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The frequency of autoimmune encephalitis antibody biomarkers and their associations with sex and age

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Star TV writer's husband woke from a coma and called her an imposter 'not my wife' | Books | Entertainment

Star TV writer's husband woke from a coma and called her an imposter 'not my wife' | Books | Entertainment | AntiNMDA | Scoop.it
AS ONE of our most respected TV writers, Abi Morgan is no stranger to a bizarre plot twist.
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The Phenomenology of Anti-NMDA Receptor Encephalitis: A Comparison with “Primary Mental Confusion” in Late 19th Century French Psychiatry

The Phenomenology of Anti-NMDA Receptor Encephalitis: A Comparison with “Primary Mental Confusion” in Late 19th Century French Psychiatry | AntiNMDA | Scoop.it
IMR Press is a leading publisher of open access peer-reviewed biomedical and life sciences journals. We aim to facilitate the dissemination of high-quality research in the area of biomedical science. With a long tradition and wide readership, IMR Press is dedicated to making positive contributions...
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Who ACTUALLY treats autoimmune encephalitis? | Part 1: My experience with doctor shopping, a psychiatrist, and a dozen neurologists

Question: Who treats autoimmune encephalitis (AE)? The traditional answer: neurologists. The jaded answer: no one does. The real answer: a haphazard smattering of medical professionals who balance their knowledge of medical literature with sound clinical judgement and the needs of the patient.
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Latest developments & research trends in autoimmune encephalitis and autoimmune-associated epilepsy

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Seronegative autoimmune encephalitis: clinical characteristics and factors associated with outcomes

Seronegative autoimmune encephalitis: clinical characteristics and factors associated with outcomes | AntiNMDA | Scoop.it
Seronegative autoimmune encephalitis (AE) is AE without any identifiable pathogenic antibody. Although it is a major subtype of AE, many unmet clinical needs exist in terms of clinical characteristics, treatments, and prognosis.
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A clinical approach to diagnosis of autoimmune encephalitis

A clinical approach to diagnosis of autoimmune encephalitis | AntiNMDA | Scoop.it
Encephalitis is a severe inflammatory disorder of the brain with many possible causes
and a complex differential diagnosis. Advances in autoimmune encephalitis research in the past 10 years have led to the identification of new syndromes and biomarkers that have transformed the diagnostic approach...
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Imaging Aspects of the Hippocampus

Imaging Aspects of the Hippocampus | AntiNMDA | Scoop.it
The hippocampus can be affected by a wide range of diseases that may have similar clinical findings, but an imaging algorithm that organizes the diseases into nodular (space occupying) versus nonno...
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Frontiers | Acute Symptomatic Seizures and Risk of Epilepsy in Autoimmune Encephalitis: A Retrospective Cohort Study | Immunology

Frontiers | Acute Symptomatic Seizures and Risk of Epilepsy in Autoimmune Encephalitis: A Retrospective Cohort Study | Immunology | AntiNMDA | Scoop.it
PurposeTo investigate the clinical characteristics of acute symptomatic seizures and the predictors of the development of epilepsy in patients with anti-NMDAR, anti-LGI1, and anti-GABABR encephalitis.MethodsWe retrospectively screened the medical records of 86 hospitalized patients with confirmed...
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Frontiers | The Antibody Assay in Suspected Autoimmune Encephalitis From Positive Rate to Test Strategies | Immunology

Frontiers | The Antibody Assay in Suspected Autoimmune Encephalitis From Positive Rate to Test Strategies | Immunology | AntiNMDA | Scoop.it
ObjectiveThe aim of this study was to analyze the positive rate and test strategies of suspected autoimmune encephalitis (SAE) based on an antibody assay.MethodsPatients who were diagnosed with suspected autoimmune encephalitis in Guizhou Province between June 1, 2020, and June 30, 2021 and who...
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Frontiers | Novel qEEG Biomarker to Distinguish Anti-NMDAR Encephalitis From Other Types of Autoimmune Encephalitis | Immunology

Frontiers | Novel qEEG Biomarker to Distinguish Anti-NMDAR Encephalitis From Other Types of Autoimmune Encephalitis | Immunology | AntiNMDA | Scoop.it
ObjectiveTo establish the diagnostic biomarker of electroencephalogram (EEG) to distinguish between anti-N-methyl-d-aspartate receptor encephalitis (NMDARE) and other types of autoimmune encephalitis (other AEs).MethodsWe reviewed the clinical records of 90 patients with acute encephalitis who...
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Case Report: Triphasic Waves in a 9-Year-Old Girl With Anti-NMDAR Encephalitis - PMC

Case Report: Triphasic Waves in a 9-Year-Old Girl With Anti-NMDAR Encephalitis - PMC | AntiNMDA | Scoop.it
Triphasic waves (TWs) are mainly described in association with metabolic encephalopathy, especially hepatic encephalopathy. Now, as different conditions including non-metabolic and structural abnormalities have been reported to be associated with TWs, ...
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Barrow Saves Woman With Rare Neuroimmune Disorder

Barrow Saves Woman With Rare Neuroimmune Disorder | AntiNMDA | Scoop.it
Barrow Saves Woman With Rare Neuroimmune Disorder Your Impact Your Impact: Overview Patient Stories Donor Stories Impact Report Barrow Saves Woman With Rare Neuroimmune Disorder In April 2020, 27-year-old Reyna Felix was working a typical night shift at her job as a 911 fire dispatcher. But her co-workers noticed that she wasn’t acting like herself. She was also sending strange text messages to her family and friends, telling them she was depressed and unhappy with her life, work, and education. Then around midnight, she collapsed and had a seizure. Reyna doesn’t remember any of it. In fact, most of her memory from the seven months prior to the seizure, as well as the two months after it, is gone. Those closest to Reyna say she had been exhibiting mood swings and erratic behavior as early as September 2019. Her husband recalls one particular incident while they were on vacation in California and she told him she had a hallucination about driving her car off of a cliff. Between that first hallucination and the seizure, Reyna went through several periods during which her family and friends noticed a considerable difference in her personality. However, she always seemed to bounce back to her normal self, so they contributed it to stress. That wasn’t the case. On that fateful April night when Reyna had the seizure she was taken immediately to the emergency room. After multiple tests and an MRI came out inconclusive, they sent her home. The next three weeks were a series of nightmares for Reyna’s husband and family. In addition to multiple seizures, Reyna continued to have hallucinations, didn’t recognize her loved ones, and didn’t have a sense of time or place. She even repeatedly tried to escape her own home, forcing her husband to buy child-proof locks to keep her from leaving. Doctors had no idea what was causing the normally happy, outgoing woman to have these distressing episodes. In the midst of being evaluated for schizophrenia, Reyna’s doctors became concerned for her safety, so they transferred her to a psychiatric facility. That’s when things took a turn for the worse. While receiving treatment at the psychiatric facility, Reyna started having heart problems and went into cardiac arrest. After being revived, she was transported back to the hospital, where she started having significant trouble breathing. “The doctor at that hospital came up with several possibilities, including meningitis and encephalitis. Unfortunately, they didn’t have the specialists available on staff to treat me, so I was sent home,” says Reyna. The next day, she went into cardiac arrest again. Reyna was revived and transported to the hospital for the second time in a week. However, doctors were still hesitant to treat her or give her a formal diagnosis. Finally, her family asked to consult Barrow Neurological Institute. At Barrow, Ram Narayan, MD, was able to give Reyna’s family what doctors at the other seven hospitals she was admitted to couldn’t: a diagnosis. Reyna was diagnosed with Anti-NMDA Receptor Encephalitis, a rare condition that causes inflammation of the brain and is often misdiagnosed as a mental illness. Luckily, Dr. Narayan holds a certification in rare neuroimmune disorders (CRND) and is trained to treat conditions such as Anti-NMDA Receptor Encephalitis. He began an intensive treatment plan for Reyna right away. “Dr. Narayan saved my life. He’s one of the few doctors who specializes in encephalitis, so I trust him over all the other doctors we’ve interacted with,” she says. While Dr. Narayan was able to treat Reyna, the encephalitis caused significant trauma to her brain. “I had to learn how to do everything again—walk, talk, write, and even eat,” she says. Reyna stayed in the Barrow Neuro-Rehabilitation Center, where she received physical therapy, speech therapy, and occupational therapy, along with continued treatment from Dr. Narayan. She recalls one of her greatest triumphs when she improved enough to go outside. “My occupational therapist took me out for a walk and helped me along as I used my cane. I’ll never forget being outside with the sun shining on me for the first time in what felt like forever.” Still, recovery from a condition like encephalitis is unpredictable, so Reyna wasn’t sure if she would be able go back to a fast-paced, high-stress job like she had as a 911 dispatcher. “With my hard work, and with the help of Dr. Narayan, my neuro-rehabilitation doctor, the neuropsychologist, my inpatient rehab team, and my outpatient rehab team, I am now back to working as a 911 dispatcher,” says Reyna. “I am even taking college courses, which helps my brain stay sharp, and I’m back to hiking and weight lifting too.” She recently celebrated her fifth wedding anniversary with a hiking trip to Zion National Park. Because of her experience, Reyna is a passionate advocate for encephalitis awareness. She shares her story with different medical and local community groups throughout Arizona in hopes of educating more people about encephalitis and the signs and symptoms of it, so others suffering from this devastating condition can get the help they need right away. “Encephalitis does have very high death rates from not getting treated properly, so if it wasn’t for Barrow, I might not be here today,” she says. Please join us in supporting the life-saving and life-changing patient care at Barrow by making a tax-deductible donation. Donate Now
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Survey - Anti-NMDA Receptor Encephalitis Foundation Newsletter

Survey - Anti-NMDA Receptor Encephalitis Foundation Newsletter | AntiNMDA | Scoop.it
Dear Subscriber, We would greatly appreciate your views and/or comments regarding our newsletter. We would be grateful if you could respond to our very brief survey. ...Read More...
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Construction of an Assisted Model Based on Natural Language Processing for Automatic Early Diagnosis of Autoimmune Encephalitis

Construction of an Assisted Model Based on Natural Language Processing for Automatic Early Diagnosis of Autoimmune Encephalitis | AntiNMDA | Scoop.it
Introduction Early diagnosis and etiological treatment can effectively improve the prognosis of patients with autoimmune encephalitis (AE). However, anti-neuronal antibody tests which provide the definitive diagnosis require time and are not always abnormal.
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A systematic review and quantitative synthesis of the long-term psychiatric sequelae of pediatric autoimmune encephalitis

A systematic review and quantitative synthesis of the long-term psychiatric sequelae of pediatric autoimmune encephalitis | AntiNMDA | Scoop.it
Chronic psychiatric and behavioral problems remain present in one-third of children months to years after onset of AE.Larger scaled prospective observational studies with a consistent standardized battery of testing are needed to examine impact of specific clinical features and immunotherapies on...
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Neuropsychiatric phenotypes of anti-NMDAR encephalitis: a prospective study | Psychological Medicine

Neuropsychiatric phenotypes of anti-NMDAR encephalitis: a prospective study | Psychological Medicine | AntiNMDA | Scoop.it
Neuropsychiatric phenotypes of anti-NMDAR encephalitis: a prospective study...
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Amanda's Story: My NMDAR/MOG Journey

Amanda's Story: My NMDAR/MOG Journey | AntiNMDA | Scoop.it
Back in 2016, while training for a 100km walk, running my own Property Management business and doing temp work, I stressed my self out to the max.Working somewhere different each day meant continuously learning, I was training every weekend, trying to fundraise, and I started to go next level; making...
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Autoimmune Encephalitis and Related Disorders of the Nervous System - Autoimmune Encephalitis and Related Disorders of the Nervous System

Autoimmune Encephalitis and Related Disorders of the Nervous System - Autoimmune Encephalitis and Related Disorders of the Nervous System | AntiNMDA | Scoop.it
Autoimmune Encephalitis and Related Disorders of the Nervous System - February 2022...
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Rapidly progressive dementias — aetiologies, diagnosis and management | Nature Reviews Neurology

Rapidly progressive dementias — aetiologies, diagnosis and management | Nature Reviews Neurology | AntiNMDA | Scoop.it
The term ‘rapidly progressive dementia’ (RPD) describes a cognitive disorder with fast progression, leading to dementia within a relatively short time. This Review discusses the wide range of RPD aetiologies, as well as the diagnostic approach and treatment options.
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7 potentially curable neurological disorders –

7 potentially curable neurological disorders – | AntiNMDA | Scoop.it
Neurologists are often at the receiving end of the jokes of other medical specialists. They facetiously remark that neurologists know a lot, but do very little to cure their patients. Admittedly we do our fair share of dispensing weak platitudes, and we do break bad news with embarrassing...
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U of U Health researchers lead a $22-million nationwide clinical trial for rare brain disorder

U of U Health researchers lead a $22-million nationwide clinical trial for rare brain disorder | AntiNMDA | Scoop.it
University of Utah Health researchers are leading a five-year, $22-million nationwide clinical trial for NMDA receptor encephalitis––a type of autoimmune encephalitis that prompts the immune system to mistakenly attack the brain, causing confusion, memory loss, seizures, and symptoms similar to...
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Recognizing New-Onset Sleep Disorders in Autoimmune Encephalitis Often Prompt Earlier Diagnosis

Recognizing New-Onset Sleep Disorders in Autoimmune Encephalitis Often Prompt Earlier Diagnosis | AntiNMDA | Scoop.it
Sleep/wake disorders are common in patients with autoimmune encephalitis, sometimes the most prominent or sole initial symptom, then delaying diagnosis.Sleep/wake disorders in autoimmune encephalitis vary and include severe sleeplessness, hypersomnia, central and/or obstructive sleep apnea, rapid...
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Frontiers | Serum-Derived Exosomal miR-140-5p as a Promising Biomarker for Differential Diagnosis of Anti-NMDAR Encephalitis With Viral Encephalitis | Immunology

Frontiers | Serum-Derived Exosomal miR-140-5p as a Promising Biomarker for Differential Diagnosis of Anti-NMDAR Encephalitis With Viral Encephalitis | Immunology | AntiNMDA | Scoop.it
BackgroundAnti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is the most common type of autoimmune encephalitis. Early recognition and treatment, especially distinguishing from viral encephalitis (VE) in the early stages, are crucial for the outcomes of patients with anti-NMDAR...
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Autoimmune Encephalitis With Multiple Auto-Antibodies With Concomitant Human Herpesvirus-7 and Ovarian Teratoma: A Case Report

Autoimmune Encephalitis With Multiple Auto-Antibodies With Concomitant Human Herpesvirus-7 and Ovarian Teratoma: A Case Report | AntiNMDA | Scoop.it
Infectious etiologies and tumors are common triggers of autoimmune encephalitis. We herein reported a rare case of autoimmune encephalitis with multiple autoantibodies in cerebrospinal fluid (CSF) and serum, with concomitant human herpesvirus 7 (HHV-7) infection and ovarian teratoma.
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