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Artículo para profundizar del día: La prescripción de ATB por fiebre en niños en Europa aún puede mejorar:" Antibiotic prescription for febrile children in European emergency departments: a cross-s...

Antibiotic prescription in European emergency departments is highly variable, with
frequent use of second-line antibiotics. To ensure successful antibiotic stewardship
initiatives in Europe aimed at reducing unnecessary prescription of antibiotics, variability
of prescription across hospitals should be considered, drivers of suboptimal antibiotic
prescription at the local level need to be identified, and European guidelines need
to be devised.
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Último de nuestros artículos Top Ten de Mayo: Bacteriemias por S. aureus  y FR de complicaciones y duración: "Risk Factors for Complications in Children with Staphylococcus aureus Bacteremia"

Último de nuestros artículos Top Ten de Mayo: Bacteriemias por S. aureus  y FR de complicaciones y duración: "Risk Factors for Complications in Children with Staphylococcus aureus Bacteremia" | GPI AEPap | Scoop.it
To determine risk factors for complications in children with Staphylococcus aureus
(S aureus) bacteremia, including methicillin resistance.
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Artículo recomendado del día: Efecto modesto de los probióticos en la prevención de la diarrea asociada a antibióticos: "Probiotics for the prevention of antibiotic-associated diarrhea in children ...

Artículo recomendado del día: Efecto modesto de los probióticos en la prevención de la diarrea asociada a antibióticos: "Probiotics for the prevention of antibiotic-associated diarrhea in children ... | GPI AEPap | Scoop.it
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7º artículo seleccionado de Mayo: Mas de FSF en lactantes pequeños. OJO: "Afebrile infants presenting to the emergency department with only a history of fever have a significant risk of serious bac...

 Ramgopal S, Janofsky S, Zuckerbraun NS, Ramilo O, Mahajan P, Kuppermann N, et al.
Risk of Serious Bacterial Infection in Infants Aged ≤60 Days Presenting to EmergencyDepartments with a History of Fever Only. J Pediatr 2019;204:191-5.

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Winter is Coming: Siguiente artículo recomendado Top Ten de MaYo: Oseltamivir para el tratamiento de la gripe en niños y adolescentes | Anales de Pediatría

Winter is Coming: Siguiente artículo recomendado Top Ten de MaYo: Oseltamivir para el tratamiento de la gripe en niños y adolescentes | Anales de Pediatría | GPI AEPap | Scoop.it
Oseltamivir para el tratamiento de la gripe en niños y adolescentes
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El artículo recomendado del día está muy relacionado con nuestros casos clínicos del #67CongresoAEP: Fever duration during treated urinary tract infections and development of permanent renal lesions 

El artículo recomendado del día está muy relacionado con nuestros casos clínicos del #67CongresoAEP: Fever duration during treated urinary tract infections and development of permanent renal lesions  | GPI AEPap | Scoop.it
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Recursos en Guía-ABE para orientar a la nueva promoción de residentes: Recomendaciones de exclusión escolar por causas infecciosas

Recursos en Guía-ABE para orientar a la nueva promoción de residentes: Recomendaciones de exclusión escolar por causas infecciosas | GPI AEPap | Scoop.it
osas
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Recursos en Guía-ABE para orientar a la nueva promoción de residentes: Generalidades sobre antibioticoterapia. Bases para un tratamiento empírico racional.

Recursos en Guía-ABE para orientar a la nueva promoción de residentes: Generalidades sobre antibioticoterapia. Bases para un tratamiento empírico racional. | GPI AEPap | Scoop.it
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Empezamos Junio con nuestra primera recomendación bibliográfica de Mayo: "Respiratory Viruses Frequently Mimic Pertussis in Young Infants" PIDJ

Empezamos Junio con nuestra primera recomendación bibliográfica de Mayo: "Respiratory Viruses Frequently Mimic Pertussis in Young Infants" PIDJ | GPI AEPap | Scoop.it
Bordetella pertussis is prevalent among infants, but its diagnosis is complicated by the fact that i
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Mas de winter is coming: "Characteristics and Outcomes of Young Children Hospitalized With Laboratory-confirmed Influenza or Respiratory Syncytial Virus in Ontario, Canada, 2009–2014". PIDJ

Mas de winter is coming: "Characteristics and Outcomes of Young Children Hospitalized With Laboratory-confirmed Influenza or Respiratory Syncytial Virus in Ontario, Canada, 2009–2014". PIDJ | GPI AEPap | Scoop.it
h laboratory-confirmed influenza or RSV between 2009 and 2014 in Ontario, Canada.
Methods:
We included hospitalized children who were tested for influenza A, influenza B and RSV and were positive for a single virus. We characterized individuals by their demographics and healthcare utilization patterns and compared their hospital outcomes, in-hospital cost and postdischarge healthcare use by virus type and by presence of underlying comorbidities.
Results:
We identified and analyzed 7659 hospitalizations during which a specimen tested positive for influenza or RSV. Children with RSV were the youngest whereas children with influenza B were the oldest [median ages 6 months (interquartile range: 2–17 months) and 25 months (interquartile range: 10–45 months), respectively]. Complex chronic conditions were more prevalent among children with all influenza (sub)types than RSV (31%–34% versus 20%). In-hospital outcomes were similar by virus type, but in children with comorbidities, postdischarge outcomes varied. We observed no differences in in-hospital cost between viruses or by presence of comorbidities [overall median cost: $4150 Canadian dollars (interquartile range: $3710–$4948)].
Conclusions:
Influenza and RSV account for large numbers of pediatric hospitalizations. RSV and influenza were similar in terms of severity and cost in hospitalized children. Influenza vaccination should be promoted in pregnant women and young children, and a vaccine against RSV would mitigate the high burden o
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Enterovirus: causa frecuente de FSF en nuestro artículo para profundizar: "PCR a enterovirus en la fiebre sin foco. Pensad en mí" - Evidencias en pediatría

Enterovirus: causa frecuente de FSF en nuestro artículo para profundizar: "PCR a enterovirus en la fiebre sin foco. Pensad en mí" - Evidencias en pediatría | GPI AEPap | Scoop.it
sepsis, PCR enterovirus en sangre, PCR enterovirus en LCR, niño, meningitis, lactante, recién nacido, infecciones por enterovirus, fiebre sin foco en Pediatría, fiebre
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Bibliografía del día para profundizar: Estudio de contactos de tuberculosis con IGRAs: "Effective Tuberculosis Contact Investigation Using Interferon-Gamma Release Assays". PIDJ

Bibliografía del día para profundizar: Estudio de contactos de tuberculosis con IGRAs: "Effective Tuberculosis Contact Investigation Using Interferon-Gamma Release Assays". PIDJ | GPI AEPap | Scoop.it
During 2000 to 2018, 1831 children were screened as part of tuberculosis contact investigation at th
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¡¡Nuevo documento en Guía-ABE!!: Bronquitis (tráqueobronquitis) bacteriana

¡¡Nuevo documento en Guía-ABE!!: Bronquitis (tráqueobronquitis) bacteriana | GPI AEPap | Scoop.it
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¿Con ganas de profundizar en bacteriemias por S. aureus tras la recomendación de ayer? Nuestra selección de artículos para profundizar empieza precisamente con este tema: Staphylococcus aureus Bact...

¿Con ganas de profundizar en bacteriemias por S. aureus tras la recomendación de ayer? Nuestra selección de artículos para profundizar empieza precisamente con este tema: Staphylococcus aureus Bact... | GPI AEPap | Scoop.it
hods:
Data from all SA bacteremia events in children (0–16 years) from 2002 to 2016 in a single Israeli tertiary center were collected. Positive cultures within 48 hours of hospitalization were considered community associated (CA). Those obtained afterward or from children hospitalized within the previous year were considered health-care associated (HA).
Results:
We recorded 427 events, 284 (66%) were HA, 64 (15%) were MRSA and 9 (2%) were CA-MRSA. There was no increase in MRSA during the study period. In-hospital, 30-day and 1-year mortality were 3% (12 cases), 3.5% (16 cases), and 12% (50 cases), respectively. A multivariable analysis controlling for demographics, admitting department and prior morbidity showed an increased 1-year mortality in children with HA bacteremia (hazard ratio [HR] 4.1; 95% confidence interval [CI]: 1.3–12) and prior chronic disease (HR 3.4; 95% CI 1.2 to 9.0). MRSA was not independently associated with increased one-year mortality compared with MSSA: HR (95% CI: 1.4 [0.6–3.1]).
Conclusions:
Short-term pediatric mortality after SA bacteremia is low. HA-SA bacteremia has an increased long-term risk for mortality, particularly in children with chronic diseases. Our data suggest mortality was not increased for MRSA compared with MSSA bacteremia. The very low rate of CA-MRSA bacteremia justifies the current practice not to include glycopeptides in the empiric treatment of CA bacteremia i
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¡Vamos a por los últimos artículos recomendados de Mayo!: Mas sobre poca utilidad de la profilaxis ATB para prevenir ciactrices renales: "Long-term antibiotics for preventing recurrent urinary trac...

¡Vamos a por los últimos artículos recomendados de Mayo!: Mas sobre poca utilidad de la profilaxis ATB para prevenir ciactrices renales: "Long-term antibiotics for preventing recurrent urinary trac... | GPI AEPap | Scoop.it
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Articulo seleccionado del día: vacuna para tos ferina en embarazadas y respuesta inmune en los RN:  "Maternal pertussis vaccination and its effects on the immune response of infants aged up to 12 m...

Articulo seleccionado del día: vacuna para tos ferina en embarazadas y respuesta inmune en los RN:  "Maternal pertussis vaccination and its effects on the immune response of infants aged up to 12 m... | GPI AEPap | Scoop.it
Lancet Infect Dis. 2019 Apr;19(4):392-401. doi: 10.1016/S1473-3099(18)30717-5. Epub 2019 Mar 27.
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Nuevo artículo del GPI para FAMILIA Y SALUD: Infecciones por rotavirus: mucho más que diarrea

Nuevo artículo del GPI para FAMILIA Y SALUD: Infecciones por rotavirus: mucho más que diarrea | GPI AEPap | Scoop.it
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5º artículo del Top Ten bibliográfico de Mayo Erythrovirus (AKA Parvovirus): Infecciones por Erythrovirus B19. Seis años de seguimiento en población adulta y pediátrica | Anales de Pediatría

5º artículo del Top Ten bibliográfico de Mayo Erythrovirus (AKA Parvovirus): Infecciones por Erythrovirus B19. Seis años de seguimiento en población adulta y pediátrica | Anales de Pediatría | GPI AEPap | Scoop.it
IntroducciónEl Erythrovirus B19 (anteriormente denominado parvovirus B19) es el agente etiológico del eritema infeccioso que afecta mayoritariamente durante la infancia y la
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Tercer puesto del Top Ten bibliográfico de MaYo: Clinical Characteristics of Infective Endocarditis in Children. PIDJ

Tercer puesto del Top Ten bibliográfico de MaYo: Clinical Characteristics of Infective Endocarditis in Children. PIDJ | GPI AEPap | Scoop.it
00 and 2017 at the Department of Pediatric Cardiology, KU Leuven, was conducted. Clinical presentation, treatment, complications, outcome of IE, underlying microorganisms and congenital heart defects were reviewed.
Results:
Fifty-three patients were diagnosed with IE. Overall, 19 patients (36%) required cardiac surgery. Seven patients (13%) died. Eighty-seven percent of patients had an underlying congenital cardiac defect. Eighteen (34%) children presented with prosthetic graft IE. A causative organism was found in 49 (92%) cases: viridans group streptococci were identified in 17 (32%), Staphylococcus aureus in 13 (25%) and coagulase-negative staphylococci in 11 (20%) children. Community-acquired (CA) IE increased significantly from 8 (33%) cases in 2000–2007 to 20 (74%) cases in 2008–2017 (P < 0.01). Even with viridans streptococci being significantly more prevalent in the CA group (P < 0.01), we did not observe an increase of streptococcal IE from 2008 to 2017. Seventeen (32%) patients presented with hospital-acquired IE during the first year of life with 14 (82%) children after surgery and a prevalence of coagulase-negative staphylococci (53%).
Conclusions:
The incidence of pediatric IE was similar over the investigated time period with a shift toward CA IE. Streptococci and staphylococci accounted for the majority of cases in both periods. Awareness of IE and its prevention is crucial in patients after implantation of prostheti
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Recursos en Guía-ABE para orientar a la nueva promoción de residentes: Infecciones en Pediatría: direcciones útiles en Internet

Recursos en Guía-ABE para orientar a la nueva promoción de residentes: Infecciones en Pediatría: direcciones útiles en Internet | GPI AEPap | Scoop.it
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Segundo artículo recomendado de Mayo: Is Polymerase Chain Reaction in Neonatal Dried Blood Spots Reliable for the Diagnosis of Congenital Cytomegalovirus Infection?

Background:Detection of cytomegalovirus (CMV) DNA by real-time polymerase chain reaction (rt-PCR) in dried blood spots (DBSs) collected for newborn screening has been assessed for retrospective diagnosis of congenital CMV (cCMV) infection, with variable results (sensitivities ranging from 34% to 100
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Novedades Mayo 2019 GPI: Ilustramos los temas de la GUIA ABE Vulvovaginitis y Bronquitis (tráqueobronquitis) aguda con Casos clínicos: Vulvovaginitis e Infecciones. Recordamos el diagnóstico mic...

Novedades Mayo 2019 GPI: Ilustramos los temas  de la GUIA ABE Vulvovaginitis y Bronquitis (tráqueobronquitis) aguda  con  Casos clínicos: Vulvovaginitis e Infecciones. Recordamos el diagnóstico mic... | GPI AEPap | Scoop.it
Queremos que este espacio sea un lugar de referencia donde encontrar reunida documentación útil sobre patología infecciosa, en todos los aspectos de nuestra actividad profesional: en la práctica de cada día, para mantener actualizados nuestros conocimientos y conocer las publicaciones más recientes, presentación de sesiones y casos clínicos, para la docencia con residentes y alumnos y material para informar a las familias.
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Winter is coming: La OMS completa la composición de la vacuna antigripal de 2019-2020 | CAV-AEP

Winter is coming: La OMS completa la composición de la vacuna antigripal de 2019-2020 | CAV-AEP | GPI AEPap | Scoop.it
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Artículo para profundizar del día. Presencia no significa causalidad :The Risk of Serious Bacterial Infection in Febrile Infants 0–90 Days of Life With a Respiratory Viral Infection. PIDJ

Artículo para profundizar del día. Presencia no significa causalidad :The Risk of Serious Bacterial Infection in Febrile Infants 0–90 Days of Life With a Respiratory Viral Infection. PIDJ | GPI AEPap | Scoop.it
spiratory viral coinfection with regard to viral characteristics.
Methods:
This was a prospective observational cohort study performed in the emergency department that included previously healthy febrile infants ≤90 days of life. Clinical and historical characteristics were documented, and a respiratory nasal wash specimen was obtained from each patient. This sample was tested for 17 common respiratory pathogens, and a chart review was conducted to ascertain whether the infant was diagnosed with an SBI.
Results:
In a 12-month period, 67% of the 104 recruited febrile infants were positive for a respiratory virus. The most commonly detected viruses were rhinovirus, respiratory syncytial virus, enterovirus and influenza. The rate of respiratory viral and SBI coinfection was 9% overall, and infants with either a systemic respiratory virus or negative viral testing were 3 times more likely to have an SBI than those with viruses typically restricted to the respiratory mucosa (95% confidence interval: 1.1, 9.7).
Conclusions:
Respiratory viruses are readily detectable via nasopharyngeal wash in febrile infants ≤90 days of life. With the enhanced sensitivity of molecular respiratory diagnostics, rates of coinfection of respiratory viruses and SBI may be higher than previously thought. Further investigation utilizing molecular diagnostics is needed to guide usage in febrile infants ≤9
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Cambiamos de tercio en el artículo para profundizar del día: Antistreptococcal interventions for guttate and chronic plaque psoriasis. Cochrane Database of Systematic Reviews 2019

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