Virology
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Rescooped by Stefan Taube from Viruses, Immunology & Bioinformatics from Virology.uvic.ca
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Enteric bacteria promote human and mouse norovirus infection of B cells

The cell tropism of human noroviruses and the development of an in vitro infection model remain elusive. Although susceptibility to individual human norovirus strains correlates with an individual's histo-blood group antigen (HBGA) profile, the biological basis of this restriction is unknown. We demonstrate that human and mouse noroviruses infected B cells in vitro and likely in vivo. Human norovirus infection of B cells required the presence of HBGA-expressing enteric bacteria. Furthermore, mouse norovirus replication was reduced in vivo when the intestinal microbiota was depleted by means of oral antibiotic administration. Thus, we have identified B cells as a cellular target of noroviruses and enteric bacteria as a stimulatory factor for norovirus infection, leading to the development of an in vitro infection model for human noroviruses.

 


Via Ed Rybicki
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Ed Rybicki's curator insight, November 9, 2014 9:04 AM

Now THAT'S interesting!

Scooped by Stefan Taube
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Norovirus: The Perfect Pathogen Emerges From the Shadows – Phenomena: The Loom

Norovirus: The Perfect Pathogen Emerges From the Shadows – Phenomena: The Loom | Virology | Scoop.it
As the year comes to a close, people are starting to puke. The notorious stomach bug known as norovirus is starting its annual rampage,, which will last from late fall through winter. A couple year...
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