Fluostatins I–K from the South China Sea-Derived Micromonospora rosaria SCSIO N160 | The identification of a sea-floor microorganism that single-handedly conducts anaerobic oxidation of methane changes our picture of how the flux of this greenhouse gas from the ocean to the atmosphere is regulated. | Scoop.it

The strain SCSIO N160 was isolated from a South China Sea sediment sample and was characterized as a Micromonospora rosaria species on the basis of its 16S rRNA gene sequence. Three new fluostatins, I–K (1–3), were isolated from the culture of M. rosaria SCSIO N160, together with six known compounds, fluostatins C–F (4–7), rabelomycin (8), and phenanthroviridone (9). The structure of fluostatin D (5) was confirmed by an X-ray crystallographic study. The absolute configuration of 1 and 3 was assigned by electronic circular dichroism calculations. Compounds 8 and 9 exhibited good antimicrobial activities against Staphylococcus aureus ATCC 29213 with MIC values of 1.0 and 0.25 μg/mL, respectively. Compound 9 also exhibited significant in vitro cytotoxic activities toward SF-268 (IC50 0.09 μM) and MCF-7 (IC50 0.17 μM).

 

Wenjun Zhang, Zhong Liu, Sumei Li, Yongzhi Lu, Yuchan Chen, Haibo Zhang, Guangtao Zhang, Yiguang Zhu, Gaiyun Zhang, Weimin Zhang, Jinsong Liu, and Changsheng Zhang

J. Nat. Prod., Article ASAP

DOI: 10.1021/np300505y


Via NatProdChem