AbstractBackground. Metabolomic scores based on age (MetaboAge) and mortality (MetaboHealth) are considered indicators of overall health, but their associa

AbstractBackground. The application of clinical practice guidelines (CPGs) across the spectrum of individuals living with diabetes can be challenging, part

Abstract. Behavioural symptoms are common manifestations of Parkinson’s disease (PD). Early behavioural symptoms characterise mild behavioural impairment (

Early DOAC initiation within 4 days after ischaemic stroke associated with atrial
fibrillation was non-inferior to delayed initiation for the composite outcome of ischaemic
stroke, intracranial haemorrhage, unclassifiable stroke, or systemic embolism at 90
days. Our findings do not support the current common and guideline-supported practice
of delaying DOAC initiation after ischaemic stroke with atrial fibrillation.

In most countries, especially in low-income and middle-income countries, diabetes
treatment has not increased at all or has not increased sufficiently in comparison
with the rise in prevalence. The burden of diabetes and untreated diabetes is increasingly
borne by low-income and middle-income countries. The expansion of health insurance
and primary health care should be accompanied with diabetes programmes that realign
and resource health services to enhance the early detection and effective treatment
of diabetes.

With the advent of the first disease-modifying, anti-amyloid β-directed passive immunotherapy
for Alzheimer's disease, questions arise who, when, and how to treat. This paper describes
shortly the pathogenic basis of and preclinical data, which have, more than two decades
ago, initiated the development of this vaccination therapy. We discuss clinical trial
results of aducanumab, lecanemab, and donanemab. We also review appropriate use recommendations
of these novel treatments on patient selection and safety monitoring.

In contrast to a mere 5 years ago, discussions about menopause are now more mainstream, with the 2024 Super Bowl advertisement for a drug to treat hot flashes and night sweats related to menopause being a recent example. The drug being advertised, fezolinetant, was the first novel dru

This is a transformative time for patients with Alzheimer disease. Alzheimer disease is increasingly viewed as a treatable condition and managed like other major chronic diseases, such as heart disease and cancer. Management of Alzheimer disease includes early diagnosis with molecula

This prospective study evaluates a clinically available Alzheimer disease blood test in primary and secondary care using predefined biomarker cutoff values.

This special article emphasizes the complex interplay between specific fracture types, their management options, and the roles of comorbidity and polypharmacy, highlighting the essential role of orthogeriatricians. Orthogeriatricians navigate the complexities posed by comorbidities, frailty, and polypharmacy, significantly influencing treatment outcomes

AbstractIntroduction. Approximately 2 million people in Italy are currently living with dementia or mild cognitive impairment (MCI), and 4 million are invo

AbstractBackground. Frailty is of increasing interest in trials, either as a target of intervention, as an outcome or as a potential treatment modifier. Ho

Nearly 80 years after the end of the National Socialist (Nazi) regime, its legacies
persist with the continued use of anatomical atlases whose precise origins remain
unknown.1 Although previous investigations on the history of anatomy during the Nazi
era have revealed unsettling evidence concerning the Pernkopf atlas and other publications
of knowledge gained from the bodies of Nazi victims in life and death,2 there remains
poor insight into the origins of other anatomical atlases of this period.

Almost 40 000 people died alone at home in Japan this year—many unnoticed for months—prompting
much concern, and new policy. Megan Tatum reports.

This review summarizes current evidence on recommended treatments for acute pericarditis, its prognosis, and the diagnostic evaluation of individuals with suspected initial or recurrent pericarditis.

This Review summarizes current evidence on pathogenesis, epidemiology, diagnosis, and treatment of community-acquired pneumonia and focuses on adults without immune-compromising conditions.

This cohort study characterizes temporal changes in plasma biomarkers, identifies factors associated with changes in plasma biomarkers over time, and evaluates the prospective associations of plasma biomarkers with late-life all-cause dementia.

Objectives: Loneliness and social isolation are associated with adverse health outcomes, especially within the older adult population, underlining the need for effective interventions. This systematic review and metaanalysis aims to summarize all available evidence regarding the effectiveness of interventions for loneliness and social isolation, to map out their working mechanisms, and to give implications for policy and practice.

Conclusions and Implications: Interventions for loneliness and social isolation can generally be effective, although some unexplained between-study heterogeneity remains. Further research is needed regarding the applicability of interventions across different settings and countries, also considering their cost-effectiveness