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Collaboration Paves the Way for Rapid Discovery in Autoimmune Neurology

Collaboration Paves the Way for Rapid Discovery in Autoimmune Neurology | AntiNMDA | Scoop.it
Using advanced technology, scientists at Chan Zuckerberg (CZ) Biohub, Mayo Clinic and University of California, San Francisco (UCSF), have discovered an autoimmune disease that appears to affect men with testicular cancer.
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Dr. Josep Dalmau speaker at "Autoimmune Encephalitis: The Bridge Between Neurology and Psychiatry"

Dr. Josep Dalmau is currently a professor at the Catalan Institution for Research and Advanced Studies (ICREA) Institut d'Investigacions Biomediques August P...
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Winning Entry for The Anti-NMDA Receptor Encephalitis Foundation’s Prize at the 54th Congress of the Canadian Neurological Sciences Federation (CNSF)

Winning Entry for The Anti-NMDA Receptor Encephalitis Foundation’s Prize at the 54th Congress of the Canadian Neurological Sciences Federation (CNSF) | AntiNMDA | Scoop.it
The Foundation was pleased to sponsor two prizes for the best abstracts in Autoimmune Encephalitis at the recent Conference of the CNSF in Montreal, June 16-19. We are equally pleased to highlight the recently published work of one of the winning entries by lead-author, Dr. Ganesh. https://cp.neurology.org/content/early/2019/08/13/CPJ.0000000000000701 Aravind Ganesh is a neurology resident at the University of Calgary’s Department of Clinical Neurosciences, having graduated from the MD program in 2012. We wish Dr. Ganesh continued success in his research and clinical work. The Foundation looks forward to offering this prize again at the next Congress to be held June 7-10, 2020 in Banff, Alberta.
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PDE10A antibodies in autoimmune encephalitis | Neurology

PDE10A antibodies in autoimmune encephalitis | Neurology | AntiNMDA | Scoop.it
SHARE August 20, 2019; 93 (8) EDITORIAL PDE10A antibodies in autoimmune encephalitis A possible marker of cancer immunotherapy? M.J. Titulaer, View ORCID ProfileS.R. Irani, H. Lassmann First published July 17, 2019, DOI: https://doi.org/10.1212/WNL.0000000000007965 FULL PDF CITATION PERMISSIONS MAKE COMMENT SEE COMMENTS Downloads0 This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased. Although paraneoplastic neurologic syndromes have been known for over half a century, developments during the last decade have reshaped the field of autoimmune neurology. The discovery of over 15 new antibodies has expanded the clinical phenotypes associated with neurologic paraneoplastic diseases, increased therapeutic opportunities, and improved outcomes.1 Initially, paraneoplastic neurologic syndromes were mainly categorized as limbic encephalitis and cerebellar degeneration, without more varied or nuanced phenotypes. More recently, hyperkinetic movement disorders have been linked to some of the newly discovered antibodies, typically as part of an autoimmune encephalitis.2 Most frequently, chorea is reported in patients with LGI1 or CV2 antibodies, and a mixture of movement disorder phenotypes occur in patients with anti-NMDAR and anti-IgLON5 encephalitis (table).3,4 Footnotes Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the editorial. See page 336 © 2019 American Academy of Neurology View Full Text AAN Members: Sign in with your AAN member credentials (e-mail or 6-digit Member ID number) Non-AAN Member subscribers: Sign in with subscriber credentials Log in using your username and password Username * Password * Purchase access AAN members must change their passwords on the AAN site For assistance, please contact: AAN Members (800) 879-1960 or (612) 928-6000 (International) Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international) Sign Up Information on how to subscribe to Neurology and Neurology: Clinical Practice can be found here  Purchase Individual access to articles is available through the Add to Cart option on the article page.  Access for 1 day (from the computer you are currently using) is US$ 39.00.  Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means.  The payee may view, download, and/or print the article for his/her personal, scholarly, research, and educational use.  Distributing copies (electronic or otherwise) of the article is not allowed. YOU MAY ALSO BE INTERESTED IN RELATED ARTICLES TOPICS DISCUSSED All Movement Disorders ALERT ME
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AE Day of Strength, 27 July 2019 – AE Leadership and Engagement at Texas Children’s Hospital

AE Day of Strength, 27 July 2019 – AE Leadership and Engagement at Texas Children’s Hospital | AntiNMDA | Scoop.it
For the second year in a row, Texas Children’s Hospital and its Autoimmune Encephalitis Clinic, under the direction of pediatric rheumatologist, Dr. Eyal Muscal, have ...Read More...
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The Anti-NMDA Receptor Encephalitis Foundation Newsletter

The Anti-NMDA Receptor Encephalitis Foundation Newsletter | AntiNMDA | Scoop.it
 













Dr.Josep Dalmau speaker at “Autoimmune Encephalitis: The Bridge Between Neurology and Psychiatry” From...
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The psychopathology of NMDAR-antibody encephalitis in adults: a systematic review and phenotypic analysis of individual patient data. - PubMed - NCBI

The psychopathology of NMDAR-antibody encephalitis in adults: a systematic review and phenotypic analysis of individual patient data. - PubMed - NCBI | AntiNMDA | Scoop.it
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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The evolution of movement disorders in NMDAR encephalitis – a video log - Morano - - Movement Disorders Clinical Practice - Wiley Online Library

The evolution of movement disorders in NMDAR encephalitis – a video log - Morano - - Movement Disorders Clinical Practice - Wiley Online Library | AntiNMDA | Scoop.it
CASE REPORT The evolution of movement disorders in NMDAR encephalitis – a video log Alessandra Morano MD Luca Manfredi Basili MD Martina Fanella MD First published: 02 August 2019 This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/mdc3.12820. Accepted Articles Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in the future.
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Acute psychosis due to non-paraneoplastic anti-NMDA-receptor encephalitis in a teenage girl: Case report. - PubMed - NCBI

Acute psychosis due to non-paraneoplastic anti-NMDA-receptor encephalitis in a teenage girl: Case report. - PubMed - NCBI | AntiNMDA | Scoop.it
PubMed comprises more than 29 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Dr. Maarten Titulaer speaker "Autoimmune Encephalitis: The Bridge Between Neurology and Psychiatry"

Dr. Maarten Tituler is Assistant Professor of Neurology at Erasmus Research Center, Rotterdam, Netherlands. He combines clinical work with translational rese...
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Dr. Robert Weir speaker at "Autoimmune Encephalitis: The Bridge Between Neurology and Psychiatry"

Dr. Robert Weir is a Post doctorate fellow at UT Southwestern dually trained in both Neurology and Psychiatry. Dr. Weir proposed their de novo curriculum whi...
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Treatment strategies for autoimmune encephalitis - Yong-Won Shin, Soon-Tae Lee, Kyung-Il Park, Keun-Hwa Jung, Ki-Young Jung, Sang Kun Lee, Kon Chu, 2018

Treatment strategies for autoimmune encephalitis - Yong-Won Shin, Soon-Tae Lee, Kyung-Il Park, Keun-Hwa Jung, Ki-Young Jung, Sang Kun Lee, Kon Chu, 2018 | AntiNMDA | Scoop.it
Autoimmune encephalitis is one of the most rapidly growing research topics in neurology. Along with discoveries of novel antibodies associated with the disease, clinical experience and outcomes wit...
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Clinical features and long-term outcomes of seizures associated with autoimmune encephalitis: A follow-up study in East China - ScienceDirect

Clinical features and long-term outcomes of seizures associated with autoimmune encephalitis: A follow-up study in East China - ScienceDirect | AntiNMDA | Scoop.it
To evaluate the clinical characteristics, treatment outcomes, prognosis and potential risk factors of patients in East China with seizure secondary to…...
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NMDA Recepter Encephalitis found in U.S War Veterans

Stacey Clardy, MD from the University of Utah Healthcare discusses a recent study that looks at NMDA recepter encephalitis in war veterans. Reference Singh G...
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Clinical Cases & Reports ǀ Peer Reviewed ǀ High Impact Journal List

Clinical Cases & Reports ǀ Peer Reviewed ǀ High Impact Journal List | AntiNMDA | Scoop.it
Journal of Clinical Cases & Reports discusses the latest research innovations and important developments in clinical and medical field.
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Texas Children’s hosts autoimmune encephalitis Day of Strength – Texas Children's News

Texas Children’s hosts autoimmune encephalitis Day of Strength – Texas Children's News | AntiNMDA | Scoop.it
For the second consecutive year, Texas Children’s Hospital hosted a day of recognition for the families and survivors of Autoimmune Encephalitis (AE). Last year, the event was called a Day of Hope. This year it was called Day of Strength. Organized by Pediatric Rheumatologist Dr. Eyal Muscal and held on July 27 at the United Way-Greater Houston, the purpose of the event was to provide a space for patients to receive updates about their disease, attend sessions about coping strategies, and take advantage of opportunities to connect with other AE patients and families. This year’s program focused on coping and resiliency and also included special activities to honor siblings of AE patients and, for the first time, breakout sessions for adult AE patients and families. Various organizations participated in the event, including the Anti-NMDA Receptor Encephalitis Foundation, Inc. Foundation President Nesrin Shaheen was a guest speaker at the event and addressed the importance and the huge strides that have been made by the AE Community of Caregivers and Survivors over the past 10 years in raising the profile of AE and particularly, anti-NMDA receptor encephalitis which still leads the pack in prevalence. “We salute, Dr. Muscal for his enlightened leadership in recognizing the families affected by this important disease,” Shaheen said. Muscal applauded everyone who participated in the event and to those who helped organize it, including Sarah Brock, Christina Cowperthwait, Monica Guevara and Chivon McMullen-Jackson. Print PDF
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Presentation videos of the Symposium titled Autoimmune Encephalitis: The Bridge between Neurology and Psychiatryat Weill Cornell Medical College, 6 April 2019

Presentation videos of the Symposium titled Autoimmune Encephalitis: The Bridge between Neurology and Psychiatryat Weill Cornell Medical College, 6 April 2019 | AntiNMDA | Scoop.it
We are pleased to share with you all the videos of the presentations made at the Symposium, entitled Autoimmune Encephalitis: The Bridge between Neurology and ...Read More...
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Worldwide survey of neurologists on approach to autoimmune encephalitis | Neurology Clinical Practice

Worldwide survey of neurologists on approach to autoimmune encephalitis | Neurology Clinical Practice | AntiNMDA | Scoop.it
Abstract Objective To explore practice differences in the diagnosis and management of autoimmune encephalitis (AE), which is complicated by issues with sensitivity/specificity of antibody testing, nonspecific MRI/EEG/CSF findings, and competing differential diagnoses. Methods We used a worldwide electronic survey with practice-related demographic questions and clinical questions about 2 cases: (1) a 20-year-old woman with a neuropsychiatric presentation strongly suspicious of AE and (2) a 40-year-old man with new temporal lobe seizures and cognitive impairment. Responses among different groups were compared using multivariable logistic regression. Results We received 1,333 responses from 94 countries; 12.0% identified as neuroimmunologists. Case 1: those treating >5 AE cases per year were more likely to send antibodies in both serum and CSF (adjusted odds ratio [aOR] vs 0 per year: 3.29, 95% CI 1.31–8.28, p = 0.011), pursue empiric immunotherapy (aOR: 2.42, 95% CI 1.33–4.40, p = 0.004), and continue immunotherapy despite no response and negative antibodies at 2 weeks (aOR: 1.65, 95% CI 1.02–2.69, p = 0.043). Case 2: neuroimmunologists were more likely to send antibodies in both serum and CSF (aOR: 1.80, 95% CI 1.12–2.90, p = 0.015). Those seeing >5 AE cases per year (aOR: 1.86, 95% CI 1.22–2.86, p = 0.004) were more likely to start immunotherapy without waiting for antibody results. Conclusions Our results highlight the heterogeneous management of AE. Neuroimmunologists and those treating more AE cases generally take a more proactive approach to testing and immunotherapy than peers. Results highlight the need for higher-quality cohorts and trials to guide empiric immunotherapy, and evidence-based guidelines aimed at both experts and nonexperts. Because the average AE patient is unlikely to be first seen by a neuroimmunologist, ensuring greater uniformity in our approach to suspected cases is essential to ensure that patients are appropriately managed. Received March 7, 2019. Accepted May 16, 2019. © 2019 American Academy of Neurology
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Ictal piloerection is associated with high-grade glioma and autoimmune encephalitis—Results from a systematic review

Autonomic changes during epileptic seizures are well-established phenomena. Cardiorespiratory symptoms are the most prominent: tachycardia, facial flushing, hyperventilation and apnoe usually accompany complex partial and generalized tonic-clonic seizures, especially those of temporal lobe origin...
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AQP4-IgG-seropositive neuromyelitis optica spectrum disorder (NMOSD) coexisting with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis: A cas... - PubMed - NCBI

AQP4-IgG-seropositive neuromyelitis optica spectrum disorder (NMOSD) coexisting with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis: A cas... - PubMed - NCBI | AntiNMDA | Scoop.it
PubMed comprises more than 29 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Encephalitis lethargica: a dying fall (un-refereed manuscript) –

Encephalitis lethargica: a dying fall (un-refereed manuscript) – | AntiNMDA | Scoop.it
This is the author’s original un-refereed manuscript as submitted for review 20th May 2019. The revised manuscript was published in Brain 29 July 2019 as the original place of publication: Encephalitis lethargica: a dying fall.
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Dr. Matthew Fink speaker at "Autoimmune Encephalitis: The Bridge Between Neurology and Psychiatry"

Dr. Matthew Fink is the Professor and Chairman of the Department of Neurology at the Weill Cornell Medical College of Cornell University, a critical care neu...
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Dr. Sander Markx speaker at "Autoimmune Encephalitis: The Bridge Between Neurology and Psychiatry"

Dr. Sander Markx is a psychiatrist at Columbia University/Precision Psychiatry which researches more modern treatments of psychiatry. He studies the genetics...
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Collaboration Paves the Way for Rapid Discovery in Autoimmune Neurology

Collaboration Paves the Way for Rapid Discovery in Autoimmune Neurology | AntiNMDA | Scoop.it
Using advanced technology, scientists at Chan Zuckerberg (CZ) Biohub, Mayo Clinic and University of California, San Francisco (UCSF), have discovered an autoimmune disease that appears to affect men with testicular cancer.
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The Anti-NMDA Receptor Encephalitis Foundation Newsletter

The Anti-NMDA Receptor Encephalitis Foundation Newsletter | AntiNMDA | Scoop.it
An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models From...
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Viral triggers of autoimmune encephalitis | Neurology

Viral triggers of autoimmune encephalitis | Neurology | AntiNMDA | Scoop.it
McCray et al. described a patient with an influenza-associated encephalitis (IAE). [1] As they stated, IAE is believed to be caused by an immune-mediated mechanism rather than direct viral toxicity. Accordingly, the patient did not respond to antiviral therapy but improved after immune-modulatory treatment with steroids and immunoglobulins. The recent discovery of antibodies to neuronal surface proteins has revolutionized clinical neurology and has led to the identification of several new autoimmune encephalitides. Importantly, a viral trigger is discussed in many of these conditions and has been demonstrated for herpes simplex virus type I and varizella zoster virus that both can trigger anti-NMDAR encephalitis. [2,3] Moreover, a past influenza A infection can predispose for the development of serum NMDAR antibodies [4], and positive influenza serology is common in acute NMDAR encephalitis. [5] In contrast to the author's notion, autoimmune encephalitides can occur with rapid onset and acute deterioration as well as with normal CSF leucocyte count. Perhaps patients with suspected IAE should be tested for neuronal antibodies using cell-based and CNS tissue assays to rule out antibody-mediated autoimmune encephalitis. In addition, this testing would further our understanding of parainfectious autoimmune encephalitides. 1. Mccray BA, Forst D, Jindal J, Henderson G V. Clinical Reasoning: A 57-year-old woman who developed acute amnesia following fever and upper respiratory symptoms. Neurology. 2015;102-106. 2. Pruss H, Finke C, Holtje M, et al. N-methyl-D-aspartate receptor antibodies in herpes simplex encephalitis. Ann Neurol 2012;72:902-911. 3. Schabitz W, Rogalewski A, Hagemeister C, Bien CG. VZV brainstem encephalitis triggers NMDA receptor immunoreaction. Neurology 2014; 83:2309-2311. 4. Hammer C, Stepniak B, Schneider A, et al. Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity. Mol Psychiatry 2014;19: 1143-1149. 5. Pruss H, Dalmau J, Harms L, et al. Retrospective analysis of NMDA receptor antibodies in encephalitis of unknown origin. Neurology 2010;75:1735-1739. For disclosures, please contact the editorial office at journal@neurology.org
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