Toxicogenética, Toxicogenómica || Toxicogenetics, Toxicogenomics
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Toxicogenética, Toxicogenómica || Toxicogenetics, Toxicogenomics
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Farmacogenética: hacia la medicina personalizada | How I met your genes

Farmacogenética: hacia la medicina personalizada | How I met your genes | Toxicogenética, Toxicogenómica || Toxicogenetics, Toxicogenomics | Scoop.it
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TOXBANK Tutorials: The basics on Toxicogenomics (Part 2 / 3)

A tutorial on basics Toxicogenomics, by Professor Roland Grafström and Dr. Pekka Kohonen, Karolinska Institute (Stockholm, Sweden) 2 / 3 LINKS: Part 1: ht...
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Inauguración del Curso de Introducción a las Especilaidades ...

Inauguración del Curso de Introducción a las Especilaidades ... | Toxicogenética, Toxicogenómica || Toxicogenetics, Toxicogenomics | Scoop.it
“La toxicogenética cuenta con gran desarrollo y se le debería prestar más atención desde el mundo forense”. Reivindicó también en su intervención la importancia del estudio de la genérica, que a su juicio tiene poco peso ...
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Entrada más reciente - Farmacogenómica del cáncer de mama.

Entrada más reciente - Farmacogenómica del cáncer de mama. | Toxicogenética, Toxicogenómica || Toxicogenetics, Toxicogenomics | Scoop.it
... con título Advances In Food Biochemistry del año 2010 y de la editorial CRC Press, este libro es muy reciente y aunque no se centra en mis intereses tiene un capítulo llamado Pharmacogenomics and Toxicogenomics in ...
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Microarrays and toxicology: The advent of toxicogenomics (Nuwaysir, 1999)

Microarrays and toxicology: The advent of toxicogenomics (Nuwaysir, 1999) | Toxicogenética, Toxicogenómica || Toxicogenetics, Toxicogenomics | Scoop.it

The availability of genome-scale DNA sequence information and reagents has radically altered life-science research. This revolution has led to the development of a new scientific subdiscipline derived from a combination of the fields of toxicology and genomics. This subdiscipline, termed toxicogenomics, is concerned with the identification of potential human and environmental toxicants, and their putative mechanisms of action, through the use of genomics resources. One such resource is DNA microarrays or “chips,” which allow the monitoring of the expression levels of thousands of genes simultaneously. Here we propose a general method by which gene expression, as measured by cDNA microarrays, can be used as a highly sensitive and informative marker for toxicity. Our purpose is to acquaint the reader with the development and current state of microarray technology and to present our view of the usefulness of microarrays to the field of toxicology.

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Toxicogenomics: unlocking the potential of the human genome (Hallingan, 2008)

Toxicogenomics merges genomics with toxicology and observes the genome-wide effects of toxicants. The field is really only taking the first steps to establish the ‘ground rules’, nomenclature and standards by which it will develop and a standardised approach to toxicogenomic evaluation is still to be agreed. There is a great need to address toxicogenomics to iatrogenic morbidity, environmental health and safety and diet. In the case of iatrogenic morbidity, 0.5% of the UK hospital population is affected and toxicogenomics could lead to personalised medicine, i.e., to define a drug dosage tailored to each patient's unique genetic make-up and medical condition that is beneficial, inadequate or toxic. Before this can become a reality, toxicogenomic profiles need to be generated for a host of commonly prescribed drugs and shown to be robust in cross-centre, cross-platform comparisons; the magnitude of the work needed will be vast and needs to be nationally coordinated and funded. The potential of predictive toxicogenomic and all tri-nomic methodologies is far greater than its current usefulness. The sequencing of genomes alone is not a panacea. Rather, genomic, tri-nomic and pharmacogenetic databases must be integrated with a comprehensive toxicant class database with validated tri-nomic profiles linked to traditional toxicity endpoints; this should be carried out as exhaustively as the sequencing effort itself. This must be undertaken in order to exploit the vast potential of this new field to provide personalised medicine, sensitive and quick environmental health and safety surveillance and accurate and scientifically supported dietary advice.

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SpringerProtocols: Abstract: 9. Toxicogenomics in Biomarker Discovery

In the area of toxicology, the subdiscipline of toxicogenomics has emerged, which is the use of genome-scale mRNA expression profiling to monitor responses to adverse xenobiotic exposure. Toxicogenomics is being investigated for use in the triage of compounds through predicting potential toxicity, defining mechanisms of toxicity, and identifying potential biomarkers of toxicity. Whereas various approaches have been reported for the development of algorithms predictive of toxicity and for the interpretation of gene expression data for deriving mechanisms of toxicity, there are no clearly defined methods for the discovery of biomarkers using gene expression technologies. Ways in which toxicogenomics may be used for biomarker discovery include analysis of large databases of gene expression profiles followed by in silico mining of the database for differentially expressed genes; the analysis of gene expression data from preclinical studies to find differentially expressed genes that correlate with pathology (coincident biomarker) or precede pathology (leading biomarker) within a lead series; or gene expression profiling can be performed directly on the blood from preclinical studies or clinical trials to find biomarkers that can be obtained noninvasively. This chapter broadly discusses the issues and the utility of applying toxicogenomics to biomarker discovery.

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Relationship Between Toxicogenomic and Environment and Lung Cancer | InTechOpen

Relationship Between Toxicogenomic and Environment and Lung Cancer | InTechOpen | Toxicogenética, Toxicogenómica || Toxicogenetics, Toxicogenomics | Scoop.it
Relationship Between Toxicogenomic and Environment and Lung Cancer | InTechOpen, Published on: 2013-02-13. Authors: M. Adonis, M. Chahuan, A. Zambrano, et
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Toxicogenómica: una nueva rama de la toxicología (M. A. Capó, 2007)

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Database Development in Toxicogenomics: Issues and Efforts (Mattes, 2004)

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EDGE: A Centralized Resource for the Comparison, Analysis, and Distribution of Toxicogenomic Information (Hayes, 2005)

Transcriptional profiling via microarrays holds great promise for toxicant classification and hazard prediction. Unfortunately, the use of different microarray platforms, protocols, and informatics often hinders the meaningful comparison of transcriptional profiling data across laboratories. One solution to this problem is to provide a low-cost and centralized resource that enables researchers to share toxicogenomic data that has been generated on a common platform. In an effort to create such a resource, we developed a standardized set of microarray reagents and reproducible protocols to simplify the analysis of liver gene expression in the mouse model. This resource, referred to as EDGE, was then used to generate a training set of 117 publicly accessible transcriptional profiles that can be accessed at http://edge.oncology.wisc.edu/.

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Toxicogenetics Trabajo de Doctorado en Salud Pública, PhD Luis E. ...

IDENTIFICACIÓN DE ESTUDIANTE ID: 16695HPU24412 LUIS ENRIQUE MEDINA MEDINA TITLE: TOXICOGENETICS

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TOXBANK Tutorials: The basics on Toxicogenomics (Part 3 / 3)

A tutorial on basics Toxicogenomics, by Professor Roland Grafström and Dr. Pekka Kohonen, Karolinska Institute (Stockholm, Sweden) 3 / 3 LINKS: Part 1: ht...
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TOXBANK Tutorials: The basics on Toxicogenomics (Part 1 / 3)

A tutorial on basics Toxicogenomics, by Professor Roland Grafström and Dr. Pekka Kohonen, Karolinska Institute (Stockholm, Sweden) 1 / 3 LINKS: Part 2: ht...
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Especialistas de la U. de Chile logran detección temprana del ... - Diario y Radio Uchile

Especialistas de la U. de Chile logran detección temprana del ... - Diario y Radio Uchile | Toxicogenética, Toxicogenómica || Toxicogenetics, Toxicogenomics | Scoop.it
Diario y Radio Uchile
Especialistas de la U. de Chile logran detección temprana del ...
Diario y Radio Uchile
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Nuevo algoritmo para evaluar y clasificar la literatura científica ...

Nuevo algoritmo para evaluar y clasificar la literatura científica ... | Toxicogenética, Toxicogenómica || Toxicogenetics, Toxicogenomics | Scoop.it
Los investigadores utilizan un algoritmo de minería de texto que dé prioridad a los trabajos de investigación para leer e incluir en su base de datos comparativa toxicogenómica (CTD), una base de datos pública mantenida y ...
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Toxicogenomics: challenges and opportunities (G. Orphanides, 2003)

Toxicogenomics describes the measurement of global gene expression changes in biological samples exposed to toxicants. This new technology promises to greatly facilitate research into toxicant mechanisms, with the possibility of assisting in the detection of compounds with the potential to cause adverse health effects earlier in the development of pharmaceutical and chemical products. In this short review, I discuss the opportunities presented by toxicogenomics, the challenges we face in the application of these tools, and the progress we have made in realising the potential of these new genomic approaches.

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DeCS Server - Toxicogenética

El estudio del conocimiento genético existente y la generación de nueva información genética, para entender y así evitar la TOXICIDAD DE MEDICAMENTOS y efectos adversos de sustancias tóxicas del medio ambiente.

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Toxicogenómica: una nueva disciplina para evaluar el riesgo de la contaminación

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Toxicogenética: Contaminantes, Metabolismo y Salud (1ª Edición)

"@cev_ugr: Curso online "Toxicogenética: Contaminantes, Metabolismo y Salud" con créditos #UGR http://t.co/zV0eC2jd"

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The Evolution of Bioinformatics in Toxicology: Advancing Toxicogenomics (Afshari, 2010)

As one reflects back through the past 50 years of scientific research, a significant accomplishment was the advance into the genomic era. Basic research scientists have uncovered the genetic code and the foundation of the most fundamental building blocks for the molecular activity that supports biological structure and function. Accompanying these structural and functional discoveries is the advance of techniques and technologies to probe molecular events, in time, across environmental and chemical exposures, within individuals, and across species. The field of toxicology has kept pace with advances in molecular study, and the past 50 years recognizes significant growth and explosive understanding of the impact of the compounds and environment to basic cellular and molecular machinery.

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Toxicogenetics: population-based testing of drug and chemical safety in mouse models (Ivan Rusyn, 2010)

The rapid decline in the cost of dense genotyping is paving the way for new DNA sequence-based laboratory tests to move quickly into clinical practice, and to ultimately help realize the promise of ‘personalized’ therapies. These advances are based on the growing appreciation of genetics as an important dimension in science and the practice of investigative pharmacology and toxicology. On the clinical side, both the regulators and the pharmaceutical industry hope that the early identification of individuals prone to adverse drug effects will keep advantageous medicines on the market for the benefit of the vast majority of prospective patients. On the environmental health protection side, there is a clear need for better science to define the range and causes of susceptibility to adverse effects of chemicals in the population, so that the appropriate regulatory limits are established. In both cases, most of the research effort is focused on genome-wide association studies in humans where de novo genotyping of each subject is required.

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