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Valuable new stem cells discovered in breast tissue - BioEdge

Valuable new stem cells discovered in breast tissue - BioEdge | Tissue Engineering&Biomedical news | Scoop.it
Valuable new stem cells discovered in breast tissue
BioEdge
Rare stem cells extracted from adult breast tissue are pluripotent and can become most cell types, researchers at the University of California at San Francisco have found.
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3D printed organs from regenerative living cells

3D printed organs from regenerative living cells | Tissue Engineering&Biomedical news | Scoop.it
artificial body tissue is 3D printed on demand using the latest regenerative and bio-engineering medical technologies.

Via Growthobjects
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Beating heart cells in a lab dish: Creating new tissue instead of transplanting hearts

Beating heart cells in a lab dish: Creating new tissue instead of transplanting hearts | Tissue Engineering&Biomedical news | Scoop.it
Embryonic stem cells can develop into any kind of tissue. Adult stem cells can still turn into different kinds of cells, but their differentiation potential is significantly reduced.
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Kidney cells grown in research lab | Nano in Regenerative Medicine & Tissue Engineering

Kidney cells grown in research lab | Nano in Regenerative Medicine & Tissue Engineering | Tissue Engineering&Biomedical news | Scoop.it
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Introduction to Tissue Engineering; Nanotechnology applications

Introduction to Tissue Engineering; Nanotechnology applications | Tissue Engineering&Biomedical news | Scoop.it
Author, editor; Tilda Barliya PhD Tissue Engineering is an emerging multidisciplinary field involving biology, medicine, and engineering that is likely to revolutionize the ways we improve the heal...

Via Luís Bastos
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Luís Bastos's curator insight, January 31, 2013 9:03 AM

Nanotechnological tools for tissue engineering may help design advanced nanocomposite scaffolds that can better mimic the ECM and eventually assemble more complex and larger functional tissues.

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3-D biomimetic scaffolds support regeneration of complex tissues from stem cells

3-D biomimetic scaffolds support regeneration of complex tissues from stem cells | Tissue Engineering&Biomedical news | Scoop.it
Stem cells can be grown on biocompatible scaffolds to form complex tissues such as bone, cartilage, and muscle for repair and regeneration of damaged or diseased tissue.
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Cell scientists aim to rebuild hearts with reprogrammed tissue

Cell scientists aim to rebuild hearts with reprogrammed tissue | Tissue Engineering&Biomedical news | Scoop.it
Researchers in Oxford and California experiment with medical technology that could make transplants unnecessary

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Every two minutes someone in the UK has a heart attack. Every six minutes, someone dies from heart failure. During an attack, the heart remodels itself and dilates around the site of the injury to try to compensate, but these repairs are rarely effective. If the attack does not kill you, heart failure later frequently will.

"No matter what other clinical interventions are available, heart transplantation is the only genuine cure for this," says Paul Riley, professor of regenerative medicine at Oxford University. "The problem is there is a dearth of heart donors."

Transplants have their own problems – successful operations require patients to remain on toxic, immune-suppressing drugs for life and their subsequent life expectancies are not usually longer than 20 years.

The solution, emerging from the laboratories of several groups of scientists around the world, is to work out how to rebuild damaged hearts. Their weapons of choice are reprogrammed stem cells.


Via Wildcat2030
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3-D biomimetic scaffolds support regeneration of complex tissues from stem cells

3-D biomimetic scaffolds support regeneration of complex tissues from stem cells | Tissue Engineering&Biomedical news | Scoop.it
Stem cells can be grown on biocompatible scaffolds to form complex tissues such as bone, cartilage, and muscle for repair and regeneration of damaged or diseased tissue.
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Shear thinning hydrogels hold promise in treating many diseases, including cancer

Gels that can be injected into the body, carrying drugs or cells that regenerate damaged tissue, hold promise for treating many types of disease, including cancer.
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This kind of gel can be mechanically stimulated with The TC-3 Bioreactor of Ebers Medical to study the biomaterial and cell behavour.

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Twitter / Ebersmedical : Hybrid scaffold holds promise ...

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New method for collagen scaffolds: Slice, stack, roll

New method for collagen scaffolds: Slice, stack, roll | Tissue Engineering&Biomedical news | Scoop.it
Engineers have developed a new technique, called bioskiving. The fabrication process creates collagen structures from thin sheets of decellularized tendon stacked with alternating fiber directions that maintain much of collagen's natural strength.

Via Luís Bastos
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Luís Bastos's curator insight, December 27, 2012 1:35 PM

Tufts University School of Engineering researchers have developed a novel method for fabricating collagen structures that maintains the collagen's natural strength and fiber structure, making it useful for a number of biomedical applications.

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New method for collagen scaffolds: Slice, stack, roll

New method for collagen scaffolds: Slice, stack, roll | Tissue Engineering&Biomedical news | Scoop.it
Engineers have developed a new technique, called bioskiving. The fabrication process creates collagen structures from thin sheets of decellularized tendon stacked with alternating fiber directions that maintain much of collagen's natural strength.

Via Luís Bastos
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Luís Bastos's curator insight, December 27, 2012 1:35 PM

Tufts University School of Engineering researchers have developed a novel method for fabricating collagen structures that maintains the collagen's natural strength and fiber structure, making it useful for a number of biomedical applications.

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Anthony Atala: Growing new organs | Video on TED.com

TED Talks Anthony Atala's state-of-the-art lab grows human organs -- from muscles to blood vessels to bladders, and more.
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Designing interlocking building blocks to create complex biological tissues

Designing interlocking building blocks to create complex biological tissues | Tissue Engineering&Biomedical news | Scoop.it

Researchers at Columbia Engineering have developed a new "plug-and-play" method to assemble complex cell microenvironments that is a scalable, highly precise way to fabricate tissues with any spatial organization or interest -- such as those found in the heart or skeleton or vasculature. The study reveals new ways to better mimic the enormous complexity of tissue development, regeneration, and disease.

 

"George Eng, an MD/PhD student in my lab who just received his doctoral degree, designed a lock-and-key technique to build cellular assemblies using a variety of shapes that lock into templates much the way you would use LEGO building blocks," says Gordana Vunjak-Novakovic, who led the study and is the Mikati Foundation Professor of Biomedical Engineering at Columbia Engineering and professor of medical sciences. "What is really important about this technique is that these shapes are tiny -- just a fraction of millimeter, the thickness of a human hair -- and that their precise arrangements are made using cell-friendly hydrogels."

 

Tissue cells in the human body form specific architectures that are critical for the function of each tissue. Cardiac cells, for example, are aligned to create maximum force acting in one direction. Cells without specific spatial organization may never become fully functional if they do not recapitulate their intrinsic organization found in the body. The Columbia Engineering technique enables researchers to construct unique and controlled cell patterns that allow precise studies of cell function, so that, Vunjak-Novakovic adds, "we can now ask some of the more complex questions about how the cells respond to the entire context of their environment. This will help us explore cellular behavior during the progression of disease and test the effects of drugs, stem cells, and various other therapeutic measures."

 

"We used a LEGO-like lock-and-key docking system to spatially localize different cell populations with high specificity and precision," Eng explains. "And, since each shape is docking independent of each other, large tissues can be organized simultaneously, instead of having to create a sequential, brick-by-brick type of organization. With this method, we can design and create better tissues for potential organ replacement."

 

"The beauty of this method is that complex configurations of living cellular material -- many different types of cells, molecules, and extracellular materials -- emerge in the lab in precise three-dimensional geometries in a way that can be used by anyone, as no special equipment is involved," Vunjak-Novakovic adds.

 

Eng is excited about leveraging the microtechnologies used to make computer chips with biomedical engineering techniques to make cells to fabricate new organs. "We develop new ideas and methods to try and alleviate disease by assembling tiny subunits of cells into larger, more functional organs," he says. "It's really like a scene from science fiction! To be on the frontier of scientific discovery, developing new methods and products that we hope will have therapeutic benefit for people is quite fulfilling and motivating. And there's such an exciting element of discovery in designing new cellular microenvironments, studying the rules that define cell communication and organization."

 

Next steps in the application of this new technique include fabrication of different types of functional tissues, such as well-organized cardiac muscle, a tissue whose function critically depends on its architecture and cell alignment, incorporating blood vessel networks along with organized cardiac cells. The method will also be extended to the design of pathological microenvironments of interest, such as tumor models.

 

"Our lab has worked for many years in building 'human-on-a-chip' systems that will allow us to see cellular responses representative of those of whole body physiology," says Vunjak-Novakovic. "We're also very interested in developing technologies that can advance biological experimentation and allow us to ask more complex questions. This study, which was conducted over the last four years, is contributing to both of these areas and helping us advance our methods for screening of therapeutic cells and factors."

 


Via Dr. Stefan Gruenwald
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Kidney cells grown in research lab

Kidney cells grown in research lab | Tissue Engineering&Biomedical news | Scoop.it
Kidney cells grown in research lab - | Get health news & research updates on beauty, body fitness, Sexual health, weight loss. Get to know all news on AIDS, Cancer, Addiction, Allergies, Anti-ageing, Backache & more news on health.

Via Luís Bastos
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Luís Bastos's curator insight, February 22, 2013 6:38 AM

Researchers from the Institute of Bioengineering and Nanotechnology (IBN) have successfully generated the renal cells under artificial conditions in the lab.

Carlos Garcia Pando's curator insight, February 22, 2013 10:13 AM

Next, we need to make a printer dedicated to print Kidneys. I guess thw easiest way will be engineering one machine for each kind of tissue.

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Small Companies Are Hubs of Future Profit in Regenerative Medicine: Gil Van Bokkelen

Small Companies Are Hubs of Future Profit in Regenerative Medicine: Gil Van Bokkelen | Tissue Engineering&Biomedical news | Scoop.it
Gil Van Bokkelen has been in the stem cell industry for more than a decade. In recent years, the co-founder, chairman and chief executive officer of Athersys Inc.
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In vitro growth factor-induced bio engineering of mature articular cartilage - Europe PMC Article - Europe PubMed Central

Europe PubMed Central (Europe PMC) is an archive of life sciences journal literature.
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Putting the squeeze on cells: By deforming cells, researchers can deliver RNA, proteins and nanoparticles for many applications

Putting the squeeze on cells: By deforming cells, researchers can deliver RNA, proteins and nanoparticles for many applications | Tissue Engineering&Biomedical news | Scoop.it
Living cells are surrounded by a membrane that tightly regulates what gets in and out of the cell.
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With TC3 bioreactor of Ebers you can deforming cells!!

More info: www.ebersmedical.com

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Tissue-engineered colon will help treat children

Tissue-engineered colon will help treat children | Tissue Engineering&Biomedical news | Scoop.it
Researchers at Childrens Hospital Los Angeles are celebrating a breakthrough: They have successfully grown a tissue-engineered human colon.

Via Carlos Garcia Pando
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Carlos Garcia Pando's curator insight, January 20, 2013 3:03 PM

 

Again, Dr. Grikscheit in the news: her approach to colon illness goes on wheels. New funding for their research

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A Piece of My Heart, From My Arm - ABC News

A Piece of My Heart, From My Arm - ABC News | Tissue Engineering&Biomedical news | Scoop.it
ABC News
A Piece of My Heart, From My Arm
ABC News
I left my heart in Minnesota -- a tiny, pulsing piece of it, anyway.
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Not all stem cells are equally efficient for use in regenerative medicine

Scientists at the University of Granada and Alcalá de Henares University have found out that not all isolated stem cells are equally valid in regenerative medicine and tissue engineering.
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New therapeutic technique to repair and rebuild muscle for degenerative muscle disorders

A study published today in BioMed Central's open access journal Skeletal Muscle reports of a new therapeutic technique to repair and rebuild muscle for sufferers of degenerative muscle disorders.
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Via News Medical

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IIMS - Asean: Hong Kong - Scientists in Hong Kong map initial anti-ageing formula

IIMS - Asean: Hong Kong - Scientists in Hong Kong map initial anti-ageing formula | Tissue Engineering&Biomedical news | Scoop.it
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via http://iims-asean.blogspot.com.es

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GEN | Magazine Articles: Regenerative Medicine: Engineering Its Continued Success

GEN | Magazine Articles: Regenerative Medicine: Engineering Its Continued Success | Tissue Engineering&Biomedical news | Scoop.it
What will it take to do well in this space going forward? (RT @GENbio: Regenerative Medicine: Engineering its continued success. What will it take to do well in this space going forward?
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Bone tissue engineering: Attaching proteins for better regeneration

Bone tissue engineering: Attaching proteins for better regeneration | Tissue Engineering&Biomedical news | Scoop.it
Researchers have demonstrated a new protein binding approach for effectively promoting bone regeneration. Current treatments for bone defects and bone tissue regeneration have significant limitations.
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