Viruses and Autophagy
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Hepatitis C Virus Induces the Localization of Lipid Rafts to Autophagosomes for Its RNA Replication

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Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death: Molecular Cell

Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death: Molecular Cell | Viruses and Autophagy | Scoop.it
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Cytoplasmic Structures Associated with an Arbovirus Infection: Loci of Viral Ribonucleic Acid Synthesis

Cytoplasmic Structures Associated with an Arbovirus Infection: Loci of Viral Ribonucleic Acid Synthesis Philip M. Grimley, Irene K. Berezesky and Robert M.
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Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis)

Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis) | Viruses and Autophagy | Scoop.it
The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) highlights the zoonotic potential of Betacoronaviruses.
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The Lancet Zika virus resource centre

The Lancet Zika virus resource centre | Viruses and Autophagy | Scoop.it
The Lancet Zika virus resource centre brings together the best evidence from across The Lancet family of journals—offered with free access—to assist researchers, policy makers, and health workers, in understanding the effects of the outbreak and how best to respond. Find out more about Zika virus in thisSpecial Report.
 
 

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Enterovirus 71 induces autophagy by regulating has-miR-30a expression to promote viral replication

The miR-30a binding to the 3′-UTR of Beclin-1 contributed to the modulation of Beclin-1 expression.

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Localization of Atg3 to autophagy-related membranes and its enhancement by the Atg8-family interacting motif to promote expansion of the membranes

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Modulation of inflammation by autophagy: consequences for human disease

Modulation of inflammation by autophagy: consequences for human disease | Viruses and Autophagy | Scoop.it
Modulation of inflammation by autophagy: consequences for human disease. . . doi: 10.1080/15548627.2015.1071759
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PML induces compaction, TRF2 depletion and DNA damage signaling at telomeres and promotes their alternative lengthening

PML induces compaction, TRF2 depletion and DNA damage signaling at telomeres and promotes their alternative lengthening | Viruses and Autophagy | Scoop.it
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Cell Research - Chaperone-mediated autophagy: roles in disease and aging

Cell Research - Chaperone-mediated autophagy: roles in disease and aging | Viruses and Autophagy | Scoop.it
Cell death and differentiation is a monthly research journal focused on the exciting field of programmed cell death and apoptosis. It provides a single accessible source of information for both scientists and clinicians, keeping them up-to-date with advances in the field. It encompasses programmed cell death, cell death induced by toxic agents, differentiation and the interrelation of these with cell proliferation.
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Cell Death and Differentiation - Abstract of article: The BCL-2 protein family, BH3-mimetics and cancer therapy

Cell death and differentiation is a monthly research journal focused on the exciting field of programmed cell death and apoptosis. It provides a single accessible source of information for both scientists and clinicians, keeping them up-to-date with advances in the field. It encompasses programmed cell death, cell death induced by toxic agents, differentiation and the interrelation of these with cell proliferation.
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Prosurvival AMBRA1 turns into a proapoptotic BH3-like protein during mitochondrial apoptosis

Prosurvival AMBRA1 turns into a proapoptotic BH3-like protein during mitochondrial apoptosis | Viruses and Autophagy | Scoop.it
Prosurvival AMBRA1 turns into a proapoptotic BH3-like protein during mitochondrial apoptosis. . ???aop.label???. doi: 10.1080/15548627.2016.1164359
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Replicative Intermediate of an Arbovirus

Replicative Intermediate of an Arbovirus Robert M.
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Emerging role of lipid droplets in Aedes aegypti immune response against bacteria and Dengue virus

Emerging role of lipid droplets in Aedes aegypti immune response against bacteria and Dengue virus | Viruses and Autophagy | Scoop.it
In mammals, lipid droplets (LDs) are ubiquitous organelles that modulate immune and inflammatory responses through the production of lipid mediators.
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Microbiology Society Journals | Early events in the generation of autophagosomes are required for the formation of membrane structures involved in hepatitis C virus genome replication

Microbiology Society Journals | Early events in the generation of autophagosomes are required for the formation of membrane structures involved in hepatitis C virus genome replication | Viruses and Autophagy | Scoop.it
Hepatitis C virus (HCV) infection has been shown to induce autophagy but the mechanisms underpinning this process remain to be elucidated. Induction of autophagy requires the Class III phosphatidylinositol 3-kinase, Vps34, which produces phosphatidylinositol 3-phosphate (PI3P) within the ER membrane. This recruits proteins with PI3P binding domains such as the double-FYVE-containing protein 1 (DFCP1). DFCP1 generates cup-shaped protrusions from the ER membrane, termed omegasomes, which provide a platform for the production of autophagosomes. Here we present data demonstrating that both Vps34 and DFCP1 are required for HCV genome replication, both in the context of a subgenomic replicon and virus infection, but did not affect virus entry or initial translation. Using live cell fluorescence microscopy we demonstrate that early during HCV infection the nascent viral genome replication complexes (identified by using non-structural protein NS5A as a marker) transiently colocalise with DFCP1-positive punctae (omegasomes), before the two structures move apart from each other. This observation is reminiscent of the transient association of LC3 and DFCP1 during omegasome formation, and therefore we propose that omegasomes are utilized by HCV to generate the double membrane vesicles which are the hallmark of HCV replication complexes.
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Autophagy and viral diseases transmitted by Aedes aegypti and Aedes albopictus

Autophagy and viral diseases transmitted by Aedes aegypti and Aedes albopictus | Viruses and Autophagy | Scoop.it

Acknowledgments LAMC and LHT are funded by CNPq and FAPERJ.

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The Origin of the Variola Virus

The Origin of the Variola Virus | Viruses and Autophagy | Scoop.it

The question of the origin of smallpox, one of the major menaces to humankind, is a constant concern for the scientific community. Smallpox is caused by the agent referred to as the variola virus (VARV), which belongs to the genus Orthopoxvirus. Presumably, the introduction of camels to Africa and the concurrent changes to the climate were the particular factors that triggered the divergent evolution of a cowpox-like ancestral virus and thereby led to the emergence of VARV.


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Capsid, membrane and NS3 are the major viral proteins involved in autophagy induced by Japanese encephalitis virus

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Micro-irradiation tools to visualize base excision repair and single-strand break repair

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HTLV-1 Tax: Senescence, Autophagy and the DNA damage response

HTLV-1 Tax: Senescence, Autophagy and the DNA damage response | Viruses and Autophagy | Scoop.it
Human T-cell lymphotropic virus type 1 (HTLV-1) is the causative agent of ATL and the HTLV-1 encoded Tax protein has been shown to induce oncogene induced senescence (OIS), apoptosis, and to be...
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Functional implications of mitochondrial reactive oxygen species generated by oncogenic viruses - Springer

Functional implications of mitochondrial reactive oxygen species generated by oncogenic viruses - Springer | Viruses and Autophagy | Scoop.it
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