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Characteristics of internalization of NMDA-type GluRs with antibodies to GluN1 and GluN2B - ScienceDirect

Characteristics of internalization of NMDA-type GluRs with antibodies to GluN1 and GluN2B - ScienceDirect | AntiNMDA | Scoop.it
To characterize internalization of NMDA-type glutamate receptors (GluRs) by antibodies to NMDA-type GluRs, we produced rabbit antibodies to N-terminal…
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Count Down to WED Conference Saturday, 20 February 2021: Meet Dr. Tom Pollak

Count Down to WED Conference Saturday, 20 February 2021: Meet Dr. Tom Pollak | AntiNMDA | Scoop.it
We are delighted to spotlight Dr. Tom Pollak from the UK. Thanks to his engagement and research, many more are now getting the help they ...Read More...
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Frontiers | Clinical and Radiological Features of Adult Onset Bilateral Medial Frontal Cerebral Cortical Encephalitis With Anti-myelin Oligodendrocyte Glycoprotein Antibody | Neurology

Frontiers | Clinical and Radiological Features of Adult Onset Bilateral Medial Frontal Cerebral Cortical Encephalitis With Anti-myelin Oligodendrocyte Glycoprotein Antibody | Neurology | AntiNMDA | Scoop.it
Objective: To clarify the clinical and radiological features of adult onset anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated bilateral medial frontal cerebral cortical encephalitis (BFCCE).Methods: We systematically reviewed the literature for patients with anti-MOG...
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Seizures in autoimmune encephalitis—A systematic review and quantitative synthesis - Yeshokumar - - Epilepsia

Seizures in autoimmune encephalitis—A systematic review and quantitative synthesis - Yeshokumar - - Epilepsia | AntiNMDA | Scoop.it
Abstract Objective This study aimed to evaluate the proportion of patients with seizures and electroencephalography (EEG) abnormalities in autoimmune encephalitis (AE) and its most common subtypes....
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High serum creatinine is associated with reduction of psychiatric symptoms in female patients with anti-NMDAR encephalitis - ScienceDirect

High serum creatinine is associated with reduction of psychiatric symptoms in female patients with anti-NMDAR encephalitis - ScienceDirect | AntiNMDA | Scoop.it
Serum creatinine (SCR) has been shown to be associated with many neurodegenerative diseases.In this study, we investigated the relationship between S…...
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Count Down to WED Conference 2021: Meet Dr. Jérôme Honnorat

Count Down to WED Conference 2021: Meet Dr. Jérôme Honnorat | AntiNMDA | Scoop.it
Dr. Honnorat has more than 25 years of experience in the field of paraneoplastic neurological syndromes (PNS) and autoimmune encephalitis (AE). The topic of his presentations will be the role of genetics in autoimmune encephalitis (AE). He is head of the Department of Neuro-Oncology at the neurological hospital, Hospices Civils de Lyon and a team leader of the “Synaptopathies and Autoantibodies (SynatAc)” at the Institute NeuroMyoGene (UMR INSERM U1217, CNRS 5310). He is also chair of the French rare disease reference center “paraneoplastic neurological syndrome and autoimmune encephalitis” since 2007, which collects samples from all over France and provides care and follow-up for people with rare diseases. He has been working on PNS and AE for more than 25 years. His main work combines Basic and Clinical Research at multiple levels (patient’s cohorts; biological collections; cellular and animal models; biomarkers...) to explore the pathophysiologies of both brain tumors and neuro-inflammatory diseases and to detect specific autoantibodies as biomarkers of these diseases and as tools to understand synaptic functions.  We invite you to register today for what promises to be just one of the fascinating presentations of the conference.
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Normally Sharp, He Was Chronically Confused. What Was Going On? - The New York Times

Normally Sharp, He Was Chronically Confused. What Was Going On? - The New York Times | AntiNMDA | Scoop.it
He was getting lost driving home from work. And he was having strange spasms. What was the cause?
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Leveraging molecular biomarkers to make the common diagnosis in the uncommon patient - ScienceDirect

Leveraging molecular biomarkers to make the common diagnosis in the uncommon patient - ScienceDirect | AntiNMDA | Scoop.it
The factors that predispose to relapse in patients recovering with autoimmune encephalitis (AE) are largely unknown, complicating efforts to distingui…...
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Flortaucipir (tau) PET in LGI1 antibody encephalitis - Day - - Annals of Clinical and Translational Neurology

Flortaucipir (tau) PET in LGI1 antibody encephalitis - Day - - Annals of Clinical and Translational Neurology | AntiNMDA | Scoop.it
Abstract The contributors to persistent cognitive impairment and hippocampal atrophy in leucine‐rich glioma‐inactivated 1 antibody encephalitis (LGI1) patients are unknown. We evaluated whether tau...
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Collection of Biological Samples From Patients With Rare Neurological...

The aim of this project is to improve biological collections of patients presenting rare neurological disorders with known or suspected autoimmune origin...
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Individuals with psychosis more likely to have certain antibodies

Individuals with psychosis more likely to have certain antibodies | AntiNMDA | Scoop.it
Individuals with psychosis were more likely to have a higher prevalence of a particular antibody vs. controls, according to results of a meta-analysis published in The Lancet Psychiatry.“The discovery of an encephalitic syndrome driven by antibodies targeting the N-methyl-D aspartate receptor...
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Diagnosis of pediatric anti-NMDAR encephalitis at the onset: A clinical challenge - ScienceDirect

Diagnosis of pediatric anti-NMDAR encephalitis at the onset: A clinical challenge - ScienceDirect | AntiNMDA | Scoop.it
To investigate the clinical and instrumental features at the onset addressing to the diagnosis of anti-NMDAR encephalitis.Twenty children (age: 15 mon…...
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Count Down to WED Conference 2021: Meet Dr. Gregory Day

Count Down to WED Conference 2021: Meet Dr. Gregory Day | AntiNMDA | Scoop.it
Happy New Year Everyone! May 2021 be a healthier and safer world for us all. Today we are pleased to launch the countdown to the World ...Read More...
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18F-FDG PET/CT in Initial Diagnosis and Treatment Response Evaluation of Anti-NMDAr and Anti-GAD Dual Antibody Autoimmune Encephalitis

18F-FDG PET/CT in Initial Diagnosis and Treatment Response Evaluation of Anti-NMDAr and Anti-GAD Dual Antibody Autoimmune Encephalitis | AntiNMDA | Scoop.it
We report a case of 34-year-old woman presenting with complaints of abnormal posturing of hand and tonic-clonic seizures of few days' duration, which soon progressed to psychotic episodes and injuries secondary to fall/abnormal movements.
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Neurological webinar series –

Neurological webinar series – | AntiNMDA | Scoop.it
By EUROIMMUN academy First Webinar: Autoimmune Encephalitis - Adult and Paediatric cases When: January 28thTime: 11-12.30PM EST Click here to register.
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Paediatric multiple sclerosis and antibody-associated demyelination: clinical, imaging, and biological considerations for diagnosis and care

Paediatric multiple sclerosis and antibody-associated demyelination: clinical, imaging, and biological considerations for diagnosis and care | AntiNMDA | Scoop.it
The field of acquired CNS neuroimmune demyelination in children is transforming. Progress in assay development, refinement of diagnostic criteria, increased biological insights provided by advanced neuroimaging techniques, and high-level evidence for the therapeutic efficacy of biological agents...
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Antineuronal antibodies and epilepsy: treat the patient, not the lab | Journal of Neurology, Neurosurgery & Psychiatry

The study results implicate that starting immunosppressive treatment in new-onset epilepsy should be guided by clinics, not simply antibody presence Epilepsy affects about 70–80 million people worldwide; about one-third of patients cannot become seizure free. New diagnostic and therapeutic avenues to improve this situation are welcome. The impact of autoimmune phenomena on pathogenesis of some epilepsies increasingly gained attention as these mechanisms open the door for alternative medical treatments beyond antiseizure medications, that is, immunosuppressants. Thus, ‘autoimmune’ has become one of the six aetiologic categories of the new Intenational League Against Epilepsy classification of seizures and epilepsies. Numerous neuronal surface autoantibodies (NSAbs) identified in the past years cause autoimmune encephalitis (AE),1 often associated with severe seizures and status epilepticus. Additionally, the prevalence of NSAbs in patients with chronic epilepsies of unknown aetiology yielded a prevalence between 3% and 21%, but the question whether all epilepsy patients with NSAbs or only those with pharmacoresistant epilepsy (PRE) and/or additional signs of AE warrant immunosuppressants remained unresolved yet. A study looking at the presence of NSAbs in PRE found that 62% of patients responded to immunotherapy, and 34% even became seizure free, indicating that a trial may be justfied.2 But how does this result relate to patients with new-onset focal epilepsy (NFE)? The paper by Mc Ginty et al,3 tackles this issue by prospectively looking at those patients with NFE and a test positive for at least one NSAbs. The authors established an NSAbs prediction score based on clinical and paraclinical information and evaluated the value of immunotherapy in patients with NFE. About 10% of their cohort was NSAbs positive and 40% of them were diagnosed with AE. They identified six features which in combination were highly predictive for the presence of NSAbs, that is, age >54 years, ictal piloerection, self-reported lowered mood, MRI changes in the limbic system, the absence of ‘conventional’ epilepsy risk factors and intact attention. This ‘NSAbs-detecting’ Score compared better with the recently published ‘antibody prevalence in epilepsy and encephalopathy’ (APE2) Score4 in terms of forecasting AE, but worse in predicting presence of NSAbs. According to the present study (with an admittedly small sample of patients), immunotherapy could be omitted in those patients with NSAbs-positive new-onset epilepsy without signs or symptoms of AE. Conversely, the study also indicates that immunosuppressants are warranted in patients with even subtle AE. This is in line with another study where patients with AE even without NSAbs benefitted from immunosuppressants.5 The authors conclude that the administration of immunotherapy in NSAbs-positive patients should be guided by clinical signs for (subtle or obvious) AE and not only by NSAbs positivity per se. The study did not rely on cerebrospinal fluid data, probably leading to some missed cases of NSAbs positivity and AE. It is also interesting that 5/16 NSAbs positive, but AE-negative patients had mRS >0 and, thus, likely were pharmacoresistant, although this information was not exactly verifiable without follow-up phone interview. Statistically, this would exactly fit the one-third of patients basically becoming pharmacoresistant in chronic epilepsy of various aetiologies. Thus, future trials should test whether immunotherapy given to these patients would prevent pharmacoresistancy despite the fact that outcome without such treatment was mostly promising in this study.
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Autoimmune encephalitis and epilepsy: evolving definition and clinical spectrum

Autoimmune encephalitis and epilepsy: evolving definition and clinical spectrum | AntiNMDA | Scoop.it
Advances in autoimmune encephalitis studies in the past 10 years have led to the identification of new syndromes and biomarkers that have transformed the diagnostic approach to the disorder.The disorder or syndrome has been linked to a wide variety of pathologic processes associated with the neuron...
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Correction to: Refractory anti‑NMDAR encephalitis successfully treated with bortezomib and associated movements disorders controlled with tramadol: a case report with literature review | SpringerLink

Correction to: Refractory anti‑NMDAR encephalitis successfully treated with bortezomib and associated movements disorders controlled with tramadol: a case report with literature review | SpringerLink | AntiNMDA | Scoop.it
The authors would like to correct some errors in the publication of the original article. The corrected and updated details are given below for your reading.
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Ca V α2δ Autoimmune Encephalitis: A Novel Antibody and its Characteristics

Ca V α2δ Autoimmune Encephalitis: A Novel Antibody and its Characteristics | AntiNMDA | Scoop.it
Here, we found a novel autoimmune encephalitis associated with anti-Ca<sub>V</sub> α2δ antibody. Further analysis of the antibody in autoimmune encephalitis might promote the early diagnosis and treatment.
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Clinical features and management of coexisting anti-N-methyl-D-aspartate receptor encephalitis and myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis: a case report and revie...

Clinical features and management of coexisting anti-N-methyl-D-aspartate receptor encephalitis and myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis: a case report and revie... | AntiNMDA | Scoop.it
The rates of coexisting anti-NMDA receptor encephalitis and MOG antibody-associated encephalomyelitis may be underestimated.Clinical symptoms such as seizures and cognitive decline accompanied by atypical central nervous system demyelination serve as warning signs of possible coexisting anti-NMDA...
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The Antibodies Contributing to focal Epilepsy Signs and symptoms (ACES) score - Bruijn - - Annals of Neurology

The Antibodies Contributing to focal Epilepsy Signs and symptoms (ACES) score - Bruijn - - Annals of Neurology | AntiNMDA | Scoop.it
Objective Diagnosing autoimmune encephalitis (AIE) is difficult in patients with less fulminant diseases, like epilepsy. However, recognition is important, as patients require immunotherapy. This s...
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Can You Identify Autoimmune Psychosis? | Psychiatric News

Can You Identify Autoimmune Psychosis? | Psychiatric News | AntiNMDA | Scoop.it
Patients with a rare neurological condition known as anti-NMDA receptor encephalitis often present first with psychosis.
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Good Article! It used to be that relapse rates were between 15-25%. In this report, Dalmau refers to a 10% relapse rate. 

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Infiltration of plasma cells in colorectal adenocarcinoma associated with autoimmune encephalitis

Infiltration of plasma cells in colorectal adenocarcinoma associated with autoimmune encephalitis | AntiNMDA | Scoop.it
Paraneoplastic autoimmune encephalitis (PAE) represents a group of rare neurological syndromes associated with neoplastic diseases.Here, we report a case that multiple anti-neuronal antibodies were present in a patient with PAE who developed both small cell lung cancer and colorectal adenocarcinoma...
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Unremitting diarrhoea in a girl diagnosed anti-N-methyl-D-aspartate-receptor encephalitis: A case report | Read by QxMD

Unremitting diarrhoea in a girl diagnosed anti-N-methyl-D-aspartate-receptor encephalitis: A case report | Read by QxMD | AntiNMDA | Scoop.it
Create a free QxMD account to take advantage of the features offered by Read like saving your papers and creating collections. Get Started Unremitting diarrhoea in a girl diagnosed anti-N-methyl-D-aspartate-receptor encephalitis: A case report Norrapat Onpoaree, Montida Veeravigrom, Anapat Sanpavat, Narissara Suratannon, Palittiya Sintusek World Journal of Clinical Cases 2020 October 26, 8 (20): 4866-4875 BACKGROUND: Asymptomatic cytomegalovirus (CMV) infection is common in children; in contrast, in children with a weakened immune system, invasive CMV can occur. This is the first case report of a severe manifestation of CMV esophago-enterocolitis in a girl diagnosed with anti-N-methyl-D-aspartate-receptor (anti-NMDAR) encephalitis who received only a moderate dose of corticosteroid therapy. CASE SUMMARY: A 12-year-old-Thai girl presented with acute behavioural change and headache for 6 d. Electroencephalogram and positivity for NMDAR autoantibodies were compatible with anti-NMDAR encephalitis. Hence, she received pulse methylprednisolone 10 mg/kg per day for 4 d and continued with prednisolone 1.2 mg/kg per day. On day 42 of corticosteroid therapy, she developed unremitting vomiting and diarrhoea. Endoscopy showed multiple ulcers and erythaematous mucosa along the gastrointestinal tract. Tissue CMV viral load and viral-infected cells confirmed CMV esophago-enterocolitis. Therefore, the patient received ganciclovir 5 mg/kg per dose every 12 h for 3 wk and then 5 mg/kg per dose once daily for 3 wk. Unremitting diarrhoea slowly improved from stool output 1-4 L per day to 1-2 L per day after 3 wk of treatment. Pulse methylprednisolone 20 mg/kg for 5 d was initiated and continued with prednisolone 1 mg/kg per day. After this repeated pulse methylprednisolone treatment, surprisingly, diarrhoea subsided. Immunologic work-up was performed to rule out underlying immune deficiency with unremarkable results. CONCLUSION: Unremitting diarrhoea from CMV esophago-enterocolitis subsided with antiviral and methylprednisolone therapy, implying the immune and NMDAR dysregulation in anti-NMDAR encephalitis. Full Text Links We have located links that may give you full text access. Additional links Discussion You are not logged in. Sign Up or Log In to join the discussion. Trending Papers 2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Steve R Ommen, Seema Mital, Michael A Burke, Sharlene M Day, Anita Deswal, Perry Elliott, Lauren L Evanovich, Judy Hung, José A Joglar, Paul Kantor, Carey Kimmelstiel, Michelle Kittleson, Mark S Link, Martin S Maron, Matthew W Martinez, Christina Y Miyake, Hartzell V Schaff, Christopher Semsarian, Sorajja Paul Circulation 2020 November 20, : CIR0000000000000938 Effectiveness of Adding a Mask Recommendation to Other Public Health Measures to Prevent SARS-CoV-2 Infection in Danish Mask Wearers : A Randomized Controlled Trial. Henning Bundgaard, Johan Skov Bundgaard, Daniel Emil Tadeusz Raaschou-Pedersen, Christian von Buchwald, Tobias Todsen, Jakob Boesgaard Norsk, Mia M Pries-Heje, Christoffer Rasmus Vissing, Pernille B Nielsen, Ulrik C Winsløw, Kamille Fogh, Rasmus Hasselbalch, Jonas H Kristensen, Anna Ringgaard, Mikkel Porsborg Andersen, Nicole Bakkegård Goecke, Ramona Trebbien, Kerstin Skovgaard, Thomas Benfield, Henrik Ullum, Christian Torp-Pedersen, Kasper Iversen Annals of Internal Medicine 2020 November 18 How to ventilate obstructive and asthmatic patients. Alexandre Demoule, Laurent Brochard, Martin Dres, Leo Heunks, Amal Jubran, Franco Laghi, Armand Mekontso-Dessap, Stefano Nava, Lamia Ouanes-Besbes, Oscar Peñuelas, Lise Piquilloud, Theodoros Vassilakopoulos, Jordi Mancebo Intensive Care Medicine 2020 November 9 Volume overload in hemodialysis: diagnosis, cardiovascular consequences, and management. Charalampos Loutradis, Pantelis A Sarafidis, Charles J Ferro, Carmine Zoccali Nephrology, Dialysis, Transplantation 2020 November 13 Clinical Management of Hyperkalemia. Biff F Palmer, Juan Jesus Carrero, Deborah J Clegg, Gates B Colbert, Michael Emmett, Steven Fishbane, Debra J Hain, Edgar Lerma, Macaulay Onuigbo, Anjay Rastogi, Simon D Roger, Bruce S Spinowitz, Matthew R Weir Mayo Clinic Proceedings 2020 November 4 Comparing Laparoscopic Elective Sigmoid Resection With Conservative Treatment in Improving Quality of Life of Patients With Diverticulitis: The Laparoscopic Elective Sigmoid Resection Following Diverticulitis (LASER) Randomized Clinical Trial. Alexandre Santos, Panu Mentula, Tarja Pinta, Shamel Ismail, Tero Rautio, Risto Juusela, Aleksi Lähdesmäki, Tom Scheinin, Ville Sallinen JAMA Surgery 2020 November 18
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Cotard syndrome in anti-NMDAR encephalitis: two patients and insights from molecular imaging: Neurocase: Vol 0, No 0

Cotard syndrome in anti-NMDAR encephalitis: two patients and insights from molecular imaging: Neurocase: Vol 0, No 0 | AntiNMDA | Scoop.it
Cotard syndrome is a clinical condition defined by the presence of nihilistic delusions. We report two patients with Cotard syndrome in whom anti-NMDAR encephalitis (ANMDARE) was confirmed. Both ca...
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