AntiNMDA
25.6K views | +2 today
Follow
 
Scooped by Nesrin Shaheen
onto AntiNMDA
Scoop.it!

Cross-reactivity of a pathogenic autoantibody to a tumor antigen in GABAA receptor encephalitis | PNAS

Cross-reactivity of a pathogenic autoantibody to a tumor antigen in GABAA receptor encephalitis | PNAS | AntiNMDA | Scoop.it
RESEARCH ARTICLE Cross-reactivity of a pathogenic autoantibody to a tumor antigen in GABAA receptor encephalitis Simone M. Brändle, Manuela Cerina, View ORCID ProfileSusanne Weber, View ORCID ProfileKathrin Held, Amélie F. Menke, Carmen Alcalá, View ORCID ProfileDavid Gebert, View ORCID ProfileAlexander M. Herrmann, Hannah Pellkofer, View ORCID ProfileLisa Ann Gerdes, View ORCID ProfileStefan Bittner, View ORCID ProfileFrank Leypoldt, View ORCID ProfileBianca Teegen, View ORCID ProfileLars Komorowski, View ORCID ProfileTania Kümpfel, View ORCID ProfileReinhard Hohlfeld, View ORCID ProfileSven G. Meuth, View ORCID ProfileBonaventura Casanova, View ORCID ProfileNico Melzer, View ORCID ProfileEduardo Beltrán, and View ORCID ProfileKlaus Dornmair PNAS March 2, 2021 118 (9) e1916337118; https://doi.org/10.1073/pnas.1916337118 Edited by Lawrence Steinman, Stanford University School of Medicine, Stanford, CA, and approved January 11, 2021 (received for review June 19, 2020) Article Figures & SI Info & Metrics PDF Significance Antibodies recognizing the neuronal gamma-aminobutyric acid A receptor (GABAA-R) cause severe encephalitis by triggering internalization of the antibody–receptor complexes in inhibitory synapses, which leads to hyperexcitability and dysfunction of neuronal networks. From the cerebrospinal fluid of a patient with GABAA-R encephalitis we cloned a highly expressed antibody and showed that it binds the GABAA-R and influences signal transduction in neurons, explaining clinical symptoms. Using several experimental techniques, we confirmed that the antibody cross-reacts to an oncoprotein which is known to be involved in several malignancies. We showed that cross-reactivity to this oncoprotein may also be detected in two other GABAA-R patients, suggesting that such cross-reactivity is presumably a key event in the pathogenesis of GABAA-R encephalitis. Abstract Encephalitis associated with antibodies against the neuronal gamma-aminobutyric acid A receptor (GABAA-R) is a rare form of autoimmune encephalitis. The pathogenesis is still unknown but autoimmune mechanisms were surmised. Here we identified a strongly expanded B cell clone in the cerebrospinal fluid of a patient with GABAA-R encephalitis. We expressed the antibody produced by it and showed by enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry that it recognizes the GABAA-R. Patch-clamp recordings revealed that it tones down inhibitory synaptic transmission and causes increased excitability of hippocampal CA1 pyramidal neurons. Thus, the antibody likely contributed to clinical disease symptoms. Hybridization to a protein array revealed the cross-reactive protein LIM-domain-only protein 5 (LMO5), which is related to cell-cycle regulation and tumor growth. We confirmed LMO5 recognition by immunoprecipitation and ELISA and showed that cerebrospinal fluid samples from two other patients with GABAA-R encephalitis also recognized LMO5. This suggests that cross-reactivity between GABAA-R and LMO5 is frequent in GABAA-R encephalitis and supports the hypothesis of a paraneoplastic etiology. Footnotes ↵1S.M.B., M.C., and S.W. contributed equally to this work. ↵2N.M., E.B., and K.D. contributed equally to this work. ↵3To whom correspondence may be addressed. Email: Klaus.Dornmair{at}med.uni-muenchen.de. Author contributions: R.H., S.G.M., B.C., N.M., E.B., and K.D. designed research; S.M.B., M.C., S.W., K.H., A.F.M., D.G., A.M.H., B.T., and E.B. performed research; C.A., H.P., L.A.G., S.B., F.L., L.K., T.K., B.C., and N.M. contributed new reagents/analytic tools; S.M.B., M.C., S.W., K.H., A.F.M., D.G., A.M.H., B.T., R.H., S.G.M., N.M., E.B., and K.D. analyzed data; and R.H., S.G.M., N.M., E.B., and K.D. wrote the paper. The authors declare no competing interest. This article is a PNAS Direct Submission. This article contains supporting information online at https://www.pnas.org/lookup/suppl/doi:10.1073/pnas.1916337118/-/DCSupplemental. Data Availability All study data are included in the article and/or SI Appendix. Published under the PNAS license. View Full Text References ↵ J. Dalmau, F. Graus, Antibody-mediated encephalitis. N. Engl. J. Med. 378, 840–851 (2018).OpenUrlCrossRefPubMed ↵ N. Melzer, S. G. Meuth, H. Wiendl, Paraneoplastic and non-paraneoplastic autoimmunity to neurons in the central nervous system. J. Neurol. 260, 1215–1233 (2013).OpenUrl ↵ C. Bost, O. Pascual, J. Honnorat, Autoimmune encephalitis in psychiatric institutions: Current perspectives. Neuropsychiatr. Dis. Treat. 12, 2775–2787 (2016).OpenUrlPubMed ↵ A. Vincent, C. G. Bien, S. R. Irani, P. Waters, Autoantibodies associated with diseases of the CNS: New developments and future challenges. Lancet Neurol. 10, 759–772 (2011).OpenUrlCrossRefPubMed ↵ M. H. van Coevorden-Hameete, E. de Graaff, M. J. Titulaer, C. C. Hoogenraad, P. A. Sillevis Smitt, Molecular and cellular mechanisms underlying anti-neuronal antibody mediated disorders of the central nervous system. Autoimmun. Rev. 13, 299–312 (2014).OpenUrlCrossRefPubMed ↵ M. J. Titulaer et al.; European Federation of Neurological Societies, Screening for tumours in paraneoplastic syndromes: Report of an EFNS task force. Eur. J. Neurol. 18, 19-e3 (2011).OpenUrlPubMed ↵ J. Dalmau, M. R. Rosenfeld, Paraneoplastic syndromes of the CNS. Lancet Neurol. 7, 327–340 (2008).OpenUrlCrossRefPubMed ↵ T. Ohkawa et al., Identification and characterization of GABA(A) receptor autoantibodies in autoimmune encephalitis. J. Neurosci. 34, 8151–8163 (2014). ↵ M. Petit-Pedrol et al., Encephalitis with refractory seizures, status epilepticus, and antibodies to the GABAA receptor: A case series, characterisation of the antigen, and analysis of the effects of antibodies. Lancet Neurol. 13, 276–286 (2014).OpenUrlCrossRefPubMed ↵ P. Pettingill et al., Antibodies to GABAA receptor α1 and γ2 subunits: Clinical and serologic characterization. Neurology 84, 1233–1241 (2015).OpenUrlCrossRefPubMed ↵ K. O’Connor et al., GABAA receptor autoimmunity: A multicenter experience. Neurol. Neuroimmunol. Neuroinflamm. 6, e552 (2019). ↵ C. Zhou et al., Altered cortical GABAA receptor composition, physiology, and endocytosis in a mouse model of a human genetic absence epilepsy syndrome. J. Biol. Chem. 288, 21458–21472 (2013). ↵ M. Spatola et al., Investigations in GABAA receptor antibody-associated encephalitis. Neurology 88, 1012–1020 (2017).OpenUrlPubMed ↵ C. Y. Guo, J. M. Gelfand, M. D. Geschwind, Anti-gamma-aminobutyric acid receptor type A encephalitis: A review. Curr. Opin. Neurol. 33, 372–380 (2020).OpenUrl ↵ M. M. Simabukuro et al., GABAA receptor and LGI1 antibody encephalitis in a patient with thymoma. Neurol. Neuroimmunol. Neuroinflamm. 2, e73 (2015). ↵ E. Lancaster, Encephalitis, severe seizures, and multifocal brain lesions: Recognizing autoimmunity to the GABAA receptor. Neurol. Neuroimmunol. Neuroinflamm. 6, e554 (2019). ↵ A. Bracher et al., An expanded parenchymal CD8+ T cell clone in GABAA receptor encephalitis. Ann. Clin. Transl. Neurol. 7, 239–244 (2020).OpenUrl ↵ J. M. Matthews, K. Lester, S. Joseph, D. J. Curtis, LIM-domain-only proteins in cancer. Nat. Rev. Cancer 13, 111–122 (2013).OpenUrlCrossRefPubMed ↵ Y. Midorikawa et al., Identification of genes associated with dedifferentiation of hepatocellular carcinoma with expression profiling analysis. Jpn. J. Cancer Res. 93, 636–643 (2002).OpenUrlCrossRef ↵ Z. Hu et al., The molecular portraits of breast tumors are conserved across microarray platforms. BMC Genomics 7, 96 (2006).OpenUrlCrossRefPubMed ↵ C. Hoffmann et al., CRP2, a new invadopodia actin bundling factor critically promotes breast cancer cell invasion and metastasis. Oncotarget 7, 13688–13705 (2016).OpenUrl ↵ B. Schlick et al., Serum autoantibodies in chronic prostate inflammation in prostate cancer patients. PLoS One 11, e0147739 (2016).OpenUrl ↵ C. Hoffmann et al., Hypoxia promotes breast cancer cell invasion through HIF-1α-mediated up-regulation of the invadopodial actin bundling protein CSRP2. Sci. Rep. 8, 10191 (2018).OpenUrlCrossRefPubMed ↵ S. J. Wang et al., Cysteine and glycine-rich protein 2 (CSRP2) transcript levels correlate with leukemia relapse and leukemia-free survival in adults with B-cell acute lymphoblastic leukemia and normal cytogenetics. Oncotarget 8, 35984–36000 (2017).OpenUrl ↵ S. M. Brändle et al., Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins. Proc. Natl. Acad. Sci. U.S.A. 113, 7864–7869 (2016). ↵ H. B. Michelson, R. K. Wong, Excitatory synaptic responses mediated by GABAA receptors in the hippocampus. Science 253, 1420–1423 (1991). ↵ S. Schuster et al., Fatal PCR-negative herpes simplex virus-1 encephalitis with GABAA receptor antibodies. Neurol. Neuroimmunol. Neuroinflamm. 6, e624 (2019). ↵ S. Sala, C. Ampe, An emerging link between LIM domain proteins and nuclear receptors. Cell. Mol. Life Sci. 75, 1959–1971 (2018).OpenUrlCrossRef ↵ B. Obermeier et al., Matching of oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis. Nat Med. 14, 688–693 (2008).OpenUrlCrossRefPubMed ↵ M. Cerina et al., Thalamic Kv 7 channels: Pharmacological properties and activity control during noxious signal processing. Br. J. Pharmacol. 172, 3126–3140 (2015).OpenUrl ↵ P. Blaesse et al., μ-Opioid receptor-mediated inhibition of Intercalated neurons and effect on synaptic transmission to the central amygdala. J. Neurosci. 35, 7317–7325 (2015). ↵ S. M. Brändle, “Analysis of oligoclonal band antibodies from patients with neurological diseases,” PhD thesis, Ludwig Maximilians University of Munich, Munich, Germany (2016). Log in using your username and password Username * Password * Log in Forgot your user name or password? Log in through your institution You may be able to gain access using your login credentials for your institution. Contact your library if you do not have a username and password. If your organization uses OpenAthens, you can log in using your OpenAthens username and password. To check if your institution is supported, please see this list. Contact your library for more details. Purchase access You may purchase access to this article. This will require you to create an account if you don't already have one. Subscribers, for more details, please visit our Subscriptions FAQ. Please click here to log into the PNAS submission website. Previous Next Share Sign up for the PNAS Highlights newsletter to get in-depth stories of science sent to your inbox twice a month: Sign up for Article Alerts Sign up ARTICLE CLASSIFICATIONS Biological SciencesImmunology and Inflammation JUMP TO SECTION YOU MAY ALSO BE INTERESTED IN Scientists should pursue a strategic approach to research, focusing on the accumulation of evidence via designed sequences of studies. Image credit: Dave Cutler (artist). Despite myriad challenges, clinicians see room for progress. Image credit: Shutterstock/David Tadevosian. Sneaky intracellular bacteria know when to defend themselves and multiply. Image credit: Camilla Ciolli Mattioli. Mara Reed and Michael Manga explore why Yellowstone's Steamboat Geyser resumed erupting in 2018. Listen Past PodcastsSubscribe A study demonstrates how two enzymes—MHETase and PETase—work synergistically to depolymerize the plastic pollutant PET. Image credit: Aaron McGeehan (artist). Similar Articles
No comment yet.
AntiNMDA
Your new post is loading...
Scooped by Nesrin Shaheen
Scoop.it!

Testing for N-methyl-D-aspartate receptor autoantibodies in clinical practice

Testing for N-methyl-D-aspartate receptor autoantibodies in clinical practice | AntiNMDA | Scoop.it
The diagnosis of anti-N-methyl-D-aspartate receptor (NMDAR)
encephalitis relies on the detection of NMDAR IgG autoantibodies in the
serum or cerebrospinal fluid of symptomatic patients. Commercial kits are
available that allow NMDAR IgG autoantibodies ...
No comment yet.
Scooped by Nesrin Shaheen
Scoop.it!

Co-occurrence of Anti-N-Methyl-D-Aspartate Receptor Encephalitis and Anti-myelin Oligodendrocyte Glycoprotein Inflammatory Demyelinating Diseases: A Clinical Phenomenon to Be Taken Seriously

Co-occurrence of Anti-N-Methyl-D-Aspartate Receptor Encephalitis and Anti-myelin Oligodendrocyte Glycoprotein Inflammatory Demyelinating Diseases: A Clinical Phenomenon to Be Taken Seriously | AntiNMDA | Scoop.it
Background: Anti-N-methyl-D-aspartate receptor (NMDAR) immunoglobulin G antibodies which exist on myelin sheaths, composed of oligodendrocytes, especially target GluN1 subunits and are highly characteristic of anti-NMDAR encephalitis which is a newly recognized autoimmune encephalitis (AE) ch
No comment yet.
Scooped by Nesrin Shaheen
Scoop.it!

Pediatric anti-NMDA receptor encephalitis associated with COVID-19

Pediatric anti-NMDA receptor encephalitis associated with COVID-19 | AntiNMDA | Scoop.it
Anti-N-methyl-D-aspartate receptor encephalitis is a clinical condition characterized by acute behavioral and mood changes, abnormal movements, autonomic instability, seizures, and encephalopathy.We describe a 7-year-old boy diagnosed with autoimmune encephalitis due to NMDAR antibody in associatio...
No comment yet.
Scooped by Nesrin Shaheen
Scoop.it!

Lincoln model raising awareness of brain disease that saw her wrongly sectioned under Mental Health Act | Calendar

Lincoln model raising awareness of brain disease that saw her wrongly sectioned under Mental Health Act | Calendar | AntiNMDA | Scoop.it
A woman from Lincoln who was sectioned after being wrongly diagnosed as mentally ill is raising awareness of what happened to her.
No comment yet.
Scooped by Nesrin Shaheen
Scoop.it!

Anti-NMDA receptor antibodies in patients with a first episode of schizophrenia

Anti-NMDA receptor antibodies in patients with a first episode of schizophrenia | AntiNMDA | Scoop.it
Encephalitis with antibodies against N-methyl-D-aspartate receptor (NMDA-R) is classified as an autoimmune disorder with psychotic symptoms, which are frequently dominant. However, it remains unclear how frequently NMDA-R antibodies lead to a condition ...
No comment yet.
Scooped by Nesrin Shaheen
Scoop.it!

Palilalia as a prominent feature of anti-NMDA receptor encephalitis in a woman with COVID-19

Palilalia as a prominent feature of anti-NMDA receptor encephalitis in a woman with COVID-19 | AntiNMDA | Scoop.it
Palilalia as a prominent feature of anti-NMDA receptor encephalitis in a woman with COVID-19
No comment yet.
Scooped by Nesrin Shaheen
Scoop.it!

Anti-NMDA receptor encephalitis associated with ovarian tumor: the gynecologist point of view

Anti-NMDA receptor encephalitis associated with ovarian tumor: the gynecologist point of view | AntiNMDA | Scoop.it
Anti-NMDA antibody encephalitis should not be ignored by gynecologists whose role in management is central.
No comment yet.
Scooped by Nesrin Shaheen
Scoop.it!

Pediatric N-Methyl-d-Aspartate (NMDA) Receptor Encephalitis, With and Without Herpes Encephalitis - Lydia Marcus, Jayne M. Ness, 2021

Pediatric N-Methyl-d-Aspartate (NMDA) Receptor Encephalitis, With and Without Herpes Encephalitis - Lydia Marcus, Jayne M. Ness, 2021 | AntiNMDA | Scoop.it
Objective:To compare clinical, diagnostic, management, and outcome factors in children with anti–N-methyl-d-aspartate receptor (NMDAR) encephalitis and a history of herpes simplex encephalitis (HSE...
No comment yet.
Scooped by Nesrin Shaheen
Scoop.it!

Oculomotor artefacts mimic extreme deltabrush EEG features of autoimmune anti NMDA receptor encephalitis - ScienceDirect

Oculomotor artefacts mimic extreme deltabrush EEG features of autoimmune anti NMDA receptor encephalitis - ScienceDirect | AntiNMDA | Scoop.it
Clinical Neurophysiology Available online 31 March 2021 Letter to the Editor Oculomotor artefacts mimic extreme deltabrush EEG features of autoimmune anti NMDA receptor encephalitis Author links open overlay panel Show more Share Cite View full text © 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
No comment yet.
Scooped by Nesrin Shaheen
Scoop.it!

Residual Fatigue and Cognitive Deficits in Patients After Leucine-Rich Glioma-Inactivated 1 Antibody Encephalitis | Dementia and Cognitive Impairment | JAMA Neurology | JAMA Network

Residual Fatigue and Cognitive Deficits in Patients After Leucine-Rich Glioma-Inactivated 1 Antibody Encephalitis | Dementia and Cognitive Impairment | JAMA Neurology | JAMA Network | AntiNMDA | Scoop.it
This study evaluates residual fatigue and cognitive defects in patients after leucine-rich glioma-inactivated 1 antibody encephalitis.
No comment yet.
Scooped by Nesrin Shaheen
Scoop.it!

MOG-IgG Among Participants in the Pediatric Optic Neuritis Prospective Outcomes Study | Demyelinating Disorders | JAMA Ophthalmology | JAMA Network

MOG-IgG Among Participants in the Pediatric Optic Neuritis Prospective Outcomes Study | Demyelinating Disorders | JAMA Ophthalmology | JAMA Network | AntiNMDA | Scoop.it
This study examines the association of myelin oligodendrocyte glycoprotein immunoglobulin G–associated disorder with pediatric optic neuritis to guide prognosis...
No comment yet.
Scooped by Nesrin Shaheen
Scoop.it!

Horizontal Saccadic Palsy as a Prominent Symptom of Anti-NMDAR Encephalitis | Neurology Clinical Practice

Horizontal Saccadic Palsy as a Prominent Symptom of Anti-NMDAR Encephalitis | Neurology Clinical Practice | AntiNMDA | Scoop.it
SHARE February 2021; 11 (1) CASE Horizontal Saccadic Palsy as a Prominent Symptom of Anti-NMDAR Encephalitis Koen Delmotte, Thomas Claeys, Koen Poesen, Bénédicte Dubois, Maarten Schrooten, Josep Dalmau, Robin Lemmens First published October 16, 2019, DOI: https://doi.org/10.1212/CPJ.0000000000000750 FULL PDF CITATION PERMISSIONS MAKE COMMENT SEE COMMENTS Downloads53 This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased. Consider the diagnosis of autoimmune encephalitis in patients with progressive disorders of voluntary eye movements in the context of encephalopathy. Footnotes Funding information and disclosures are provided at the end of the article. Full disclosure form information provided by the authors is available with the full text of this article at Neurology.org/cp. Received June 24, 2019. Accepted September 9, 2019. © 2019 American Academy of Neurology View Full Text AAN Members We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page. Google Safari Microsoft Edge Firefox CLICK HERE TO LOGIN AAN Non-Member Subscribers CLICK HERE TO LOGIN Purchase access For assistance, please contact: AAN Members (800) 879-1960 or (612) 928-6000 (International) Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international) Sign Up Information on how to subscribe to Neurology and Neurology: Clinical Practice can be found here  Purchase Individual access to articles is available through the Add to Cart option on the article page.  Access for 1 day (from the computer you are currently using) is US$ 39.00.  Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means.  The payee may view, download, and/or print the article for his/her personal, scholarly, research, and educational use.  Distributing copies (electronic or otherwise) of the article is not allowed. YOU MAY ALSO BE INTERESTED IN Back to top Advertisement RELATED ARTICLES No related articles found. TOPICS DISCUSSED Autoimmune diseases ALERT ME
No comment yet.
Scooped by Nesrin Shaheen
Scoop.it!

Clinical Characteristics and Outcome of Neuronal Surface Antibody-Mediated Autoimmune Encephalitis Patients in a National Cohort

Clinical Characteristics and Outcome of Neuronal Surface Antibody-Mediated Autoimmune Encephalitis Patients in a National Cohort | AntiNMDA | Scoop.it
<span><b>Background:</b> In our previous single-center study of autoimmune encephalitis (AE) related autoantibody test results we found positivity in 60 patients out of 1,034 with suspected AE from 2012 through 2018 as part of a Hungarian nationwide program.
No comment yet.
Scooped by Nesrin Shaheen
Scoop.it!

Service Dogs Are Not For Petting, They're Keeping People Alive

Service Dogs Are Not For Petting, They're Keeping People Alive | AntiNMDA | Scoop.it
Please do not touch a service dog. My Auggie may be cuter than oxygen monitors and feeding tubes, but she is every bit as important.
No comment yet.
Scooped by Nesrin Shaheen
Scoop.it!

Recurrent anti-NMDAR encephalitis during pregnancy combined with two antibodies positive

Recurrent anti-NMDAR encephalitis during pregnancy combined with two antibodies positive | AntiNMDA | Scoop.it
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune synaptic encephalitis likely mediated by neuronal surface antibody. Clinically, it is characterized by a variety of neurological and psychiatric symptoms, predominantly affecting young women.
No comment yet.
Scooped by Nesrin Shaheen
Scoop.it!

Cells | Free Full-Text | Neurodegeneration Induced by Anti-IgLON5 Antibodies Studied in Induced Pluripotent Stem Cell-Derived Human Neurons

Cells | Free Full-Text | Neurodegeneration Induced by Anti-IgLON5 Antibodies Studied in Induced Pluripotent Stem Cell-Derived Human Neurons | AntiNMDA | Scoop.it
Anti-IgLON5 disease is a progressive neurological disorder associated with autoantibodies against a neuronal cell adhesion molecule, IgLON5. In human postmortem brain tissue, the neurodegeneration and accumulation of hyperphosphorylated tau (p-tau) are found.
No comment yet.
Scooped by Nesrin Shaheen
Scoop.it!

Remission of subacute psychosis in a COVID-19 patient with an anti-neuronal autoantibody after treatment with intravenous immunoglobulin

Remission of subacute psychosis in a COVID-19 patient with an anti-neuronal autoantibody after treatment with intravenous immunoglobulin | AntiNMDA | Scoop.it
COVID-19 patients are at increased risk for developing new or recurrent psychosis.(1) Viral infections—including SARS-CoV-2 (2-4)—can cause psychosis in the context of autoimmune encephalitis.(5) However, some individuals with para-infectious psychosis do not meet criteria for autoimmune...
No comment yet.
Scooped by Nesrin Shaheen
Scoop.it!

Autoimmune Encephalitis in Autism

Autoimmune Encephalitis in Autism | AntiNMDA | Scoop.it
Autoimmune encephalitis, inflammatory diseases of the brain, present with a wide range of neurological and psychiatric symptoms, most of them common in autism...
No comment yet.
Scooped by Nesrin Shaheen
Scoop.it!

COVID‐19 and anti‐N‐methyl‐d‐aspartate receptor (anti‐NMDAR) encephalitis: Are we facing an increase in the prevalence of autoimmune encephalitis? - Zandifar - 2021 - Journal of Medical Virology

COVID‐19 and anti‐N‐methyl‐d‐aspartate receptor (anti‐NMDAR) encephalitis: Are we facing an increase in the prevalence of autoimmune encephalitis? - Zandifar - 2021 - Journal of Medical Virology | AntiNMDA | Scoop.it
Click on the article title to read more.
No comment yet.
Scooped by Nesrin Shaheen
Scoop.it!

Clinical Features and Outcomes of Anti-N-Methyl-d-Aspartate Receptor Encephalitis in Infants and Toddlers

Clinical Features and Outcomes of Anti-N-Methyl-d-Aspartate Receptor Encephalitis in Infants and Toddlers | AntiNMDA | Scoop.it
Anti-NMDAR encephalitis in infants and toddlers clinically presents with movement disorders, developmental regression, and abnormal behaviors. Interestingly, this group had a higher proportion of patients after viral encephalitis, which is regarded as the only risk factor for poor outcomes.
No comment yet.
Scooped by Nesrin Shaheen
Scoop.it!

Hystero-epilepsy in the Tuesday Lessons and NMDA receptor function: A hypothesis for dissociative disorder

Hystero-epilepsy in the Tuesday Lessons and NMDA receptor function: A hypothesis for dissociative disorder | AntiNMDA | Scoop.it
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis patients demonstrate characteristic multistage progression and movement disorders, which are analogous to hystero-epilepsy in Jean-Martin Charcot's Tuesday Lessons.
No comment yet.
Scooped by Nesrin Shaheen
Scoop.it!

Brain on Fire disease: Regina woman recovering in hospital | CTV News

Brain on Fire disease: Regina woman recovering in hospital | CTV News | AntiNMDA | Scoop.it
Kerry Wallen began to display strange behaviour: confusion, repeating herself, showing signs of memory loss. Here's what doctors discovered.
No comment yet.
Scooped by Nesrin Shaheen
Scoop.it!

Familial autoimmunity in neurological patients with GAD65 antibodies: an interview-based study | SpringerLink

Familial autoimmunity in neurological patients with GAD65 antibodies: an interview-based study | SpringerLink | AntiNMDA | Scoop.it
The common co-occurrence of autoimmune systemic diseases in patients with neurological disorders and antibodies against glutamic acid decarboxylase 65 (GAD65) suggests a shared genetic predisposition to these disorders.
No comment yet.
Scooped by Nesrin Shaheen
Scoop.it!

Autoimmune Movement Disorders: A Video-Based Case Series of 11 Patients

Autoimmune Movement Disorders: A Video-Based Case Series of 11 Patients | AntiNMDA | Scoop.it
Autoimmune encephalitis (AIE) constitutes an important treatable cause of movement disorders.We aimed to highlight the spectrum of movement disorder and other salient features of AIE patients diagnosed at our tertiary care centre and describe their clinical symptoms, diagnostic approach, treatment,...
No comment yet.
Scooped by Nesrin Shaheen
Scoop.it!

Autoimmune encephalitis after Japanese encephalitis in children: A prospective study

Autoimmune encephalitis after Japanese encephalitis in children: A prospective study | AntiNMDA | Scoop.it
In addition to anti-NMDAR antibodies, anti-GABA<sub>B</sub>R antibodies and antibodies against unknown neuronal surface antigens can trigger autoimmune encephalitis following JE. Patients who developed autoimmune encephalitis had a poorer prognosis at the one-year follow-up.
No comment yet.