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Human gestational N‐methyl‐d‐aspartate receptor autoantibodies impair neonatal murine brain function - Jurek - - Annals of Neurology

Human gestational N‐methyl‐d‐aspartate receptor autoantibodies impair neonatal murine brain function - Jurek - - Annals of Neurology | AntiNMDA | Scoop.it

Objective
Maternal autoantibodies are a risk factor for impaired brain development in offspring. Antibodies (ABs) against the NR1 (GluN1) subunit of the N‐methyl‐d‐aspartate receptor (NMDAR) ar
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My Brain is on Fire – Six-Episode Podcast produced by Laura Vander Steen of i lobe you

My Brain is on Fire – Six-Episode Podcast produced by Laura Vander Steen of i lobe you | AntiNMDA | Scoop.it
What happens when you have a creative social worker, with an interest in the altered brain, working out of a large city hospital and who ...Read More...
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Anti-Glutamic Acid Decarboxylase-65 Autoimmune Encephalitis Presenting with Mania and Delirium - ScienceDirect

Anti-Glutamic Acid Decarboxylase-65 Autoimmune Encephalitis Presenting with Mania and Delirium - ScienceDirect | AntiNMDA | Scoop.it
JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page. Psychosomatics Available online 13 September 2019 Case Report Anti-Glutamic Acid Decarboxylase-65 Autoimmune Encephalitis Presenting with Mania and Delirium Author links open overlay panel Show more View full text © 2019 Academy of Consultation-Liaison Psychiatry. Published by Elsevier Inc. All rights reserved.
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A metabolic brain pattern associated with Anti-N-Methyl-D-Aspartate Receptor Encephalitis - ScienceDirect

A metabolic brain pattern associated with Anti-N-Methyl-D-Aspartate Receptor Encephalitis - ScienceDirect | AntiNMDA | Scoop.it
JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page. Psychosomatics Available online 5 September 2019 Original Research Article A metabolic brain pattern associated with Anti-N-Methyl-D-Aspartate Receptor Encephalitis Author links open overlay panel Show more Keywords NeuropsychiatryPSY0440Acute DisorderPSY0010 Key Words Positron emission tomographyencephalitisfdg First page preview Open this preview in PDF View full text © 2019 Academy of Consultation-Liaison Psychiatry. Published by Elsevier Inc. All rights reserved.
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Understanding parental perspectives on outcomes following paediatric encephalitis: A qualitative study

Understanding parental perspectives on outcomes following paediatric encephalitis: A qualitative study | AntiNMDA | Scoop.it
Background Encephalitis, characterised as inflammation of the brain tissue, is an important cause of acquired brain injury in children. Objective clinical outcomes vary significantly between affected patients, however they do not always correlate with quality of life as reported by parents.
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Thymoma associated paraneoplastic encephalitis (TAPE), a potential cause of limbic encephalitis | Read by QxMD

Thymoma associated paraneoplastic encephalitis (TAPE), a potential cause of limbic encephalitis | Read by QxMD | AntiNMDA | Scoop.it
JOURNAL ARTICLE Thymoma associated paraneoplastic encephalitis (TAPE), a potential cause of limbic encephalitis Henry Liu, Randall S Edson BMJ Case Reports 2019 August 30, 12 (8) A 59-year-old man presents with expressive aphasia and short term memory deficits. Shortly thereafter, he started developing staring spells and intermittent right hand spasms, preliminarily thought to be simple partial seizures. Subsequent MRI brain imaging was highly suggestive of herpes simplex virus (HSV) encephalitis; however, HSV PCR from cerebrospinal fluid was negative. On further testing, the patient was found to have an autoimmune encephalitis thought to be related to an incidentally found thymoma. His clinical presentation, in conjunction with imaging and response to therapy, was strongly suggestive of thymoma associated paraneoplastic encephalitis. Early recognition is the only way to ensure prompt initiation of appropriate treatment. Immunotherapy and cancer directed therapy (including tumour resection, if indicated) have been shown to have favourable outcomes, improved speed of neurological recovery and reduced risk of relapses. Without treatment, progressive neurologic deterioration can occur over months to years, eventually resulting in death. Comments You need to log in or sign up for an account to be able to comment. No comments yet, be the first to post one! Related Papers
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Prevalence and clinical characteristics of serum neuronal cell surface antibodies in first-episode psychosis: a case-control study

Some patients with first-episode psychosis had antibodies against NMDAR that might
be relevant to their illness, but did not differ from patients without NMDAR antibodies
in clinical characteristics. Our study suggests that the only way to detect patients with these potentially pathogenic...
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General principles and escalation options of immunotherapy in autoantibody-associated disorders of the CNS | Neurological Research and Practice | Full Text

General principles and escalation options of immunotherapy in autoantibody-associated disorders of the CNS | Neurological Research and Practice | Full Text | AntiNMDA | Scoop.it
Autoimmune diseases associated with antineuronal and antiglial autoantibodies (Abs) is one of the most rapidly expanding research fields in clinical neuroimmunology, with more than 30 autoantibodies described so far.
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Long‐term cognitive and neuropsychiatric outcomes in patients with anti‐NMDAR encephalitis - Liu - - Acta Neurologica Scandinavica

Long‐term cognitive and neuropsychiatric outcomes in patients with anti‐NMDAR encephalitis - Liu - - Acta Neurologica Scandinavica | AntiNMDA | Scoop.it
Abstract Objectives To evaluate the long‐term cognitive or neuropsychiatric outcomes and potential risk factors associated with prolonged cognitive deficits or neuropsychiatric symptoms in patients...
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Anti-NMDA receptor encephalitis: report of ten cases and comparison with viral encephalitis. - PubMed - NCBI

Anti-NMDA receptor encephalitis: report of ten cases and comparison with viral encephalitis. - PubMed - NCBI | AntiNMDA | Scoop.it
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Severe Anti-N-Methyl-D-Aspartate Receptor Encephalitis Under Immunosuppression After Liver Transplantation | MyNeuroNews

Anti-NMDA receptor encephalitis is a rare and often therapy-responsive autoimmune disease that usually affects young adults and causes neuropsychiatric symptoms.Here, we describe a 69-year-old patien...
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Antibody testing reveals dogs can suffer from same autoimmune encephalitis as humans

Antibody testing reveals dogs can suffer from same autoimmune encephalitis as humans | AntiNMDA | Scoop.it
Researchers from North Carolina State University have found that dogs can suffer from the same type of autoimmune encephalitis that people do. The finding could lead to better screening methods for diagnosis and possibly ...
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Understanding auto-immune encephalitis in the ICU

Understanding auto-immune encephalitis in the ICU | AntiNMDA | Scoop.it
1. Venkatesan A, Tunkel AR, Bloch KC et al (2013) Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the international encephalitis consortium. Clin Infect Dis 57:1114–1128.  https://doi.org/10.1093/cid/cit458 CrossRefPubMedPubMedCentralGoogle Scholar 2. Venkatesan A, Michael BD, Probasco JC et al (2019) Acute encephalitis in immunocompetent adults. Lancet 393:702–716.  https://doi.org/10.1016/S0140-6736(18)32526-1 CrossRefPubMedGoogle Scholar 3. Dalmau J, Graus F (2018) Antibody-mediated encephalitis. N Engl J Med 378:840–851.  https://doi.org/10.1056/NEJMra1708712 CrossRefPubMedPubMedCentralGoogle Scholar 4. Jeannin-Mayer S, André-Obadia N, Rosenberg S et al (2019) EEG analysis in anti-NMDA receptor encephalitis: description of typical patterns. Clin Neurophysiol 130:289–296.  https://doi.org/10.1016/j.clinph.2018.10.017 CrossRefPubMedGoogle Scholar 5. Probasco JC, Solnes L, Nalluri A et al (2017) Abnormal brain metabolism on FDG-PET/CT is a common early finding in autoimmune encephalitis. Neurol Neuroimmunol Neuroinflamm 11:e352.  https://doi.org/10.1212/NXI.0000000000000352 CrossRefGoogle Scholar 6. Graus F, Titulaer MJ, Balu R et al (2016) A clinical approach to diagnosis of autoimmune encephalitis. Lancet Neurol 15:391–404.  https://doi.org/10.1016/S1474-4422(15)00401-9 CrossRefPubMedPubMedCentralGoogle Scholar 7. Titulaer MJ, McCracken L, Gabilondo I et al (2013) Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study. Lancet Neurol 12:157–165.  https://doi.org/10.1016/S1474-4422(12)70310-1 CrossRefPubMedPubMedCentralGoogle Scholar 8. Viaccoz A, Desestret V, Ducray F et al (2014) Clinical specificities of adult male patients with NMDA receptor antibodies encephalitis. Neurology 82:556–563.  https://doi.org/10.1212/WNL.0000000000000126 CrossRefPubMedGoogle Scholar 9. Armangue T, Spatola M, Vlagea A et al (2018) Frequency, symptoms, risk factors, and outcomes of autoimmune encephalitis after herpes simplex encephalitis: a prospective observational study and retrospective analysis. Lancet Neurol 17:760–772.  https://doi.org/10.1016/S1474-4422(18)30244-8 CrossRefPubMedPubMedCentralGoogle Scholar 10. Sonneville R, Demeret S, Klein I et al (2008) Acute disseminated encephalomyelitis in the intensive care unit: clinical features and outcome of 20 adults. Intensive Care Med 34:528–532.  https://doi.org/10.1007/s00134-007-0926-2 CrossRefPubMedGoogle Scholar 11. de Montmollin E, Demeret S, Brulé N et al (2017) Anti-N-methyl-d-aspartate receptor encephalitis in adult patients requiring intensive care. Am J Respir Crit Care Med 195:491–499.  https://doi.org/10.1164/rccm.201603-0507OC CrossRefPubMedGoogle Scholar 12. Lancaster E (2016) The diagnosis and treatment of autoimmune encephalitis. J Clin Neurol 12:1–13.  https://doi.org/10.3988/jcn.2016.12.1.1 CrossRefPubMedGoogle Scholar 13. Scheibe F, Prüss H, Mengel AM et al (2017) Bortezomib for treatment of therapy-refractory anti-NMDA receptor encephalitis. Neurology 88:366–370.  https://doi.org/10.1212/WNL.0000000000003536 CrossRefPubMedGoogle Scholar 14. Cohen J, Sotoca J, Gandhi S et al (2019) Autoimmune encephalitis: a costly condition. Neurology.  https://doi.org/10.1212/WNL.0000000000006990.10.1212/WNL.0000000000006990 CrossRefPubMedGoogle Scholar 15. Sonneville R, Mariotte E, Neuville M et al (2016) Early-onset status epilepticus in patients with acute encephalitis. Medicine 95:e4092.  https://doi.org/10.1097/MD.0000000000004092 CrossRefPubMedPubMedCentralGoogle Scholar 16. Geis C, Planagumà J, Carreño M et al (2019) Autoimmune seizures and epilepsy. J Clin Investig 129:926–940.  https://doi.org/10.1172/JCI125178 CrossRefPubMedGoogle Scholar 17. de Bruijn MAAM, van Sonderen A, van Coevorden-Hameete MH et al (2019) Evaluation of seizure treatment in anti-LGI1, anti-NMDAR, and anti-GABABR encephalitis. Neurology 92:e2185–e2196.  https://doi.org/10.1212/WNL.0000000000007475 CrossRefPubMedPubMedCentralGoogle Scholar 18. Lejuste F, Thomas L, Picard G et al (2016) Neuroleptic intolerance in patients with anti-NMDAR encephalitis. Neurol Neuroimmunol Neuroinflamm 3:e280.  https://doi.org/10.1212/NXI.0000000000000280 CrossRefPubMedPubMedCentralGoogle Scholar 19. Schubert J, Brämer D, Huttner HB et al (2019) Management and prognostic markers in patients with autoimmune encephalitis requiring ICU treatment. Neurol Neuroimmunol Neuroinflamm 6:e514.  https://doi.org/10.1212/NXI.0000000000000514 CrossRefPubMedGoogle Scholar 20. Balu R, McCracken L, Lancaster E et al (2019) A score that predicts 1 year functional status in patients with anti-NMDA receptor encephalitis. Neurology 92:e244–e252.  https://doi.org/10.1212/WNL.0000000000006783 CrossRefPubMedPubMedCentralGoogle Scholar 21. Mittal MK, Rabinstein AA, Hocker SE et al (2016) Autoimmune encephalitis in the ICU: analysis of phenotypes, serologic findings, and outcomes. Neurocrit Care 24:240–250.  https://doi.org/10.1007/s12028-015-0196-8 CrossRefPubMedGoogle Scholar 22. Wells E, Hacohen Y, Waldman A et al (2018) Neuroimmune disorders of the central nervous system in children in the molecular era. Nat Rev Neurol 14:433–445.  https://doi.org/10.1038/s41582-018-0024-9 CrossRefPubMedGoogle Scholar
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Winning Entry for The Anti-NMDA Receptor Encephalitis Foundation’s Prize at the 54th Congress of the Canadian Neurological Sciences Federation (CNSF)

Winning Entry for The Anti-NMDA Receptor Encephalitis Foundation’s Prize at the 54th Congress of the Canadian Neurological Sciences Federation (CNSF) | AntiNMDA | Scoop.it
The Foundation was pleased to sponsor two prizes for the best abstracts in Autoimmune Encephalitis at the recent Conference of the CNSF in Montreal, June ...Read More...
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Catatonia: Practice Essentials, Background, Pathophysiology and Etiology

Catatonia is a state of apparent unresponsiveness to external stimuli in a person who is apparently awake. It occurs in children, adolescents, and adults; is associated with a heterogeneous group of comorbid conditions; and is characterized by a variety of symptoms and signs of impairment of the...
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Clinical approach to the diagnosis and successful management of anti-NMDA receptor encephalitis when antibody testing is not possible. - PubMed - NCBI

Clinical approach to the diagnosis and successful management of anti-NMDA receptor encephalitis when antibody testing is not possible. - PubMed - NCBI | AntiNMDA | Scoop.it
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Human gestational N‐methyl‐d‐aspartate receptor autoantibodies impair neonatal murine brain function - Jurek - - Annals of Neurology

Human gestational N‐methyl‐d‐aspartate receptor autoantibodies impair neonatal murine brain function - Jurek - - Annals of Neurology | AntiNMDA | Scoop.it

Objective
Maternal autoantibodies are a risk factor for impaired brain development in offspring. Antibodies (ABs) against the NR1 (GluN1) subunit of the N‐methyl‐d‐aspartate receptor (NMDAR) ar
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Multiparametric serological testing in autoimmune encephalitis

Multiparametric serological testing in autoimmune encephalitis | AntiNMDA | Scoop.it
Autoimmune encephalitis typically manifests with seizures and neuropsychiatric symptoms and may occur with or without cancer. The most frequent and best characterised type is anti-N-methyl-D-aspartate (NMDA) receptor encephalitis. The target antigen of the autoantibodies is the membrane-spanning channel subunit NR1 of the NMDA receptor. Symptoms of anti-NMDA receptor encephalitis encompass psychosis, catatonia, seizures, dyskinesia, autonomic dysfunction and decreased consciousness. It is most common in young adults, and approximately 40-50 per cent of patients present with a neoplasm, predominantly ovarian teratoma. Other forms of autoimmune encephalitis are linked to autoantibodies against a multitude of further antigens. LGI1 and CASPR2 are specific target antigens of autoantibodies formerly thought to be directed against voltage-gated potassium channels. Anti-LGI1 reactivity is tightly associated with limbic encephalitis, with tumours occurring in 5-10 per cent of cases. Anti-CASPR2 autoantibodies have been described in patients with mostly encephalitis and/or peripheral nerve dysfunction (Morvan’s syndrome). 20-50 per cent of cases are linked to thymoma. Anti-DPPX encephalitis is a multifocal neurological disorder with prominent hyperexcitability of the central nervous system and rare (<10 per cent) association with lymphoma. Autoimmune encephalitis with reactivity against GABAB receptors is characterised by very prominent seizures, memory loss and confusion. Neoplasms, especially small-cell lung carcinoma, occur in about half of patients. Patients with anti-AMPA receptor encephalitis commonly exhibit subacute confusion, memory deficits, seizures and sometimes dementia. 70 per cent of cases are paraneoplastic, affecting the lungs, thymus and breast. There is evidence that autoantibodies in autoimmune encephalitis play a direct pathogenic role through antibody-driven inflammation and/or functional manipulation of the target antigen, which results in impairment of synaptic signal transduction. This is supported by the fact that these disorders can be effectively treated by immunotherapy.
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Development of the Clinical Assessment Scale in Autoimmune Encephalitis (CASE) | MyNeuroNews

Abstract

Objective
There is no scale for rating the severity of autoimmune encephalitis (AE). In this study, we aimed to develop a novel scale for rating severity in patients with diverse AE syndrome
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Japanese encephalitis-induced anti-N-methyl-d-aspartate receptor encephalitis: A hospital-based prospective study. - PubMed - NCBI

Japanese encephalitis-induced anti-N-methyl-d-aspartate receptor encephalitis: A hospital-based prospective study. - PubMed - NCBI | AntiNMDA | Scoop.it
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Do maternal anti–N‐methyl‐D‐aspartate receptor antibodies promote development of neuropsychiatric disease in children? - Pröbstel - - Annals of Neurology

Do maternal anti–N‐methyl‐D‐aspartate receptor antibodies promote development of neuropsychiatric disease in children? - Pröbstel - - Annals of Neurology | AntiNMDA | Scoop.it
Click on the article title to read more.
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Anti-NMDA receptor encephalitis: a case study and illness overview. - PubMed - NCBI

Anti-NMDA receptor encephalitis: a case study and illness overview. - PubMed - NCBI | AntiNMDA | Scoop.it
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Brain astrocytoma misdiagnosed as anti-NMDAR encephalitis: a case report | BMC Neurology | Full Text

Brain astrocytoma misdiagnosed as anti-NMDAR encephalitis: a case report | BMC Neurology | Full Text | AntiNMDA | Scoop.it
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, which is the most common type of autoimmune encephalitis, is caused by the production of autoantibodies against NMDA receptor. Anti-NMDAR encephalitis patients present with various non-specific symptoms, such as abnormal psychiatric or...
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My Brain is on Fire – Six-Episode Podcast produced by Laura Vander Steen of i lobe you

My Brain is on Fire – Six-Episode Podcast produced by Laura Vander Steen of i lobe you | AntiNMDA | Scoop.it
What happens when you have a creative social worker, with an interest in the altered brain, working out of a large city hospital and who is also a producer of podcasts?  Our brains become lit with excitement, as today she has published her podcast, titled My Brain is on Fire. The Anti-NMDA Receptor Encephalitis Foundation in collaboration with Laura Vander Steen the producer of the i lobe you podcast is excited to present the six-episode podcaston the “mother of all maladies”, anti-NMDA receptor encephalitis. The podcast combines interviews with survivors, caregivers and features neurologist and Partner Physician, Dr. C. Uy, with storytelling, sound effects and music, to present anti-NMDA receptor encephalitis, in all its facets, from its presumed past of demonic possession to its discovery in the present. You can either binge listen to all the episodes or space them out. For those that you are currently going through this illness or are in early recovery, we recommend listening in reverse order, as the first 3 episodes have sound effects and content that may be triggering. Listen here, now: https://www.ilobeyou.ca/ and don’t forget to rate, review and share widely, to help raise awareness but to also be eligible for a gift draw from i lobeyou. Meet the lovely host with the silky, smooth voice, Laura Vander Steen, here: https://www.ilobeyou.ca/about
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Acute encephalitis in immunocompetent adults

Acute encephalitis in immunocompetent adults | AntiNMDA | Scoop.it
Encephalitis is a condition of inflammation of the brain parenchyma, occurs as a result
of infectious or autoimmune causes, and can lead to encephalopathy, seizures, focal
neurological deficits, neurological disability, and death.
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Evaluation of seizure treatment in anti-LGI1, anti-NMDAR, and anti-GABABR encephalitis

Evaluation of seizure treatment in anti-LGI1, anti-NMDAR, and anti-GABABR encephalitis | AntiNMDA | Scoop.it
This nationwide cohort study evaluates seizure responses to immunotherapy and antiepileptic drugs (AEDs) in patients with anti-leucine-rich glioma-inactivated 1 (LGI1), anti-NMDA receptor (NMDAR), and anti-gamma-aminobutyric-acid B receptor (GABA[B] R) ...
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