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IN-VIVO: CRISPR Used To Edit Genes Inside A Patient With A Rare Form Of Blindness

IN-VIVO: CRISPR Used To Edit Genes Inside A Patient With A Rare Form Of Blindness | Design, Comm, Sci and Tech | Scoop.it
Doctors used CRISPR to edit genes of cells inside a patient's eye, hoping to restore vision to a person blinded by a rare genetic disorder. A similar strategy might work for some brain diseases.

 

For the first time, scientists have used the gene-editing technique CRISPR to try to edit a gene while the DNA is still inside a person's body. The groundbreaking procedure involved injecting the microscopic gene-editing tool into the eye of a patient blinded by a rare genetic disorder, in hopes of enabling the volunteer to see. They hope to know within weeks whether the approach is working and, if so, to know within two or three months how much vision will be restored.

 

 


Via Dr. Stefan Gruenwald
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Mercury may paradoxically use intense heat to make huge amounts of ice

Mercury may paradoxically use intense heat to make huge amounts of ice | Design, Comm, Sci and Tech | Scoop.it

Despite being the closest planet to the Sun, Mercury is home to a surprising amount of ice. Now, researchers at Georgia Tech have put forward an explanation for how at least some of it got there – and it turns out, the heat plays an important role.

 

Most of Mercury is a broiling hot hell, where daytime temperatures peak at a toasty 427 °C (800 °F). But with no atmosphere to spread the heat around, the poles remain chilly, and the floors of some deep craters never see sunlight. There, temperatures can be as low as -170 °C (-274 °F) – the perfect conditions for ice to form.

And form it does, with spacecraft observations and other calculations showing large deposits at both poles of the planet. How it actually got there in the first place has remained a mystery, but now the Georgia Tech team has proposed at least a partial explanation.

 

 


Via Dr. Stefan Gruenwald
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Human genome editing – the issues explained

Human genome editing – the issues explained | Design, Comm, Sci and Tech | Scoop.it

Hayley Clissold from the Sanger Institute's policy team team explores the issues surrounding gene editing and human embryos.

 

Genome editing is a technique used to modify a specific section of DNA. As all living things contain DNA, genome editing has an almost unlimited range of applications in organisms including bacteria, plants, animals and humans.

 

Genome editing is not a new technology. In fact, it has been around for decades. Genome editing has only recently taken the scientific world by storm because of the discovery of a new tool called CRISPR. CRISPR is simpler, faster, cheaper and much more efficient than any of its predecessor genome editing tools and because of its accessibility, CRISPR is now used in a vast spectrum of applications in labs all around the world.

 

CRISPR was originally discovered as a bacterial immune system. Some bacteria deploy CRISPR as a defense mechanism to chop up the DNA of an invading virus. Because of its ability to target and cut specific stretches of DNA, CRISPR is capable of removing any particular sequence – for example, disease-causing gene variants can be taken out of a genome. The technology also allows DNA sequences to be added or changed – so a disease-causing variant can be replaced with a ‘healthy’ one. Clearly, this technology offers almost limitless possibilities for science and in particular for healthcare.

 

Via Dr. Stefan Gruenwald
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Coronavirus won’t make a dent in the growing climate problem our planet has

Coronavirus won’t make a dent in the growing climate problem our planet has | Design, Comm, Sci and Tech | Scoop.it

The surge in New York City's coronavirus infections is already so critical that the chief medical officer at a major hospital system warned staff of the grim reality: "...there will be loss, and suffering, and at times perhaps each of us will question our will to fight."

 

The coronavirus — which is hospitalizing severely sick young and old people alike — has already had a punishing, paramount influence on human civilization, and it will get much worse. But today's wide-scale shutdown of cities, extreme social distancing measures, and plummeting transportation usage will have no immediate, meaningful impact on Earth's colossal carbon dioxide woes or the planet's relentless warming trend.

 

 


Via Dr. Stefan Gruenwald
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Best Coronavirus maps to update you about the global cases of COVID-19

Best Coronavirus maps to update you about the global cases of COVID-19 | Design, Comm, Sci and Tech | Scoop.it
Track the spread of coronavirus around the world using these live maps
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NASA Makes Their Entire Media Library Publicly Accessible And Copyright Free

NASA Makes Their Entire Media Library Publicly Accessible And Copyright Free | Design, Comm, Sci and Tech | Scoop.it

No matter if you enjoy taking or just watching images of space, NASA has a treat for you. They have made their entire collection of images, sounds, and video available and publicly searchable online. It’s 140,000 photos and other resources available for you to see, or even download and use it any way you like.

 

You can type in the term you want to search for and browse through the database of stunning images of outer space. Additionally, there are also images of astronauts, rocket launches, events at NASA and other interesting stuff. What’s also interesting is that almost every image comes with the EXIF data, which could be useful for astrophotography enthusiasts.

 

NASA recently launched a GIPHY account full of awesome animated gifs. It’s also great that photography is an important part of their missions, and so it was even before “pics or it didn’t happen” became the rule. The vast media library they have now published is available to everyone, free of charge and free of copyright. Therefore, you can take a peek at the fascinating mysteries of space, check out what it’s like inside NASA’s premises, or download the images to make something awesome from them. Either way, you will enjoy it!


Via Dr. Stefan Gruenwald
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Joe Boutte's curator insight, March 17, 8:41 AM

Thank you NASA!

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An app for tracking coronavirus in your community is almost here

An app for tracking coronavirus in your community is almost here | Design, Comm, Sci and Tech | Scoop.it
Knowledge is power—and when it comes to the coronavirus, it can also save lives.

Via Al Cannistra
Al Cannistra's curator insight, March 19, 2:55 PM

and another app coming soon... COVID-19...
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Robots on the march to walking like humans

Robots on the march to walking like humans | Design, Comm, Sci and Tech | Scoop.it

A psychological theory could kickstart improvements in the way robots are able to walk, thanks to a University of Manchester study.

 

The study - a unique collaboration between a clinical psychologist, robotics engineers and a robotics entrepreneur is published in the Journal of Intelligent and Robotic Systems. It analyzed what happens when standard algorithms driving a self-balancing robot - made from simple Lego - were replaced with those based on ‘perceptual control theory’.

 

The theory was encoded into the little droid, allowing it to control what it sensed so that it moved around more effectively, just as humans and other animals can. Though the robot moves on two wheels, it is an ‘inverted pendulum’, which requires nimble balancing in a similar way to how our bodies are kept upright when we walk. So, the better the robot can balance, the better prepared it will be for walking like a human.

 

In the study, the more lifelike robot balanced more accurately, more promptly and more efficiently than its rivals by assessing its environment at least 100 times a second. It also moved to a new location, even when disturbed by sideways nudges, more effectively than its competitors.


Via Dr. Stefan Gruenwald
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How the World’s Largest Coronavirus Outbreaks Are Growing

How the World’s Largest Coronavirus Outbreaks Are Growing | Design, Comm, Sci and Tech | Scoop.it
The world’s hardest-hit countries are trying a variety of measures to stop the spread of the virus. Here’s how they’re doing.

 

Milan, Italy. Daegu, South Korea. Qom, Iran. Many of the world’s largest coronavirus outbreaks took root in and around well-traveled cities, but they have since grown to encompass entire countries.

Cases have spread across Italy’s north and down to Rome, leading to a lockdown of the entire country. Iran’s capital, where leaders dismissed the virus just two weeks ago, has seen thousands infected. And cases continue to surge across Europe.

 

The outbreaks are not all heading in the same direction. South Korea has managed to slow growth of new cases for now, through intensive testing and monitoring of infections. Italy, Iran and the United States are still reporting large numbers of new cases every day.

 

Official case totals are an imperfect method of judging the world’s outbreaks. Every country has more cases than it has been able to detect through lab tests. And a shortage of testing kits in some countries, like Indonesia and the United States, along with a lack of public disclosure in others, like Egypt, means official reports are probably masking large outbreaks.

 

Here’s the extent of some of the largest outbreaks in the world and information on how these countries are trying to slow the spread of the virus.


Via Dr. Stefan Gruenwald
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Coronavirus: Study shows that half of patients have no fever during hospital admission

Coronavirus: Study shows that half of patients have no fever during hospital admission | Design, Comm, Sci and Tech | Scoop.it

More than half of mainland China’s Covid-19 patients did not have a fever when admitted to hospital, a leading researcher said on Saturday, calling on the Hong Kong government to introduce social distancing measures such as flexible lunch hours when civil servants resume work next week, as the city recorded its 95th infection.

 

Chinese University respiratory medicine expert Professor David Hui Shu-cheong, who co-authored the study, also urged for more tests to be conducted in private and public clinics to enable early detection and isolation of suspected cases after the study findings showed more than 80 per cent of coronavirus inpatients had reduced lymphocyte count in their blood.

 

Hong Kong has been battling the spread of a novel strain of coronavirus, which causes the disease Covid-19. The newest case, announced by the Centre for Health Protection late on Saturday, concerned a 46-year-old woman admitted to United Christian Hospital in Kwun Tong. She is the daughter-in-law of a 70-year-old woman infected on Thursday after visiting the Fook Wai Ching She Buddhist worship hall. The infection was the 15th related to the North Point venue.

 

“She developed sore throat today and her deep throat saliva specimen was tested positive for Covid-19 virus,” the center said in a statement. It said the woman was in a stable condition. She had not travelled during the virus’s incubation period, and did not visit the worship hall. Her husband and son, who live with her, were also under quarantine.


Via Dr. Stefan Gruenwald
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Coronavirus: South Korea’s aggressive testing gives clues about true fatality rate, which is much lower than reported

Coronavirus: South Korea’s aggressive testing gives clues about true fatality rate, which is much lower than reported | Design, Comm, Sci and Tech | Scoop.it
Coronavirus can kill, but experts are still puzzling over how deadly the disease it causes truly is. Seoul’s aggressive screening regime might hold the answer.

 

Within a month of confirming its first case of Covid-19 on January 20, South Korea had tested nearly 8,000 people suspected of infection with the new coronavirus that causes the disease. A little over a week later, that number had soared to 82,000 as health officials mobilized to carry out as many 10,000 tests each day Neighboring Japan on the other hand, tested only a fraction of that number, with fewer than 2,000 people checked on any given day since the beginning of its outbreak in late January. So far, more than 6,000 cases have been confirmed in South Korea and over 1,000 in Japan, if you include the  Diamond Princess cruise ship that was quarantined in the Port of Yokohoma.
 
In the United States, where the number of confirmed cases has surpassed 100, health authorities had as recently as this week tested fewer than 500 people in total, hindered by legal and technical barriers to mass screening.
 
Which is where South Korea’s massive testing effort can come in, providing a valuable reference point for public health experts around the world who are starved of hard data – offering potentially the most comprehensive picture yet of the threat posed by Covid-19 to the general public.

Via Dr. Stefan Gruenwald
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Boom! Scientists spot the biggest explosion in the history of the universe | Space

Boom! Scientists spot the biggest explosion in the history of the universe | Space | Design, Comm, Sci and Tech | Scoop.it
Boom! Scientists spot the biggest known explosion in the history of the universe
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50 Ideas to Change Our World [FT]

50 Ideas to Change Our World [FT] | Design, Comm, Sci and Tech | Scoop.it
The FT has enlisted the help of readers, researchers and entrepreneurs to find 50 new ideas that will shape the world in the future.

 

 

Read all 50 ideas


Via Dr. Stefan Gruenwald
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