Cardiovascular Disease: PHARMACO-THERAPY
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New target for chronic pain treatment found

New target for chronic pain treatment found | Cardiovascular Disease: PHARMACO-THERAPY | Scoop.it

Researchers at the University of North Carolina (UNC) School of Medicine have found a new target for treating chronic pain: an enzyme called PIP5K1C. In a paper published May 21 in the journal Neuron, a team of researchers led by Mark Zylka, PhD, Associate Professor of Cell Biology and Physiology, shows that PIP5K1C controls the activity of cellular receptors that signal pain.


By reducing the level of the enzyme, researchers showed that the levels of a crucial lipid called PIP2in pain-sensing neurons is also lessened, thus decreasing pain.


They also found a compound that could dampen the activity of PIP5K1C. This compound, currently named UNC3230, could lead to a new kind of pain reliever for the more than 100 million people who suffer from chronic pain in the United States alone.


In particular, the researchers showed that the compound might be able to significantly reduce inflammatory pain, such as arthritis, as well as neuropathic pain – damage to nerve fibers. The latter is common in conditions such as shingles, back pain, or when bodily extremities become numb due to side effects of chemotherapy or diseases such as diabetes.


Brittany Wright, a graduate student in Zylka’s lab, found that the PIP5K1C kinase was expressed at the highest level in sensory neurons compared to other related kinases. Then the researchers used a mouse model to show that PIP5K1C was responsible for generating at least half of all PIP2 in these neurons.


“That told us that a 50 percent reduction in the levels of PIP5K1C was sufficient to reduce PIP2levels in the tissue we were interested in – where pain-sensing neurons are located” Zylka said. “That’s what we wanted to do – block signaling at this first relay in the pain pathway.”


Once Zylka and colleagues realized that they could reduce PIP2 in sensory neurons by targeting PIP5K1C, they teamed up with Stephen Frye, PhD, the Director of the Center for Integrative Chemical Biology and Drug Discovery at the UNC Eshelman School of Pharmacy.


They screened about 5,000 small molecules to identify compounds that might block PIP5K1C. There were a number of hits, but UNC3230 was the strongest. It turned out that Zylka, Frye, and their team members had come upon a drug candidate. They realized that the chemical structure of UNC3230 could be manipulated to potentially turn it into an even better inhibitor of PIP5K1C. Experiments to do so are now underway at UNC.


Via Dr. Stefan Gruenwald
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Should medical evaluation be made compulsory for political aspirants?

Should medical evaluation be made compulsory for political aspirants? | Cardiovascular Disease: PHARMACO-THERAPY | Scoop.it
Medical evaluation should be part of what aspirants should go through to be certified mentally and physically fit for every position aspired for
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Cardio Update Europe 2017, Prague | 29 Jun – 1 Jul 2017

14 expert speakers from across Europe will summarize the most relevant scientific information for practitioners to implement into thei
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Heart damage caused by chemotherapy keeps rising rapidly... chemo is poison

Heart damage caused by chemotherapy keeps rising rapidly... chemo is poison | Cardiovascular Disease: PHARMACO-THERAPY | Scoop.it
Yet another disturbing warning has emerged about the toxic side effects of chemotherapy drugs, in this instance as a risk factor for cardiotoxicity, a condition which is apparently more pronounced for those diagnosed with diabetes.

Chemotherapy is an invasive and toxic treatment meant to kill can
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Inflammation halts fat-burning

Inflammation halts fat-burning | Cardiovascular Disease: PHARMACO-THERAPY | Scoop.it
Prof. Alexander Pfeifer from the Institute of Pharmacology and Toxicology at the University of Bonn.Credit: Barbara Frommann/Uni Bonn
Immune responses prevent conversion into slimming cells
Scientists at the University of Bonn have shown in mice that excess pounds can simply be melted away by conv
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New study finds limited information on role played by primary care providers in care of cancer survivors

New study finds limited information on role played by primary care providers in care of cancer survivors | Cardiovascular Disease: PHARMACO-THERAPY | Scoop.it
For more than a decade, there has been a focus on involving primary care providers in the follow-up care of cancer survivors.
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Eat More Fruits and Veggies: What Happens When You Don’t | Reader’s Digest

Eat More Fruits and Veggies: What Happens When You Don’t | Reader’s Digest | Cardiovascular Disease: PHARMACO-THERAPY | Scoop.it
You might not love ’em, but here’s why you should eat your fruits and veggies anyway.
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Swapping one soda for water cuts your risk of heart disease

Swapping one soda for water cuts your risk of heart disease | Cardiovascular Disease: PHARMACO-THERAPY | Scoop.it
According to experts at Virginia Tech University, every little calorie helps when it comes to your heart. And people who avoid diet drinks become more driven to eat fruits and vegetables.
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Beta-blockers following angioplasty show little benefit for some older patients

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Vitamin D: More Is Not Better

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High bad cholesterol levels linked to amyloid plaque deposits characteristic of Alzheimer’s disease: Study

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High LDL (bad) cholesterol levels are linked to amyloid plaque deposits, a signature characteristic of Alzheimer’s disease.
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Caring for elderly stroke survivors costs $40 BILLION a year

Caring for elderly stroke survivors costs $40 BILLION a year | Cardiovascular Disease: PHARMACO-THERAPY | Scoop.it
According to numbers crunched by the University of Michigan, each of America's 6.5 million stroke survivors need around $11,000 in care and treatment each week.
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Why are so many white Americans dying young?

Why are so many white Americans dying young? | Cardiovascular Disease: PHARMACO-THERAPY | Scoop.it
A 15-year study shows the life expectancy of white Americans seems to have plateaued, while for blacks and Hispanics it keeps rising.
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Mortality risk proportional to PPM severity in aortic value surgery

Mortality risk proportional to PPM severity in aortic value surgery | Cardiovascular Disease: PHARMACO-THERAPY | Scoop.it
Prosthesis-patient mismatch during surgical aortic valve replacement is associated with a perioperative mortality risk that increases with increasing PPM severity, study findings indicate.
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Comparison of lercanidipine plus hydrochlorothiazide vs. lercanidipine plus enalapril on micro and macrocirculation in patients with mild essential... - PubMed - NCBI

Comparison of lercanidipine plus hydrochlorothiazide vs. lercanidipine plus enalapril on micro and macrocirculation in patients with mild essential... - PubMed - NCBI | Cardiovascular Disease: PHARMACO-THERAPY | Scoop.it
Intern Emerg Med. 2017 Jun 24. doi: 10.1007/s11739-017-1696-7. [Epub ahead of print]
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Lifestyle Changes Might Prevent or Slow Dementia - Drugs.com MedNews

Simple changes to your lifestyle might delay the start of dementia or slow its progression, a new report suggests. Some scientific evidence indicates that keepi
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Yes, you CAN die of a broken heart

Yes, you CAN die of a broken heart | Cardiovascular Disease: PHARMACO-THERAPY | Scoop.it
Just hours before Debbie Reynolds (pictured) suffered a stroke in Los Angeles after the death of her daughter Carrie Fisher, she told her family: 'I miss her so much. I just want to be with her.'
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RiseEarth : The Longevity Diet: 12 Sacred Herbs and Foods For Creating Lifelong Health into Your 100’s and Beyond

RiseEarth : The Longevity Diet: 12 Sacred Herbs and Foods For Creating Lifelong Health into Your 100’s and Beyond | Cardiovascular Disease: PHARMACO-THERAPY | Scoop.it
Only together we can make a difference! The truth awaits to be known.
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New test can diagnose cancer and other diseases by "smelling" your breath

New test can diagnose cancer and other diseases by "smelling" your breath | Cardiovascular Disease: PHARMACO-THERAPY | Scoop.it
An "artificially intelligent nanoarray" can offer a fast and inexpensive diagnosis of 17 diseases, by identifying their unique chemical signatures in your breath.
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Family genetics hold clues to life expectancy

Family genetics hold clues to life expectancy | Cardiovascular Disease: PHARMACO-THERAPY | Scoop.it
The journal of the American college of cardiology published a study that shows the longer your parents live, the longer you could stick arou…
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Your parents hold clues to your life expectancy, heart health

Your parents hold clues to your life expectancy, heart health | Cardiovascular Disease: PHARMACO-THERAPY | Scoop.it
Your parents may have a significant influence on how likely you are to stay healthy later in life.
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LDL cholesterol variability associated with declining cognitive performance in old0@er adults: Study

LDL cholesterol variability associated with declining cognitive performance in old0@er adults: Study | Cardiovascular Disease: PHARMACO-THERAPY | Scoop.it
LDL cholesterol variability is associated with declining cognitive performance in older adults, according to research findings. “Bad” LDL cholesterol has been associated with artery plaque buildup contributing to heart disease.
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How Sitting Is Killing Us

We spend most of our days on our behinds, and that's taking a toll on everything from our health to our mood and creativity
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The dark side to juicing

The dark side to juicing | Cardiovascular Disease: PHARMACO-THERAPY | Scoop.it
The craze for juicing can cause a range of health problems, experts warn. These include migraines, fatigue, constipation, fertility problems, loss of muscle and liver damage.
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Top 10 Things That Are Surprisingly Good For You - Listverse

Top 10 Things That Are Surprisingly Good For You - Listverse | Cardiovascular Disease: PHARMACO-THERAPY | Scoop.it
Grab a doughnut and beer and check out ten things that are healthier than you think.^Ten things that are healthier than you think.^Grab a doughnut and beer and check out ten things that are healthier than you think they are.
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These Healthcare Data Companies Earn Millions by Making Employees Healthier, Saving Their Employers Boatloads of Money

These Healthcare Data Companies Earn Millions by Making Employees Healthier, Saving Their Employers Boatloads of Money | Cardiovascular Disease: PHARMACO-THERAPY | Scoop.it
Like everything else, your health information is moving online. A growing class of companies are delivering ever more personalized medical advice as a result.
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