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Video: Intranasal Norovirus VLP vaccine demonstrating clinical efficacy in Phase I/II Trial - Vaccine Nation - Strategy and innovation in vaccines

Video: Intranasal Norovirus VLP vaccine demonstrating clinical efficacy in Phase I/II Trial - Vaccine Nation - Strategy and innovation in vaccines | Virology News | Scoop.it
The presentation covered:
Phase I/II randomized, double blind, multi-center, placebo-controlled safety and efficacy study designed to evaluate the norovirus monovalent GI.1 VLP vaccine versus placebo

Results from the Norovirus vaccine proof-of-concept, multi-center challenge study

Ongoing clinical study of an intramuscular bivalent formulation of norovirus vaccine candidate

 

Of course, they don't mention you can make it in plants too....

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Virology News
Topical news snippets about viruses that affect people.  And other things. Like zombies B-)
Curated by Ed Rybicki
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Marburg cases in Uganda: the lowdown about Ebola's 'sister' virus

Marburg cases in Uganda: the lowdown about Ebola's 'sister' virus | Virology News | Scoop.it

What is the Marburg virus and why is it considered dangerous? The Marburg virus is probably most easily introduced as the sister of the infamous Ebola virus. The viruses are similar in their genetic and structural makeup, they’re transmitted from human-to-human and their clinical presentation in humans is similar. But there are some marked differences. For example, apart from overlapping in two countries, they have been detected in different parts of the African continent. Marburg virus has been reported in sporadic outbreaks in eastern and southern Africa – including Uganda, Kenya, the Democratic Republic of Congo (DRC) and Angola. A case of Marburg virus disease in South Africa was traced back to potential exposure in Zimbabwe. For its part, Ebola has also been reported in the DRC and Uganda, as well as Sudan, Gabon, Guinea, Sierra Leone and Liberia. There are also differences in the natural ecology of the two viruses. Current evidence supports the hypothesis of circulation of Marburg virus in cave dwelling bats such as Rousettus aegyptiacus (or Egyptian fruit bat), while most believe that the Ebola virus are associated with forest dwelling bat species.

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Bird flu in Uganda highlights gaps in Africa's plans to manage pandemics

Bird flu in Uganda highlights gaps in Africa's plans to manage pandemics | Virology News | Scoop.it

The strain of avian influenza detected in wild and domestic birds in Uganda recently is the same virus that has spread through Asia and Europe over the past four months. Revealed as the H5N8 avian influenza strain, it is thought to have spread across continents via wild migratory birds. In Africa, aside from Uganda, the H5N8 outbreak has also been recorded in Nigeria and Tunisia this year. The risk of humans being infected by H5N8 is low, but should this happen, the virus can cause severe illness and death. Since the outbreak in Uganda was reported, a number of East African countries have increased their monitoring while the Democratic Republic of Congo, Kenya, Rwanda, South Sudan, and Tanzania have imposed a ban on poultry from Uganda. But African countries face challenges in detecting such outbreaks because they have weak avian influenza surveillance systems.

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This is the kind of shit that kills people. "Biafra Today:  How IPOB Curtailed The Spread Of Monkeypox Virus"

This is the kind of shit that kills people. "Biafra Today:  How IPOB Curtailed The Spread Of Monkeypox Virus" | Virology News | Scoop.it

Complete HORSESHIT from start to finish - and this sort of thing keeps coming out of Nigeria. And Kenya, BTW.

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Health care workers refused to get vaccinated. Now they're out of jobs

Health care workers refused to get vaccinated. Now they're out of jobs | Virology News | Scoop.it
A Midwest health system fired 50 people who refused to get flu shots. Doctors say mandatory vaccination against influenza protects patients.
Ed Rybicki's insight:
Excellent!
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Bat cave solves mystery of deadly SARS virus — and suggests new outbreak could occur

Bat cave solves mystery of deadly SARS virus — and suggests new outbreak could occur | Virology News | Scoop.it

Chinese scientists find all the genetic building blocks of SARS in a single population of horseshoe bats.

After a detective hunt across China, researchers chasing the origin of the deadly SARS virus have finally found their smoking gun. In a remote cave in Yunnan province, virologists have identified a single population of horseshoe bats that harbours virus strains with all the genetic building blocks of the one that jumped to humans in 2002, killing almost 800 people around the world. The killer strain could easily have arisen from such a bat population, the researchers report in PLoS Pathogens1 on 30 November. They warn that the ingredients are in place for a similar disease to emerge again.

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The crackpot conspiracy theories and deadly denial fuelling Russia’s HIV epidemic

The crackpot conspiracy theories and deadly denial fuelling Russia’s HIV epidemic | Virology News | Scoop.it
Fewer than half of Russians with HIV are taking antiretrovirals, in part because of a conspiracy theory that the virus is a myth invented by the West
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Australia's flu season has U.S. health officials bracing for a bad winter — and wishing for a new vaccine

Australia's flu season has U.S. health officials bracing for a bad winter — and wishing for a new vaccine | Virology News | Scoop.it
The way the flu season has gone in Australia dos not bode well for us in North America. Our flu vaccine is not that effective against the type of strains that predominated down under.
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Human Trials of 'Global HIV Vaccine' Begin in Southern Africa

Human Trials of 'Global HIV Vaccine' Begin in Southern Africa | Virology News | Scoop.it
Human testing of a new experimental HIV vaccine has been launched in southern Africa, the first time in more than a decade that two big HIV vaccine efficacy trials are being carried out concurrently.
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Evidence of porcine circovirus-like virus P1 in piglets with an unusual congenital tremor.

Outbreaks of trembling and shaking were reported among pigs at two pig farms in Jiangsu Province, China. Serum and tissue samples tested positive for porcin
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HIV/AIDS: Fewer deaths, but infections still rising

HIV/AIDS: Fewer deaths, but infections still rising | Virology News | Scoop.it
Although the number of AIDS-related deaths has decreased over the years, the number of total infections is still rising.
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‘Alien’ DNA makes proteins in living cells for the first time

‘Alien’ DNA makes proteins in living cells for the first time | Virology News | Scoop.it
Expanded genetic alphabet could allow for the production of new protein-based drugs.
Ed Rybicki's insight:
Yes, yes, it can be used for new vaccines and therapeutics yadda yadda. But right now it's just cool B-)
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A single cycle influenza virus coated in H7 hemagglutinin provides heterotypic protection and neutralising antibody responses to both glycoproteins.

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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An outbreak of Ebola in the DRC has been contained. What went right this time?

An outbreak of Ebola in the DRC has been contained. What went right this time? | Virology News | Scoop.it

The World Health Organisation recently declared the end of the most recent outbreak of Ebola in the Democratic Republic of Congo (DRC). By the time the outbreak was contained, eight people had been infected. Four survived. The first patient diagnosed in the outbreak (the index case) – a middle aged man who died on his way to hospital - got ill in April. It’s not clear how he became infected. But those who helped transport him to the hospital also became sick. This outbreak had the second lowest number of patients among all the eight Ebola outbreaks in DRC since 1976. The last one in 2014 lasted for three months and three quarters of the 66 people diagnosed with the disease died. The outbreak was traced back to a pregnant woman who had slaughtered a monkey brought home by her husband. The disease spread when she underwent a traditional surgical operation after becoming ill.

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Sanofi updates information on dengue vaccine | Sanofi

New analysis of long-term Dengvaxia® data found differences in vaccine performance based on prior dengue infection Company will ask regulators to update product

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WHO supports the immunization of 874 000 people against yellow fever in Nigeria

WHO supports the immunization of 874 000 people against yellow fever in Nigeria | Virology News | Scoop.it
The International Coordinating Group (ICG) on vaccine provision for yellow fever has provided 1.4 million vaccine doses for an immunization campaign that starts on Saturday (2 December) to help control an ongoing yellow fever outbreak in Nigeria.
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UN voices alarm about spread of HIV in Egypt | African Independent

UN voices alarm about spread of HIV in Egypt | African Independent | Virology News | Scoop.it
The UN is voicing alarm over the spread of HIV in Egypt, where the number of new cases is growing by up to 40 percent a year.
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HPV vaccine is effective, safe 10 years after it’s given

Credit: Phil Jones, Senior Photographer, Augusta University AUGUSTA, Ga. (Nov. 29, 2017) - A decade of data on hundreds of boys and girls who received the HPV vaccine indicates the vaccine is safe ..
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Australia's new cervical cancer test 'much more sensitive' – Cancer Council

Australia's new cervical cancer test 'much more sensitive' – Cancer Council | Virology News | Scoop.it
Women will need the test for the human papillomavirus (HPV) every five years rather than a pap smear every two years
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Japanese doctor wins global prize for standing up to anti-vaccine activists

Japanese doctor wins global prize for standing up to anti-vaccine activists | Virology News | Scoop.it
Japanese doctor wins global Maddox prize for standing up for science in the face of a lawsuit, media blacklisting and other harassment by anti-vaccine activists.
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Circovirus in Dogs: Symptoms, Causes, and Treatment | petMD

Circovirus in Dogs: Symptoms, Causes, and Treatment | petMD | Virology News | Scoop.it
Circoviruses are small viruses that can affect our canine companions. Researchers and veterinarians say the prevention and treatment of dog circovirus involves a large dose of common sense, yet the source of the illness and how it functions remain largely a mystery.
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Estimated rotavirus deaths for children under 5 years of age: 2013, 215 000

Estimated rotavirus deaths for children under 5 years of age: 2013,  215 000 | Virology News | Scoop.it
Estimated rotavirus deaths for children under 5 years of age: 2013, 215 000 As of April 2016, the World Health Organization estimates that globally 215 000 (197 000 - 233 000) child deaths occurred during 2013 due to rotavirus infection compared to 528 000 (465 000 – 591 000) in 2000.
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The secret ring helping women protect themselves from HIV

The secret ring helping women protect themselves from HIV | Virology News | Scoop.it
Could this vaginal ring help protect women from HIV in communities where men refuse to use condoms?
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The pH stability of foot-and-mouth disease virus

The pH stability of foot-and-mouth disease virus | Virology News | Scoop.it
This review summarized the molecular determinants of the acid stability of FMDV in order to explore the uncoating mechanism of FMDV and improve the acid stability of vaccines. The foot-and-mouth disease virus (FMDV) capsid is highly acid labile and tends to dissociate into pentameric subunits at acidic condition to release viral RNA for initiating virus replication. However, the acid stability of virus capsid is greatly required for the maintenance of intact virion during the process of virus culture and vaccine production. The conflict between the acid lability in vivo and acid stability in vitro of FMDV capsid promotes the selection of a series of amino acid substitutions which can confer resistance to acid-induced FMDV inactivation. In order to explore the uncoating activity of FMDV and enhance the acid stability of vaccines, we summarized the available works about the pH stability of FMDV. In this review, we analyzed the intrinsic reasons for the acid instability of FMDV from the structural and functional aspects. We also listed all substitutions obtained by different research methods and showed them in the partial capsid of FMDV. We found that a quadrangle region in the viral capsid was the place where a great many pH-sensitive residues were distributed. As the uncoating event of FMDV is dependent on the pH-sensitive amino acid residues in the capsid, this most pH-sensitive position indicates a potential candidate location for RNA delivery triggered by the acid-induced coat disassociation. This review provided an overview of the pH stability of FMDV. The study of pH stability of FMDV not only contributes to the exploration of molecule and mechanism information for FMDV uncoating, but also enlightens the development of FMDV vaccines, including the traditionally inactivated vaccines and the new VLP (virus-like particle) vaccines.
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"Mind Who you Kiss; HPV Virus That Kills Faster Than HIV/AIDS can be Gotten Through Kissing." NOT!!

"Mind Who you Kiss; HPV Virus That Kills Faster Than HIV/AIDS can be Gotten Through Kissing." NOT!! | Virology News | Scoop.it
Students from Kisii University, Kenya and the general public at large have been warned against kissing carelessly due to an outbreak of Human papilloma virus, which has seen several people admitted at Kisii level 5 hospital after testing positive to the disease. HPV is an infectious viral disease which cause mouth cancer and is transmitted…
Ed Rybicki's insight:
I don't know what this is, but it ain't HPV: herpes type 1, maybe; from the look of those tonsils, something NASTY and bacterial as well - but this type of hype has to get stamped on for being the rubbish that it is. Kenyan newspapers obviously don't have decent fact checkers.
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