the mitochondrion
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the mitochondrion
how this semiautonomous subcellular organelle rules life and death
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Telomeres and Mitochondria in the Aging Heart

Telomeres and Mitochondria in the Aging Heart | the mitochondrion | Scoop.it

Telomere dysfunction induces a profound p53-dependent repression of the master regulators of mitochondrial biogenesis and function, peroxisome proliferator-activated receptor gamma coactivator (PGC)-1α and PGC-1β in the heart, which leads to bioenergetic compromise due to impaired oxidative phosphorylation and ATP generation.

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Mitochondrial Stress Engages E2F1 Apoptotic Signaling to Cause Deafness

Mitochondrial Stress Engages E2F1 Apoptotic Signaling to Cause Deafness | the mitochondrion | Scoop.it

In patient-derived A1555G cells, we show that 12S rRNA hypermethylation causes ROS-dependent activation of AMP kinase and the proapoptotic nuclear transcription factor E2F1. This retrograde mitochondrial-stress relay is operative in vivo, as transgenic-mtTFB1 mice exhibit enhanced 12S rRNA methylation in multiple tissues, increased E2F1 and apoptosis in the stria vascularis and spiral ganglion neurons of the inner ear, and progressive E2F1-dependent hearing loss.

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Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction

Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction | the mitochondrion | Scoop.it
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Reductive carboxylation supports growth in tumour cel... [Nature. 2011] - PubMed - NCBI

Reductive carboxylation supports growth in tumour cel... [Nature. 2011] - PubMed - NCBI | the mitochondrion | Scoop.it

Our findings reveal the novel induction of a versatile glutamine-dependent pathway that reverses many of the reactions of the canonical CAC, supports tumour cell growth, and explains how cells generate pools of CAC intermediates in the face of impaired mitochondrial metabolism.

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Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer

Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer | the mitochondrion | Scoop.it

ALT+ tumors acquired amplification/overexpression of PGC-1β, a master regulator of mitochondrial biogenesis and function, and they showed marked sensitivity to PGC-1β or SOD2 knockdown. Genetic modeling of telomerase extinction reveals vulnerabilities that motivate coincidental inhibition of mitochondrial maintenance and oxidative defense mechanisms to enhance antitelomerase cancer therapy.

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A third of the yeast mitochondrial proteome is dual localized: A question of evolution - Ben-Menachem - 2011 - PROTEOMICS - Wiley Online Library

A third of the yeast mitochondrial proteome is dual localized: A question of evolution - Ben-Menachem - 2011 - PROTEOMICS - Wiley Online Library | the mitochondrion | Scoop.it

http://onlinelibrary.wiley.com/doi/10.1002/pmic.201100199/full

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Influence of Inositol Pyrophosphates on Cellular Energy Dynamics

Influence of Inositol Pyrophosphates on Cellular Energy Dynamics | the mitochondrion | Scoop.it

Thus, inositol pyrophosphates regulate ATP concentration by altering the glycolytic/mitochondrial metabolic ratio. Metabolic reprogramming through inositol pyrophosphates is an evolutionary conserved mechanism that is also preserved in mammalian systems.

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Cell Metabolism - Power Surge: Supporting Cells “Fuel” Cancer Cell Mitochondria

Cell Metabolism - Power Surge: Supporting Cells “Fuel” Cancer Cell Mitochondria | the mitochondrion | Scoop.it

An emerging paradigm in tumor metabolism is that catabolism in host cells “fuels” the anabolic growth of cancer cells via energy transfer. A study in Nature Medicine (Nieman et al., 2011) supports this; they show that triglyceride catabolism in adipocytes drives ovarian cancer metastasis by providing fatty acids as mitochondrial fuels.

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