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Nishard Abdeen MD1, Katya Rozovsky MD2, Nagwa Wilson MD3 - ppt download

Nishard Abdeen MD1, Katya Rozovsky MD2, Nagwa Wilson MD3 - ppt download | AntiNMDA | Scoop.it
Disclosures We have no disclosures with respect to this presentation PUV
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The mystery of the inflamed brain - All In The Mind - ABC Radio National (Australian Broadcasting Corporation)

The mystery of the inflamed brain - All In The Mind - ABC Radio National (Australian Broadcasting Corporation) | AntiNMDA | Scoop.it
The Netflix drama ‘Brain on Fire is the story of a young woman in the U.S. who suddenly develops severe psychiatric symptoms. Some clever detective work reveals that she has a rare and mysterious condition causing brain inflammation.
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A transdiagnostic pattern of psychiatric symptoms in autoimmune encephalitis

A transdiagnostic pattern of psychiatric symptoms in autoimmune encephalitis | AntiNMDA | Scoop.it
(The Lancet Psychiatry) – N-methyl-D-aspartate receptor (NMDAR)-antibody encephalitis is a neuropsychiatric disorder1, 2 that is caused by antibodies against the NR1 subunit of the NMDA receptor. Many patients with NMDAR-antibody encephalitis are...
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My brothers Hospital diagnosis of Autoimmune encephalitis

This is what we have been going through since the last time we made a video My brother Alex had a seizure on December 5 2018 and then on December 17 2018 and...
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Paraneoplastic Teratoma-associated Anti-N-Methyl-D-Aspartate Receptor Encephalitis: The First Published Report from Saudi Arabia. - PubMed - NCBI

Cureus. 2018 Oct 31;10(10):e3527. doi: 10.7759/cureus.3527.
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AE Insight with Dr. Eyal Muscal

AE Insight with Dr. Eyal Muscal | AntiNMDA | Scoop.it
For World Encephalitis Day 2019, Dr. Muscal talks about his work and research and how he sees the field of AE evolving. Dr. Eyal Muscal is a pediatric rheumatologist at Texas Children’s Hospital with a MS Degree in Clinical Research whose activities include patient care, fellowship education,...
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Ⓜ Content Spotlight: Movement disorders associated with autoimmune encephalitis

Ⓜ Content Spotlight: Movement disorders associated with autoimmune encephalitis | AntiNMDA | Scoop.it
Your first place to look. The leading information source for clinical neurology.
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Diet of butter and cream helps Que. girl's rare brain disorder | CTV News

The family of a six-year-old Laval, Que., girl says the high-fat diet they feed her loaded with mayonnaise, avocados, and cream is helping to keep her epilepsy at bay.
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Antibody-LGI 1 autoimmune encephalitis manifesting as rapidly progressive dementia and hyponatremia: a case report and literature review | BMC Neurology | Full Text

Antibody-LGI 1 autoimmune encephalitis manifesting as rapidly progressive dementia and hyponatremia: a case report and literature review | BMC Neurology | Full Text | AntiNMDA | Scoop.it
Anti leucine-rich glioma inactivated 1 (LGI1) encephalitis is a rare autoimmune encephalitis (AE), characterized by acute or subacute cognitive impairment, faciobrachial dystonic seizures, psychiatric disturbances and hyponatremia.
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A Neurology and Psychiatry Merger: Quest for the Inevitable?

A Neurology and Psychiatry Merger: Quest for the Inevitable? | AntiNMDA | Scoop.it
Perhaps it is that tension between undeniable differences and inevitable merging that has led to more recent calls for cross-disciplinary cooperation.
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Encephalitis Global Winter 2018/19

Encephalitis Global Winter 2018/19 | AntiNMDA | Scoop.it
Where the Amazing Story Began… Nesrin Shaheen, Director and Founding Member of the Anti-NMDA Receptor Encephalitis Foundation, writes: It has been nearly twelve years since the discovery of anti-NMDA receptor encephalitis and I never dreamed that I would become so fascinated with this imminently fascinating disease. Here is my latest piece, which outlines the evolution of the illness, over the past 10 years, from my perspective. My extreme gratitude goes out to Ms. Erica Snyder who has hosted me as a guest blogger on her blog, When Pigs take Flight. I look forward to the next 10 years of better, targeted treatments, the discovery of new antibodies and dare I say it, a cure. Click When Pigs Take Flight to read Nesrin Shaheen's article, "Where the Amazing Story Began." Nesrin Shaheen Director and Founding Member Anti-NMDA Receptor Encephalitis Foundation
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A mouse model of seizures in anti–N‐methyl‐d‐aspartate receptor encephalitis | MyNeuroNews

Summary

Objective
Seizures develop in 80% of patients with anti–N‐methyl‐d‐aspartate receptor (NMDAR) encephalitis, and these represent a major cause of morbidity and mortality.Anti‐NMDAR...
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A mouse model of seizures in anti–N‐methyl‐d‐aspartate receptor encephalitis - Taraschenko - - Epilepsia - Wiley Online Library

Objective Seizures develop in 80% of patients with anti–N‐methyl‐d‐aspartate receptor (NMDAR) encephalitis, and these represent a major cause of morbidity and mortality. Anti‐NMDAR antibodies have been linked to memory loss in encephalitis; however, their role in seizures has not been established. We determined whether anti‐NMDAR antibodies from autoimmune encephalitis patients are pathogenic for seizures. Methods We performed continuous intracerebroventricular infusion of cerebrospinal fluid (CSF) or purified immunoglobulin (IgG) from the CSF of patients with anti‐NMDAR encephalitis or polyclonal rabbit anti‐NMDAR IgG, in male C57BL/6 mice. Seizure status during a 2‐week treatment was assessed with video‐electroencephalography. We assessed memory, anxiety‐related behavior, and motor function at the end of treatment and assessed the extent of neuronal damage and gliosis in the CA1 region of hippocampus. We also performed whole‐cell patch recordings from the CA1 pyramidal neurons in hippocampal slices of mice with seizures. Results Prolonged exposure to rabbit anti‐NMDAR IgG, patient CSF, or human IgG purified from the CSF of patients with encephalitis induced seizures in 33 of 36 mice. The median number of seizures recorded in 2 weeks was 13, 39, and 35 per mouse in these groups, respectively. We observed only 18 brief nonconvulsive seizures in 11 of 29 control mice (median seizure count of 0) infused with vehicle (n = 4), normal CSF obtained from patients with noninflammatory central nervous system (CNS) conditions (n = 12), polyclonal rabbit IgG (n = 7), albumin (n = 3), and normal human IgG (n = 3). We did not observe memory deficits, anxiety‐related behavior, or motor impairment measured at 2 weeks in animals treated with CSF from affected patients or rabbit IgG. Furthermore, there was no evidence of hippocampal cell loss or astrocyte proliferation in the same mice. Significance Our findings indicate that autoantibodies can induce seizures in anti‐NMDAR encephalitis and offer a model for testing novel therapies for refractory autoimmune seizures.
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Development of the clinical assessment scale in autoimmune encephalitis. - PubMed - NCBI

Development of the clinical assessment scale in autoimmune encephalitis. - PubMed - NCBI | AntiNMDA | Scoop.it
Ann Neurol. 2019 Jan 24. doi: 10.1002/ana.25421. [Epub ahead of print]
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High school hockey player thriving after battling rare disease

High school hockey player thriving after battling rare disease | AntiNMDA | Scoop.it
Ann Arbor Skyline's Noah Bradburn spent three weeks in the hospital battling a rare auto-immune disease, but he's made a full recovery and is leading the team in scoring.
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New Study: Sleep Disturbances in Autoimmune Encephalitis

New Study: Sleep Disturbances in Autoimmune Encephalitis | AntiNMDA | Scoop.it
Seizures and movement disorders are very common in anti-NMDA receptor encephalitis, as well as other forms of autoimmune encephalitis (AE) and researchers have undertaken to ...Read More...
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Glutamate Receptor Antibodies in Autoimmune Central Nervous System Disease: Basic Mechanisms, Clinical Features, and Antibody Detection. - PubMed - NCBI

Glutamate Receptor Antibodies in Autoimmune Central Nervous System Disease: Basic Mechanisms, Clinical Features, and Antibody Detection. - PubMed - NCBI | AntiNMDA | Scoop.it
Methods Mol Biol. 2019;1941:225-255. doi: 10.1007/978-1-4939-9077-1_15.
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A Rasmussen encephalitis, autoimmune encephalitis, and mitochondrial disease mimicker: expanding the DNM1L-associated intractable epilepsy and ence... - PubMed - NCBI

A Rasmussen encephalitis, autoimmune encephalitis, and mitochondrial disease mimicker: expanding the DNM1L-associated intractable epilepsy and ence... - PubMed - NCBI | AntiNMDA | Scoop.it
Epileptic Disord. 2019 Feb 15. doi: 10.1684/epd.2019.1036.[Epub ahead of print]...
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Thank you and Congratulations – Travel Award Recipient

Thank you and Congratulations – Travel Award Recipient | AntiNMDA | Scoop.it
The Foundation would like to thank all those neurology and psychiatry trainees who applied for the Foundation’s Travel award to attend the Symposium titled Autoimmune ...Read More...
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GAD antibodies & HHV-6 limbic encephalitis – a case of molecular mimicry? | HHV-6 Foundation | HHV-6 Disease Information for Patients, Clinicians, and Researchers | Apply for a Grant

GAD antibodies & HHV-6 limbic encephalitis – a case of molecular mimicry? | HHV-6 Foundation | HHV-6 Disease Information for Patients, Clinicians, and Researchers | Apply for a Grant | AntiNMDA | Scoop.it
A fifth case of limbic encephalitis associated with GAD antibodies and HHV-6 infection has been reported, this time in an immunocompetent woman with chromosomally integrated HHV-6, epilepsy, and psychosis. The patient’s condition improved (with a drop in GAD antibody titers and stabilization of psychotic symptoms) in response to three weeks of antiviral therapy but relapsed when antiviral therapy was withdrawn. Previously, the same neuropathology group in Germany reported two GAD-antibody-positive limbic encephalitis patients with HHV-6 DNA detected in surgically removed hippocampal tissue (Niehusmann 2010). Another publication reported two patients who had HHV-6-associated limbic encephalitis, autoimmune thyroid disease, and elevated antibodies to GAD (Mata 2008). GAD antibodies occur in a number of neurological disorders, and when the antibodies are extremely high, they can cause Stiff Person Syndrome. High level GAD antibodies define a relevant group of patients with chronic, nonremitting, and nonparaneoplastic limbic encephalitis (Malter 2010). At low levels, these antibodies are a predictive factor for type 1 diabetes. The authors note that antibodies against NMDAR, the surface protein N-methyl-D-aspartate receptor, have been identified as a cause of encephalopathy post HSV-1 encephalitis, and speculate that HHV-6 may trigger a similar cascade. They recommend further study to determine the frequency of simultaneous active HHV-6 infection and GAD65 antibodies. Of interest, a 1998 report identified GAD65 antibody stimulation in response to the HHV-6 U2 gene, via mimicry (Bach 1998). HHV-6 reactivation has been linked to many of the conditions associated with GAD antibodies. For example, HHV-6 reactivation has been found in cases of  fulminant type 1 diabetes after drug induced hypersensitivity syndrome (DIHS). In one series, HHV-6 reactivation was linked to 11 cases of fulminant type 1 diabetes (Onuma 2012). Two other cases of drug hypersensitivity and type 1 diabetes were reported by Taiwanese investigators in association with DRESS (Chiou 2006). Immunohistochemistry of brain tissue from this case showed T-lymphocytic infiltrates, a moderate activation of microglia, and moderate reactive astrogliosis. Anti-neuronal antibodies binding to pyramidal cells of the hippocampus and cerebellar Purkinje cells within the serum and CSF were identified using an indirect immunohistochemistry approach. The study was led by neuropathologist Pitt Niehusmann, MD from University Hospital Oslo, Norway and Albert Becker, MD from the Translational Epilepsy Research Section at the University of Bonn, Germany. For more information, read the full paper (Niehusmann 2016).
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Ariana Pila's remarkable recovery from the rare disease anti-NMDA receptor encephalitis - ABC News (Australian Broadcasting Corporation)

Ariana Pila's remarkable recovery from the rare disease anti-NMDA receptor encephalitis - ABC News (Australian Broadcasting Corporation) | AntiNMDA | Scoop.it
Twelve months ago, young Perth woman Ariana Pila spent most of her days in a comatose state, unable to eat, walk or talk. Today, the 21-year-old is making plans to walk the Great Wall of China, as well as study and work, thanks to an astonishing recovery from a rare autoimmune disease. She has got rid of her wheelchair, feeding tube and tracheostomy tube. With the help of therapists and her stubbornly determined personality, she has learned to sit, stand, walk and climb the stairs to her bedroom at home — and now she wants to take up jogging. "She always says 'I can't do it', but once she makes that first step past that word 'can't' and that fear, then all confidence comes in and she just smashes it," her mother, Kirstine Bruce, said. Struck down in her teens Five years ago, a 16-year-old Ms Pila collapsed in a fast food restaurant with anti-NMDA receptor encephalitis, a disease causing brain inflammation and psychiatric symptoms. Doctors held little hope she would ever regain any of her cognitive or physical abilities. "She was in a severely vegetative state," Ms Bruce said. "Thrashing. Her body was thrashing about the bed for the majority of the time. "High temps, high blood pressure, just absolutely everything." After being discharged from hospital, Ms Pila was forced to live in an aged care facility where she had little physiotherapy and spent her days watching television. Her mother saw occasional signs of a spark in her daughter and agitated for a different course of treatment for her, but it was a struggle. "We couldn't get any help for her," she said. "Because she was so severely vegetative, everyone was fobbing her off, saying, 'No, there's nothing we can do, she's got to fit a certain criteria'. "Everyone wrote her off." Now, after five months of intensive therapy at Perth disability services organisation Rocky Bay, as well as Fiona Stanley Hospital, Ms Pila has broken down physical barrier after physical barrier. "They doubted me that I was going to walk," she said. "They even thought that I wasn't ever going to wake up." Rare disease began with headaches Anti-NMDA receptor encephalitis was only identified as a condition in 2007, and it is understood only a few thousand people have been diagnosed with it worldwide. It affects the receptors in the brain which control, among other things, memory function. In Ms Pila's case, the disease has been linked to a benign teratoma tumour on her left ovary. Ms Bruce said her daughter was lucky to be diagnosed by her neurologist because many in her situation were incorrectly treated for mental health disorders like schizophrenia. Some neurologists believed many more people could have the disease but had been misdiagnosed. For Ms Pila, the onset of her disease began with headaches at age 13. She began to act strangely — "like bipolar, schizophrenic behaviours," Ms Bruce said — and then suffered memory loss. In April 2013, she deteriorated rapidly. After collapsing in the fast-food restaurant, she was taken to hospital and lost her ability to talk three days later. Five lost years Five years to the day later, Ms Pila began to speak again. Her first words were, "Hey Mama". But there were reminders of Ms Pila's lost teenage years, like the hole in her throat where her tracheostomy tube was inserted and the big chunks of her life missing from her memory. When she first began to wake from her comatose state about a year ago, she thought it was still 2012 and was shocked that her siblings looked so different. "She remembers everything from birth to 15 and then nothing from 16 to 21," Ms Bruce said. "She missed her formative years." But Ms Pila has big plans to fill in the gaps, starting with her first music concert next month. "She wants to work, she wants to study, she wants to go back home to New Zealand and we're going to do the Great Wall of China in 2020, that's what we're working towards," Ms Bruce said Ms Pila said she was proud of what she had achieved with the support of her family and therapy team. Her physiotherapist Jocelyn MacRae said the biggest factors behind Ms Pila's recovery were her family support and sheer determination. "As much as she says 'I can't' sometimes, she just breaks that barrier down and still gives it a go," she said. "There's never been a gym session where she hasn't given it a go or worked hard at it."
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A mouse model of seizures in anti–N‐methyl‐d‐aspartate receptor encephalitis - Taraschenko - - Epilepsia - Wiley Online Library

Objective Seizures develop in 80% of patients with anti–N‐methyl‐d‐aspartate receptor (NMDAR) encephalitis, and these represent a major cause of morbidity and mortality. Anti‐NMDAR antibodies have been linked to memory loss in encephalitis; however, their role in seizures has not been established. We determined whether anti‐NMDAR antibodies from autoimmune encephalitis patients are pathogenic for seizures. Methods We performed continuous intracerebroventricular infusion of cerebrospinal fluid (CSF) or purified immunoglobulin (IgG) from the CSF of patients with anti‐NMDAR encephalitis or polyclonal rabbit anti‐NMDAR IgG, in male C57BL/6 mice. Seizure status during a 2‐week treatment was assessed with video‐electroencephalography. We assessed memory, anxiety‐related behavior, and motor function at the end of treatment and assessed the extent of neuronal damage and gliosis in the CA1 region of hippocampus. We also performed whole‐cell patch recordings from the CA1 pyramidal neurons in hippocampal slices of mice with seizures. Results Prolonged exposure to rabbit anti‐NMDAR IgG, patient CSF, or human IgG purified from the CSF of patients with encephalitis induced seizures in 33 of 36 mice. The median number of seizures recorded in 2 weeks was 13, 39, and 35 per mouse in these groups, respectively. We observed only 18 brief nonconvulsive seizures in 11 of 29 control mice (median seizure count of 0) infused with vehicle (n = 4), normal CSF obtained from patients with noninflammatory central nervous system (CNS) conditions (n = 12), polyclonal rabbit IgG (n = 7), albumin (n = 3), and normal human IgG (n = 3). We did not observe memory deficits, anxiety‐related behavior, or motor impairment measured at 2 weeks in animals treated with CSF from affected patients or rabbit IgG. Furthermore, there was no evidence of hippocampal cell loss or astrocyte proliferation in the same mice. Significance Our findings indicate that autoantibodies can induce seizures in anti‐NMDAR encephalitis and offer a model for testing novel therapies for refractory autoimmune seizures.
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Autoimmune Encephalitis Secondary to Melanoma | Annals of Internal Medicine | American College of Physicians

Background: The receptor for α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) is a glutamate receptor that mediates synaptic transmission in the central nervous system. Antibodies against the AMPA receptor are found in encephalitis associated with lung, breast, and thymus tumors ( 1 ).
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Sleep disturbances are common in patients with autoimmune encephalitis. - PubMed - NCBI

Sleep disturbances are common in patients with autoimmune encephalitis. - PubMed - NCBI | AntiNMDA | Scoop.it
J Neurol. 2019 Feb 11. doi: 10.1007/s00415-019-09230-2.[Epub ahead of print]...
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The Woman Who Went Crazy: Anti-NMDA Receptor Encephalitis | Medical Documentary | Reel Truth

Kristin Gunther begins to suffer from great anxiety, confusion, and seizure-like movements. At first, doctors believe she simply has a viral form of meningit...
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