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This study in semi-arid climates in Spain looked at nitrous oxide (NO) emissions and related microbial communities and their interaction with enhanced efficiency N-fertilizers in the transition year from tillage to no-tillage. They looked at the effectiveness of DMPSA (nitrification inhibitor) + NBPT (nitrogen stabilizer that slows the conversion of urea to crop available nitrogen) applied with urea and calcium ammonium nitrate to mitigate NO in rainfed barley. The highest N2O emissions were measured 49 days after harvest (immediately after a rainfall event that reactivated soil microorganisms), for the treatment with fertiliser without inhibitor combined with tillage. No tillage led to a higher abundance of Cyanobacteria, Verrucomicrobia and Bacteroidetes and resulted in better crop and higher plant density compared with tillage, thus increasing yields and N use efficiency and decreasing N2O emissions. They concluded that shifting from conventional tillage to no tillage enhanced the balance between N use efficiency and yield-scaled N2O emissions in the first year of conversion, particularity with the use of the double inhibitors.