Zinc Finger Nucleases
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Zinc Finger Nucleases
Info on biotech applications of Zinc Finger Nucleases
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EMBL Symposium - The Use of Zinc Finger Nucleases for the Development of Next Generation Cell Lines and Animal Models - 5 December 2011

EMBL Symposium - The Use of Zinc Finger Nucleases for the Development of Next Generation Cell Lines and Animal Models - 5 December 2011 | Zinc Finger Nucleases | Scoop.it

For those interested: A symposium on the use of ZFN in Germany.

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Targeted gene correction of [agr]1-antitrypsin deficiency in induced pluripotent stem cells

Targeted gene correction of [agr]1-antitrypsin deficiency in induced pluripotent stem cells | Zinc Finger Nucleases | Scoop.it
Human induced pluripotent stem cells (iPSCs) represent a unique opportunity for regenerative medicine because they offer the prospect of generating unlimited quantities of cells for autologous transplantation, with potential application in...

 

Nathan-This introduces the concept of combining homologous recombination with zinc finger technology, which allows for the traditional method of gene targeting which is fairly inefficient and coupling it with zinc fingers to increase its efficiency.

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Zinc Finger Nucleases targeting genes in a frog near you! « the Node

Zinc Finger Nucleases targeting genes in a frog near you! « the Node | Zinc Finger Nucleases | Scoop.it
Loss-of-function studies in Xenopus have been, until recently, limited to transient knockdowns by injection of morpholino antisense oligonucleotides. In part because of X. laevis' complex allotetraploid genome, the system ...
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Gene targeting by zinc finger nucleases (ZFNs) « S e q u e n c e S

Gene targeting by zinc finger nucleases (ZFNs) « S e q u e n c e S | Zinc Finger Nucleases | Scoop.it
By taking the advantage of design synthetic zinc finger nucleases, gene targeting (GT) was tested in various organisms (yeast, plant and mouse cell lines). This approach is promising for plant genetic engineering beacuse ...
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Scientists 'switch off' defective genes in cure for skin blistering diseases - HealthCanal.com

Scientists 'switch off' defective genes in cure for skin blistering diseasesHealthCanal.comThe team of scientists in the Institute of Cellular Medicine, headed by Dr.
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Breaking News For KBLB! | Stock Market Newsletters

The zinc finger nuclease were designed to cleave the silkworm`s native heavy chain gene. The resulting silkworms were inter-mated to produce 50 mating pairs, which each produced clutches of approximately 100 eggs.
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Progressive Methods Pave Just how Towards A good HIV Remedy ...

Zinc finger nucleases will be the essential. These kinds of nucleases are totally manufactured meats, allowing the cellular Genetic to become lower in certain particular points. We were holding utilized in any medical trial ...
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Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection : Nature Methods

Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection : Nature Methods | Zinc Finger Nucleases | Scoop.it
An in vitro method for examining cleavage patterns of zinc-finger nucleases (ZFNs) identifies previously unknown off-target cleavage sites.

Via dromius
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SAFC launches new cell line for biopharmaceutical production - Pharmaceutical Business Review

SAFC launches new cell line for biopharmaceutical productionPharmaceutical Business ReviewSigma-Aldrich's manufacturing and services business unit, SAFC, is introducing a novel CHOZN GS Zinc Finger Nuclease (ZFN)-modified Chinese Hamster Ovary...
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CompoZr® Knockout Zinc Finger Nuclease is Where Bio Begins!

Shondra Miller, PhD, talks about how CompoZr® Knockout ZFNs can permanently knockout any gene in the entire human genome.

 

Nathan-A good video to help explain the process of ZFNs

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Sigma® Life Science Reaches Milestone in Gene Editing ...

Sigma® Life Science Reaches Milestone in Gene Editing ... | Zinc Finger Nucleases | Scoop.it
... today announced a major breakthrough in the development of its proprietary CompoZr zinc finger nuclease (ZFN) technology with the release of more Knockout ZFNs covering the entire genomes of both mice and rats, while ...
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Zinc Plex medicine

Zinc Plex medicine | Zinc Finger Nucleases | Scoop.it
The DNA structural motif known as a Zinc finger is a site of transcriptional regulation, with Zinc-binding proteins involved in the genetic expression of various biological compounds.Zinc metalloenzymes catalyze approximately 50 important...
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Targeted Gene Therapy for Haemophilia - The Naked Scientists ...

Targeted Gene Therapy for Haemophilia - The Naked Scientists ... | Zinc Finger Nucleases | Scoop.it
It was accomplished using a synthetic molecule called a zinc finger nuclease that was delivered along with a donor sequence. The zinc finger nuclease cleaves the DNA at the site that you want to correct and then the cell's ...
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Success for charity-funded research - Grantham Today

Success for charity-funded researchGrantham TodayThe team of scientists, headed by Dr Julia Reichelt, have successfully proven that their technique based on zinc-finger nucleases (ZFN), can now be applied to the actual defective blister-causing...
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How Patient X Could Save Millions of Lives - Wall Street Daily

How Patient X Could Save Millions of LivesWall Street DailyIt's a moniker we use to describe Sangamo Biosciences' (Nasdaq: SGMO) gene therapy called “zinc finger nuclease” (ZFN), which allows them to cut harmful genes from cells in the body.
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Advances in Sophisticated Genome Editing - Genetic Engineering News

Advances in Sophisticated Genome Editing - Genetic Engineering News | Zinc Finger Nucleases | Scoop.it
Advances in Sophisticated Genome EditingGenetic Engineering NewsCompoZr® zinc finger nucleases (ZFNs) from Sigma® Life Science enable efficient and affordable gene editing across many species and cell types, including humans, rats, mice, frogs,...
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"Evaluation and application of modularly assembled zinc-finger ...

Zinc-finger nucleases (ZFNs) allow targeted gene inactivation in a wide range of model organisms. However, construction of target-specific ZFNs is technically challenging. Here, we evaluate a straightforward modular ...
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Zinc-finger nucleases | NIMML

Zinc-finger nucleases | NIMML | Zinc Finger Nucleases | Scoop.it
Gene Function Validation via Zinc Finger Nuclease • Zinc-finger nucleases (ZFNs) are synthetic restriction enzymes generated by fusing a zinc finger DNA-binding domain to a DNA-cleavage domain. Zinc finger domains can be engineered to ...
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