | Oxford Academic | Hashimoto's Encephalopathy | Scoop.it
Abstract. Encephalitic syndromes are a common medical emergency. The importance of early diagnosis and appropriate treatment is paramount. If initial investiga
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Diagnosis of AE on clinical basis confirmed by pediatric study

Diagnosis of AE on clinical basis confirmed by pediatric study | Hashimoto's Encephalopathy | Scoop.it
Experts in the field of AE came together in 2016 to establish a set of clinical diagnostic criteria to be used early in the course of disease (Graus et al). This was developed so that patients might be diagnosed with suspected AE and treated promptly, while still awaiting test results or in areas where antibody …
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Happy 5th birthday to

Happy 5th birthday to | Hashimoto's Encephalopathy | Scoop.it
The AE Alliance turned five years old yesterday!  Five years ago on Dec. 17, two families that had kids with AE came together in hopes that they could start something to help others suffering from this little-understood disease.  The vision was to not only disseminate information to help patients but also to give support to …
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Neuroinflammation And Psychiatric Illness | Back Clinic ® • 915-850-0900

Neuroinflammation And Psychiatric Illness | Back Clinic ® • 915-850-0900 | Hashimoto's Encephalopathy | Scoop.it
El Paso, TX. Multiple lines of evidence support the pathogenic role of neuroinflammation in psychiatric illness.
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Autoimmune Encephalitis Alliance - In Conversation with Leslie McDow

Autoimmune Encephalitis Alliance -  In Conversation with Leslie McDow | Hashimoto's Encephalopathy | Scoop.it
Ever since I learned of the Autoimmune Encephalitis Alliance from Susannah Cahalan, who recalls her own harrowing 2009 battle with a then little-known condition called “Anti-NMDA receptor autoimmune encephalitis” in her 2012 book Brain o
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Clinical course, therapeutic responses and outcomes in relapsing MOG antibody-associated demyelination

Objective We characterised the clinical course, treatment and outcomes in 59 patients with relapsing myelin oligodendrocyte glycoprotein (MOG) antibody-associated demyelination.

Methods We evaluated clinical phenotypes, annualised relapse rates (ARR) prior and on immunotherapy and Expanded Disability Status Scale (EDSS), in 218 demyelinating episodes from 33 paediatric and 26 adult patients.

Results The most common initial presentation in the cohort was optic neuritis (ON) in 54% (bilateral (BON) 32%, unilateral (UON) 22%), followed by acute disseminated encephalomyelitis (ADEM) (20%), which occurred exclusively in children. ON was the dominant phenotype (UON 35%, BON 19%) of all clinical episodes. 109/226 (48%) MRIs had no brain lesions. Patients were steroid responsive, but 70% of episodes treated with oral prednisone relapsed, particularly at doses <10 mg daily or within 2 months of cessation. Immunotherapy, including maintenance prednisone (P=0.0004), intravenous immunoglobulin, rituximab and mycophenolate, all reduced median ARRs on-treatment. Treatment failure rates were lower in patients on maintenance steroids (5%) compared with non-steroidal maintenance immunotherapy (38%) (P=0.016). 58% of patients experienced residual disability (average follow-up 61 months, visual loss in 24%). Patients with ON were less likely to have sustained disability defined by a final EDSS of ≥2 (OR 0.15, P=0.032), while those who had any myelitis were more likely to have sustained residual deficits (OR 3.56, P=0.077).

Conclusion Relapsing MOG antibody-associated demyelination is strongly associated with ON across all age groups and ADEM in children. Patients are highly responsive to steroids, but vulnerable to relapse on steroid reduction and cessation.
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Clinical course, therapeutic responses and outcomes in relapsing MOG antibody-associated demyelination

Objective We characterised the clinical course, treatment and outcomes in 59 patients with relapsing myelin oligodendrocyte glycoprotein (MOG) antibody-associated demyelination.

Methods We evaluated clinical phenotypes, annualised relapse rates (ARR) prior and on immunotherapy and Expanded Disability Status Scale (EDSS), in 218 demyelinating episodes from 33 paediatric and 26 adult patients.

Results The most common initial presentation in the cohort was optic neuritis (ON) in 54% (bilateral (BON) 32%, unilateral (UON) 22%), followed by acute disseminated encephalomyelitis (ADEM) (20%), which occurred exclusively in children. ON was the dominant phenotype (UON 35%, BON 19%) of all clinical episodes. 109/226 (48%) MRIs had no brain lesions. Patients were steroid responsive, but 70% of episodes treated with oral prednisone relapsed, particularly at doses <10 mg daily or within 2 months of cessation. Immunotherapy, including maintenance prednisone (P=0.0004), intravenous immunoglobulin, rituximab and mycophenolate, all reduced median ARRs on-treatment. Treatment failure rates were lower in patients on maintenance steroids (5%) compared with non-steroidal maintenance immunotherapy (38%) (P=0.016). 58% of patients experienced residual disability (average follow-up 61 months, visual loss in 24%). Patients with ON were less likely to have sustained disability defined by a final EDSS of ≥2 (OR 0.15, P=0.032), while those who had any myelitis were more likely to have sustained residual deficits (OR 3.56, P=0.077).

Conclusion Relapsing MOG antibody-associated demyelination is strongly associated with ON across all age groups and ADEM in children. Patients are highly responsive to steroids, but vulnerable to relapse on steroid reduction and cessation.
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Entrevista Dr Josep Dalmau - Encefalitis Autoinmune - Mark Vermattian

En los 11 minutos de duración de esta entrevista, el Dr Josep Dalmau, médico neurólogo, experto en neuro-oncología y descubridor de 16 tipos de encefaliti
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Drug’s effectiveness for neurosarcoidosis studied

Drug’s effectiveness for neurosarcoidosis studied | Hashimoto's Encephalopathy | Scoop.it
A drug commonly prescribed for Crohn’s disease and rheumatoid arthritis is also effective for treating neurosarcoidosis, according to new research led by Vanderbilt neurologists.
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"Giving Tuesday" celebrated around the world on November 28

"Giving Tuesday" celebrated around the world on November 28 | Hashimoto's Encephalopathy | Scoop.it
Giving Tuesday, celebrated on the Tuesday following Thanksgiving (in the US), is a global giving movement in it’s sixth year. In response to  shopping events Black Friday and Cyber Monday, #GivingTuesday kicks off the charitable season, when many focus on their holiday and end-of-year giving. We are always so touched at AEA by the generous spirit …
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