tumor immunology and immunotherapy
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Men with no sperm have higher cancer risk, study finds - NBCNews.com (blog)

Men with no sperm have higher cancer risk, study finds - NBCNews.com (blog) | tumor immunology and immunotherapy | Scoop.it
Counsel & Heal Men with no sperm have higher cancer risk, study finds NBCNews.com (blog) But all infertile men in the study had a somewhat higher risk of cancer than the general population, a finding that suggests the same genetic defects that...
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The HER2 Pathway in Breast Cancer

The HER2 Pathway in Breast Cancer | tumor immunology and immunotherapy | Scoop.it

"The human epidermal growth factor receptor (HER) family consists of four members: the epidermal growth factor receptor (EGFR) and HER1, HER2, HER3, and HER4, which are transmembrane receptor tyrosine kinases that regulate cell growth survival, differentiation, and migration, as well as other cellular responses.1 HER2 and HER3 are unique members in that HER2 has no known ligand that stimulates its activity, and HER3 has very little enzymatic kinase activity and mainly functions as a ligand-activated dimer partner for the other family members.2 Dimerization and activation of these receptors promotes tumor growth by promoting signaling through commonly used growth factor signaling pathways such as the RAS/RAF/MEK/ERK pathway and the PI3K/AKT/mTOR pathway.3 Oncogenic activation of the HER family members can occur through a var."iety of mechanisms including gene amplification, mutation, and truncation. The HER2 receptor was the first family member associated with cancer because its activation was shown to transform normal cells into cancer cells and its overexpression was found in breast tumors more than 25 years ago. HER2 protein was shown to be highly expressed in approximately 20% of breast tumors as a result of amplification of the HER2 gene. Its presence portends an aggressive natural history compared to other breast tumors."


Via Curated by A4BC.ORG
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Curated by A4BC.ORG's curator insight, June 1, 2013 1:09 PM

This article has excellent information about the Her2 pathway in breast cancer.

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Inhalable chemo-carrying nanoparticles target lung cancer directly

Inhalable chemo-carrying nanoparticles target lung cancer directly | tumor immunology and immunotherapy | Scoop.it

U.S. researchers have developed a novel lung cancer treatment that uses nanoparticles to deliver an inhaled form of chemotherapy.

 

The scientists from Oregon State University, Rutgers University in New Jersey and the Cancer Institute of New Jersey developed "nanostructured lipid nanocarriers" that find cancer cells in the lung, attach to them and deliver drugs locally. With the inhaled substance, the patient receives an unadulterated form of the cancer drug compared with conventional intravenous administration, which can accumulate in other organs such as the liver or kidneys with toxic effects.

 

What's more, the nanoparticle comes with a bundle of small interfering RNA, siRNA, which helps silence certain genes to make the cancer cells more vulnerable to the drugs. Overall, the study showed 83% of the drug reaching its target in the lungs as opposed to 23% with the traditional approach, according to the article published in the Journal of Controlled Release.

 

"A drug delivery system that can be inhaled is a much more efficient approach, targeting just the cancer cells as much as possible," said co-author Oleh Taratula. "Other chemotherapeutic approaches only tend to suppress tumors, but this system appears to eliminate it."

 

The team has applied for a patent for the delivery platform, but human clinical trials will have to await further testing.


Via Dr. Stefan Gruenwald
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Immunotherapy offers hope for some cancer patients - NBCNews.com

Immunotherapy offers hope for some cancer patients - NBCNews.com | tumor immunology and immunotherapy | Scoop.it
Immunotherapy offers hope for some cancer patients
NBCNews.com
Immune therapy drugs work by coaxing white blood cells that usually fight bacteria and viruses to kill cancer cells.
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