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Extend virus alert to visitors from UK, urges doctor - Hong Kong Standard

Extend virus alert to visitors from UK, urges doctor - Hong Kong Standard | Virology News | Scoop.it
Hong Kong Standard
Extend virus alert to visitors from UK, urges doctor
Hong Kong Standard
The alert over a mysterious SARS-like virus should be extended to travelers from Britain, an infectious diseases doctor says.
Ed Rybicki's insight:

Excellent!  Stop those vile disease-ridden Brits from transmitting their nasty SARS-like virus around the world...B-)

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Virology News
Topical news snippets about viruses that affect people.  And other things. Like zombies B-)
Curated by Ed Rybicki
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Making It In Botswana - Botswana Vaccine Institute BVI & Fibre Land

Click once and get to know how Botswana Vaccine (BVI) and Fibre Land thrive in Botswana.
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There's a once-a-week HIV pill coming that will change the lives of millions of people

There's a once-a-week HIV pill coming that will change the lives of millions of people | Virology News | Scoop.it
Research has shown that 20% to 30% of medication prescriptions are never filled, while 50% of medications for chronic disease are not taken as prescribed.
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Efficacy, safety, cost: India’s decade-old debate on the cervical cancer vaccine erupts again

The health ministry recently indicated that it would not include the HPV vaccine in the national immunisation programme.
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Sigh...if African countries can do it, surely India could too??
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Missouri is epicenter of US national flu outbreak, according to 'smart thermometer' app 

The flu is bad this year and no state in the country is seeing higher rates of it than Missouri. That’s according to Kinsa, a company that makes “smart thermometers” and has analyzed data collected from more than 1 million users nationwide.
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This Man With HIV Just Won His Battle To Change The Rules So He Can Become An Airline Pilot

This Man With HIV Just Won His Battle To Change The Rules So He Can Become An Airline Pilot | Virology News | Scoop.it
Following a BuzzFeed News story, the Civil Aviation Authority announced on Thursday that people with HIV would no longer be barred from becoming commercial pilots.
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Transcriptome profiling of whitefly guts in response to Tomato yellow leaf curl virus infection

Transcriptome profiling of whitefly guts in response to Tomato yellow leaf curl virus infection | Virology News | Scoop.it
Plant viruses in agricultural crops are of great concern worldwide, and over 75% of them are transmitted from infected to healthy plants by insect vectors. Tomato yellow leaf curl virus (TYLCV) is a begomovirus, which is the largest and most economically important group of plant viruses, transmitted by the whitefly Bemisia tabaci. The circulation of TYLCV in the insect involves complex insect-virus interactions, whereas the molecular mechanisms of these interactions remain ambiguous. The insect gut as a barrier for viral entry and dissemination is thought to regulate the vector specificity. However, due to its tiny size, information for the responses of whitefly gut to virus infection is limited. We investigated the transcriptional response of the gut of B. tabaci Middle East-Asia Minor 1 species to TYLCV infection using Illumina sequencing. A total of 5207 differentially expressed genes (DEGs) between viruliferous and non-viruliferous whitefly guts were identified. Enrichment analyses showed that cargo receptor and ATP-binding cassette (ABC) transporters were enriched in DEGs, and might help the virus to cross gut barrier. TYLCV could perturb cell cycle and DNA repair as a possible result of its replication in the whitefly. Our data also demonstrated that TYLCV can activate whitefly defense responses, such as antimicrobial peptides. Meanwhile, a number of genes involved in intracellular signaling were activated by TYLCV infection. Our results reveal the complex insect-virus relationship in whitefly gut and provide substantial molecular information for the role of insect midguts in virus transmission.
Ed Rybicki's insight:
Back to my mid-term roots in geminivirology...it is an open question as to whether geminiviruses and especially TYLCV can replicate in vector insects, seeing as they do seem to be able to set them up to be persistent circulative vectors. Some swear they do; others that they don't - but I am willing to bet that TYLCV at any rate undergoes either partial replication, or expression from "repaired" dsDNA forms of the genomic DNA, in insect cells, so as to effect some of the changes seen in insect transcription.

I have another theory concerning trans-replication of gemini- and other ssDNA virus genomes by Reps or RCR-mediating proteins endogenous to or from viruses or even bacteria co-infecting the vectors, but that is the subject for another posting.
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New shingles vaccine should be free, argues seniors advocate

New shingles vaccine should be free, argues seniors advocate | Virology News | Scoop.it
As the cases of shingles rise, especially among seniors, advocates are pushing for provincial governments to cover the cost of a new and effective vaccine.
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Light controls variants of active ingredient in cannabis

Light controls variants of active ingredient in cannabis | Virology News | Scoop.it
Synthesizing variants of THC could lead to better understanding of the body's endocannabinoid system.
Ed Rybicki's insight:
...OR JUST USE GOOD LIGHTS??
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Aluminum toxicity in vaccines – here we go again with bad science

Aluminum toxicity in vaccines – here we go again with bad science | Virology News | Scoop.it
This year I got a special birthday gift; someone sent me a piece about vaccine aluminum toxicity written by the noted anti-vaccine activist, J B Handley.
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After flu vaccine mismatch, calls for delayed selection intensify

After flu vaccine mismatch, calls for delayed selection intensify | Virology News | Scoop.it
This collection includes Reviews and Research articles from across the Nature group of journals to showcase advances in our understanding of influenza virus biology, evolution and adaptation, and in surveillance and drug and vaccine development.
Ed Rybicki's insight:
...and after delayed selection, A MORE MODERN AND MUCH QUICKER MEANS OF PRODUCTION?? Like - plants, maybe?
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GSK's Influenza Vaccine Receives FDA Approval for Expanded Indication

GSK's Influenza Vaccine Receives FDA Approval for Expanded Indication | Virology News | Scoop.it
The influenza vaccine can now be used to protect recommended persons aged 6 months and older.
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Six Caribbean territories and states eliminate mother-to-child transmission of HIV and syphilis

Six Caribbean territories and states eliminate mother-to-child transmission of HIV and syphilis | Virology News | Scoop.it
Anguilla, Antigua and Barbuda, Bermuda, Cayman Islands, Montserrat and Saint Kitts and Nevis were today certified by the World Health Organization (WHO) as having eliminated mother-to-child transmission of HIV
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Meditation or exercise for preventing acute respiratory infection: a randomized controlled trial

PURPOSE:
This study was designed to evaluate potential preventive effects of meditation or exercise on incidence, duration, and severity of acute respiratory infection (ARI) illness.

METHODS:
Community-recruited adults aged 50 years and older were randomized to 1 of 3 study groups: 8-week training in mindfulness meditation, matched 8-week training in moderate-intensity sustained exercise, or observational control. The primary outcome was area-under-the-curve global illness severity during a single cold and influenza season, using the Wisconsin Upper Respiratory Symptom Survey (WURSS-24) to assess severity. Health care visits and days of missed work were counted. Nasal wash collected during ARI illness was assayed for neutrophils, interleukin-8, and viral nucleic acid.

RESULTS:
Of 154 adults randomized into the study, 149 completed the trial (82% female, 94% white, mean age 59.3 ± 6.6 years). There were 27 ARI episodes and 257 days of ARI illness in the meditation group (n = 51), 26 episodes and 241 illness days in the exercise group (n = 47), and 40 episodes and 453 days in the control group (n = 51). Mean global severity was 144 for meditation, 248 for exercise, and 358 for control. Compared with control, global severity was significantly lower for meditation (P = .004). Both global severity and total days of illness (duration) trended toward being lower for the exercise group (P=.16 and P=.032, respectively), as did illness duration for the meditation group (P=.034). Adjusting for covariates using zero-inflated multivariate regression models gave similar results. There were 67 ARI-related days of-work missed in the control group, 32 in the exercise group (P = .041), and 16 in the meditation group (P <.001). Health care visits did not differ significantly. Viruses were identified in 54% of samples from meditation, 42% from exercise, and 54% from control groups. Neutrophil count and interleukin-8 levels were similar among intervention groups.

CONCLUSIONS:
Training in meditation or exercise may be effective in reducing ARI illness burden.

Ed Rybicki's insight:
Surprising spoiler: may help??
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Important changes in the timing of influenza epidemics in Western and Eastern Europe

Important changes in the timing of influenza epidemics in Western and Eastern Europe | Virology News | Scoop.it
A study carried out by Nivel and published in Eurosurveillance has found that the timing of influenza epidemics has changed in Europe over the last 20 years. These findings have important implications for influenza vaccination programmes in the region. Climate change and/or changes in population movement may be underlying factors that explain these developments.Main findings
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A Coxsackievirus B vaccine protects against virus-induced diabetes in an experimental mouse model of type 1 diabetes

A Coxsackievirus B vaccine protects against virus-induced diabetes in an experimental mouse model of type 1 diabetes | Virology News | Scoop.it
E pidemiological studies suggest a role for Coxsackievirus B (CVB) seroty pes i n the pathoge nesis of ty pe 1 diabetes, but their actual co ntributio n remai ns elusive. I n the prese nt study, we ha
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The Not-Aussie Flu crisis continues: Stark UK NHS warning as hospitals struggle to cope

There were 27 flu-related deaths in the first week of January, bringing the winter total up to 85, statistics released today revealed. Health experts warne
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Bird Flu Prevention Zone Introduced Across England

Bird Flu Prevention Zone Introduced Across England | Virology News | Scoop.it
The NGO is advising its members that Defra has today (18 January 2018) introduced an Avian Influenza Prevention Zone to cover the whole of England. Strict biosecurity is now a legal requirement.
Ed Rybicki's insight:
You can leave the EU, but diseases know no borders...
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A rapid virus-induced gene silencing (VIGS) method for assessing resistance and susceptibility to cassava mosaic disease

A rapid virus-induced gene silencing (VIGS) method for assessing resistance and susceptibility to cassava mosaic disease | Virology News | Scoop.it
Cassava mosaic disease (CMD) is a major constraint to cassava production in sub-Saharan Africa. Under field conditions, evaluation for resistance to CMD takes 12–18 months, often conducted across multiple years and locations under pressure from whitefly-mediated transmission. Under greenhouse or laboratory settings, evaluation for resistance or susceptibility to CMD involves transmission of the causal viruses from an infected source to healthy plants through grafting, or by using Agrobacterium-mediated or biolistic delivery of infectious clones. Following inoculation, visual assessment for CMD symptom development and recovery requires 12–22 weeks. Here we report a rapid screening system for determining resistance and susceptibility to CMD based on virus-induced gene silencing (VIGS) of an endogenous cassava gene. A VIGS vector was developed based on an infectious clone of the virulent strain of East African cassava mosaic virus (EACMV-K201). A sequence from the cassava (Manihot esculenta) ortholog of Arabidopsis SPINDLY (SPY) was cloned into the CP position of the DNA-A genomic component and used to inoculate cassava plants by Helios® Gene Gun microparticle bombardment. Silencing of Manihot esculenta SPY (MeSPY) using MeSPY1-VIGS resulted in shoot-tip necrosis followed by death of the whole plant in CMD susceptible cassava plants within 2–4 weeks. CMD resistant cultivars were not affected and remained healthy after challenge with MeSPY1-VIGS. Significantly higher virus titers were detected in CMD-susceptible cassava lines compared to resistant controls and were correlated with a concomitant reduction in MeSPY expression in susceptible plants. A rapid VIGS-based screening system was developed for assessing resistance and susceptibility to CMD. The method is space and resource efficient, reducing the time required to perform CMD screening to as little as 2–4 weeks. It can be employed as a high throughput rapid screening system to assess new cassava cultivars and for screening transgenic, gene edited and breeding lines under controlled growth conditions.
Ed Rybicki's insight:
Geminiviruses: seriously useful toys.
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[NO] Association between Human Papilloma Virus (HPV) vaccination and risk of Multiple Sclerosis: a systematic review

[NO] Association between Human Papilloma Virus (HPV) vaccination and risk of Multiple Sclerosis: a systematic review | Virology News | Scoop.it
Hum Vaccin Immunother. 2018 Jan 15:0. doi: 10.1080/21645515.2017.1423155. [Epub ahead of print]
Ed Rybicki's insight:
Spoiler necessary B-)
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Dentists asked to help stop spread of HPV by asking about patient's oral sex life

Dentists asked to help stop spread of HPV by asking about patient's oral sex life | Virology News | Scoop.it
Health News - Read more at AsiaOne
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Evidence for Viral Interference and Cross-reactive Protective Immunity Between Influenza B Virus Lineages

Evidence for Viral Interference and Cross-reactive Protective Immunity Between Influenza B Virus Lineages | Virology News | Scoop.it
Using a ferret model of human influenza, we demonstrate that infection with one influenza B virus can prevent or limit infection with an influenza B virus of th
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Saliva test aims to detect HPV throat cancers

Saliva test aims to detect HPV throat cancers | Virology News | Scoop.it
A QUT researcher is developing a simple saliva test to detect Human papilloma virus (HPV) in throat cancers.
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Flu season widespread across US with at least 2,500 dead

At least 2,500 people, including 20 children, have died of flu or pneumonia over the past 3 months in a "severe" season that U.S. health experts hope won't surpass the record number of infections during the 2014/2015 outbreak.
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Sigh...severe flu hype syndrome strikes! "Aussie flu: Deadly virus infection to be worse than Spanish flu 1918 pandemic?"

Aussie flu symptoms include fever, headaches, muscles aches and fatigue.The lethal H3N2 Aussie flu virus travelled to the UK from Australia, and has now been spotted in the US.Exactly 100 years ago, Spanish flu
Ed Rybicki's insight:
Answer: NOT.
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The World's First Universal Flu Vaccine Is Already Undergoing Clinical Trials

The World's First Universal Flu Vaccine Is Already Undergoing Clinical Trials | Virology News | Scoop.it

A company in the UK is currently conducting a clinical trial of what could become the first universal flu vaccine in the world - an elusive goal that would have massive benefits for global public health and eliminate our need for annual injections.
Ed Rybicki's insight:
"Vaccitech's patented vaccine MVA-NP+M1 has so far been successfully tested for safety across 145 people, so the next step is to find out if it's actually good at protecting humans against the flu." This has actually been around for years - shows how long it takes to get to human clinical trial!
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